Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QG77_LEIMA

TriTrypDb:

LmjF.13.0770 , LMJLV39_130011700 , LMJSD75_130011800

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG77

Function

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Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.674
CLV_NRD_NRD_1	358	360	PF00675	0.483
CLV_NRD_NRD_1	537	539	PF00675	0.447
CLV_NRD_NRD_1	64	66	PF00675	0.560
CLV_PCSK_FUR_1	356	360	PF00082	0.478
CLV_PCSK_KEX2_1	358	360	PF00082	0.483
CLV_PCSK_KEX2_1	537	539	PF00082	0.447
CLV_PCSK_KEX2_1	66	68	PF00082	0.552
CLV_PCSK_KEX2_1	72	74	PF00082	0.618
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.560

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI5	Leptomonas seymouri	32%	93%
A0A3S7WSG2	Leishmania donovani	90%	100%
A4H766	Leishmania braziliensis	68%	99%
A4HVK5	Leishmania infantum	90%	100%
E9APA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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