Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG92_LEIMA

TriTrypDb:

LmjF.13.0620 , LMJLV39_130010200 , LMJSD75_130010300

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.707
CLV_NRD_NRD_1	182	184	PF00675	0.646
CLV_NRD_NRD_1	276	278	PF00675	0.484
CLV_NRD_NRD_1	306	308	PF00675	0.443
CLV_NRD_NRD_1	313	315	PF00675	0.439
CLV_NRD_NRD_1	339	341	PF00675	0.426
CLV_NRD_NRD_1	382	384	PF00675	0.439
CLV_NRD_NRD_1	395	397	PF00675	0.425
CLV_NRD_NRD_1	73	75	PF00675	0.644
CLV_PCSK_KEX2_1	119	121	PF00082	0.707
CLV_PCSK_KEX2_1	276	278	PF00082	0.484
CLV_PCSK_KEX2_1	306	308	PF00082	0.443
CLV_PCSK_KEX2_1	313	315	PF00082	0.439
CLV_PCSK_KEX2_1	339	341	PF00082	0.394
CLV_PCSK_SKI1_1	313	317	PF00082	0.438
CLV_PCSK_SKI1_1	343	347	PF00082	0.426
CLV_PCSK_SKI1_1	383	387	PF00082	0.516
CLV_PCSK_SKI1_1	410	414	PF00082	0.435
DEG_APCC_DBOX_1	409	417	PF00400	0.414
DEG_SCF_FBW7_1	212	217	PF00400	0.699
DEG_SCF_FBW7_1	35	42	PF00400	0.653
DEG_SCF_FBW7_1	99	105	PF00400	0.566
DEG_SPOP_SBC_1	132	136	PF00917	0.650
DEG_SPOP_SBC_1	154	158	PF00917	0.822
DEG_SPOP_SBC_1	252	256	PF00917	0.634
DEG_SPOP_SBC_1	59	63	PF00917	0.619
DEG_SPOP_SBC_1	86	90	PF00917	0.677
DEG_SPOP_SBC_1	92	96	PF00917	0.612
DOC_CKS1_1	20	25	PF01111	0.583
DOC_CKS1_1	211	216	PF01111	0.703
DOC_CKS1_1	36	41	PF01111	0.654
DOC_CKS1_1	99	104	PF01111	0.565
DOC_MAPK_DCC_7	414	422	PF00069	0.509
DOC_MAPK_MEF2A_6	414	422	PF00069	0.509
DOC_USP7_MATH_1	102	106	PF00917	0.468
DOC_USP7_MATH_1	109	113	PF00917	0.628
DOC_USP7_MATH_1	132	136	PF00917	0.672
DOC_USP7_MATH_1	154	158	PF00917	0.648
DOC_USP7_MATH_1	230	234	PF00917	0.716
DOC_USP7_MATH_1	252	256	PF00917	0.619
DOC_USP7_MATH_1	59	63	PF00917	0.619
DOC_USP7_MATH_1	86	90	PF00917	0.777
DOC_USP7_MATH_1	92	96	PF00917	0.717
DOC_WW_Pin1_4	128	133	PF00397	0.754
DOC_WW_Pin1_4	147	152	PF00397	0.664
DOC_WW_Pin1_4	155	160	PF00397	0.786
DOC_WW_Pin1_4	172	177	PF00397	0.523
DOC_WW_Pin1_4	19	24	PF00397	0.543
DOC_WW_Pin1_4	210	215	PF00397	0.675
DOC_WW_Pin1_4	28	33	PF00397	0.535
DOC_WW_Pin1_4	35	40	PF00397	0.598
DOC_WW_Pin1_4	98	103	PF00397	0.574
LIG_14-3-3_CanoR_1	306	315	PF00244	0.438
LIG_14-3-3_CanoR_1	340	346	PF00244	0.360
LIG_14-3-3_CanoR_1	383	392	PF00244	0.508
LIG_APCC_ABBA_1	315	320	PF00400	0.442
LIG_APCC_ABBAyCdc20_2	314	320	PF00400	0.442
LIG_BRCT_BRCA1_1	23	27	PF00533	0.616
LIG_EH_1	47	51	PF12763	0.664
LIG_FHA_1	136	142	PF00498	0.611
LIG_FHA_1	292	298	PF00498	0.492
LIG_FHA_1	40	46	PF00498	0.659
LIG_FHA_1	79	85	PF00498	0.695
LIG_FHA_1	94	100	PF00498	0.522
LIG_FHA_2	321	327	PF00498	0.472
LIG_LIR_Apic_2	208	214	PF02991	0.633
LIG_LIR_Gen_1	9	19	PF02991	0.721
LIG_LIR_Nem_3	9	14	PF02991	0.745
LIG_LYPXL_yS_3	18	21	PF13949	0.609
LIG_PCNA_yPIPBox_3	354	364	PF02747	0.408
LIG_SH2_CRK	11	15	PF00017	0.674
LIG_SH2_CRK	190	194	PF00017	0.504
LIG_SH2_CRK	225	229	PF00017	0.697
LIG_SH3_3	148	154	PF00018	0.663
LIG_SH3_3	213	219	PF00018	0.705
LIG_SH3_3	267	273	PF00018	0.518
LIG_SH3_3	46	52	PF00018	0.585
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.432
LIG_SUMO_SIM_par_1	94	101	PF11976	0.596
LIG_TRAF2_1	324	327	PF00917	0.445
LIG_TRAF2_1	335	338	PF00917	0.429
LIG_TYR_ITIM	188	193	PF00017	0.450
LIG_TYR_ITIM	223	228	PF00017	0.655
MOD_CK1_1	105	111	PF00069	0.579
MOD_CK1_1	130	136	PF00069	0.605
MOD_CK1_1	217	223	PF00069	0.660
MOD_CK1_1	255	261	PF00069	0.623
MOD_CK1_1	282	288	PF00069	0.531
MOD_CK1_1	58	64	PF00069	0.783
MOD_CK1_1	73	79	PF00069	0.585
MOD_CK1_1	82	88	PF00069	0.631
MOD_CK1_1	95	101	PF00069	0.738
MOD_CK2_1	320	326	PF00069	0.489
MOD_Cter_Amidation	311	314	PF01082	0.442
MOD_GlcNHglycan	107	110	PF01048	0.667
MOD_GlcNHglycan	111	114	PF01048	0.648
MOD_GlcNHglycan	219	222	PF01048	0.608
MOD_GlcNHglycan	230	233	PF01048	0.690
MOD_GlcNHglycan	242	245	PF01048	0.543
MOD_GlcNHglycan	289	292	PF01048	0.603
MOD_GlcNHglycan	331	335	PF01048	0.377
MOD_GlcNHglycan	404	409	PF01048	0.448
MOD_GlcNHglycan	57	60	PF01048	0.672
MOD_GlcNHglycan	81	84	PF01048	0.749
MOD_GlcNHglycan	89	92	PF01048	0.723
MOD_GSK3_1	105	112	PF00069	0.554
MOD_GSK3_1	127	134	PF00069	0.774
MOD_GSK3_1	155	162	PF00069	0.779
MOD_GSK3_1	210	217	PF00069	0.687
MOD_GSK3_1	236	243	PF00069	0.802
MOD_GSK3_1	247	254	PF00069	0.586
MOD_GSK3_1	279	286	PF00069	0.562
MOD_GSK3_1	287	294	PF00069	0.526
MOD_GSK3_1	341	348	PF00069	0.406
MOD_GSK3_1	35	42	PF00069	0.668
MOD_GSK3_1	55	62	PF00069	0.492
MOD_GSK3_1	75	82	PF00069	0.526
MOD_GSK3_1	87	94	PF00069	0.587
MOD_GSK3_1	97	104	PF00069	0.523
MOD_N-GLC_1	55	60	PF02516	0.601
MOD_NEK2_1	253	258	PF00069	0.650
MOD_NEK2_1	308	313	PF00069	0.439
MOD_NEK2_1	341	346	PF00069	0.428
MOD_NEK2_1	93	98	PF00069	0.605
MOD_PKA_1	119	125	PF00069	0.709
MOD_PKA_1	383	389	PF00069	0.487
MOD_PKA_2	119	125	PF00069	0.689
MOD_PKA_2	390	396	PF00069	0.452
MOD_PKA_2	73	79	PF00069	0.747
MOD_PKB_1	77	85	PF00069	0.573
MOD_Plk_4	390	396	PF00069	0.503
MOD_ProDKin_1	128	134	PF00069	0.753
MOD_ProDKin_1	147	153	PF00069	0.660
MOD_ProDKin_1	155	161	PF00069	0.786
MOD_ProDKin_1	172	178	PF00069	0.524
MOD_ProDKin_1	19	25	PF00069	0.543
MOD_ProDKin_1	210	216	PF00069	0.673
MOD_ProDKin_1	28	34	PF00069	0.529
MOD_ProDKin_1	35	41	PF00069	0.602
MOD_ProDKin_1	98	104	PF00069	0.575
TRG_DiLeu_BaEn_1	337	342	PF01217	0.424
TRG_DiLeu_BaEn_4	327	333	PF01217	0.533
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.438
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.585
TRG_ENDOCYTIC_2	11	14	PF00928	0.632
TRG_ENDOCYTIC_2	18	21	PF00928	0.555
TRG_ENDOCYTIC_2	190	193	PF00928	0.482
TRG_ENDOCYTIC_2	225	228	PF00928	0.704
TRG_ER_diArg_1	119	121	PF00400	0.630
TRG_ER_diArg_1	275	277	PF00400	0.474
TRG_ER_diArg_1	306	308	PF00400	0.443
TRG_ER_diArg_1	313	315	PF00400	0.439
TRG_ER_diArg_1	339	341	PF00400	0.369
TRG_ER_diArg_1	77	80	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE7	Leptomonas seymouri	46%	100%
A0A3Q8I9J2	Leishmania donovani	90%	100%
A4H751	Leishmania braziliensis	74%	100%
A4HVJ1	Leishmania infantum	90%	100%
E9AP86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%