Putative lectin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lectin

Gene product:

mannose-specific lectin, putative

Species:

Leishmania major

UniProt:

Q4QG87_LEIMA

TriTrypDb:

LmjF.13.0670 , LMJLV39_130010700 , LMJSD75_130010800

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	2
GO:0016020	membrane	2	5
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031090	organelle membrane	3	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QG87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG87

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006996	organelle organization	4	2
GO:0007029	endoplasmic reticulum organization	5	2
GO:0007030	Golgi organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005537	mannose binding	4	2
GO:0030246	carbohydrate binding	2	4
GO:0036094	small molecule binding	2	2
GO:0048029	monosaccharide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	444	448	PF00656	0.601
CLV_NRD_NRD_1	138	140	PF00675	0.533
CLV_NRD_NRD_1	421	423	PF00675	0.609
CLV_NRD_NRD_1	455	457	PF00675	0.664
CLV_NRD_NRD_1	458	460	PF00675	0.652
CLV_NRD_NRD_1	461	463	PF00675	0.644
CLV_NRD_NRD_1	467	469	PF00675	0.632
CLV_PCSK_FUR_1	453	457	PF00082	0.849
CLV_PCSK_FUR_1	459	463	PF00082	0.720
CLV_PCSK_KEX2_1	138	140	PF00082	0.568
CLV_PCSK_KEX2_1	421	423	PF00082	0.562
CLV_PCSK_KEX2_1	455	457	PF00082	0.657
CLV_PCSK_KEX2_1	458	460	PF00082	0.653
CLV_PCSK_KEX2_1	461	463	PF00082	0.645
CLV_PCSK_KEX2_1	467	469	PF00082	0.634
CLV_PCSK_SKI1_1	17	21	PF00082	0.458
DEG_SCF_FBW7_2	8	15	PF00400	0.442
DOC_MAPK_gen_1	138	146	PF00069	0.331
DOC_MAPK_gen_1	220	227	PF00069	0.239
DOC_MAPK_MEF2A_6	138	146	PF00069	0.331
DOC_MAPK_MEF2A_6	192	199	PF00069	0.294
DOC_MIT_MIM_1	417	426	PF04212	0.517
DOC_PIKK_1	439	446	PF02985	0.585
DOC_PP1_RVXF_1	185	192	PF00149	0.291
DOC_PP2B_LxvP_1	216	219	PF13499	0.336
DOC_PP4_FxxP_1	117	120	PF00568	0.320
DOC_PP4_FxxP_1	28	31	PF00568	0.291
DOC_USP7_MATH_1	142	146	PF00917	0.321
DOC_WW_Pin1_4	243	248	PF00397	0.452
DOC_WW_Pin1_4	462	467	PF00397	0.705
DOC_WW_Pin1_4	8	13	PF00397	0.481
LIG_14-3-3_CanoR_1	119	124	PF00244	0.291
LIG_14-3-3_CanoR_1	281	287	PF00244	0.661
LIG_BRCT_BRCA1_1	169	173	PF00533	0.355
LIG_FHA_1	18	24	PF00498	0.528
LIG_FHA_1	206	212	PF00498	0.374
LIG_FHA_1	229	235	PF00498	0.333
LIG_FHA_1	281	287	PF00498	0.692
LIG_FHA_1	403	409	PF00498	0.604
LIG_FHA_1	433	439	PF00498	0.718
LIG_FHA_1	66	72	PF00498	0.430
LIG_HP1_1	142	146	PF01393	0.333
LIG_LIR_Apic_2	27	31	PF02991	0.291
LIG_LIR_Gen_1	239	249	PF02991	0.474
LIG_LIR_Gen_1	54	62	PF02991	0.338
LIG_LIR_Gen_1	80	90	PF02991	0.298
LIG_LIR_Nem_3	121	126	PF02991	0.345
LIG_LIR_Nem_3	174	178	PF02991	0.350
LIG_LIR_Nem_3	239	245	PF02991	0.359
LIG_LIR_Nem_3	54	60	PF02991	0.359
LIG_LIR_Nem_3	80	85	PF02991	0.313
LIG_MYND_1	8	12	PF01753	0.446
LIG_Pex14_2	126	130	PF04695	0.333
LIG_SH2_CRK	112	116	PF00017	0.239
LIG_SH2_GRB2like	133	136	PF00017	0.333
LIG_SH2_GRB2like	273	276	PF00017	0.620
LIG_SH2_PTP2	57	60	PF00017	0.333
LIG_SH2_SRC	312	315	PF00017	0.644
LIG_SH2_SRC	325	328	PF00017	0.531
LIG_SH2_SRC	339	342	PF00017	0.519
LIG_SH2_SRC	352	355	PF00017	0.469
LIG_SH2_SRC	361	364	PF00017	0.460
LIG_SH2_SRC	371	374	PF00017	0.500
LIG_SH2_SRC	385	388	PF00017	0.559
LIG_SH2_STAP1	253	257	PF00017	0.563
LIG_SH2_STAP1	273	277	PF00017	0.622
LIG_SH2_STAT5	190	193	PF00017	0.348
LIG_SH2_STAT5	198	201	PF00017	0.299
LIG_SH2_STAT5	224	227	PF00017	0.270
LIG_SH2_STAT5	57	60	PF00017	0.333
LIG_SH3_3	103	109	PF00018	0.274
LIG_SH3_3	87	93	PF00018	0.416
LIG_TRAF2_1	12	15	PF00917	0.505
LIG_WW_1	109	112	PF00397	0.239
LIG_WW_3	108	112	PF00397	0.333
MOD_CDK_SPK_2	462	467	PF00069	0.690
MOD_CDK_SPxK_1	462	468	PF00069	0.633
MOD_CK1_1	167	173	PF00069	0.322
MOD_CK1_1	200	206	PF00069	0.333
MOD_CK1_1	228	234	PF00069	0.354
MOD_CK1_1	48	54	PF00069	0.333
MOD_DYRK1A_RPxSP_1	462	466	PF00069	0.704
MOD_GlcNHglycan	227	230	PF01048	0.601
MOD_GlcNHglycan	47	50	PF01048	0.497
MOD_GSK3_1	228	235	PF00069	0.300
MOD_GSK3_1	281	288	PF00069	0.746
MOD_GSK3_1	47	54	PF00069	0.310
MOD_NEK2_1	164	169	PF00069	0.364
MOD_NEK2_1	211	216	PF00069	0.296
MOD_NEK2_1	225	230	PF00069	0.437
MOD_PIKK_1	63	69	PF00454	0.291
MOD_PKA_2	118	124	PF00069	0.291
MOD_PKA_2	200	206	PF00069	0.313
MOD_PKA_2	280	286	PF00069	0.647
MOD_PKA_2	432	438	PF00069	0.633
MOD_PKA_2	58	64	PF00069	0.327
MOD_Plk_4	142	148	PF00069	0.333
MOD_Plk_4	291	297	PF00069	0.643
MOD_Plk_4	48	54	PF00069	0.333
MOD_ProDKin_1	243	249	PF00069	0.472
MOD_ProDKin_1	462	468	PF00069	0.706
MOD_ProDKin_1	8	14	PF00069	0.472
MOD_SUMO_for_1	191	194	PF00179	0.333
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.291
TRG_ENDOCYTIC_2	224	227	PF00928	0.270
TRG_ENDOCYTIC_2	57	60	PF00928	0.333
TRG_ENDOCYTIC_2	91	94	PF00928	0.291
TRG_ER_diArg_1	413	416	PF00400	0.596
TRG_ER_diArg_1	421	423	PF00400	0.575
TRG_ER_diArg_1	453	456	PF00400	0.654
TRG_ER_diArg_1	457	459	PF00400	0.654
TRG_ER_diArg_1	460	462	PF00400	0.647
TRG_ER_diArg_1	466	468	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8H3	Leishmania donovani	96%	100%
A4H756	Leishmania braziliensis	67%	100%
D0A6R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	87%