C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QG78_LEIMA

TriTrypDb:

LmjF.13.0760 , LMJLV39_130011600 , LMJSD75_130011700

Length:

2063

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QG78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010827	regulation of glucose transmembrane transport	5	2
GO:0010828	positive regulation of glucose transmembrane transport	6	2
GO:0015031	protein transport	4	2
GO:0031338	regulation of vesicle fusion	5	2
GO:0031340	positive regulation of vesicle fusion	5	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	2
GO:0005543	phospholipid binding	3	6
GO:0005544	calcium-dependent phospholipid binding	4	6
GO:0008289	lipid binding	2	6
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1191	1195	PF00656	0.709
CLV_C14_Caspase3-7	1509	1513	PF00656	0.462
CLV_C14_Caspase3-7	1805	1809	PF00656	0.753
CLV_C14_Caspase3-7	1861	1865	PF00656	0.480
CLV_C14_Caspase3-7	1952	1956	PF00656	0.610
CLV_C14_Caspase3-7	2051	2055	PF00656	0.654
CLV_C14_Caspase3-7	248	252	PF00656	0.579
CLV_C14_Caspase3-7	441	445	PF00656	0.582
CLV_C14_Caspase3-7	679	683	PF00656	0.695
CLV_C14_Caspase3-7	747	751	PF00656	0.411

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSG4	Leishmania donovani	94%	100%
A4H765	Leishmania braziliensis	74%	100%
A4HVK4	Leishmania infantum	94%	100%
E9APA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%

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