SPX domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG91_LEIMA

TriTrypDb:

LmjF.13.0630 , LMJLV39_130010300 , LMJSD75_130010400

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.562
CLV_NRD_NRD_1	150	152	PF00675	0.588
CLV_PCSK_KEX2_1	150	152	PF00082	0.588
CLV_PCSK_KEX2_1	41	43	PF00082	0.432
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.543
DEG_SPOP_SBC_1	87	91	PF00917	0.647
DOC_PP4_FxxP_1	283	286	PF00568	0.571
DOC_USP7_MATH_1	103	107	PF00917	0.707
DOC_USP7_MATH_1	138	142	PF00917	0.732
DOC_USP7_MATH_1	258	262	PF00917	0.625
DOC_USP7_MATH_1	26	30	PF00917	0.590
DOC_WW_Pin1_4	161	166	PF00397	0.646
DOC_WW_Pin1_4	88	93	PF00397	0.735
LIG_14-3-3_CanoR_1	120	126	PF00244	0.622
LIG_Actin_WH2_2	43	61	PF00022	0.527
LIG_BRCT_BRCA1_1	209	213	PF00533	0.517
LIG_deltaCOP1_diTrp_1	186	193	PF00928	0.652
LIG_eIF4E_1	52	58	PF01652	0.422
LIG_FHA_1	263	269	PF00498	0.693
LIG_FHA_1	52	58	PF00498	0.439
LIG_LIR_Apic_2	110	116	PF02991	0.526
LIG_LIR_Apic_2	282	286	PF02991	0.572
LIG_LIR_Gen_1	195	205	PF02991	0.495
LIG_LIR_Gen_1	3	12	PF02991	0.454
LIG_LIR_Nem_3	164	169	PF02991	0.670
LIG_LIR_Nem_3	195	201	PF02991	0.510
LIG_LIR_Nem_3	209	215	PF02991	0.494
LIG_LIR_Nem_3	3	8	PF02991	0.502
LIG_MLH1_MIPbox_1	209	213	PF16413	0.479
LIG_SH2_CRK	113	117	PF00017	0.535
LIG_SH2_NCK_1	73	77	PF00017	0.572
LIG_SH2_STAT5	218	221	PF00017	0.520
MOD_CK1_1	121	127	PF00069	0.666
MOD_CK1_1	146	152	PF00069	0.576
MOD_CK1_1	161	167	PF00069	0.614
MOD_CK1_1	262	268	PF00069	0.571
MOD_CK1_1	29	35	PF00069	0.562
MOD_CK1_1	60	66	PF00069	0.483
MOD_CK1_1	82	88	PF00069	0.652
MOD_CK1_1	91	97	PF00069	0.575
MOD_CK2_1	103	109	PF00069	0.580
MOD_GlcNHglycan	105	108	PF01048	0.645
MOD_GlcNHglycan	133	136	PF01048	0.649
MOD_GlcNHglycan	146	149	PF01048	0.573
MOD_GlcNHglycan	160	163	PF01048	0.733
MOD_GlcNHglycan	175	178	PF01048	0.660
MOD_GlcNHglycan	28	31	PF01048	0.501
MOD_GlcNHglycan	292	295	PF01048	0.536
MOD_GlcNHglycan	74	77	PF01048	0.583
MOD_GlcNHglycan	84	87	PF01048	0.585
MOD_GSK3_1	103	110	PF00069	0.683
MOD_GSK3_1	120	127	PF00069	0.506
MOD_GSK3_1	138	145	PF00069	0.617
MOD_GSK3_1	146	153	PF00069	0.586
MOD_GSK3_1	207	214	PF00069	0.525
MOD_GSK3_1	258	265	PF00069	0.728
MOD_GSK3_1	82	89	PF00069	0.661
MOD_N-GLC_1	103	108	PF02516	0.679
MOD_N-GLC_1	158	163	PF02516	0.750
MOD_N-GLC_1	258	263	PF02516	0.591
MOD_NEK2_1	108	113	PF00069	0.684
MOD_NEK2_1	125	130	PF00069	0.695
MOD_NEK2_1	267	272	PF00069	0.728
MOD_NEK2_1	51	56	PF00069	0.433
MOD_NEK2_1	57	62	PF00069	0.462
MOD_NEK2_1	72	77	PF00069	0.469
MOD_NEK2_2	97	102	PF00069	0.664
MOD_PIKK_1	118	124	PF00454	0.622
MOD_PIKK_1	207	213	PF00454	0.527
MOD_PIKK_1	29	35	PF00454	0.524
MOD_PIKK_1	45	51	PF00454	0.309
MOD_PIKK_1	79	85	PF00454	0.687
MOD_PKA_1	150	156	PF00069	0.582
MOD_PKA_2	150	156	PF00069	0.716
MOD_Plk_1	108	114	PF00069	0.676
MOD_Plk_1	15	21	PF00069	0.625
MOD_Plk_4	108	114	PF00069	0.667
MOD_Plk_4	279	285	PF00069	0.575
MOD_ProDKin_1	161	167	PF00069	0.641
MOD_ProDKin_1	88	94	PF00069	0.733
MOD_SUMO_rev_2	34	43	PF00179	0.537
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C2	Leptomonas seymouri	63%	100%
A0A3Q8I9G5	Leishmania donovani	96%	100%
A0A422NQM7	Trypanosoma rangeli	35%	100%
A4H752	Leishmania braziliensis	78%	100%
D0A6R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGJ9	Leishmania infantum	96%	100%
E9AP87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5AVG0	Trypanosoma cruzi	39%	100%