Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG75_LEIMA

TriTrypDb:

LmjF.13.0790 , LMJLV39_130011900 , LMJSD75_130012000

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG75

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	7
GO:0002098	tRNA wobble uridine modification	8	7
GO:0002143	tRNA wobble position uridine thiolation	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034227	tRNA thio-modification	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	7
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	2
GO:0016782	transferase activity, transferring sulphur-containing groups	3	2
GO:0016783	sulfurtransferase activity	4	2
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	615	619	PF00656	0.630
CLV_NRD_NRD_1	172	174	PF00675	0.557
CLV_NRD_NRD_1	523	525	PF00675	0.637
CLV_NRD_NRD_1	548	550	PF00675	0.553
CLV_NRD_NRD_1	82	84	PF00675	0.557
CLV_PCSK_KEX2_1	194	196	PF00082	0.612
CLV_PCSK_KEX2_1	548	550	PF00082	0.553
CLV_PCSK_KEX2_1	82	84	PF00082	0.557
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.609
CLV_PCSK_PC7_1	78	84	PF00082	0.492
CLV_PCSK_SKI1_1	282	286	PF00082	0.527
CLV_PCSK_SKI1_1	295	299	PF00082	0.376
CLV_PCSK_SKI1_1	381	385	PF00082	0.300
CLV_PCSK_SKI1_1	406	410	PF00082	0.390
CLV_PCSK_SKI1_1	419	423	PF00082	0.475
CLV_PCSK_SKI1_1	524	528	PF00082	0.693
CLV_Separin_Metazoa	490	494	PF03568	0.544
DEG_APCC_DBOX_1	547	555	PF00400	0.518
DEG_SCF_FBW7_1	219	225	PF00400	0.711
DEG_SCF_FBW7_1	604	609	PF00400	0.644
DEG_SPOP_SBC_1	137	141	PF00917	0.676
DOC_CKS1_1	219	224	PF01111	0.709
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	541	547	PF00134	0.654
DOC_MAPK_gen_1	368	375	PF00069	0.440
DOC_MAPK_gen_1	548	556	PF00069	0.517
DOC_PP2B_LxvP_1	130	133	PF13499	0.458
DOC_PP2B_LxvP_1	134	137	PF13499	0.576
DOC_PP2B_LxvP_1	541	544	PF13499	0.653
DOC_USP7_MATH_1	108	112	PF00917	0.630
DOC_USP7_MATH_1	113	117	PF00917	0.549
DOC_USP7_MATH_1	137	141	PF00917	0.619
DOC_USP7_MATH_1	245	249	PF00917	0.761
DOC_USP7_MATH_1	347	351	PF00917	0.720
DOC_USP7_MATH_1	448	452	PF00917	0.538
DOC_USP7_MATH_1	606	610	PF00917	0.691
DOC_USP7_MATH_1	611	615	PF00917	0.642
DOC_USP7_MATH_1	620	624	PF00917	0.667
DOC_USP7_MATH_1	678	682	PF00917	0.581
DOC_USP7_UBL2_3	194	198	PF12436	0.716
DOC_USP7_UBL2_3	521	525	PF12436	0.696
DOC_WW_Pin1_4	109	114	PF00397	0.571
DOC_WW_Pin1_4	141	146	PF00397	0.657
DOC_WW_Pin1_4	218	223	PF00397	0.708
DOC_WW_Pin1_4	233	238	PF00397	0.541
DOC_WW_Pin1_4	437	442	PF00397	0.460
DOC_WW_Pin1_4	48	53	PF00397	0.427
DOC_WW_Pin1_4	602	607	PF00397	0.683
DOC_WW_Pin1_4	609	614	PF00397	0.622
DOC_WW_Pin1_4	623	628	PF00397	0.477
DOC_WW_Pin1_4	84	89	PF00397	0.570
DOC_WW_Pin1_4	99	104	PF00397	0.565
LIG_14-3-3_CanoR_1	160	169	PF00244	0.492
LIG_14-3-3_CanoR_1	289	299	PF00244	0.412
LIG_14-3-3_CanoR_1	303	308	PF00244	0.416
LIG_14-3-3_CanoR_1	381	390	PF00244	0.312
LIG_14-3-3_CanoR_1	406	415	PF00244	0.479
LIG_BIR_III_2	643	647	PF00653	0.495
LIG_CSL_BTD_1	644	647	PF09270	0.495
LIG_deltaCOP1_diTrp_1	643	650	PF00928	0.560
LIG_EVH1_1	132	136	PF00568	0.592
LIG_EVH1_2	646	650	PF00568	0.532
LIG_FHA_1	219	225	PF00498	0.628
LIG_FHA_1	253	259	PF00498	0.566
LIG_FHA_1	327	333	PF00498	0.414
LIG_FHA_1	382	388	PF00498	0.301
LIG_FHA_1	407	413	PF00498	0.487
LIG_FHA_1	438	444	PF00498	0.474
LIG_FHA_1	447	453	PF00498	0.459
LIG_FHA_1	529	535	PF00498	0.527
LIG_FHA_1	680	686	PF00498	0.552
LIG_FHA_2	202	208	PF00498	0.574
LIG_FHA_2	613	619	PF00498	0.624
LIG_FHA_2	654	660	PF00498	0.660
LIG_LIR_Gen_1	166	176	PF02991	0.488
LIG_LIR_Gen_1	296	307	PF02991	0.486
LIG_LIR_Gen_1	426	436	PF02991	0.392
LIG_LIR_Gen_1	469	478	PF02991	0.379
LIG_LIR_Nem_3	166	172	PF02991	0.488
LIG_LIR_Nem_3	27	32	PF02991	0.368
LIG_LIR_Nem_3	296	302	PF02991	0.414
LIG_LIR_Nem_3	426	432	PF02991	0.389
LIG_LIR_Nem_3	469	475	PF02991	0.371
LIG_LIR_Nem_3	630	636	PF02991	0.416
LIG_SH2_CRK	299	303	PF00017	0.410
LIG_SH2_CRK	429	433	PF00017	0.460
LIG_SH2_STAP1	269	273	PF00017	0.466
LIG_SH2_STAP1	283	287	PF00017	0.369
LIG_SH2_STAT3	175	178	PF00017	0.512
LIG_SH2_STAT3	581	584	PF00017	0.483
LIG_SH2_STAT3	636	639	PF00017	0.448
LIG_SH2_STAT5	175	178	PF00017	0.560
LIG_SH2_STAT5	24	27	PF00017	0.360
LIG_SH2_STAT5	277	280	PF00017	0.404
LIG_SH2_STAT5	32	35	PF00017	0.354
LIG_SH2_STAT5	429	432	PF00017	0.448
LIG_SH2_STAT5	439	442	PF00017	0.421
LIG_SH3_3	130	136	PF00018	0.494
LIG_SH3_CIN85_PxpxPR_1	235	240	PF14604	0.591
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.482
LIG_SUMO_SIM_par_1	594	602	PF11976	0.598
LIG_TRAF2_1	164	167	PF00917	0.483
LIG_TRAF2_1	337	340	PF00917	0.706
LIG_TRAF2_1	487	490	PF00917	0.505
LIG_TYR_ITIM	427	432	PF00017	0.468
LIG_WW_3	179	183	PF00397	0.587
MOD_CDK_SPK_2	602	607	PF00069	0.683
MOD_CDK_SPxK_1	84	90	PF00069	0.578
MOD_CDK_SPxxK_3	103	110	PF00069	0.653
MOD_CDK_SPxxK_3	233	240	PF00069	0.591
MOD_CK1_1	139	145	PF00069	0.674
MOD_CK1_1	233	239	PF00069	0.696
MOD_CK1_1	248	254	PF00069	0.532
MOD_CK1_1	288	294	PF00069	0.437
MOD_CK1_1	466	472	PF00069	0.562
MOD_CK1_1	515	521	PF00069	0.604
MOD_CK1_1	576	582	PF00069	0.513
MOD_CK1_1	602	608	PF00069	0.670
MOD_CK1_1	609	615	PF00069	0.607
MOD_CK1_1	623	629	PF00069	0.488
MOD_CK1_1	99	105	PF00069	0.715
MOD_CK2_1	160	166	PF00069	0.485
MOD_CK2_1	201	207	PF00069	0.574
MOD_CK2_1	290	296	PF00069	0.423
MOD_CK2_1	618	624	PF00069	0.617
MOD_CK2_1	651	657	PF00069	0.793
MOD_GlcNHglycan	151	154	PF01048	0.617
MOD_GlcNHglycan	162	165	PF01048	0.444
MOD_GlcNHglycan	232	235	PF01048	0.696
MOD_GlcNHglycan	247	250	PF01048	0.560
MOD_GlcNHglycan	273	276	PF01048	0.453
MOD_GlcNHglycan	496	501	PF01048	0.604
MOD_GlcNHglycan	517	520	PF01048	0.577
MOD_GlcNHglycan	57	60	PF01048	0.416
MOD_GlcNHglycan	601	604	PF01048	0.626
MOD_GlcNHglycan	608	611	PF01048	0.594
MOD_GlcNHglycan	620	623	PF01048	0.490
MOD_GSK3_1	109	116	PF00069	0.564
MOD_GSK3_1	136	143	PF00069	0.604
MOD_GSK3_1	218	225	PF00069	0.719
MOD_GSK3_1	229	236	PF00069	0.695
MOD_GSK3_1	248	255	PF00069	0.601
MOD_GSK3_1	267	274	PF00069	0.395
MOD_GSK3_1	358	365	PF00069	0.617
MOD_GSK3_1	423	430	PF00069	0.354
MOD_GSK3_1	442	449	PF00069	0.656
MOD_GSK3_1	459	466	PF00069	0.363
MOD_GSK3_1	496	503	PF00069	0.532
MOD_GSK3_1	515	522	PF00069	0.660
MOD_GSK3_1	598	605	PF00069	0.624
MOD_GSK3_1	623	630	PF00069	0.680
MOD_GSK3_1	98	105	PF00069	0.643
MOD_N-GLC_1	534	539	PF02516	0.486
MOD_N-GLC_1	598	603	PF02516	0.535
MOD_N-GLC_1	663	668	PF02516	0.661
MOD_NEK2_1	114	119	PF00069	0.524
MOD_NEK2_1	138	143	PF00069	0.660
MOD_NEK2_1	273	278	PF00069	0.516
MOD_NEK2_1	285	290	PF00069	0.439
MOD_NEK2_1	362	367	PF00069	0.655
MOD_NEK2_1	374	379	PF00069	0.329
MOD_NEK2_1	459	464	PF00069	0.386
MOD_NEK2_1	598	603	PF00069	0.602
MOD_NEK2_2	448	453	PF00069	0.530
MOD_OFUCOSY	573	580	PF10250	0.472
MOD_PIKK_1	513	519	PF00454	0.679
MOD_PKA_2	267	273	PF00069	0.418
MOD_PKA_2	288	294	PF00069	0.416
MOD_PKA_2	606	612	PF00069	0.695
MOD_PKA_2	651	657	PF00069	0.611
MOD_PKB_1	301	309	PF00069	0.462
MOD_Plk_2-3	358	364	PF00069	0.605
MOD_Plk_2-3	653	659	PF00069	0.653
MOD_Plk_4	10	16	PF00069	0.392
MOD_Plk_4	114	120	PF00069	0.524
MOD_Plk_4	273	279	PF00069	0.513
MOD_Plk_4	423	429	PF00069	0.340
MOD_Plk_4	459	465	PF00069	0.364
MOD_Plk_4	560	566	PF00069	0.488
MOD_Plk_4	60	66	PF00069	0.392
MOD_Plk_4	645	651	PF00069	0.574
MOD_ProDKin_1	109	115	PF00069	0.560
MOD_ProDKin_1	141	147	PF00069	0.653
MOD_ProDKin_1	218	224	PF00069	0.708
MOD_ProDKin_1	233	239	PF00069	0.538
MOD_ProDKin_1	437	443	PF00069	0.460
MOD_ProDKin_1	48	54	PF00069	0.420
MOD_ProDKin_1	602	608	PF00069	0.684
MOD_ProDKin_1	609	615	PF00069	0.622
MOD_ProDKin_1	623	629	PF00069	0.467
MOD_ProDKin_1	84	90	PF00069	0.579
MOD_ProDKin_1	99	105	PF00069	0.566
TRG_ENDOCYTIC_2	269	272	PF00928	0.471
TRG_ENDOCYTIC_2	299	302	PF00928	0.411
TRG_ENDOCYTIC_2	429	432	PF00928	0.464
TRG_ENDOCYTIC_2	467	470	PF00928	0.431
TRG_ER_diArg_1	547	549	PF00400	0.553
TRG_ER_diArg_1	81	83	PF00400	0.539
TRG_NLS_MonoExtC_3	193	198	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	493	497	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC5	Leptomonas seymouri	41%	100%
A0A3Q8I9K2	Leishmania donovani	88%	100%
A4H768	Leishmania braziliensis	66%	100%
A4HVK7	Leishmania infantum	88%	100%
E9APA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%