RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG88_LEIMA

TriTrypDb:

LmjF.13.0660 , LMJLV39_130010600 , LMJSD75_130010700

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG88

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.749
CLV_C14_Caspase3-7	599	603	PF00656	0.633
CLV_NRD_NRD_1	596	598	PF00675	0.745
CLV_NRD_NRD_1	616	618	PF00675	0.626
CLV_PCSK_FUR_1	694	698	PF00082	0.484
CLV_PCSK_KEX2_1	595	597	PF00082	0.750
CLV_PCSK_KEX2_1	616	618	PF00082	0.762
CLV_PCSK_KEX2_1	696	698	PF00082	0.620
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.672
CLV_PCSK_SKI1_1	123	127	PF00082	0.550
CLV_PCSK_SKI1_1	142	146	PF00082	0.330
CLV_PCSK_SKI1_1	319	323	PF00082	0.579
CLV_PCSK_SKI1_1	398	402	PF00082	0.358
CLV_PCSK_SKI1_1	466	470	PF00082	0.458
DEG_APCC_DBOX_1	141	149	PF00400	0.579
DEG_APCC_DBOX_1	465	473	PF00400	0.340
DEG_SCF_TRCP1_1	525	530	PF00400	0.523
DEG_SPOP_SBC_1	116	120	PF00917	0.418
DOC_MAPK_gen_1	639	647	PF00069	0.339
DOC_MAPK_MEF2A_6	425	432	PF00069	0.521
DOC_PP1_RVXF_1	247	253	PF00149	0.510
DOC_PP1_RVXF_1	393	400	PF00149	0.346
DOC_PP2B_LxvP_1	186	189	PF13499	0.541
DOC_USP7_MATH_1	116	120	PF00917	0.557
DOC_USP7_MATH_1	179	183	PF00917	0.536
DOC_USP7_MATH_1	201	205	PF00917	0.745
DOC_USP7_MATH_1	211	215	PF00917	0.734
DOC_USP7_MATH_1	25	29	PF00917	0.561
DOC_USP7_MATH_1	557	561	PF00917	0.656
DOC_USP7_MATH_1	6	10	PF00917	0.513
DOC_USP7_MATH_1	608	612	PF00917	0.809
DOC_USP7_MATH_2	113	119	PF00917	0.464
DOC_USP7_UBL2_3	619	623	PF12436	0.584
DOC_WW_Pin1_4	257	262	PF00397	0.609
DOC_WW_Pin1_4	362	367	PF00397	0.657
DOC_WW_Pin1_4	454	459	PF00397	0.547
DOC_WW_Pin1_4	516	521	PF00397	0.584
LIG_14-3-3_CanoR_1	249	253	PF00244	0.534
LIG_14-3-3_CanoR_1	330	335	PF00244	0.461
LIG_14-3-3_CanoR_1	478	482	PF00244	0.624
LIG_14-3-3_CanoR_1	588	592	PF00244	0.758
LIG_14-3-3_CanoR_1	597	607	PF00244	0.777
LIG_Actin_WH2_2	384	400	PF00022	0.453
LIG_Actin_WH2_2	633	650	PF00022	0.378
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_Clathr_ClatBox_1	441	445	PF01394	0.455
LIG_CtBP_PxDLS_1	261	265	PF00389	0.713
LIG_CtBP_PxDLS_1	458	462	PF00389	0.519
LIG_FAT_LD_1	241	249	PF03623	0.537
LIG_FHA_1	125	131	PF00498	0.384
LIG_FHA_1	15	21	PF00498	0.486
LIG_FHA_1	35	41	PF00498	0.327
LIG_FHA_1	377	383	PF00498	0.609
LIG_FHA_1	386	392	PF00498	0.378
LIG_FHA_1	407	413	PF00498	0.481
LIG_FHA_1	454	460	PF00498	0.500
LIG_FHA_1	573	579	PF00498	0.684
LIG_FHA_1	635	641	PF00498	0.335
LIG_FHA_1	88	94	PF00498	0.420
LIG_FHA_2	132	138	PF00498	0.535
LIG_FHA_2	193	199	PF00498	0.656
LIG_FHA_2	33	39	PF00498	0.556
LIG_FHA_2	571	577	PF00498	0.630
LIG_FHA_2	599	605	PF00498	0.748
LIG_GBD_Chelix_1	140	148	PF00786	0.585
LIG_LIR_Gen_1	124	133	PF02991	0.418
LIG_LIR_Gen_1	302	311	PF02991	0.449
LIG_LIR_Gen_1	518	529	PF02991	0.437
LIG_LIR_Gen_1	654	663	PF02991	0.447
LIG_LIR_Nem_3	124	129	PF02991	0.420
LIG_LIR_Nem_3	170	176	PF02991	0.403
LIG_LIR_Nem_3	302	307	PF02991	0.447
LIG_LIR_Nem_3	462	468	PF02991	0.415
LIG_LIR_Nem_3	508	512	PF02991	0.502
LIG_LIR_Nem_3	518	524	PF02991	0.371
LIG_LIR_Nem_3	654	658	PF02991	0.447
LIG_NRBOX	240	246	PF00104	0.537
LIG_NRBOX	392	398	PF00104	0.396
LIG_NRBOX	48	54	PF00104	0.475
LIG_NRBOX	573	579	PF00104	0.635
LIG_PCNA_PIPBox_1	177	186	PF02747	0.532
LIG_PCNA_yPIPBox_3	101	110	PF02747	0.608
LIG_Pex14_1	300	304	PF04695	0.513
LIG_Rb_LxCxE_1	67	81	PF01857	0.285
LIG_SH2_CRK	465	469	PF00017	0.491
LIG_SH2_STAP1	136	140	PF00017	0.527
LIG_SH2_STAP1	184	188	PF00017	0.518
LIG_SH2_STAT5	632	635	PF00017	0.355
LIG_SH2_STAT5	78	81	PF00017	0.422
LIG_SH3_3	452	458	PF00018	0.565
LIG_SH3_3	679	685	PF00018	0.363
LIG_SH3_3	80	86	PF00018	0.504
LIG_Sin3_3	141	148	PF02671	0.503
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.484
LIG_SUMO_SIM_anti_2	530	536	PF11976	0.459
LIG_SUMO_SIM_par_1	440	445	PF11976	0.341
LIG_TRAF2_1	103	106	PF00917	0.492
LIG_TRAF2_1	43	46	PF00917	0.609
LIG_TRAF2_1	539	542	PF00917	0.557
LIG_UBA3_1	468	476	PF00899	0.450
LIG_WRC_WIRS_1	216	221	PF05994	0.649
MOD_CK1_1	118	124	PF00069	0.508
MOD_CK1_1	204	210	PF00069	0.743
MOD_CK1_1	215	221	PF00069	0.529
MOD_CK1_1	260	266	PF00069	0.648
MOD_CK1_1	302	308	PF00069	0.513
MOD_CK1_1	333	339	PF00069	0.447
MOD_CK1_1	34	40	PF00069	0.495
MOD_CK1_1	370	376	PF00069	0.629
MOD_CK1_1	385	391	PF00069	0.472
MOD_CK1_1	482	488	PF00069	0.677
MOD_CK1_1	611	617	PF00069	0.785
MOD_CK1_1	672	678	PF00069	0.447
MOD_CK1_1	99	105	PF00069	0.591
MOD_CK2_1	111	117	PF00069	0.579
MOD_CK2_1	118	124	PF00069	0.530
MOD_CK2_1	179	185	PF00069	0.479
MOD_CK2_1	248	254	PF00069	0.483
MOD_CK2_1	570	576	PF00069	0.655
MOD_CK2_1	598	604	PF00069	0.688
MOD_CK2_1	6	12	PF00069	0.579
MOD_CK2_1	672	678	PF00069	0.449
MOD_CK2_1	99	105	PF00069	0.486
MOD_GlcNHglycan	120	123	PF01048	0.472
MOD_GlcNHglycan	206	209	PF01048	0.720
MOD_GlcNHglycan	23	26	PF01048	0.456
MOD_GlcNHglycan	27	30	PF01048	0.448
MOD_GlcNHglycan	287	290	PF01048	0.617
MOD_GlcNHglycan	301	304	PF01048	0.404
MOD_GlcNHglycan	342	345	PF01048	0.512
MOD_GlcNHglycan	362	365	PF01048	0.398
MOD_GlcNHglycan	371	375	PF01048	0.553
MOD_GlcNHglycan	525	528	PF01048	0.584
MOD_GlcNHglycan	578	581	PF01048	0.705
MOD_GlcNHglycan	598	601	PF01048	0.491
MOD_GlcNHglycan	62	65	PF01048	0.532
MOD_GlcNHglycan	66	69	PF01048	0.473
MOD_GlcNHglycan	671	674	PF01048	0.408
MOD_GSK3_1	111	118	PF00069	0.462
MOD_GSK3_1	131	138	PF00069	0.505
MOD_GSK3_1	14	21	PF00069	0.462
MOD_GSK3_1	152	159	PF00069	0.501
MOD_GSK3_1	184	191	PF00069	0.440
MOD_GSK3_1	207	214	PF00069	0.628
MOD_GSK3_1	244	251	PF00069	0.470
MOD_GSK3_1	253	260	PF00069	0.530
MOD_GSK3_1	385	392	PF00069	0.511
MOD_GSK3_1	479	486	PF00069	0.622
MOD_GSK3_1	523	530	PF00069	0.543
MOD_GSK3_1	572	579	PF00069	0.634
MOD_GSK3_1	60	67	PF00069	0.498
MOD_GSK3_1	608	615	PF00069	0.720
MOD_GSK3_1	96	103	PF00069	0.571
MOD_N-GLC_1	100	105	PF02516	0.457
MOD_N-GLC_1	257	262	PF02516	0.638
MOD_N-GLC_1	459	464	PF02516	0.470
MOD_N-GLC_1	482	487	PF02516	0.629
MOD_N-GLC_1	527	532	PF02516	0.493
MOD_N-GLC_1	60	65	PF02516	0.571
MOD_N-GLC_1	608	613	PF02516	0.719
MOD_NEK2_1	108	113	PF00069	0.488
MOD_NEK2_1	131	136	PF00069	0.404
MOD_NEK2_1	156	161	PF00069	0.411
MOD_NEK2_1	244	249	PF00069	0.531
MOD_NEK2_1	406	411	PF00069	0.444
MOD_NEK2_1	412	417	PF00069	0.404
MOD_NEK2_1	461	466	PF00069	0.462
MOD_NEK2_1	468	473	PF00069	0.408
MOD_NEK2_1	570	575	PF00069	0.580
MOD_NEK2_1	60	65	PF00069	0.528
MOD_NEK2_1	93	98	PF00069	0.483
MOD_NEK2_2	179	184	PF00069	0.493
MOD_PIKK_1	557	563	PF00454	0.648
MOD_PIKK_1	587	593	PF00454	0.717
MOD_PIKK_1	78	84	PF00454	0.491
MOD_PK_1	55	61	PF00069	0.485
MOD_PKA_1	596	602	PF00069	0.683
MOD_PKA_1	623	629	PF00069	0.566
MOD_PKA_1	696	702	PF00069	0.685
MOD_PKA_2	131	137	PF00069	0.392
MOD_PKA_2	248	254	PF00069	0.535
MOD_PKA_2	477	483	PF00069	0.628
MOD_PKA_2	587	593	PF00069	0.756
MOD_PKA_2	596	602	PF00069	0.777
MOD_PKA_2	696	702	PF00069	0.685
MOD_PKB_1	328	336	PF00069	0.506
MOD_Plk_1	100	106	PF00069	0.446
MOD_Plk_1	184	190	PF00069	0.541
MOD_Plk_1	527	533	PF00069	0.418
MOD_Plk_4	152	158	PF00069	0.422
MOD_Plk_4	179	185	PF00069	0.430
MOD_Plk_4	188	194	PF00069	0.450
MOD_Plk_4	382	388	PF00069	0.513
MOD_Plk_4	389	395	PF00069	0.484
MOD_Plk_4	55	61	PF00069	0.485
MOD_ProDKin_1	257	263	PF00069	0.617
MOD_ProDKin_1	362	368	PF00069	0.651
MOD_ProDKin_1	454	460	PF00069	0.546
MOD_ProDKin_1	516	522	PF00069	0.579
MOD_SUMO_rev_2	316	324	PF00179	0.547
MOD_SUMO_rev_2	599	608	PF00179	0.736
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.553
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.517
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.557
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.512
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.325
TRG_ENDOCYTIC_2	434	437	PF00928	0.407
TRG_ENDOCYTIC_2	465	468	PF00928	0.495
TRG_ER_diArg_1	327	330	PF00400	0.522
TRG_ER_diArg_1	594	597	PF00400	0.748
TRG_NES_CRM1_1	501	516	PF08389	0.576
TRG_NES_CRM1_1	554	566	PF08389	0.566
TRG_NLS_MonoExtN_4	619	626	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP8	Leptomonas seymouri	64%	100%
A0A1X0NN36	Trypanosomatidae	28%	100%
A0A3S7WSF2	Leishmania donovani	94%	100%
A0A422NQL1	Trypanosoma rangeli	30%	100%
A4H755	Leishmania braziliensis	80%	100%
A4HVJ4	Leishmania infantum	94%	100%
D0A6R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AP90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BAU6	Trypanosoma cruzi	30%	100%