Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania major

UniProt:

Q4QG83_LEIMA

TriTrypDb:

LmjF.13.0710 , LMJLV39_130011100 , LMJSD75_130011200

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG83

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0048200	Golgi transport vesicle coating	7	2
GO:0048205	COPI coating of Golgi vesicle	8	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	8
GO:0008047	enzyme activator activity	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0030695	GTPase regulator activity	4	8
GO:0060589	nucleoside-triphosphatase regulator activity	3	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.596
CLV_NRD_NRD_1	218	220	PF00675	0.496
CLV_NRD_NRD_1	252	254	PF00675	0.514
CLV_PCSK_KEX2_1	118	120	PF00082	0.356
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.356
CLV_PCSK_SKI1_1	426	430	PF00082	0.412
CLV_PCSK_SKI1_1	84	88	PF00082	0.286
CLV_PCSK_SKI1_1	94	98	PF00082	0.233
DEG_SCF_FBW7_1	170	177	PF00400	0.566
DEG_SPOP_SBC_1	318	322	PF00917	0.727
DEG_SPOP_SBC_1	348	352	PF00917	0.533
DOC_MAPK_gen_1	58	66	PF00069	0.262
DOC_MAPK_MEF2A_6	58	66	PF00069	0.262
DOC_MAPK_MEF2A_6	78	87	PF00069	0.144
DOC_MAPK_RevD_3	190	206	PF00069	0.550
DOC_PP1_RVXF_1	28	34	PF00149	0.262
DOC_PP2B_LxvP_1	7	10	PF13499	0.461
DOC_PP4_FxxP_1	33	36	PF00568	0.262
DOC_USP7_MATH_1	165	169	PF00917	0.673
DOC_USP7_MATH_1	172	176	PF00917	0.576
DOC_USP7_MATH_1	194	198	PF00917	0.526
DOC_USP7_MATH_1	406	410	PF00917	0.451
DOC_USP7_UBL2_3	217	221	PF12436	0.611
DOC_USP7_UBL2_3	94	98	PF12436	0.321
DOC_WW_Pin1_4	108	113	PF00397	0.413
DOC_WW_Pin1_4	135	140	PF00397	0.572
DOC_WW_Pin1_4	145	150	PF00397	0.516
DOC_WW_Pin1_4	153	158	PF00397	0.524
DOC_WW_Pin1_4	168	173	PF00397	0.522
DOC_WW_Pin1_4	174	179	PF00397	0.565
DOC_WW_Pin1_4	182	187	PF00397	0.444
DOC_WW_Pin1_4	319	324	PF00397	0.581
DOC_WW_Pin1_4	349	354	PF00397	0.706
LIG_14-3-3_CanoR_1	349	353	PF00244	0.514
LIG_14-3-3_CanoR_1	394	403	PF00244	0.535
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BRCT_BRCA1_1	155	159	PF00533	0.564
LIG_FHA_1	2	8	PF00498	0.550
LIG_FHA_1	202	208	PF00498	0.607
LIG_FHA_1	235	241	PF00498	0.570
LIG_FHA_1	296	302	PF00498	0.659
LIG_FHA_1	416	422	PF00498	0.476
LIG_FHA_1	44	50	PF00498	0.242
LIG_FHA_2	10	16	PF00498	0.437
LIG_FHA_2	230	236	PF00498	0.497
LIG_FHA_2	393	399	PF00498	0.538
LIG_LIR_Apic_2	107	112	PF02991	0.420
LIG_LIR_Gen_1	41	50	PF02991	0.262
LIG_LIR_Nem_3	369	373	PF02991	0.537
LIG_LIR_Nem_3	41	45	PF02991	0.262
LIG_LIR_Nem_3	46	50	PF02991	0.263
LIG_PDZ_Class_3	427	432	PF00595	0.425
LIG_PTB_Apo_2	372	379	PF02174	0.575
LIG_PTB_Phospho_1	372	378	PF10480	0.577
LIG_SH2_CRK	109	113	PF00017	0.361
LIG_SH2_NCK_1	109	113	PF00017	0.361
LIG_SH2_STAP1	246	250	PF00017	0.538
LIG_SH2_STAT5	109	112	PF00017	0.388
LIG_SH2_STAT5	378	381	PF00017	0.591
LIG_SH3_1	283	289	PF00018	0.631
LIG_SH3_2	323	328	PF14604	0.580
LIG_SH3_3	283	289	PF00018	0.631
LIG_SH3_3	320	326	PF00018	0.614
LIG_SH3_3	350	356	PF00018	0.679
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.281
LIG_SUMO_SIM_par_1	185	191	PF11976	0.544
LIG_TRAF2_1	12	15	PF00917	0.445
LIG_TRAF2_1	232	235	PF00917	0.501
MOD_CK1_1	107	113	PF00069	0.376
MOD_CK1_1	145	151	PF00069	0.600
MOD_CK1_1	168	174	PF00069	0.564
MOD_CK1_1	185	191	PF00069	0.709
MOD_CK1_1	197	203	PF00069	0.478
MOD_CK1_1	385	391	PF00069	0.482
MOD_CK1_1	41	47	PF00069	0.262
MOD_CK2_1	229	235	PF00069	0.503
MOD_CK2_1	9	15	PF00069	0.423
MOD_Cter_Amidation	217	220	PF01082	0.706
MOD_DYRK1A_RPxSP_1	349	353	PF00069	0.599
MOD_GlcNHglycan	135	138	PF01048	0.548
MOD_GlcNHglycan	174	177	PF01048	0.633
MOD_GlcNHglycan	209	212	PF01048	0.649
MOD_GlcNHglycan	303	306	PF01048	0.606
MOD_GlcNHglycan	341	344	PF01048	0.577
MOD_GlcNHglycan	358	361	PF01048	0.647
MOD_GlcNHglycan	387	390	PF01048	0.595
MOD_GlcNHglycan	412	415	PF01048	0.495
MOD_GlcNHglycan	70	73	PF01048	0.321
MOD_GSK3_1	104	111	PF00069	0.441
MOD_GSK3_1	155	162	PF00069	0.567
MOD_GSK3_1	166	173	PF00069	0.595
MOD_GSK3_1	174	181	PF00069	0.551
MOD_GSK3_1	193	200	PF00069	0.599
MOD_GSK3_1	229	236	PF00069	0.555
MOD_GSK3_1	313	320	PF00069	0.593
MOD_GSK3_1	344	351	PF00069	0.644
MOD_GSK3_1	380	387	PF00069	0.591
MOD_GSK3_1	406	413	PF00069	0.443
MOD_GSK3_1	64	71	PF00069	0.262
MOD_N-GLC_1	339	344	PF02516	0.604
MOD_NEK2_1	1	6	PF00069	0.723
MOD_NEK2_1	159	164	PF00069	0.476
MOD_NEK2_1	207	212	PF00069	0.600
MOD_NEK2_1	313	318	PF00069	0.635
MOD_NEK2_1	344	349	PF00069	0.764
MOD_NEK2_1	358	363	PF00069	0.675
MOD_NEK2_1	410	415	PF00069	0.460
MOD_PKA_2	295	301	PF00069	0.737
MOD_PKA_2	348	354	PF00069	0.572
MOD_Plk_1	339	345	PF00069	0.492
MOD_Plk_1	380	386	PF00069	0.568
MOD_Plk_4	104	110	PF00069	0.321
MOD_Plk_4	155	161	PF00069	0.670
MOD_Plk_4	188	194	PF00069	0.508
MOD_Plk_4	276	282	PF00069	0.629
MOD_ProDKin_1	108	114	PF00069	0.406
MOD_ProDKin_1	135	141	PF00069	0.580
MOD_ProDKin_1	145	151	PF00069	0.516
MOD_ProDKin_1	153	159	PF00069	0.524
MOD_ProDKin_1	168	174	PF00069	0.518
MOD_ProDKin_1	182	188	PF00069	0.552
MOD_ProDKin_1	319	325	PF00069	0.579
MOD_ProDKin_1	349	355	PF00069	0.698
MOD_SUMO_rev_2	11	19	PF00179	0.379
TRG_DiLeu_BaEn_1	15	20	PF01217	0.415
TRG_ENDOCYTIC_2	117	120	PF00928	0.410
TRG_ENDOCYTIC_2	47	50	PF00928	0.262
TRG_NLS_Bipartite_1	205	223	PF00514	0.557
TRG_NLS_MonoExtN_4	217	223	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	371	376	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I148	Leptomonas seymouri	61%	97%
A0A0S4JHE6	Bodo saltans	37%	100%
A0A3Q8IHZ4	Leishmania donovani	91%	98%
A1L520	Bos taurus	27%	83%
A4H760	Leishmania braziliensis	76%	98%
A4HVJ9	Leishmania infantum	91%	98%
E9AP95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q28CM8	Xenopus tropicalis	29%	82%
Q3MID3	Rattus norvegicus	29%	83%
Q5RAT7	Pongo abelii	27%	83%
Q8N6H7	Homo sapiens	27%	83%
Q99K28	Mus musculus	28%	83%