Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania major

UniProt:

Q4QG82_LEIMA

TriTrypDb:

LmjF.13.0720 , LMJLV39_130011200 , LMJSD75_130011300

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0016491	oxidoreductase activity	2	15
GO:0003960	NADPH:quinone reductase activity	5	6
GO:0005488	binding	1	5
GO:0008270	zinc ion binding	6	5
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	6
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0046914	transition metal ion binding	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.413
CLV_NRD_NRD_1	314	316	PF00675	0.349
CLV_PCSK_KEX2_1	161	163	PF00082	0.452
CLV_PCSK_SKI1_1	137	141	PF00082	0.311
CLV_PCSK_SKI1_1	162	166	PF00082	0.340
CLV_PCSK_SKI1_1	234	238	PF00082	0.336
CLV_PCSK_SKI1_1	88	92	PF00082	0.277
DOC_CYCLIN_RxL_1	290	301	PF00134	0.229
DOC_MAPK_gen_1	169	179	PF00069	0.349
DOC_MAPK_gen_1	315	322	PF00069	0.296
DOC_MAPK_MEF2A_6	172	179	PF00069	0.350
DOC_MAPK_MEF2A_6	315	322	PF00069	0.349
DOC_MAPK_MEF2A_6	383	392	PF00069	0.307
DOC_MAPK_NFAT4_5	172	180	PF00069	0.318
DOC_PP4_FxxP_1	332	335	PF00568	0.287
DOC_USP7_MATH_1	272	276	PF00917	0.253
DOC_USP7_MATH_1	311	315	PF00917	0.371
DOC_USP7_MATH_1	72	76	PF00917	0.481
DOC_USP7_UBL2_3	383	387	PF12436	0.310
DOC_WW_Pin1_4	228	233	PF00397	0.348
LIG_14-3-3_CanoR_1	293	298	PF00244	0.366
LIG_Actin_WH2_2	125	142	PF00022	0.370
LIG_BIR_II_1	1	5	PF00653	0.380
LIG_BRCT_BRCA1_1	11	15	PF00533	0.394
LIG_BRCT_BRCA1_1	329	333	PF00533	0.345
LIG_BRCT_BRCA1_1	66	70	PF00533	0.392
LIG_CtBP_PxDLS_1	176	180	PF00389	0.264
LIG_deltaCOP1_diTrp_1	377	380	PF00928	0.409
LIG_FHA_1	105	111	PF00498	0.374
LIG_FHA_1	181	187	PF00498	0.342
LIG_FHA_1	237	243	PF00498	0.426
LIG_FHA_1	329	335	PF00498	0.305
LIG_FHA_2	362	368	PF00498	0.245
LIG_LIR_Apic_2	330	335	PF02991	0.256
LIG_LIR_Gen_1	155	164	PF02991	0.300
LIG_LIR_Gen_1	370	380	PF02991	0.405
LIG_LIR_Nem_3	147	153	PF02991	0.279
LIG_LIR_Nem_3	155	159	PF02991	0.285
LIG_LIR_Nem_3	173	177	PF02991	0.460
LIG_LIR_Nem_3	364	369	PF02991	0.404
LIG_LIR_Nem_3	370	376	PF02991	0.403
LIG_LIR_Nem_3	57	61	PF02991	0.444
LIG_LIR_Nem_3	67	73	PF02991	0.406
LIG_LIR_Nem_3	78	84	PF02991	0.492
LIG_LYPXL_SIV_4	272	280	PF13949	0.370
LIG_MLH1_MIPbox_1	329	333	PF16413	0.370
LIG_PDZ_Class_2	387	392	PF00595	0.283
LIG_Pex14_2	119	123	PF04695	0.287
LIG_Pex14_2	333	337	PF04695	0.397
LIG_SH2_CRK	156	160	PF00017	0.285
LIG_SH2_CRK	340	344	PF00017	0.420
LIG_SH2_NCK_1	273	277	PF00017	0.287
LIG_SH2_NCK_1	373	377	PF00017	0.407
LIG_SH2_STAT5	174	177	PF00017	0.395
LIG_SH2_STAT5	96	99	PF00017	0.345
LIG_SH3_3	112	118	PF00018	0.311
LIG_SH3_3	188	194	PF00018	0.343
LIG_SH3_3	74	80	PF00018	0.475
LIG_SH3_3	81	87	PF00018	0.399
LIG_SUMO_SIM_par_1	128	134	PF11976	0.311
LIG_SUMO_SIM_par_1	175	180	PF11976	0.265
LIG_SUMO_SIM_par_1	5	10	PF11976	0.387
LIG_TYR_ITIM	271	276	PF00017	0.306
LIG_WRC_WIRS_1	329	334	PF05994	0.253
MOD_CDC14_SPxK_1	231	234	PF00782	0.274
MOD_CDK_SPxK_1	228	234	PF00069	0.274
MOD_CK1_1	180	186	PF00069	0.334
MOD_CK1_1	2	8	PF00069	0.381
MOD_CK1_1	22	28	PF00069	0.469
MOD_CK1_1	230	236	PF00069	0.370
MOD_CK1_1	328	334	PF00069	0.316
MOD_CK2_1	361	367	PF00069	0.246
MOD_CK2_1	72	78	PF00069	0.478
MOD_GlcNHglycan	133	136	PF01048	0.375
MOD_GlcNHglycan	178	182	PF01048	0.353
MOD_GlcNHglycan	2	5	PF01048	0.377
MOD_GlcNHglycan	24	27	PF01048	0.406
MOD_GlcNHglycan	325	328	PF01048	0.273
MOD_GlcNHglycan	38	41	PF01048	0.477
MOD_GSK3_1	221	228	PF00069	0.339
MOD_GSK3_1	323	330	PF00069	0.343
MOD_GSK3_1	7	14	PF00069	0.389
MOD_N-GLC_1	36	41	PF02516	0.668
MOD_N-GLC_1	99	104	PF02516	0.287
MOD_NEK2_1	177	182	PF00069	0.267
MOD_NEK2_1	19	24	PF00069	0.394
MOD_NEK2_1	238	243	PF00069	0.428
MOD_NEK2_1	323	328	PF00069	0.320
MOD_NEK2_1	9	14	PF00069	0.406
MOD_OFUCOSY	223	229	PF10250	0.365
MOD_PIKK_1	144	150	PF00454	0.314
MOD_PKB_1	291	299	PF00069	0.237
MOD_Plk_1	36	42	PF00069	0.667
MOD_Plk_2-3	362	368	PF00069	0.245
MOD_Plk_4	2	8	PF00069	0.423
MOD_Plk_4	221	227	PF00069	0.320
MOD_Plk_4	328	334	PF00069	0.293
MOD_Plk_4	72	78	PF00069	0.448
MOD_Plk_4	80	86	PF00069	0.415
MOD_ProDKin_1	228	234	PF00069	0.348
MOD_SUMO_rev_2	134	141	PF00179	0.370
TRG_ENDOCYTIC_2	150	153	PF00928	0.334
TRG_ENDOCYTIC_2	156	159	PF00928	0.318
TRG_ENDOCYTIC_2	174	177	PF00928	0.449
TRG_ENDOCYTIC_2	273	276	PF00928	0.309
TRG_ENDOCYTIC_2	340	343	PF00928	0.448
TRG_ENDOCYTIC_2	373	376	PF00928	0.402
TRG_ENDOCYTIC_2	58	61	PF00928	0.344
TRG_ENDOCYTIC_2	96	99	PF00928	0.414
TRG_ER_diArg_1	290	293	PF00400	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	41%	100%
A0A0N0P7C5	Leptomonas seymouri	74%	100%
A0A0N1I913	Leptomonas seymouri	38%	100%
A0A0S4JMB1	Bodo saltans	52%	100%
A0A1X0P0B2	Trypanosomatidae	52%	100%
A0A1X0P8R2	Trypanosomatidae	29%	100%
A0A3Q8IRG0	Leishmania donovani	44%	100%
A0A3S7WSH2	Leishmania donovani	96%	100%
A0A3S7X2E3	Leishmania donovani	27%	100%
A0A422NF38	Trypanosoma rangeli	25%	100%
A0A422NKE0	Trypanosoma rangeli	55%	100%
A0A451EJQ8	Leishmania donovani	31%	100%
A4H3L9	Leishmania braziliensis	31%	100%
A4H761	Leishmania braziliensis	90%	100%
A4HPT6	Leishmania braziliensis	43%	100%
A4HVK0	Leishmania infantum	96%	100%
A4I4G0	Leishmania infantum	27%	100%
A4IE56	Leishmania infantum	43%	100%
A6QQF5	Bos taurus	29%	100%
A7RK30	Nematostella vectensis	27%	100%
B0BNC9	Rattus norvegicus	29%	100%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ACK2	Leishmania major	31%	100%
E9ADV9	Leishmania major	27%	100%
E9AG46	Leishmania infantum	31%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
K4BW79	Solanum lycopersicum	26%	100%
O23939	Fragaria vesca	25%	100%
O34812	Bacillus subtilis (strain 168)	28%	100%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P11415	Cavia porcellus	27%	100%
P19333	Tetronarce californica	25%	100%
P42865	Leishmania amazonensis	43%	100%
P47199	Mus musculus	26%	100%
P76113	Escherichia coli (strain K12)	27%	100%
Q24K16	Bos taurus	43%	100%
Q39173	Arabidopsis thaliana	28%	100%
Q3MIE4	Rattus norvegicus	29%	97%
Q3UNZ8	Mus musculus	29%	100%
Q4Q0Z7	Leishmania major	44%	100%
Q53FA7	Homo sapiens	29%	100%
Q54YT4	Dictyostelium discoideum	25%	100%
Q62465	Mus musculus	29%	97%
Q6AYT0	Rattus norvegicus	26%	100%
Q6WAU0	Mentha piperita	29%	100%
Q80TB8	Mus musculus	24%	94%
Q84V25	Fragaria ananassa	25%	100%
Q8BGC4	Mus musculus	43%	100%
Q8JFV8	Danio rerio	28%	81%
Q8N4Q0	Homo sapiens	41%	100%
Q941I0	Fragaria ananassa	24%	100%
Q99536	Homo sapiens	30%	100%
Q9C0Y6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9HCJ6	Homo sapiens	24%	94%
Q9SV68	Arabidopsis thaliana	26%	100%
Q9V6U9	Drosophila melanogaster	24%	100%
Q9Z311	Rattus norvegicus	26%	100%