Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania major

UniProt:

Q4QG82_LEIMA

TriTrypDb:

LmjF.13.0720 , LMJLV39_130011200 , LMJSD75_130011300

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG82

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0003960	NADPH:quinone reductase activity	5	6
GO:0005488	binding	1	5
GO:0008270	zinc ion binding	6	5
GO:0016491	oxidoreductase activity	2	15
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	6
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.413
CLV_NRD_NRD_1	314	316	PF00675	0.349
CLV_PCSK_KEX2_1	161	163	PF00082	0.452
CLV_PCSK_SKI1_1	137	141	PF00082	0.311
CLV_PCSK_SKI1_1	162	166	PF00082	0.340
CLV_PCSK_SKI1_1	234	238	PF00082	0.336
CLV_PCSK_SKI1_1	88	92	PF00082	0.277
DOC_CYCLIN_RxL_1	290	301	PF00134	0.229
DOC_MAPK_gen_1	169	179	PF00069	0.349
DOC_MAPK_gen_1	315	322	PF00069	0.296

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	41%	100%
A0A0N0P7C5	Leptomonas seymouri	74%	100%
A0A0N1I913	Leptomonas seymouri	38%	100%
A0A0S4JMB1	Bodo saltans	52%	100%
A0A1X0P0B2	Trypanosomatidae	52%	100%
A0A1X0P8R2	Trypanosomatidae	29%	100%
A0A3Q8IRG0	Leishmania donovani	44%	100%
A0A3S7WSH2	Leishmania donovani	96%	100%
A0A3S7X2E3	Leishmania donovani	27%	100%
A0A422NF38	Trypanosoma rangeli	25%	100%

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