Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QG77_LEIMA

TriTrypDb:

LmjF.13.0770 , LMJLV39_130011700 , LMJSD75_130011800

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG77

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.674
CLV_NRD_NRD_1	358	360	PF00675	0.483
CLV_NRD_NRD_1	537	539	PF00675	0.447
CLV_NRD_NRD_1	64	66	PF00675	0.560
CLV_PCSK_FUR_1	356	360	PF00082	0.478
CLV_PCSK_KEX2_1	358	360	PF00082	0.483
CLV_PCSK_KEX2_1	537	539	PF00082	0.447
CLV_PCSK_KEX2_1	66	68	PF00082	0.552
CLV_PCSK_KEX2_1	72	74	PF00082	0.618
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.560
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.570
CLV_PCSK_PC7_1	62	68	PF00082	0.699
CLV_PCSK_SKI1_1	110	114	PF00082	0.556
CLV_PCSK_SKI1_1	122	126	PF00082	0.603
CLV_PCSK_SKI1_1	202	206	PF00082	0.506
CLV_PCSK_SKI1_1	295	299	PF00082	0.552
CLV_PCSK_SKI1_1	358	362	PF00082	0.515
CLV_PCSK_SKI1_1	417	421	PF00082	0.523
CLV_PCSK_SKI1_1	67	71	PF00082	0.528
CLV_PCSK_SKI1_1	72	76	PF00082	0.578
DEG_APCC_DBOX_1	109	117	PF00400	0.555
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DEG_SPOP_SBC_1	398	402	PF00917	0.534
DOC_CKS1_1	360	365	PF01111	0.424
DOC_CKS1_1	542	547	PF01111	0.555
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.560
DOC_MAPK_gen_1	519	528	PF00069	0.347
DOC_MAPK_gen_1	62	71	PF00069	0.536
DOC_MAPK_HePTP_8	516	528	PF00069	0.425
DOC_MAPK_MEF2A_6	519	528	PF00069	0.424
DOC_MAPK_RevD_3	52	67	PF00069	0.485
DOC_PP2B_LxvP_1	462	465	PF13499	0.505
DOC_USP7_MATH_1	148	152	PF00917	0.694
DOC_USP7_MATH_1	195	199	PF00917	0.561
DOC_USP7_MATH_1	216	220	PF00917	0.497
DOC_USP7_MATH_1	23	27	PF00917	0.440
DOC_USP7_MATH_1	312	316	PF00917	0.679
DOC_USP7_MATH_1	318	322	PF00917	0.669
DOC_USP7_MATH_1	398	402	PF00917	0.574
DOC_USP7_MATH_1	407	411	PF00917	0.620
DOC_USP7_MATH_1	496	500	PF00917	0.593
DOC_USP7_MATH_1	81	85	PF00917	0.615
DOC_WW_Pin1_4	129	134	PF00397	0.739
DOC_WW_Pin1_4	135	140	PF00397	0.615
DOC_WW_Pin1_4	211	216	PF00397	0.532
DOC_WW_Pin1_4	25	30	PF00397	0.523
DOC_WW_Pin1_4	299	304	PF00397	0.577
DOC_WW_Pin1_4	308	313	PF00397	0.545
DOC_WW_Pin1_4	325	330	PF00397	0.500
DOC_WW_Pin1_4	359	364	PF00397	0.435
DOC_WW_Pin1_4	403	408	PF00397	0.680
DOC_WW_Pin1_4	410	415	PF00397	0.561
DOC_WW_Pin1_4	475	480	PF00397	0.386
DOC_WW_Pin1_4	541	546	PF00397	0.587
DOC_WW_Pin1_4	8	13	PF00397	0.476
DOC_WW_Pin1_4	83	88	PF00397	0.643
DOC_WW_Pin1_4	93	98	PF00397	0.727
LIG_14-3-3_CanoR_1	110	116	PF00244	0.558
LIG_14-3-3_CanoR_1	228	232	PF00244	0.601
LIG_14-3-3_CanoR_1	358	363	PF00244	0.575
LIG_14-3-3_CanoR_1	417	422	PF00244	0.493
LIG_14-3-3_CanoR_1	495	505	PF00244	0.532
LIG_14-3-3_CanoR_1	73	81	PF00244	0.571
LIG_14-3-3_CanoR_1	82	89	PF00244	0.652
LIG_Actin_WH2_2	264	282	PF00022	0.493
LIG_Actin_WH2_2	420	438	PF00022	0.427
LIG_Actin_WH2_2	480	497	PF00022	0.467
LIG_APCC_ABBA_1	342	347	PF00400	0.415
LIG_Clathr_ClatBox_1	484	488	PF01394	0.364
LIG_Clathr_ClatBox_1	539	543	PF01394	0.405
LIG_CSL_BTD_1	145	148	PF09270	0.666
LIG_FHA_1	104	110	PF00498	0.645
LIG_FHA_1	332	338	PF00498	0.468
LIG_FHA_1	359	365	PF00498	0.454
LIG_FHA_1	381	387	PF00498	0.454
LIG_FHA_1	411	417	PF00498	0.507
LIG_FHA_1	53	59	PF00498	0.466
LIG_FHA_1	9	15	PF00498	0.450
LIG_FHA_2	350	356	PF00498	0.473
LIG_FHA_2	4	10	PF00498	0.529
LIG_GBD_Chelix_1	285	293	PF00786	0.435
LIG_LIR_Gen_1	105	116	PF02991	0.633
LIG_LIR_Nem_3	105	111	PF02991	0.637
LIG_LIR_Nem_3	534	539	PF02991	0.369
LIG_NRBOX	288	294	PF00104	0.513
LIG_NRBOX	53	59	PF00104	0.538
LIG_SH2_CRK	340	344	PF00017	0.542
LIG_SH2_STAT3	162	165	PF00017	0.576
LIG_SH2_STAT5	345	348	PF00017	0.431
LIG_SH3_2	545	550	PF14604	0.593
LIG_SH3_3	142	148	PF00018	0.622
LIG_SH3_3	297	303	PF00018	0.587
LIG_SH3_3	375	381	PF00018	0.492
LIG_SH3_3	445	451	PF00018	0.642
LIG_SH3_3	486	492	PF00018	0.369
LIG_SH3_3	542	548	PF00018	0.608
LIG_SH3_3	91	97	PF00018	0.619
LIG_SUMO_SIM_anti_2	418	423	PF11976	0.370
LIG_SUMO_SIM_par_1	207	214	PF11976	0.447
LIG_TYR_ITIM	484	489	PF00017	0.362
LIG_UBA3_1	70	75	PF00899	0.568
LIG_WW_3	79	83	PF00397	0.626
MOD_CDC14_SPxK_1	547	550	PF00782	0.601
MOD_CDK_SPxK_1	544	550	PF00069	0.586
MOD_CDK_SPxxK_3	410	417	PF00069	0.523
MOD_CK1_1	151	157	PF00069	0.608
MOD_CK1_1	230	236	PF00069	0.692
MOD_CK1_1	28	34	PF00069	0.649
MOD_CK1_1	308	314	PF00069	0.630
MOD_CK1_1	400	406	PF00069	0.640
MOD_CK1_1	410	416	PF00069	0.495
MOD_CK2_1	349	355	PF00069	0.481
MOD_CK2_1	496	502	PF00069	0.500
MOD_GlcNHglycan	150	153	PF01048	0.617
MOD_GlcNHglycan	21	24	PF01048	0.500
MOD_GlcNHglycan	30	33	PF01048	0.572
MOD_GlcNHglycan	314	317	PF01048	0.651
MOD_GlcNHglycan	318	321	PF01048	0.606
MOD_GlcNHglycan	498	501	PF01048	0.636
MOD_GlcNHglycan	528	531	PF01048	0.524
MOD_GlcNHglycan	76	79	PF01048	0.716
MOD_GlcNHglycan	83	86	PF01048	0.648
MOD_GlcNHglycan	97	100	PF01048	0.552
MOD_GSK3_1	147	154	PF00069	0.615
MOD_GSK3_1	19	26	PF00069	0.477
MOD_GSK3_1	191	198	PF00069	0.680
MOD_GSK3_1	295	302	PF00069	0.667
MOD_GSK3_1	3	10	PF00069	0.535
MOD_GSK3_1	306	313	PF00069	0.650
MOD_GSK3_1	380	387	PF00069	0.523
MOD_GSK3_1	394	401	PF00069	0.641
MOD_GSK3_1	403	410	PF00069	0.613
MOD_GSK3_1	473	480	PF00069	0.406
MOD_GSK3_1	81	88	PF00069	0.654
MOD_N-GLC_1	135	140	PF02516	0.604
MOD_N-GLC_1	316	321	PF02516	0.533
MOD_N-GLC_2	525	527	PF02516	0.439
MOD_NEK2_1	111	116	PF00069	0.583
MOD_NEK2_1	191	196	PF00069	0.557
MOD_NEK2_1	306	311	PF00069	0.653
MOD_NEK2_1	430	435	PF00069	0.423
MOD_NEK2_1	473	478	PF00069	0.422
MOD_NEK2_1	58	63	PF00069	0.518
MOD_NEK2_1	7	12	PF00069	0.569
MOD_NEK2_1	74	79	PF00069	0.587
MOD_NEK2_2	103	108	PF00069	0.596
MOD_NEK2_2	195	200	PF00069	0.475
MOD_PIKK_1	380	386	PF00454	0.516
MOD_PIKK_1	435	441	PF00454	0.590
MOD_PIKK_1	456	462	PF00454	0.581
MOD_PK_1	477	483	PF00069	0.370
MOD_PKA_1	358	364	PF00069	0.465
MOD_PKA_2	227	233	PF00069	0.534
MOD_PKA_2	3	9	PF00069	0.567
MOD_PKA_2	358	364	PF00069	0.514
MOD_PKA_2	81	87	PF00069	0.705
MOD_PKB_1	356	364	PF00069	0.466
MOD_Plk_1	331	337	PF00069	0.409
MOD_Plk_4	103	109	PF00069	0.647
MOD_Plk_4	111	117	PF00069	0.552
MOD_Plk_4	477	483	PF00069	0.370
MOD_Plk_4	531	537	PF00069	0.411
MOD_ProDKin_1	129	135	PF00069	0.738
MOD_ProDKin_1	211	217	PF00069	0.527
MOD_ProDKin_1	25	31	PF00069	0.528
MOD_ProDKin_1	299	305	PF00069	0.583
MOD_ProDKin_1	308	314	PF00069	0.544
MOD_ProDKin_1	325	331	PF00069	0.489
MOD_ProDKin_1	359	365	PF00069	0.433
MOD_ProDKin_1	403	409	PF00069	0.682
MOD_ProDKin_1	410	416	PF00069	0.550
MOD_ProDKin_1	475	481	PF00069	0.384
MOD_ProDKin_1	541	547	PF00069	0.595
MOD_ProDKin_1	8	14	PF00069	0.466
MOD_ProDKin_1	83	89	PF00069	0.644
MOD_ProDKin_1	93	99	PF00069	0.725
TRG_DiLeu_BaEn_1	426	431	PF01217	0.443
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.445
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.424
TRG_ENDOCYTIC_2	340	343	PF00928	0.543
TRG_ENDOCYTIC_2	486	489	PF00928	0.378
TRG_ER_diArg_1	356	359	PF00400	0.484
TRG_ER_diArg_1	519	522	PF00400	0.362
TRG_ER_diArg_1	536	538	PF00400	0.378
TRG_NLS_MonoExtN_4	62	69	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI5	Leptomonas seymouri	32%	93%
A0A3S7WSG2	Leishmania donovani	90%	100%
A4H766	Leishmania braziliensis	68%	99%
A4HVK5	Leishmania infantum	90%	100%
E9APA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%