Ubiquitin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-like protein

Species:

Leishmania major

UniProt:

Q4QG81_LEIMA

TriTrypDb:

LmjF.13.0730 , LMJLV39_130011300 , LMJSD75_130011400

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.648
CLV_C14_Caspase3-7	701	705	PF00656	0.649
CLV_C14_Caspase3-7	722	726	PF00656	0.742
CLV_NRD_NRD_1	474	476	PF00675	0.545
CLV_NRD_NRD_1	645	647	PF00675	0.587
CLV_PCSK_KEX2_1	473	475	PF00082	0.554
CLV_PCSK_KEX2_1	645	647	PF00082	0.587
CLV_PCSK_SKI1_1	734	738	PF00082	0.751
CLV_Separin_Metazoa	538	542	PF03568	0.419
DEG_Nend_UBRbox_1	1	4	PF02207	0.588
DEG_SCF_FBW7_1	154	161	PF00400	0.655
DEG_SPOP_SBC_1	410	414	PF00917	0.596
DOC_CKS1_1	743	748	PF01111	0.699
DOC_MAPK_gen_1	370	380	PF00069	0.619
DOC_MAPK_gen_1	645	653	PF00069	0.605
DOC_MAPK_MEF2A_6	28	35	PF00069	0.446
DOC_PP2B_LxvP_1	445	448	PF13499	0.521
DOC_PP2B_LxvP_1	464	467	PF13499	0.300
DOC_PP4_FxxP_1	100	103	PF00568	0.731
DOC_PP4_MxPP_1	340	343	PF00568	0.590
DOC_SPAK_OSR1_1	34	38	PF12202	0.557
DOC_USP7_MATH_1	10	14	PF00917	0.613
DOC_USP7_MATH_1	110	114	PF00917	0.648
DOC_USP7_MATH_1	127	131	PF00917	0.520
DOC_USP7_MATH_1	189	193	PF00917	0.746
DOC_USP7_MATH_1	212	216	PF00917	0.654
DOC_USP7_MATH_1	235	239	PF00917	0.682
DOC_USP7_MATH_1	273	277	PF00917	0.600
DOC_USP7_MATH_1	336	340	PF00917	0.700
DOC_USP7_MATH_1	40	44	PF00917	0.538
DOC_USP7_MATH_1	517	521	PF00917	0.547
DOC_USP7_MATH_1	526	530	PF00917	0.434
DOC_USP7_MATH_1	620	624	PF00917	0.500
DOC_USP7_MATH_1	672	676	PF00917	0.639
DOC_USP7_MATH_1	752	756	PF00917	0.615
DOC_USP7_MATH_1	818	822	PF00917	0.609
DOC_USP7_MATH_2	742	748	PF00917	0.673
DOC_WW_Pin1_4	154	159	PF00397	0.725
DOC_WW_Pin1_4	161	166	PF00397	0.662
DOC_WW_Pin1_4	249	254	PF00397	0.746
DOC_WW_Pin1_4	286	291	PF00397	0.731
DOC_WW_Pin1_4	322	327	PF00397	0.724
DOC_WW_Pin1_4	338	343	PF00397	0.542
DOC_WW_Pin1_4	357	362	PF00397	0.457
DOC_WW_Pin1_4	428	433	PF00397	0.555
DOC_WW_Pin1_4	479	484	PF00397	0.539
DOC_WW_Pin1_4	623	628	PF00397	0.510
DOC_WW_Pin1_4	660	665	PF00397	0.687
DOC_WW_Pin1_4	734	739	PF00397	0.751
DOC_WW_Pin1_4	742	747	PF00397	0.639
DOC_WW_Pin1_4	793	798	PF00397	0.589
LIG_14-3-3_CanoR_1	28	32	PF00244	0.538
LIG_14-3-3_CanoR_1	373	380	PF00244	0.617
LIG_14-3-3_CanoR_1	392	396	PF00244	0.539
LIG_14-3-3_CanoR_1	495	504	PF00244	0.496
LIG_14-3-3_CanoR_1	556	564	PF00244	0.484
LIG_14-3-3_CanoR_1	645	653	PF00244	0.586
LIG_14-3-3_CanoR_1	758	766	PF00244	0.527
LIG_14-3-3_CanoR_1	786	793	PF00244	0.541
LIG_Actin_WH2_2	12	30	PF00022	0.394
LIG_BRCT_BRCA1_1	136	140	PF00533	0.661
LIG_BRCT_BRCA1_1	649	653	PF00533	0.531
LIG_CaM_IQ_9	487	502	PF13499	0.360
LIG_deltaCOP1_diTrp_1	829	833	PF00928	0.720
LIG_FHA_1	212	218	PF00498	0.667
LIG_FHA_1	39	45	PF00498	0.557
LIG_FHA_1	429	435	PF00498	0.517
LIG_FHA_1	67	73	PF00498	0.557
LIG_FHA_2	21	27	PF00498	0.557
LIG_FHA_2	250	256	PF00498	0.691
LIG_FHA_2	358	364	PF00498	0.614
LIG_FHA_2	397	403	PF00498	0.742
LIG_FHA_2	522	528	PF00498	0.541
LIG_HCF-1_HBM_1	544	547	PF13415	0.475
LIG_IBAR_NPY_1	836	838	PF08397	0.650
LIG_LIR_Apic_2	394	398	PF02991	0.707
LIG_LIR_Gen_1	113	123	PF02991	0.657
LIG_LIR_Gen_1	544	554	PF02991	0.471
LIG_LIR_Gen_1	710	721	PF02991	0.716
LIG_LIR_Nem_3	113	118	PF02991	0.649
LIG_LIR_Nem_3	124	128	PF02991	0.566
LIG_LIR_Nem_3	544	550	PF02991	0.473
LIG_LIR_Nem_3	710	716	PF02991	0.707
LIG_LYPXL_yS_3	615	618	PF13949	0.554
LIG_NRBOX	628	634	PF00104	0.496
LIG_Pex14_1	636	640	PF04695	0.512
LIG_SH2_CRK	115	119	PF00017	0.640
LIG_SH2_CRK	395	399	PF00017	0.657
LIG_SH2_CRK	458	462	PF00017	0.423
LIG_SH2_PTP2	547	550	PF00017	0.465
LIG_SH2_SRC	542	545	PF00017	0.470
LIG_SH2_STAP1	640	644	PF00017	0.550
LIG_SH2_STAT3	345	348	PF00017	0.669
LIG_SH2_STAT5	117	120	PF00017	0.632
LIG_SH2_STAT5	542	545	PF00017	0.470
LIG_SH2_STAT5	547	550	PF00017	0.411
LIG_SH2_STAT5	575	578	PF00017	0.448
LIG_SH2_STAT5	787	790	PF00017	0.575
LIG_SH3_3	260	266	PF00018	0.601
LIG_SH3_3	289	295	PF00018	0.846
LIG_SH3_3	340	346	PF00018	0.619
LIG_SH3_3	655	661	PF00018	0.694
LIG_SH3_3	666	672	PF00018	0.581
LIG_SH3_3	70	76	PF00018	0.557
LIG_SH3_3	804	810	PF00018	0.695
LIG_SUMO_SIM_anti_2	13	20	PF11976	0.411
LIG_SUMO_SIM_par_1	13	20	PF11976	0.411
LIG_SxIP_EBH_1	370	384	PF03271	0.612
LIG_TRAF2_1	360	363	PF00917	0.623
LIG_TRAF2_1	399	402	PF00917	0.708
LIG_TRAF2_1	467	470	PF00917	0.437
LIG_TRAF2_1	657	660	PF00917	0.564
LIG_TRAF2_1	762	765	PF00917	0.523
LIG_WW_1	342	345	PF00397	0.593
LIG_WW_3	325	329	PF00397	0.667
MOD_CDC14_SPxK_1	325	328	PF00782	0.713
MOD_CDK_SPK_2	734	739	PF00069	0.700
MOD_CDK_SPxK_1	322	328	PF00069	0.724
MOD_CK1_1	106	112	PF00069	0.726
MOD_CK1_1	134	140	PF00069	0.657
MOD_CK1_1	152	158	PF00069	0.544
MOD_CK1_1	161	167	PF00069	0.633
MOD_CK1_1	180	186	PF00069	0.512
MOD_CK1_1	223	229	PF00069	0.705
MOD_CK1_1	288	294	PF00069	0.618
MOD_CK1_1	422	428	PF00069	0.653
MOD_CK1_1	555	561	PF00069	0.536
MOD_CK1_1	58	64	PF00069	0.420
MOD_CK1_1	623	629	PF00069	0.453
MOD_CK1_1	647	653	PF00069	0.559
MOD_CK1_1	748	754	PF00069	0.581
MOD_CK2_1	20	26	PF00069	0.420
MOD_CK2_1	249	255	PF00069	0.718
MOD_CK2_1	357	363	PF00069	0.614
MOD_CK2_1	396	402	PF00069	0.735
MOD_CK2_1	521	527	PF00069	0.553
MOD_CK2_1	758	764	PF00069	0.579
MOD_CK2_1	819	825	PF00069	0.677
MOD_CMANNOS	830	833	PF00535	0.728
MOD_GlcNHglycan	112	115	PF01048	0.703
MOD_GlcNHglycan	118	121	PF01048	0.633
MOD_GlcNHglycan	154	157	PF01048	0.716
MOD_GlcNHglycan	191	194	PF01048	0.724
MOD_GlcNHglycan	275	278	PF01048	0.607
MOD_GlcNHglycan	421	424	PF01048	0.668
MOD_GlcNHglycan	504	507	PF01048	0.447
MOD_GlcNHglycan	519	522	PF01048	0.461
MOD_GlcNHglycan	557	560	PF01048	0.503
MOD_GlcNHglycan	582	585	PF01048	0.476
MOD_GlcNHglycan	590	593	PF01048	0.419
MOD_GlcNHglycan	608	611	PF01048	0.369
MOD_GlcNHglycan	749	753	PF01048	0.573
MOD_GlcNHglycan	760	763	PF01048	0.565
MOD_GlcNHglycan	802	805	PF01048	0.702
MOD_GlcNHglycan	825	829	PF01048	0.601
MOD_GlcNHglycan	840	843	PF01048	0.616
MOD_GlcNHglycan	88	93	PF01048	0.732
MOD_GSK3_1	106	113	PF00069	0.695
MOD_GSK3_1	127	134	PF00069	0.637
MOD_GSK3_1	154	161	PF00069	0.720
MOD_GSK3_1	219	226	PF00069	0.687
MOD_GSK3_1	245	252	PF00069	0.729
MOD_GSK3_1	253	260	PF00069	0.650
MOD_GSK3_1	314	321	PF00069	0.699
MOD_GSK3_1	387	394	PF00069	0.750
MOD_GSK3_1	418	425	PF00069	0.703
MOD_GSK3_1	437	444	PF00069	0.304
MOD_GSK3_1	512	519	PF00069	0.521
MOD_GSK3_1	601	608	PF00069	0.467
MOD_GSK3_1	619	626	PF00069	0.390
MOD_GSK3_1	640	647	PF00069	0.506
MOD_GSK3_1	689	696	PF00069	0.628
MOD_GSK3_1	744	751	PF00069	0.655
MOD_GSK3_1	754	761	PF00069	0.468
MOD_GSK3_1	793	800	PF00069	0.574
MOD_GSK3_1	820	827	PF00069	0.738
MOD_N-GLC_1	418	423	PF02516	0.732
MOD_N-GLC_1	476	481	PF02516	0.469
MOD_N-GLC_1	797	802	PF02516	0.610
MOD_N-GLC_1	819	824	PF02516	0.665
MOD_NEK2_1	128	133	PF00069	0.636
MOD_NEK2_1	220	225	PF00069	0.636
MOD_NEK2_1	27	32	PF00069	0.394
MOD_NEK2_1	318	323	PF00069	0.756
MOD_NEK2_1	502	507	PF00069	0.459
MOD_NEK2_1	546	551	PF00069	0.413
MOD_NEK2_1	554	559	PF00069	0.414
MOD_NEK2_1	578	583	PF00069	0.453
MOD_NEK2_1	605	610	PF00069	0.513
MOD_NEK2_1	628	633	PF00069	0.496
MOD_NEK2_2	40	45	PF00069	0.394
MOD_NEK2_2	640	645	PF00069	0.495
MOD_PIKK_1	212	218	PF00454	0.767
MOD_PIKK_1	235	241	PF00454	0.705
MOD_PIKK_1	373	379	PF00454	0.596
MOD_PIKK_1	426	432	PF00454	0.615
MOD_PIKK_1	509	515	PF00454	0.520
MOD_PIKK_1	526	532	PF00454	0.336
MOD_PIKK_1	752	758	PF00454	0.614
MOD_PKA_2	27	33	PF00069	0.394
MOD_PKA_2	372	378	PF00069	0.565
MOD_PKA_2	391	397	PF00069	0.596
MOD_PKA_2	410	416	PF00069	0.749
MOD_PKA_2	5	11	PF00069	0.576
MOD_PKA_2	555	561	PF00069	0.492
MOD_PKA_2	644	650	PF00069	0.573
MOD_PKA_2	785	791	PF00069	0.525
MOD_Plk_1	640	646	PF00069	0.500
MOD_Plk_1	647	653	PF00069	0.476
MOD_Plk_1	748	754	PF00069	0.607
MOD_Plk_2-3	20	26	PF00069	0.420
MOD_Plk_2-3	363	369	PF00069	0.447
MOD_Plk_4	220	226	PF00069	0.674
MOD_Plk_4	27	33	PF00069	0.394
MOD_Plk_4	348	354	PF00069	0.703
MOD_Plk_4	437	443	PF00069	0.369
MOD_Plk_4	546	552	PF00069	0.420
MOD_Plk_4	601	607	PF00069	0.460
MOD_Plk_4	620	626	PF00069	0.356
MOD_Plk_4	628	634	PF00069	0.429
MOD_Plk_4	682	688	PF00069	0.596
MOD_ProDKin_1	154	160	PF00069	0.724
MOD_ProDKin_1	161	167	PF00069	0.664
MOD_ProDKin_1	249	255	PF00069	0.746
MOD_ProDKin_1	286	292	PF00069	0.729
MOD_ProDKin_1	322	328	PF00069	0.724
MOD_ProDKin_1	338	344	PF00069	0.545
MOD_ProDKin_1	357	363	PF00069	0.454
MOD_ProDKin_1	428	434	PF00069	0.544
MOD_ProDKin_1	479	485	PF00069	0.533
MOD_ProDKin_1	623	629	PF00069	0.505
MOD_ProDKin_1	660	666	PF00069	0.691
MOD_ProDKin_1	734	740	PF00069	0.750
MOD_ProDKin_1	742	748	PF00069	0.637
MOD_ProDKin_1	793	799	PF00069	0.596
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.420
TRG_ENDOCYTIC_2	115	118	PF00928	0.695
TRG_ENDOCYTIC_2	458	461	PF00928	0.422
TRG_ENDOCYTIC_2	547	550	PF00928	0.465
TRG_ENDOCYTIC_2	575	578	PF00928	0.448
TRG_ENDOCYTIC_2	615	618	PF00928	0.554
TRG_ER_diArg_1	472	475	PF00400	0.533
TRG_ER_diArg_1	48	51	PF00400	0.420
TRG_ER_diArg_1	644	646	PF00400	0.562
TRG_NES_CRM1_1	26	38	PF08389	0.420
TRG_NES_CRM1_1	436	449	PF08389	0.572
TRG_NES_CRM1_1	538	552	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSG5	Leishmania donovani	90%	100%
A4H762	Leishmania braziliensis	67%	98%
A4HVK1	Leishmania infantum	90%	100%
E9AP97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%