Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 6, putative

Species:

Leishmania major

UniProt:

Q4QG89_LEIMA

TriTrypDb:

LmjF.13.0650 , LMJLV39_130010500 , LMJSD75_130010600

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QG89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG89

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016409	palmitoyltransferase activity	5	9
GO:0016417	S-acyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	9
GO:0019707	protein-cysteine S-acyltransferase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.752
CLV_MEL_PAP_1	80	86	PF00089	0.426
CLV_NRD_NRD_1	167	169	PF00675	0.520
CLV_NRD_NRD_1	244	246	PF00675	0.460
CLV_NRD_NRD_1	250	252	PF00675	0.434
CLV_NRD_NRD_1	262	264	PF00675	0.378
CLV_NRD_NRD_1	275	277	PF00675	0.434
CLV_PCSK_KEX2_1	167	169	PF00082	0.520
CLV_PCSK_KEX2_1	244	246	PF00082	0.460
CLV_PCSK_KEX2_1	250	252	PF00082	0.434
CLV_PCSK_SKI1_1	20	24	PF00082	0.303
CLV_PCSK_SKI1_1	263	267	PF00082	0.446
CLV_Separin_Metazoa	118	122	PF03568	0.671
DEG_APCC_DBOX_1	249	257	PF00400	0.599
DEG_APCC_DBOX_1	262	270	PF00400	0.582
DEG_APCC_DBOX_1	313	321	PF00400	0.495
DEG_APCC_DBOX_1	500	508	PF00400	0.603
DEG_Kelch_Keap1_1	218	223	PF01344	0.677
DEG_SIAH_1	593	601	PF03145	0.687
DOC_CKS1_1	475	480	PF01111	0.589
DOC_MAPK_gen_1	244	255	PF00069	0.639
DOC_MAPK_gen_1	276	283	PF00069	0.574
DOC_MAPK_MEF2A_6	248	257	PF00069	0.603
DOC_MAPK_MEF2A_6	497	504	PF00069	0.579
DOC_MAPK_NFAT4_5	497	505	PF00069	0.583
DOC_PP4_FxxP_1	283	286	PF00568	0.562
DOC_USP7_MATH_1	123	127	PF00917	0.767
DOC_USP7_MATH_1	5	9	PF00917	0.690
DOC_USP7_MATH_1	533	537	PF00917	0.753
DOC_USP7_MATH_1	555	559	PF00917	0.803
DOC_USP7_MATH_2	77	83	PF00917	0.608
DOC_WW_Pin1_4	167	172	PF00397	0.694
DOC_WW_Pin1_4	3	8	PF00397	0.643
DOC_WW_Pin1_4	444	449	PF00397	0.716
DOC_WW_Pin1_4	474	479	PF00397	0.631
DOC_WW_Pin1_4	549	554	PF00397	0.784
DOC_WW_Pin1_4	581	586	PF00397	0.723
LIG_14-3-3_CanoR_1	128	135	PF00244	0.664
LIG_14-3-3_CanoR_1	167	171	PF00244	0.660
LIG_14-3-3_CanoR_1	358	363	PF00244	0.245
LIG_14-3-3_CanoR_1	503	508	PF00244	0.587
LIG_14-3-3_CanoR_1	83	89	PF00244	0.593
LIG_Actin_WH2_2	152	169	PF00022	0.686
LIG_AP2alpha_1	492	496	PF02296	0.573
LIG_APCC_ABBA_1	187	192	PF00400	0.704
LIG_APCC_ABBAyCdc20_2	186	192	PF00400	0.703
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	380	384	PF00533	0.342
LIG_EH1_1	16	24	PF00400	0.573
LIG_eIF4E_1	17	23	PF01652	0.573
LIG_eIF4E_1	333	339	PF01652	0.410
LIG_eIF4E_1	340	346	PF01652	0.340
LIG_eIF4E_1	41	47	PF01652	0.485
LIG_FHA_1	160	166	PF00498	0.634
LIG_FHA_1	195	201	PF00498	0.677
LIG_FHA_1	405	411	PF00498	0.659
LIG_FHA_1	475	481	PF00498	0.599
LIG_FHA_1	565	571	PF00498	0.725
LIG_FHA_1	65	71	PF00498	0.282
LIG_FHA_2	113	119	PF00498	0.723
LIG_FHA_2	170	176	PF00498	0.677
LIG_FHA_2	270	276	PF00498	0.597
LIG_FHA_2	461	467	PF00498	0.603
LIG_LIR_Apic_2	280	286	PF02991	0.562
LIG_LIR_Gen_1	142	151	PF02991	0.715
LIG_LIR_Gen_1	32	42	PF02991	0.391
LIG_LIR_Gen_1	331	341	PF02991	0.495
LIG_LIR_Gen_1	357	366	PF02991	0.346
LIG_LIR_Gen_1	372	382	PF02991	0.205
LIG_LIR_Gen_1	383	392	PF02991	0.263
LIG_LIR_Nem_3	142	148	PF02991	0.719
LIG_LIR_Nem_3	32	37	PF02991	0.361
LIG_LIR_Nem_3	331	337	PF02991	0.495
LIG_LIR_Nem_3	357	363	PF02991	0.346
LIG_LIR_Nem_3	372	378	PF02991	0.205
LIG_LIR_Nem_3	381	387	PF02991	0.267
LIG_LIR_Nem_3	427	432	PF02991	0.739
LIG_LIR_Nem_3	60	64	PF02991	0.340
LIG_NRBOX	405	411	PF00104	0.562
LIG_PCNA_PIPBox_1	347	356	PF02747	0.348
LIG_PCNA_yPIPBox_3	11	20	PF02747	0.616
LIG_Pex14_2	374	378	PF04695	0.377
LIG_Pex14_2	492	496	PF04695	0.589
LIG_Pex14_2	57	61	PF04695	0.302
LIG_PTB_Apo_2	327	334	PF02174	0.495
LIG_PTB_Phospho_1	327	333	PF10480	0.495
LIG_REV1ctd_RIR_1	360	369	PF16727	0.293
LIG_SH2_CRK	429	433	PF00017	0.702
LIG_SH2_GRB2like	328	331	PF00017	0.562
LIG_SH2_GRB2like	587	590	PF00017	0.672
LIG_SH2_NCK_1	41	45	PF00017	0.436
LIG_SH2_SRC	328	331	PF00017	0.562
LIG_SH2_SRC	395	398	PF00017	0.516
LIG_SH2_SRC	429	432	PF00017	0.757
LIG_SH2_STAP1	360	364	PF00017	0.315
LIG_SH2_STAP1	380	384	PF00017	0.162
LIG_SH2_STAP1	41	45	PF00017	0.465
LIG_SH2_STAT5	190	193	PF00017	0.663
LIG_SH2_STAT5	334	337	PF00017	0.302
LIG_SH2_STAT5	340	343	PF00017	0.264
LIG_SH2_STAT5	354	357	PF00017	0.162
LIG_SH2_STAT5	360	363	PF00017	0.162
LIG_SH2_STAT5	375	378	PF00017	0.377
LIG_SH2_STAT5	395	398	PF00017	0.364
LIG_SH2_STAT5	587	590	PF00017	0.672
LIG_SH3_3	137	143	PF00018	0.670
LIG_SH3_3	475	481	PF00018	0.551
LIG_SH3_3	539	545	PF00018	0.714
LIG_SH3_3	568	574	PF00018	0.715
LIG_SH3_3	71	77	PF00018	0.381
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.569
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.266
LIG_SUMO_SIM_anti_2	566	573	PF11976	0.660
LIG_SUMO_SIM_par_1	254	259	PF11976	0.569
LIG_TRAF2_1	172	175	PF00917	0.672
LIG_TRAF2_1	440	443	PF00917	0.680
LIG_TRAF2_1	448	451	PF00917	0.638
LIG_TYR_ITIM	338	343	PF00017	0.317
LIG_WRC_WIRS_1	58	63	PF05994	0.414
MOD_CK1_1	169	175	PF00069	0.614
MOD_CK1_1	198	204	PF00069	0.662
MOD_CK1_1	29	35	PF00069	0.496
MOD_CK1_1	434	440	PF00069	0.632
MOD_CK1_1	548	554	PF00069	0.742
MOD_CK1_1	581	587	PF00069	0.685
MOD_CK1_1	6	12	PF00069	0.589
MOD_CK1_1	65	71	PF00069	0.493
MOD_CK1_1	82	88	PF00069	0.359
MOD_CK2_1	112	118	PF00069	0.628
MOD_CK2_1	169	175	PF00069	0.610
MOD_CK2_1	460	466	PF00069	0.460
MOD_GlcNHglycan	200	203	PF01048	0.656
MOD_GlcNHglycan	223	228	PF01048	0.651
MOD_GlcNHglycan	3	6	PF01048	0.647
MOD_GlcNHglycan	366	369	PF01048	0.399
MOD_GlcNHglycan	380	383	PF01048	0.308
MOD_GlcNHglycan	42	45	PF01048	0.451
MOD_GlcNHglycan	442	447	PF01048	0.617
MOD_GlcNHglycan	535	538	PF01048	0.656
MOD_GlcNHglycan	580	583	PF01048	0.650
MOD_GlcNHglycan	590	593	PF01048	0.707
MOD_GlcNHglycan	71	74	PF01048	0.492
MOD_GlcNHglycan	84	87	PF01048	0.503
MOD_GSK3_1	1	8	PF00069	0.566
MOD_GSK3_1	123	130	PF00069	0.724
MOD_GSK3_1	194	201	PF00069	0.799
MOD_GSK3_1	354	361	PF00069	0.407
MOD_GSK3_1	449	456	PF00069	0.610
MOD_GSK3_1	545	552	PF00069	0.748
MOD_GSK3_1	583	590	PF00069	0.679
MOD_GSK3_1	65	72	PF00069	0.436
MOD_N-GLC_1	128	133	PF02516	0.702
MOD_N-GLC_1	299	304	PF02516	0.348
MOD_N-GLC_1	564	569	PF02516	0.515
MOD_N-GLC_1	588	593	PF02516	0.520
MOD_N-GLC_2	289	291	PF02516	0.348
MOD_N-GLC_2	309	311	PF02516	0.396
MOD_NEK2_1	1	6	PF00069	0.593
MOD_NEK2_1	166	171	PF00069	0.624
MOD_NEK2_1	18	23	PF00069	0.506
MOD_NEK2_1	299	304	PF00069	0.317
MOD_NEK2_1	341	346	PF00069	0.390
MOD_NEK2_1	378	383	PF00069	0.338
MOD_NEK2_1	449	454	PF00069	0.592
MOD_NEK2_1	57	62	PF00069	0.310
MOD_NEK2_1	64	69	PF00069	0.311
MOD_PIKK_1	150	156	PF00454	0.722
MOD_PK_1	503	509	PF00069	0.486
MOD_PKA_2	127	133	PF00069	0.606
MOD_PKA_2	166	172	PF00069	0.669
MOD_PKA_2	198	204	PF00069	0.561
MOD_PKA_2	82	88	PF00069	0.512
MOD_PKB_1	501	509	PF00069	0.483
MOD_Plk_1	434	440	PF00069	0.622
MOD_Plk_2-3	512	518	PF00069	0.624
MOD_Plk_4	341	347	PF00069	0.381
MOD_Plk_4	358	364	PF00069	0.259
MOD_Plk_4	369	375	PF00069	0.381
MOD_Plk_4	57	63	PF00069	0.357
MOD_Plk_4	583	589	PF00069	0.671
MOD_Plk_4	65	71	PF00069	0.428
MOD_ProDKin_1	167	173	PF00069	0.625
MOD_ProDKin_1	3	9	PF00069	0.551
MOD_ProDKin_1	444	450	PF00069	0.652
MOD_ProDKin_1	474	480	PF00069	0.544
MOD_ProDKin_1	549	555	PF00069	0.749
MOD_ProDKin_1	581	587	PF00069	0.670
MOD_SUMO_for_1	138	141	PF00179	0.504
MOD_SUMO_for_1	602	605	PF00179	0.626
TRG_DiLeu_BaEn_1	280	285	PF01217	0.407
TRG_DiLeu_BaEn_2	278	284	PF01217	0.455
TRG_DiLeu_LyEn_5	466	471	PF01217	0.366
TRG_ENDOCYTIC_2	333	336	PF00928	0.307
TRG_ENDOCYTIC_2	340	343	PF00928	0.259
TRG_ENDOCYTIC_2	360	363	PF00928	0.162
TRG_ENDOCYTIC_2	375	378	PF00928	0.377
TRG_ENDOCYTIC_2	429	432	PF00928	0.640
TRG_ER_diArg_1	105	108	PF00400	0.412
TRG_ER_diArg_1	166	168	PF00400	0.659
TRG_ER_diArg_1	243	245	PF00400	0.586
TRG_ER_diArg_1	249	251	PF00400	0.566
TRG_ER_diArg_1	500	503	PF00400	0.463
TRG_ER_diArg_1	556	559	PF00400	0.643
TRG_NES_CRM1_1	232	246	PF08389	0.566
TRG_NLS_MonoExtC_3	246	251	PF00514	0.561
TRG_NLS_MonoExtN_4	244	251	PF00514	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C7	Leptomonas seymouri	49%	96%
A0A3Q8ICU7	Leishmania donovani	92%	100%
A4H754	Leishmania braziliensis	71%	99%
A4HVJ3	Leishmania infantum	92%	100%
D0A6R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AP89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5AVF5	Trypanosoma cruzi	27%	100%