Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CMGC/MAPK protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QG76_LEIMA

TriTrypDb:

LmjF.13.0780 , LMJLV39_130011800 , LMJSD75_130011900

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG76

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004707	MAP kinase activity	5	2
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.515
CLV_C14_Caspase3-7	338	342	PF00656	0.378
CLV_C14_Caspase3-7	57	61	PF00656	0.466
CLV_NRD_NRD_1	195	197	PF00675	0.583
CLV_NRD_NRD_1	278	280	PF00675	0.449
CLV_PCSK_KEX2_1	18	20	PF00082	0.469
CLV_PCSK_KEX2_1	195	197	PF00082	0.557
CLV_PCSK_KEX2_1	511	513	PF00082	0.629
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.494
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.635
CLV_PCSK_SKI1_1	101	105	PF00082	0.402
CLV_PCSK_SKI1_1	173	177	PF00082	0.437
CLV_PCSK_SKI1_1	195	199	PF00082	0.512
CLV_PCSK_SKI1_1	280	284	PF00082	0.396
CLV_PCSK_SKI1_1	301	305	PF00082	0.341
CLV_PCSK_SKI1_1	388	392	PF00082	0.344
CLV_PCSK_SKI1_1	429	433	PF00082	0.397
CLV_PCSK_SKI1_1	438	442	PF00082	0.403
CLV_PCSK_SKI1_1	528	532	PF00082	0.423
DEG_APCC_DBOX_1	527	535	PF00400	0.424
DEG_COP1_1	507	516	PF00400	0.623
DEG_ODPH_VHL_1	186	199	PF01847	0.507
DEG_SPOP_SBC_1	211	215	PF00917	0.518
DOC_CYCLIN_RxL_1	385	395	PF00134	0.385
DOC_CYCLIN_RxL_1	98	105	PF00134	0.407
DOC_MAPK_gen_1	18	24	PF00069	0.482
DOC_MAPK_gen_1	301	310	PF00069	0.344
DOC_MAPK_RevD_3	5	19	PF00069	0.587
DOC_PP4_FxxP_1	136	139	PF00568	0.405
DOC_USP7_MATH_1	14	18	PF00917	0.513
DOC_USP7_MATH_1	270	274	PF00917	0.570
DOC_USP7_MATH_1	412	416	PF00917	0.434
DOC_USP7_UBL2_3	437	441	PF12436	0.427
DOC_WW_Pin1_4	213	218	PF00397	0.662
DOC_WW_Pin1_4	356	361	PF00397	0.417
DOC_WW_Pin1_4	447	452	PF00397	0.407
DOC_WW_Pin1_4	456	461	PF00397	0.312
LIG_14-3-3_CanoR_1	212	217	PF00244	0.521
LIG_Actin_WH2_2	157	175	PF00022	0.411
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BIR_III_1	1	5	PF00653	0.615
LIG_BIR_III_3	1	5	PF00653	0.615
LIG_EH_1	491	495	PF12763	0.398
LIG_eIF4E_1	89	95	PF01652	0.514
LIG_FHA_1	114	120	PF00498	0.415
LIG_FHA_1	234	240	PF00498	0.557
LIG_FHA_1	266	272	PF00498	0.580
LIG_FHA_1	29	35	PF00498	0.510
LIG_FHA_1	331	337	PF00498	0.442
LIG_FHA_1	350	356	PF00498	0.363
LIG_FHA_1	426	432	PF00498	0.385
LIG_FHA_1	448	454	PF00498	0.420
LIG_FHA_1	89	95	PF00498	0.469
LIG_FHA_2	169	175	PF00498	0.418
LIG_FHA_2	180	186	PF00498	0.508
LIG_FHA_2	336	342	PF00498	0.375
LIG_FHA_2	79	85	PF00498	0.587
LIG_LIR_Apic_2	134	139	PF02991	0.413
LIG_LIR_Apic_2	344	350	PF02991	0.328
LIG_LIR_Gen_1	147	154	PF02991	0.451
LIG_LIR_Gen_1	159	170	PF02991	0.411
LIG_LIR_Gen_1	33	43	PF02991	0.484
LIG_LIR_Gen_1	544	551	PF02991	0.539
LIG_LIR_Nem_3	134	140	PF02991	0.414
LIG_LIR_Nem_3	147	151	PF02991	0.444
LIG_LIR_Nem_3	157	161	PF02991	0.420
LIG_LIR_Nem_3	275	281	PF02991	0.348
LIG_LIR_Nem_3	33	38	PF02991	0.477
LIG_LIR_Nem_3	367	372	PF02991	0.449
LIG_LIR_Nem_3	39	44	PF02991	0.419
LIG_LIR_Nem_3	404	409	PF02991	0.449
LIG_LIR_Nem_3	498	503	PF02991	0.496
LIG_LIR_Nem_3	51	55	PF02991	0.431
LIG_LIR_Nem_3	544	549	PF02991	0.544
LIG_LRP6_Inhibitor_1	431	437	PF00058	0.320
LIG_NRBOX	33	39	PF00104	0.541
LIG_PTB_Apo_2	489	496	PF02174	0.399
LIG_REV1ctd_RIR_1	492	501	PF16727	0.574
LIG_SH2_CRK	148	152	PF00017	0.538
LIG_SH2_CRK	500	504	PF00017	0.548
LIG_SH2_CRK	52	56	PF00017	0.436
LIG_SH2_NCK_1	347	351	PF00017	0.363
LIG_SH2_NCK_1	41	45	PF00017	0.518
LIG_SH2_NCK_1	75	79	PF00017	0.547
LIG_SH2_SRC	500	503	PF00017	0.544
LIG_SH2_SRC	75	78	PF00017	0.573
LIG_SH2_STAP1	148	152	PF00017	0.526
LIG_SH2_STAP1	190	194	PF00017	0.519
LIG_SH2_STAP1	392	396	PF00017	0.413
LIG_SH2_STAT5	162	165	PF00017	0.420
LIG_SH2_STAT5	170	173	PF00017	0.494
LIG_SH2_STAT5	292	295	PF00017	0.385
LIG_SH2_STAT5	335	338	PF00017	0.389
LIG_SH2_STAT5	392	395	PF00017	0.355
LIG_SH2_STAT5	54	57	PF00017	0.524
LIG_SH3_3	259	265	PF00018	0.629
LIG_SH3_3	500	506	PF00018	0.535
LIG_SUMO_SIM_par_1	267	273	PF11976	0.647
LIG_SUMO_SIM_par_1	351	359	PF11976	0.449
LIG_TRAF2_1	71	74	PF00917	0.545
LIG_TRAF2_1	81	84	PF00917	0.568
LIG_TYR_ITIM	290	295	PF00017	0.381
MOD_CK1_1	213	219	PF00069	0.678
MOD_CK1_1	313	319	PF00069	0.443
MOD_CK2_1	168	174	PF00069	0.416
MOD_CK2_1	179	185	PF00069	0.510
MOD_CK2_1	36	42	PF00069	0.464
MOD_CK2_1	412	418	PF00069	0.431
MOD_CK2_1	78	84	PF00069	0.546
MOD_GlcNHglycan	131	134	PF01048	0.413
MOD_GlcNHglycan	247	250	PF01048	0.695
MOD_GlcNHglycan	411	415	PF01048	0.418
MOD_GlcNHglycan	525	528	PF01048	0.525
MOD_GlcNHglycan	56	59	PF01048	0.431
MOD_GSK3_1	175	182	PF00069	0.494
MOD_GSK3_1	239	246	PF00069	0.718
MOD_GSK3_1	397	404	PF00069	0.443
MOD_GSK3_1	412	419	PF00069	0.447
MOD_GSK3_1	443	450	PF00069	0.421
MOD_GSK3_1	519	526	PF00069	0.563
MOD_N-GLC_1	240	245	PF02516	0.673
MOD_N-GLC_1	329	334	PF02516	0.475
MOD_N-GLC_1	341	346	PF02516	0.191
MOD_NEK2_1	168	173	PF00069	0.400
MOD_NEK2_1	176	181	PF00069	0.441
MOD_NEK2_1	310	315	PF00069	0.449
MOD_NEK2_1	390	395	PF00069	0.369
MOD_NEK2_1	432	437	PF00069	0.386
MOD_NEK2_1	545	550	PF00069	0.501
MOD_PIKK_1	341	347	PF00454	0.363
MOD_PIKK_1	397	403	PF00454	0.439
MOD_PK_1	512	518	PF00069	0.620
MOD_PKA_2	211	217	PF00069	0.753
MOD_PKA_2	316	322	PF00069	0.449
MOD_PKA_2	482	488	PF00069	0.326
MOD_Plk_1	168	174	PF00069	0.416
MOD_Plk_1	176	182	PF00069	0.480
MOD_Plk_1	28	34	PF00069	0.586
MOD_Plk_1	310	316	PF00069	0.449
MOD_Plk_1	341	347	PF00069	0.369
MOD_Plk_1	76	82	PF00069	0.594
MOD_Plk_2-3	144	150	PF00069	0.474
MOD_Plk_4	147	153	PF00069	0.478
MOD_Plk_4	176	182	PF00069	0.490
MOD_Plk_4	189	195	PF00069	0.514
MOD_Plk_4	335	341	PF00069	0.348
MOD_Plk_4	401	407	PF00069	0.389
MOD_Plk_4	545	551	PF00069	0.519
MOD_Plk_4	6	12	PF00069	0.605
MOD_Plk_4	90	96	PF00069	0.473
MOD_ProDKin_1	213	219	PF00069	0.662
MOD_ProDKin_1	356	362	PF00069	0.417
MOD_ProDKin_1	447	453	PF00069	0.407
MOD_ProDKin_1	456	462	PF00069	0.312
MOD_SUMO_for_1	303	306	PF00179	0.385
MOD_SUMO_for_1	551	554	PF00179	0.593
MOD_SUMO_rev_2	537	545	PF00179	0.523
MOD_SUMO_rev_2	554	559	PF00179	0.525
TRG_DiLeu_BaEn_1	33	38	PF01217	0.510
TRG_ENDOCYTIC_2	148	151	PF00928	0.453
TRG_ENDOCYTIC_2	162	165	PF00928	0.389
TRG_ENDOCYTIC_2	278	281	PF00928	0.362
TRG_ENDOCYTIC_2	284	287	PF00928	0.297
TRG_ENDOCYTIC_2	292	295	PF00928	0.145
TRG_ENDOCYTIC_2	41	44	PF00928	0.439
TRG_ENDOCYTIC_2	500	503	PF00928	0.485
TRG_ENDOCYTIC_2	52	55	PF00928	0.398
TRG_ER_diArg_1	194	196	PF00400	0.590
TRG_ER_FFAT_1	73	81	PF00635	0.509
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	301	306	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ0	Leptomonas seymouri	73%	98%
A0A0S4ILC2	Bodo saltans	23%	100%
A0A0S4JGZ1	Bodo saltans	25%	100%
A0A1X0NPK9	Trypanosomatidae	53%	100%
A0A3Q8I9M4	Leishmania donovani	88%	92%
A0A3S5IR55	Trypanosoma rangeli	53%	100%
A4H767	Leishmania braziliensis	79%	92%
A4HVK6	Leishmania infantum	89%	79%
E9APA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
V5AVM7	Trypanosoma cruzi	50%	100%