PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania major

UniProt:

Q4QG85_LEIMA

TriTrypDb:

LmjF.13.0690 , LMJLV39_130010900 , LMJSD75_130011000

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.734
CLV_C14_Caspase3-7	346	350	PF00656	0.784
CLV_C14_Caspase3-7	816	820	PF00656	0.563
CLV_NRD_NRD_1	179	181	PF00675	0.819
CLV_NRD_NRD_1	292	294	PF00675	0.672
CLV_NRD_NRD_1	387	389	PF00675	0.741
CLV_NRD_NRD_1	450	452	PF00675	0.712
CLV_NRD_NRD_1	504	506	PF00675	0.724
CLV_NRD_NRD_1	742	744	PF00675	0.745
CLV_NRD_NRD_1	783	785	PF00675	0.493
CLV_NRD_NRD_1	838	840	PF00675	0.628
CLV_PCSK_KEX2_1	292	294	PF00082	0.687
CLV_PCSK_KEX2_1	386	388	PF00082	0.748
CLV_PCSK_KEX2_1	421	423	PF00082	0.803
CLV_PCSK_KEX2_1	450	452	PF00082	0.712
CLV_PCSK_KEX2_1	504	506	PF00082	0.724
CLV_PCSK_KEX2_1	742	744	PF00082	0.745
CLV_PCSK_KEX2_1	783	785	PF00082	0.504
CLV_PCSK_KEX2_1	794	796	PF00082	0.551
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.846
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.803
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.634
CLV_PCSK_SKI1_1	176	180	PF00082	0.730
CLV_PCSK_SKI1_1	623	627	PF00082	0.720
CLV_PCSK_SKI1_1	681	685	PF00082	0.582
CLV_PCSK_SKI1_1	783	787	PF00082	0.493
CLV_PCSK_SKI1_1	848	852	PF00082	0.411
CLV_PCSK_SKI1_1	911	915	PF00082	0.411
DEG_APCC_DBOX_1	910	918	PF00400	0.411
DEG_COP1_1	603	612	PF00400	0.720
DEG_SCF_FBW7_1	470	475	PF00400	0.725
DEG_SCF_FBW7_1	576	581	PF00400	0.809
DEG_SCF_FBW7_1	628	635	PF00400	0.689
DEG_SCF_FBW7_1	930	936	PF00400	0.563
DEG_SPOP_SBC_1	185	189	PF00917	0.721
DEG_SPOP_SBC_1	408	412	PF00917	0.667
DEG_SPOP_SBC_1	632	636	PF00917	0.715
DEG_SPOP_SBC_1	710	714	PF00917	0.677
DEG_SPOP_SBC_1	717	721	PF00917	0.681
DEG_SPOP_SBC_1	787	791	PF00917	0.499
DOC_CKS1_1	601	606	PF01111	0.724
DOC_CKS1_1	629	634	PF01111	0.725
DOC_CKS1_1	930	935	PF01111	0.579
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.720
DOC_CYCLIN_yCln2_LP_2	880	886	PF00134	0.411
DOC_MAPK_gen_1	794	801	PF00069	0.593
DOC_MAPK_MEF2A_6	191	200	PF00069	0.701
DOC_MAPK_MEF2A_6	794	801	PF00069	0.593
DOC_MAPK_MEF2A_6	879	886	PF00069	0.411
DOC_PP1_RVXF_1	895	901	PF00149	0.411
DOC_PP1_RVXF_1	905	911	PF00149	0.411
DOC_PP2B_LxvP_1	880	883	PF13499	0.411
DOC_PP4_FxxP_1	601	604	PF00568	0.728
DOC_USP7_MATH_1	104	108	PF00917	0.696
DOC_USP7_MATH_1	133	137	PF00917	0.749
DOC_USP7_MATH_1	146	150	PF00917	0.718
DOC_USP7_MATH_1	209	213	PF00917	0.514
DOC_USP7_MATH_1	281	285	PF00917	0.821
DOC_USP7_MATH_1	310	314	PF00917	0.691
DOC_USP7_MATH_1	34	38	PF00917	0.697
DOC_USP7_MATH_1	372	376	PF00917	0.733
DOC_USP7_MATH_1	390	394	PF00917	0.709
DOC_USP7_MATH_1	408	412	PF00917	0.692
DOC_USP7_MATH_1	43	47	PF00917	0.574
DOC_USP7_MATH_1	481	485	PF00917	0.755
DOC_USP7_MATH_1	491	495	PF00917	0.676
DOC_USP7_MATH_1	566	570	PF00917	0.773
DOC_USP7_MATH_1	578	582	PF00917	0.748
DOC_USP7_MATH_1	612	616	PF00917	0.733
DOC_USP7_MATH_1	632	636	PF00917	0.501
DOC_USP7_MATH_1	66	70	PF00917	0.765
DOC_USP7_MATH_1	668	672	PF00917	0.783
DOC_USP7_MATH_1	679	683	PF00917	0.642
DOC_USP7_MATH_1	698	702	PF00917	0.730
DOC_USP7_MATH_1	71	75	PF00917	0.678
DOC_USP7_MATH_1	717	721	PF00917	0.707
DOC_USP7_MATH_1	760	764	PF00917	0.798
DOC_USP7_MATH_1	787	791	PF00917	0.611
DOC_USP7_MATH_1	937	941	PF00917	0.763
DOC_USP7_UBL2_3	357	361	PF12436	0.742
DOC_WW_Pin1_4	179	184	PF00397	0.702
DOC_WW_Pin1_4	213	218	PF00397	0.685
DOC_WW_Pin1_4	259	264	PF00397	0.817
DOC_WW_Pin1_4	381	386	PF00397	0.732
DOC_WW_Pin1_4	468	473	PF00397	0.729
DOC_WW_Pin1_4	482	487	PF00397	0.696
DOC_WW_Pin1_4	5	10	PF00397	0.663
DOC_WW_Pin1_4	574	579	PF00397	0.755
DOC_WW_Pin1_4	58	63	PF00397	0.752
DOC_WW_Pin1_4	594	599	PF00397	0.803
DOC_WW_Pin1_4	600	605	PF00397	0.705
DOC_WW_Pin1_4	628	633	PF00397	0.723
DOC_WW_Pin1_4	688	693	PF00397	0.819
DOC_WW_Pin1_4	76	81	PF00397	0.655
DOC_WW_Pin1_4	762	767	PF00397	0.696
DOC_WW_Pin1_4	832	837	PF00397	0.619
DOC_WW_Pin1_4	901	906	PF00397	0.513
DOC_WW_Pin1_4	929	934	PF00397	0.563
LIG_14-3-3_CanoR_1	261	267	PF00244	0.593
LIG_14-3-3_CanoR_1	292	301	PF00244	0.642
LIG_14-3-3_CanoR_1	504	508	PF00244	0.719
LIG_14-3-3_CanoR_1	623	632	PF00244	0.719
LIG_14-3-3_CanoR_1	681	690	PF00244	0.719
LIG_14-3-3_CanoR_1	783	792	PF00244	0.491
LIG_14-3-3_CanoR_1	848	856	PF00244	0.438
LIG_Actin_WH2_2	778	796	PF00022	0.514
LIG_BRCT_BRCA1_1	483	487	PF00533	0.719
LIG_BRCT_BRCA1_1	7	11	PF00533	0.657
LIG_BRCT_BRCA1_1	722	726	PF00533	0.734
LIG_BRCT_BRCA1_1	94	98	PF00533	0.667
LIG_FHA_1	180	186	PF00498	0.576
LIG_FHA_1	254	260	PF00498	0.674
LIG_FHA_1	296	302	PF00498	0.620
LIG_FHA_1	33	39	PF00498	0.723
LIG_FHA_1	330	336	PF00498	0.702
LIG_FHA_1	369	375	PF00498	0.648
LIG_FHA_1	392	398	PF00498	0.756
LIG_FHA_1	408	414	PF00498	0.820
LIG_FHA_1	42	48	PF00498	0.616
LIG_FHA_1	437	443	PF00498	0.740
LIG_FHA_1	526	532	PF00498	0.844
LIG_FHA_1	601	607	PF00498	0.743
LIG_FHA_1	624	630	PF00498	0.719
LIG_FHA_1	682	688	PF00498	0.587
LIG_FHA_1	73	79	PF00498	0.693
LIG_FHA_1	832	838	PF00498	0.615
LIG_FHA_2	167	173	PF00498	0.818
LIG_FHA_2	244	250	PF00498	0.733
LIG_FHA_2	371	377	PF00498	0.801
LIG_FHA_2	378	384	PF00498	0.581
LIG_FHA_2	432	438	PF00498	0.745
LIG_FHA_2	849	855	PF00498	0.398
LIG_FHA_2	904	910	PF00498	0.513
LIG_LIR_Apic_2	899	905	PF02991	0.513
LIG_LIR_Gen_1	144	154	PF02991	0.716
LIG_LIR_Gen_1	203	209	PF02991	0.759
LIG_LIR_Gen_1	216	223	PF02991	0.602
LIG_LIR_Gen_1	916	925	PF02991	0.411
LIG_LIR_Gen_1	95	105	PF02991	0.733
LIG_LIR_Nem_3	144	150	PF02991	0.717
LIG_LIR_Nem_3	203	208	PF02991	0.760
LIG_LIR_Nem_3	216	221	PF02991	0.600
LIG_LIR_Nem_3	8	14	PF02991	0.656
LIG_LIR_Nem_3	853	859	PF02991	0.411
LIG_LIR_Nem_3	909	913	PF02991	0.411
LIG_LIR_Nem_3	916	921	PF02991	0.411
LIG_LIR_Nem_3	95	101	PF02991	0.736
LIG_MAD2	478	486	PF02301	0.707
LIG_MYND_1	845	849	PF01753	0.436
LIG_Pex14_2	201	205	PF04695	0.671
LIG_SH2_CRK	14	18	PF00017	0.698
LIG_SH2_CRK	147	151	PF00017	0.730
LIG_SH2_CRK	773	777	PF00017	0.497
LIG_SH2_NCK_1	123	127	PF00017	0.650
LIG_SH2_NCK_1	147	151	PF00017	0.730
LIG_SH2_NCK_1	316	320	PF00017	0.675
LIG_SH2_NCK_1	902	906	PF00017	0.513
LIG_SH2_SRC	316	319	PF00017	0.611
LIG_SH2_SRC	860	863	PF00017	0.513
LIG_SH2_STAP1	147	151	PF00017	0.730
LIG_SH2_STAP1	773	777	PF00017	0.497
LIG_SH2_STAT3	16	19	PF00017	0.738
LIG_SH2_STAT5	16	19	PF00017	0.738
LIG_SH2_STAT5	49	52	PF00017	0.548
LIG_SH3_3	190	196	PF00018	0.661
LIG_SH3_3	257	263	PF00018	0.773
LIG_SH3_3	56	62	PF00018	0.647
LIG_SH3_3	722	728	PF00018	0.688
LIG_SH3_3	77	83	PF00018	0.622
LIG_SH3_3	843	849	PF00018	0.389
LIG_SH3_3	909	915	PF00018	0.411
LIG_TRAF2_1	851	854	PF00917	0.411
LIG_TYR_ITIM	12	17	PF00017	0.735
LIG_WRC_WIRS_1	38	43	PF05994	0.763
MOD_CDC14_SPxK_1	691	694	PF00782	0.815
MOD_CDC14_SPxK_1	904	907	PF00782	0.513
MOD_CDK_SPK_2	381	386	PF00069	0.833
MOD_CDK_SPxK_1	381	387	PF00069	0.732
MOD_CDK_SPxK_1	472	478	PF00069	0.720
MOD_CDK_SPxK_1	574	580	PF00069	0.766
MOD_CDK_SPxK_1	688	694	PF00069	0.821
MOD_CDK_SPxK_1	901	907	PF00069	0.513
MOD_CDK_SPxxK_3	381	388	PF00069	0.734
MOD_CDK_SPxxK_3	832	839	PF00069	0.616
MOD_CK1_1	100	106	PF00069	0.698
MOD_CK1_1	109	115	PF00069	0.584
MOD_CK1_1	262	268	PF00069	0.828
MOD_CK1_1	295	301	PF00069	0.724
MOD_CK1_1	328	334	PF00069	0.794
MOD_CK1_1	37	43	PF00069	0.674
MOD_CK1_1	393	399	PF00069	0.760
MOD_CK1_1	519	525	PF00069	0.729
MOD_CK1_1	536	542	PF00069	0.637
MOD_CK1_1	57	63	PF00069	0.651
MOD_CK1_1	643	649	PF00069	0.740
MOD_CK1_1	652	658	PF00069	0.724
MOD_CK1_1	682	688	PF00069	0.718
MOD_CK1_1	719	725	PF00069	0.778
MOD_CK1_1	750	756	PF00069	0.800
MOD_CK1_1	79	85	PF00069	0.622
MOD_CK1_1	832	838	PF00069	0.615
MOD_CK1_1	91	97	PF00069	0.609
MOD_CK1_1	916	922	PF00069	0.513
MOD_CK2_1	166	172	PF00069	0.814
MOD_CK2_1	243	249	PF00069	0.737
MOD_CK2_1	370	376	PF00069	0.796
MOD_CK2_1	377	383	PF00069	0.737
MOD_CK2_1	426	432	PF00069	0.818
MOD_CK2_1	657	663	PF00069	0.798
MOD_CK2_1	682	688	PF00069	0.718
MOD_CK2_1	848	854	PF00069	0.411
MOD_GlcNHglycan	102	105	PF01048	0.676
MOD_GlcNHglycan	106	109	PF01048	0.673
MOD_GlcNHglycan	136	139	PF01048	0.791
MOD_GlcNHglycan	155	158	PF01048	0.744
MOD_GlcNHglycan	283	286	PF01048	0.833
MOD_GlcNHglycan	294	297	PF01048	0.558
MOD_GlcNHglycan	327	330	PF01048	0.800
MOD_GlcNHglycan	335	338	PF01048	0.700
MOD_GlcNHglycan	366	369	PF01048	0.824
MOD_GlcNHglycan	493	496	PF01048	0.814
MOD_GlcNHglycan	510	514	PF01048	0.555
MOD_GlcNHglycan	518	521	PF01048	0.758
MOD_GlcNHglycan	610	613	PF01048	0.730
MOD_GlcNHglycan	614	617	PF01048	0.733
MOD_GlcNHglycan	635	638	PF01048	0.799
MOD_GlcNHglycan	642	645	PF01048	0.760
MOD_GlcNHglycan	659	662	PF01048	0.555
MOD_GlcNHglycan	663	667	PF01048	0.776
MOD_GlcNHglycan	696	699	PF01048	0.816
MOD_GlcNHglycan	722	725	PF01048	0.799
MOD_GlcNHglycan	728	731	PF01048	0.699
MOD_GlcNHglycan	750	753	PF01048	0.809
MOD_GlcNHglycan	831	834	PF01048	0.603
MOD_GlcNHglycan	939	942	PF01048	0.703
MOD_GlcNHglycan	94	97	PF01048	0.725
MOD_GSK3_1	100	107	PF00069	0.734
MOD_GSK3_1	109	116	PF00069	0.704
MOD_GSK3_1	141	148	PF00069	0.711
MOD_GSK3_1	207	214	PF00069	0.588
MOD_GSK3_1	249	256	PF00069	0.676
MOD_GSK3_1	279	286	PF00069	0.796
MOD_GSK3_1	325	332	PF00069	0.632
MOD_GSK3_1	339	346	PF00069	0.792
MOD_GSK3_1	348	355	PF00069	0.704
MOD_GSK3_1	364	371	PF00069	0.565
MOD_GSK3_1	37	44	PF00069	0.672
MOD_GSK3_1	372	379	PF00069	0.589
MOD_GSK3_1	393	400	PF00069	0.705
MOD_GSK3_1	404	411	PF00069	0.678
MOD_GSK3_1	422	429	PF00069	0.606
MOD_GSK3_1	464	471	PF00069	0.703
MOD_GSK3_1	482	489	PF00069	0.695
MOD_GSK3_1	491	498	PF00069	0.791
MOD_GSK3_1	50	57	PF00069	0.524
MOD_GSK3_1	505	512	PF00069	0.610
MOD_GSK3_1	521	528	PF00069	0.735
MOD_GSK3_1	533	540	PF00069	0.785
MOD_GSK3_1	555	562	PF00069	0.769
MOD_GSK3_1	574	581	PF00069	0.620
MOD_GSK3_1	608	615	PF00069	0.775
MOD_GSK3_1	624	631	PF00069	0.720
MOD_GSK3_1	639	646	PF00069	0.719
MOD_GSK3_1	648	655	PF00069	0.800
MOD_GSK3_1	657	664	PF00069	0.734
MOD_GSK3_1	694	701	PF00069	0.783
MOD_GSK3_1	716	723	PF00069	0.683
MOD_GSK3_1	72	79	PF00069	0.669
MOD_GSK3_1	742	749	PF00069	0.762
MOD_GSK3_1	783	790	PF00069	0.505
MOD_GSK3_1	831	838	PF00069	0.595
MOD_GSK3_1	88	95	PF00069	0.551
MOD_GSK3_1	929	936	PF00069	0.573
MOD_GSK3_1	946	953	PF00069	0.717
MOD_LATS_1	503	509	PF00433	0.832
MOD_N-GLC_1	4	9	PF02516	0.762
MOD_N-GLC_1	559	564	PF02516	0.716
MOD_N-GLC_1	623	628	PF02516	0.760
MOD_N-GLC_1	632	637	PF02516	0.678
MOD_N-GLC_1	699	704	PF02516	0.761
MOD_NEK2_1	39	44	PF00069	0.662
MOD_NEK2_1	4	9	PF00069	0.731
MOD_NEK2_1	443	448	PF00069	0.691
MOD_NEK2_1	47	52	PF00069	0.677
MOD_NEK2_1	521	526	PF00069	0.735
MOD_NEK2_1	588	593	PF00069	0.761
MOD_NEK2_1	65	70	PF00069	0.648
MOD_NEK2_1	709	714	PF00069	0.599
MOD_NEK2_1	718	723	PF00069	0.562
MOD_NEK2_1	92	97	PF00069	0.704
MOD_NEK2_2	34	39	PF00069	0.698
MOD_NEK2_2	416	421	PF00069	0.599
MOD_NEK2_2	896	901	PF00069	0.513
MOD_PIKK_1	110	116	PF00454	0.714
MOD_PIKK_1	166	172	PF00454	0.699
MOD_PIKK_1	200	206	PF00454	0.747
MOD_PIKK_1	283	289	PF00454	0.747
MOD_PIKK_1	301	307	PF00454	0.416
MOD_PIKK_1	310	316	PF00454	0.652
MOD_PIKK_1	32	38	PF00454	0.701
MOD_PIKK_1	339	345	PF00454	0.755
MOD_PIKK_1	711	717	PF00454	0.819
MOD_PIKK_1	737	743	PF00454	0.734
MOD_PK_1	438	444	PF00069	0.718
MOD_PKA_1	292	298	PF00069	0.756
MOD_PKA_1	742	748	PF00069	0.763
MOD_PKA_1	783	789	PF00069	0.476
MOD_PKA_2	124	130	PF00069	0.755
MOD_PKA_2	231	237	PF00069	0.839
MOD_PKA_2	292	298	PF00069	0.736
MOD_PKA_2	343	349	PF00069	0.745
MOD_PKA_2	363	369	PF00069	0.779
MOD_PKA_2	503	509	PF00069	0.794
MOD_PKA_2	525	531	PF00069	0.842
MOD_PKA_2	612	618	PF00069	0.732
MOD_PKA_2	698	704	PF00069	0.733
MOD_PKA_2	742	748	PF00069	0.763
MOD_PKA_2	783	789	PF00069	0.466
MOD_PKB_1	174	182	PF00069	0.577
MOD_PKB_1	277	285	PF00069	0.602
MOD_Plk_1	509	515	PF00069	0.723
MOD_Plk_1	623	629	PF00069	0.761
MOD_Plk_1	866	872	PF00069	0.411
MOD_Plk_2-3	431	437	PF00069	0.697
MOD_Plk_4	34	40	PF00069	0.773
MOD_Plk_4	43	49	PF00069	0.620
MOD_Plk_4	438	444	PF00069	0.718
MOD_Plk_4	624	630	PF00069	0.719
MOD_Plk_4	788	794	PF00069	0.542
MOD_Plk_4	896	902	PF00069	0.411
MOD_Plk_4	913	919	PF00069	0.411
MOD_ProDKin_1	179	185	PF00069	0.700
MOD_ProDKin_1	213	219	PF00069	0.688
MOD_ProDKin_1	259	265	PF00069	0.819
MOD_ProDKin_1	381	387	PF00069	0.732
MOD_ProDKin_1	468	474	PF00069	0.728
MOD_ProDKin_1	482	488	PF00069	0.695
MOD_ProDKin_1	5	11	PF00069	0.661
MOD_ProDKin_1	574	580	PF00069	0.756
MOD_ProDKin_1	58	64	PF00069	0.752
MOD_ProDKin_1	594	600	PF00069	0.803
MOD_ProDKin_1	628	634	PF00069	0.723
MOD_ProDKin_1	688	694	PF00069	0.821
MOD_ProDKin_1	76	82	PF00069	0.657
MOD_ProDKin_1	762	768	PF00069	0.691
MOD_ProDKin_1	832	838	PF00069	0.615
MOD_ProDKin_1	901	907	PF00069	0.513
MOD_ProDKin_1	929	935	PF00069	0.569
TRG_DiLeu_BaEn_1	318	323	PF01217	0.571
TRG_DiLeu_BaEn_2	482	488	PF01217	0.672
TRG_DiLeu_BaEn_4	854	860	PF01217	0.411
TRG_DiLeu_BaLyEn_6	909	914	PF01217	0.411
TRG_ENDOCYTIC_2	14	17	PF00928	0.637
TRG_ENDOCYTIC_2	147	150	PF00928	0.729
TRG_ENDOCYTIC_2	773	776	PF00928	0.501
TRG_ENDOCYTIC_2	856	859	PF00928	0.411
TRG_ENDOCYTIC_2	860	863	PF00928	0.411
TRG_ER_diArg_1	173	176	PF00400	0.576
TRG_ER_diArg_1	292	294	PF00400	0.691
TRG_ER_diArg_1	387	389	PF00400	0.688
TRG_ER_diArg_1	783	785	PF00400	0.493
TRG_NLS_MonoExtC_3	385	390	PF00514	0.749
TRG_NLS_MonoExtN_4	385	390	PF00514	0.827
TRG_Pf-PMV_PEXEL_1	857	862	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9G3	Leptomonas seymouri	44%	88%
A0A3S5H6N7	Leishmania donovani	92%	100%
A4H758	Leishmania braziliensis	70%	90%
A4HVJ7	Leishmania infantum	92%	100%
E9AP93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%