Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG74_LEIMA

TriTrypDb:

LmjF.13.0800 , LMJLV39_130012000 , LMJSD75_130012100

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.689
CLV_C14_Caspase3-7	194	198	PF00656	0.540
CLV_C14_Caspase3-7	29	33	PF00656	0.658
CLV_NRD_NRD_1	107	109	PF00675	0.618
CLV_NRD_NRD_1	205	207	PF00675	0.671
CLV_NRD_NRD_1	212	214	PF00675	0.591
CLV_NRD_NRD_1	3	5	PF00675	0.644
CLV_PCSK_FUR_1	21	25	PF00082	0.696
CLV_PCSK_KEX2_1	107	109	PF00082	0.576
CLV_PCSK_KEX2_1	209	211	PF00082	0.651
CLV_PCSK_KEX2_1	23	25	PF00082	0.704
CLV_PCSK_KEX2_1	3	5	PF00082	0.668
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.651
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.704
CLV_PCSK_SKI1_1	115	119	PF00082	0.675
CLV_PCSK_SKI1_1	200	204	PF00082	0.575
CLV_PCSK_SKI1_1	209	213	PF00082	0.592
CLV_PCSK_SKI1_1	214	218	PF00082	0.624
CLV_PCSK_SKI1_1	93	97	PF00082	0.666
DEG_APCC_DBOX_1	92	100	PF00400	0.573
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SPOP_SBC_1	189	193	PF00917	0.561
DEG_SPOP_SBC_1	25	29	PF00917	0.714
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.564
DOC_MAPK_gen_1	3	11	PF00069	0.617
DOC_USP7_MATH_1	149	153	PF00917	0.733
DOC_USP7_MATH_1	188	192	PF00917	0.660
DOC_USP7_MATH_1	25	29	PF00917	0.729
DOC_USP7_MATH_1	31	35	PF00917	0.670
DOC_USP7_MATH_1	36	40	PF00917	0.646
DOC_USP7_UBL2_3	118	122	PF12436	0.734
DOC_USP7_UBL2_3	203	207	PF12436	0.672
DOC_WW_Pin1_4	128	133	PF00397	0.637
DOC_WW_Pin1_4	143	148	PF00397	0.608
DOC_WW_Pin1_4	76	81	PF00397	0.541
LIG_14-3-3_CanoR_1	213	223	PF00244	0.582
LIG_14-3-3_CanoR_1	59	68	PF00244	0.592
LIG_FHA_1	191	197	PF00498	0.579
LIG_FHA_1	215	221	PF00498	0.599
LIG_FHA_1	55	61	PF00498	0.596
LIG_FHA_1	77	83	PF00498	0.598
LIG_FHA_2	192	198	PF00498	0.633
LIG_HP1_1	102	106	PF01393	0.562
LIG_LIR_Gen_1	69	80	PF02991	0.560
LIG_LIR_Nem_3	63	68	PF02991	0.552
LIG_LIR_Nem_3	69	75	PF02991	0.483
LIG_PDZ_Class_2	220	225	PF00595	0.625
LIG_Pex14_1	54	58	PF04695	0.575
LIG_RPA_C_Fungi	103	115	PF08784	0.569
LIG_SH2_STAT5	46	49	PF00017	0.621
LIG_SH3_3	145	151	PF00018	0.592
LIG_SH3_3	42	48	PF00018	0.618
LIG_TRAF2_1	184	187	PF00917	0.623
MOD_CK1_1	124	130	PF00069	0.645
MOD_CK1_1	15	21	PF00069	0.533
MOD_CK1_1	191	197	PF00069	0.659
MOD_CK1_1	205	211	PF00069	0.784
MOD_CK1_1	215	221	PF00069	0.615
MOD_CK2_1	31	37	PF00069	0.616
MOD_GlcNHglycan	123	126	PF01048	0.596
MOD_GlcNHglycan	137	140	PF01048	0.630
MOD_GlcNHglycan	14	17	PF01048	0.662
MOD_GlcNHglycan	151	154	PF01048	0.663
MOD_GlcNHglycan	214	217	PF01048	0.621
MOD_GlcNHglycan	28	31	PF01048	0.614
MOD_GlcNHglycan	32	36	PF01048	0.555
MOD_GlcNHglycan	37	41	PF01048	0.514
MOD_GSK3_1	11	18	PF00069	0.682
MOD_GSK3_1	124	131	PF00069	0.659
MOD_GSK3_1	143	150	PF00069	0.592
MOD_GSK3_1	205	212	PF00069	0.538
MOD_NEK2_1	11	16	PF00069	0.707
MOD_NEK2_1	135	140	PF00069	0.682
MOD_NEK2_1	196	201	PF00069	0.719
MOD_NEK2_1	2	7	PF00069	0.628
MOD_NEK2_1	202	207	PF00069	0.656
MOD_NEK2_1	67	72	PF00069	0.530
MOD_PIKK_1	130	136	PF00454	0.666
MOD_PIKK_1	182	188	PF00454	0.616
MOD_PIKK_1	60	66	PF00454	0.553
MOD_PKA_1	209	215	PF00069	0.596
MOD_PKA_2	135	141	PF00069	0.538
MOD_PKA_2	2	8	PF00069	0.695
MOD_PKA_2	205	211	PF00069	0.663
MOD_PKA_2	212	218	PF00069	0.588
MOD_Plk_4	191	197	PF00069	0.599
MOD_Plk_4	67	73	PF00069	0.532
MOD_ProDKin_1	128	134	PF00069	0.638
MOD_ProDKin_1	143	149	PF00069	0.612
MOD_ProDKin_1	76	82	PF00069	0.541
TRG_ER_diArg_1	106	108	PF00400	0.574
TRG_ER_diArg_1	2	4	PF00400	0.624
TRG_NLS_MonoExtC_3	205	210	PF00514	0.667
TRG_NLS_MonoExtN_4	203	210	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	115	120	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9H5	Leishmania donovani	89%	100%
A4H769	Leishmania braziliensis	70%	97%
A4HVK8	Leishmania infantum	89%	100%
E9APA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%