Glucosamine 6-phosphate N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actyltransferase-like protein

Species:

Leishmania major

UniProt:

Q4QG93_LEIMA

TriTrypDb:

LmjF.13.0610 , LMJLV39_130010100 , LMJSD75_130010200

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG93

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	7
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	7
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009225	nucleotide-sugar metabolic process	4	7
GO:0009226	nucleotide-sugar biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046349	amino sugar biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	7	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.626
CLV_NRD_NRD_1	177	179	PF00675	0.499
CLV_PCSK_FUR_1	175	179	PF00082	0.480
CLV_PCSK_KEX2_1	132	134	PF00082	0.648
CLV_PCSK_KEX2_1	177	179	PF00082	0.499
CLV_PCSK_SKI1_1	116	120	PF00082	0.532
CLV_PCSK_SKI1_1	164	168	PF00082	0.550
CLV_PCSK_SKI1_1	222	226	PF00082	0.438
CLV_PCSK_SKI1_1	228	232	PF00082	0.382
CLV_PCSK_SKI1_1	42	46	PF00082	0.513
CLV_PCSK_SKI1_1	59	63	PF00082	0.464
DOC_MAPK_gen_1	250	258	PF00069	0.436
DOC_MAPK_MEF2A_6	253	260	PF00069	0.355
DOC_MAPK_NFAT4_5	253	261	PF00069	0.319
DOC_PP2B_LxvP_1	258	261	PF13499	0.397
DOC_PP4_FxxP_1	79	82	PF00568	0.587
DOC_USP7_MATH_1	154	158	PF00917	0.598
DOC_USP7_MATH_1	36	40	PF00917	0.478
DOC_USP7_MATH_1	5	9	PF00917	0.559
DOC_WW_Pin1_4	245	250	PF00397	0.473
LIG_14-3-3_CanoR_1	164	169	PF00244	0.585
LIG_14-3-3_CanoR_1	228	234	PF00244	0.424
LIG_Actin_WH2_2	104	121	PF00022	0.502
LIG_APCC_ABBA_1	70	75	PF00400	0.539
LIG_APCC_ABBAyCdc20_2	69	75	PF00400	0.483
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BRCT_BRCA1_1	237	241	PF00533	0.513
LIG_eIF4E_1	163	169	PF01652	0.534
LIG_eIF4E_1	98	104	PF01652	0.451
LIG_FHA_1	171	177	PF00498	0.361
LIG_FHA_1	187	193	PF00498	0.280
LIG_FHA_2	246	252	PF00498	0.482
LIG_GBD_Chelix_1	95	103	PF00786	0.468
LIG_LIR_Apic_2	76	82	PF02991	0.590
LIG_LIR_Gen_1	22	31	PF02991	0.515
LIG_LIR_Gen_1	232	241	PF02991	0.417
LIG_LIR_Gen_1	46	55	PF02991	0.587
LIG_LIR_Nem_3	22	28	PF02991	0.517
LIG_LIR_Nem_3	232	236	PF02991	0.417
LIG_LIR_Nem_3	43	48	PF02991	0.486
LIG_LIR_Nem_3	86	91	PF02991	0.475
LIG_Pex14_1	229	233	PF04695	0.375
LIG_Pex14_2	225	229	PF04695	0.513
LIG_SH2_CRK	233	237	PF00017	0.439
LIG_SH2_CRK	48	52	PF00017	0.424
LIG_SH2_GRB2like	98	101	PF00017	0.414
LIG_SH2_NCK_1	242	246	PF00017	0.513
LIG_SH2_STAT5	242	245	PF00017	0.436
LIG_SH2_STAT5	247	250	PF00017	0.457
LIG_SH2_STAT5	48	51	PF00017	0.474
LIG_SH2_STAT5	98	101	PF00017	0.436
LIG_SH3_4	151	158	PF00018	0.689
LIG_SxIP_EBH_1	162	175	PF03271	0.541
LIG_TRAF2_1	81	84	PF00917	0.567
LIG_TYR_ITIM	231	236	PF00017	0.375
MOD_CDK_SPK_2	245	250	PF00069	0.436
MOD_CK1_1	150	156	PF00069	0.695
MOD_CK1_1	180	186	PF00069	0.690
MOD_CK1_1	65	71	PF00069	0.568
MOD_GlcNHglycan	124	128	PF01048	0.595
MOD_GlcNHglycan	152	155	PF01048	0.707
MOD_GlcNHglycan	182	185	PF01048	0.453
MOD_GlcNHglycan	202	205	PF01048	0.408
MOD_GSK3_1	1	8	PF00069	0.553
MOD_GSK3_1	143	150	PF00069	0.738
MOD_GSK3_1	46	53	PF00069	0.482
MOD_N-GLC_1	36	41	PF02516	0.466
MOD_N-GLC_1	5	10	PF02516	0.598
MOD_NEK2_1	1	6	PF00069	0.781
MOD_NEK2_1	117	122	PF00069	0.624
MOD_NEK2_1	123	128	PF00069	0.586
MOD_NEK2_1	62	67	PF00069	0.536
MOD_NEK2_2	154	159	PF00069	0.689
MOD_NEK2_2	170	175	PF00069	0.335
MOD_PKA_1	177	183	PF00069	0.651
MOD_PKA_2	177	183	PF00069	0.651
MOD_PKB_1	175	183	PF00069	0.629
MOD_Plk_1	5	11	PF00069	0.564
MOD_Plk_4	164	170	PF00069	0.552
MOD_Plk_4	46	52	PF00069	0.454
MOD_ProDKin_1	245	251	PF00069	0.473
MOD_SUMO_for_1	193	196	PF00179	0.397
MOD_SUMO_rev_2	106	111	PF00179	0.469
MOD_SUMO_rev_2	39	44	PF00179	0.454
MOD_SUMO_rev_2	53	61	PF00179	0.471
TRG_DiLeu_BaEn_1	107	112	PF01217	0.485
TRG_DiLeu_BaEn_1	30	35	PF01217	0.468
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.523
TRG_ENDOCYTIC_2	101	104	PF00928	0.465
TRG_ENDOCYTIC_2	233	236	PF00928	0.391
TRG_ENDOCYTIC_2	48	51	PF00928	0.474
TRG_ER_diArg_1	174	177	PF00400	0.397
TRG_ER_diArg_1	66	69	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B9	Leptomonas seymouri	56%	100%
A0A3S7WSF7	Leishmania donovani	92%	100%
A4H750	Leishmania braziliensis	70%	99%
A4HVJ0	Leishmania infantum	91%	100%
E9AP85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%