Peptidase_M24 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metallopeptidase family M24, putative

Species:

Leishmania major

UniProt:

Q4QG86_LEIMA

TriTrypDb:

LmjF.13.0680 , LMJLV39_130010800 , LMJSD75_130010900

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QG86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004177	aminopeptidase activity	5	4
GO:0008233	peptidase activity	3	4
GO:0008238	exopeptidase activity	4	4
GO:0016787	hydrolase activity	2	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	550	554	PF00656	0.558
CLV_MEL_PAP_1	486	492	PF00089	0.276
CLV_NRD_NRD_1	129	131	PF00675	0.598
CLV_NRD_NRD_1	214	216	PF00675	0.431
CLV_NRD_NRD_1	290	292	PF00675	0.235
CLV_NRD_NRD_1	371	373	PF00675	0.430
CLV_NRD_NRD_1	418	420	PF00675	0.337
CLV_NRD_NRD_1	537	539	PF00675	0.417
CLV_NRD_NRD_1	62	64	PF00675	0.682
CLV_NRD_NRD_1	72	74	PF00675	0.681
CLV_PCSK_FUR_1	18	22	PF00082	0.517
CLV_PCSK_FUR_1	356	360	PF00082	0.302
CLV_PCSK_FUR_1	70	74	PF00082	0.674
CLV_PCSK_KEX2_1	129	131	PF00082	0.614
CLV_PCSK_KEX2_1	20	22	PF00082	0.496
CLV_PCSK_KEX2_1	214	216	PF00082	0.360
CLV_PCSK_KEX2_1	292	294	PF00082	0.238
CLV_PCSK_KEX2_1	358	360	PF00082	0.363
CLV_PCSK_KEX2_1	371	373	PF00082	0.430
CLV_PCSK_KEX2_1	418	420	PF00082	0.321
CLV_PCSK_KEX2_1	499	501	PF00082	0.321
CLV_PCSK_KEX2_1	537	539	PF00082	0.503
CLV_PCSK_KEX2_1	563	565	PF00082	0.561
CLV_PCSK_KEX2_1	72	74	PF00082	0.671
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.488
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.195
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.363
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.360
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.561
CLV_PCSK_SKI1_1	202	206	PF00082	0.339
CLV_PCSK_SKI1_1	371	375	PF00082	0.454
CLV_PCSK_SKI1_1	412	416	PF00082	0.455
CLV_PCSK_SKI1_1	499	503	PF00082	0.363
CLV_PCSK_SKI1_1	63	67	PF00082	0.704
CLV_Separin_Metazoa	60	64	PF03568	0.548
DEG_APCC_DBOX_1	128	136	PF00400	0.474
DEG_APCC_DBOX_1	313	321	PF00400	0.236
DEG_APCC_DBOX_1	62	70	PF00400	0.588
DEG_COP1_1	354	365	PF00400	0.309
DOC_ANK_TNKS_1	358	365	PF00023	0.301
DOC_CYCLIN_RxL_1	199	208	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	536	542	PF00134	0.336
DOC_MAPK_FxFP_2	445	448	PF00069	0.413
DOC_MAPK_gen_1	18	27	PF00069	0.532
DOC_MAPK_gen_1	459	466	PF00069	0.456
DOC_MAPK_MEF2A_6	11	19	PF00069	0.512
DOC_MAPK_MEF2A_6	247	256	PF00069	0.236
DOC_MAPK_MEF2A_6	459	466	PF00069	0.339
DOC_PP4_FxxP_1	445	448	PF00568	0.413
DOC_USP7_MATH_1	313	317	PF00917	0.224
DOC_USP7_MATH_1	509	513	PF00917	0.509
DOC_USP7_MATH_1	7	11	PF00917	0.638
DOC_USP7_UBL2_3	95	99	PF12436	0.688
DOC_WW_Pin1_4	233	238	PF00397	0.422
DOC_WW_Pin1_4	292	297	PF00397	0.186
DOC_WW_Pin1_4	417	422	PF00397	0.460
DOC_WW_Pin1_4	556	561	PF00397	0.602
DOC_WW_Pin1_4	85	90	PF00397	0.522
LIG_14-3-3_CanoR_1	113	121	PF00244	0.560
LIG_14-3-3_CanoR_1	21	26	PF00244	0.497
LIG_14-3-3_CanoR_1	218	223	PF00244	0.272
LIG_14-3-3_CanoR_1	314	318	PF00244	0.443
LIG_14-3-3_CanoR_1	371	378	PF00244	0.440
LIG_14-3-3_CanoR_1	406	416	PF00244	0.410
LIG_14-3-3_CanoR_1	489	495	PF00244	0.267
LIG_14-3-3_CanoR_1	500	504	PF00244	0.305
LIG_14-3-3_CanoR_1	520	528	PF00244	0.260
LIG_14-3-3_CanoR_1	555	560	PF00244	0.415
LIG_14-3-3_CanoR_1	73	79	PF00244	0.537
LIG_Actin_WH2_2	311	327	PF00022	0.368
LIG_BIR_III_4	553	557	PF00653	0.412
LIG_BRCT_BRCA1_1	124	128	PF00533	0.600
LIG_DLG_GKlike_1	23	30	PF00625	0.502
LIG_FHA_1	184	190	PF00498	0.256
LIG_FHA_1	268	274	PF00498	0.312
LIG_FHA_1	332	338	PF00498	0.302
LIG_FHA_1	491	497	PF00498	0.320
LIG_FHA_1	508	514	PF00498	0.425
LIG_FHA_2	190	196	PF00498	0.396
LIG_FHA_2	280	286	PF00498	0.335
LIG_FHA_2	372	378	PF00498	0.444
LIG_FHA_2	406	412	PF00498	0.411
LIG_FHA_2	418	424	PF00498	0.394
LIG_FHA_2	434	440	PF00498	0.392
LIG_FHA_2	520	526	PF00498	0.498
LIG_FHA_2	548	554	PF00498	0.503
LIG_LIR_Apic_2	442	448	PF02991	0.406
LIG_LIR_Gen_1	541	549	PF02991	0.417
LIG_LIR_Nem_3	541	545	PF02991	0.392
LIG_MAD2	67	75	PF02301	0.556
LIG_PCNA_yPIPBox_3	218	232	PF02747	0.286
LIG_PCNA_yPIPBox_3	325	337	PF02747	0.299
LIG_Pex14_2	445	449	PF04695	0.409
LIG_RPA_C_Fungi	18	30	PF08784	0.622
LIG_SH2_STAT3	344	347	PF00017	0.368
LIG_SH2_STAT5	485	488	PF00017	0.365
LIG_SH3_3	510	516	PF00018	0.376
LIG_SUMO_SIM_anti_2	531	537	PF11976	0.466
LIG_SUMO_SIM_par_1	269	275	PF11976	0.270
LIG_SUMO_SIM_par_1	491	497	PF11976	0.313
LIG_TRAF2_1	436	439	PF00917	0.354
MOD_CDC14_SPxK_1	236	239	PF00782	0.368
MOD_CDK_SPxK_1	233	239	PF00069	0.388
MOD_CDK_SPxxK_3	556	563	PF00069	0.601
MOD_CK1_1	221	227	PF00069	0.288
MOD_CK1_1	279	285	PF00069	0.320
MOD_CK1_1	301	307	PF00069	0.379
MOD_CK1_1	354	360	PF00069	0.291
MOD_CK1_1	51	57	PF00069	0.766
MOD_CK1_1	521	527	PF00069	0.479
MOD_CK1_1	559	565	PF00069	0.610
MOD_CK1_1	77	83	PF00069	0.641
MOD_CK2_1	143	149	PF00069	0.552
MOD_CK2_1	189	195	PF00069	0.240
MOD_CK2_1	224	230	PF00069	0.352
MOD_CK2_1	279	285	PF00069	0.273
MOD_CK2_1	405	411	PF00069	0.410
MOD_CK2_1	433	439	PF00069	0.402
MOD_CK2_1	519	525	PF00069	0.390
MOD_Cter_Amidation	212	215	PF01082	0.336
MOD_GlcNHglycan	106	109	PF01048	0.641
MOD_GlcNHglycan	11	14	PF01048	0.514
MOD_GlcNHglycan	117	120	PF01048	0.511
MOD_GlcNHglycan	124	127	PF01048	0.460
MOD_GlcNHglycan	265	268	PF01048	0.327
MOD_GlcNHglycan	278	281	PF01048	0.259
MOD_GlcNHglycan	303	306	PF01048	0.368
MOD_GlcNHglycan	490	493	PF01048	0.267
MOD_GlcNHglycan	5	8	PF01048	0.534
MOD_GlcNHglycan	54	57	PF01048	0.795
MOD_GlcNHglycan	83	86	PF01048	0.655
MOD_GSK3_1	100	107	PF00069	0.797
MOD_GSK3_1	111	118	PF00069	0.577
MOD_GSK3_1	149	156	PF00069	0.471
MOD_GSK3_1	19	26	PF00069	0.489
MOD_GSK3_1	263	270	PF00069	0.286
MOD_GSK3_1	272	279	PF00069	0.324
MOD_GSK3_1	292	299	PF00069	0.344
MOD_GSK3_1	3	10	PF00069	0.523
MOD_GSK3_1	44	51	PF00069	0.721
MOD_GSK3_1	484	491	PF00069	0.354
MOD_GSK3_1	519	526	PF00069	0.385
MOD_GSK3_1	52	59	PF00069	0.670
MOD_GSK3_1	555	562	PF00069	0.599
MOD_GSK3_1	73	80	PF00069	0.650
MOD_GSK3_1	81	88	PF00069	0.619
MOD_N-GLC_1	154	159	PF02516	0.541
MOD_N-GLC_1	224	229	PF02516	0.236
MOD_N-GLC_1	233	238	PF02516	0.236
MOD_N-GLC_1	354	359	PF02516	0.287
MOD_N-GLC_1	433	438	PF02516	0.390
MOD_NEK2_1	154	159	PF00069	0.494
MOD_NEK2_1	19	24	PF00069	0.615
MOD_NEK2_1	205	210	PF00069	0.481
MOD_NEK2_1	490	495	PF00069	0.318
MOD_NEK2_1	519	524	PF00069	0.424
MOD_NEK2_1	78	83	PF00069	0.582
MOD_NEK2_2	94	99	PF00069	0.528
MOD_PIKK_1	120	126	PF00454	0.713
MOD_PKA_1	371	377	PF00069	0.448
MOD_PKA_1	499	505	PF00069	0.308
MOD_PKA_2	112	118	PF00069	0.539
MOD_PKA_2	13	19	PF00069	0.533
MOD_PKA_2	313	319	PF00069	0.180
MOD_PKA_2	371	377	PF00069	0.444
MOD_PKA_2	405	411	PF00069	0.383
MOD_PKA_2	488	494	PF00069	0.269
MOD_PKA_2	499	505	PF00069	0.308
MOD_PKA_2	519	525	PF00069	0.263
MOD_PKB_1	21	29	PF00069	0.507
MOD_Plk_1	149	155	PF00069	0.561
MOD_Plk_1	224	230	PF00069	0.236
MOD_Plk_1	433	439	PF00069	0.462
MOD_Plk_1	48	54	PF00069	0.531
MOD_Plk_1	524	530	PF00069	0.381
MOD_Plk_4	149	155	PF00069	0.382
MOD_Plk_4	241	247	PF00069	0.314
MOD_Plk_4	313	319	PF00069	0.346
MOD_Plk_4	412	418	PF00069	0.312
MOD_Plk_4	499	505	PF00069	0.308
MOD_Plk_4	74	80	PF00069	0.546
MOD_ProDKin_1	233	239	PF00069	0.422
MOD_ProDKin_1	292	298	PF00069	0.186
MOD_ProDKin_1	417	423	PF00069	0.474
MOD_ProDKin_1	556	562	PF00069	0.603
MOD_ProDKin_1	85	91	PF00069	0.520
TRG_ER_diArg_1	128	130	PF00400	0.528
TRG_ER_diArg_1	214	216	PF00400	0.397
TRG_ER_diArg_1	371	373	PF00400	0.430
TRG_ER_diArg_1	417	419	PF00400	0.306
TRG_ER_diArg_1	536	538	PF00400	0.502
TRG_ER_diArg_1	564	567	PF00400	0.589
TRG_ER_diArg_1	69	72	PF00400	0.685
TRG_NLS_MonoExtC_3	562	568	PF00514	0.515
TRG_NLS_MonoExtN_4	18	24	PF00514	0.508
TRG_NLS_MonoExtN_4	560	567	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM06	Leptomonas seymouri	70%	99%
A0A1X0NPS8	Trypanosomatidae	45%	100%
A0A3Q8IBA7	Leishmania donovani	30%	98%
A0A3Q8IBP5	Leishmania donovani	93%	100%
A0A3R7KN75	Trypanosoma rangeli	45%	100%
A4H757	Leishmania braziliensis	79%	100%
A4H9X3	Leishmania braziliensis	30%	95%
A4HVJ6	Leishmania infantum	93%	100%
D0A6Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AGR8	Leishmania infantum	30%	98%
E9AP92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9ARW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
O60180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q4QDK5	Leishmania major	30%	98%
Q6BI90	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
V5BFG1	Trypanosoma cruzi	46%	100%