Succinate dehydrogenase assembly factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex1_LYR-like, putative

Species:

Leishmania major

UniProt:

Q4QG72_LEIMA

TriTrypDb:

LmjF.13.0820 , LMJLV39_130012300 , LMJSD75_130012400

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	2
GO:0005759	mitochondrial matrix	5	7
GO:0031970	organelle envelope lumen	5	2
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QG72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG72

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006105	succinate metabolic process	7	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0019752	carboxylic acid metabolic process	5	2
GO:0022607	cellular component assembly	4	7
GO:0033108	mitochondrial respiratory chain complex assembly	6	7
GO:0034552	respiratory chain complex II assembly	6	7
GO:0034553	mitochondrial respiratory chain complex II assembly	7	7
GO:0043436	oxoacid metabolic process	4	2
GO:0043648	dicarboxylic acid metabolic process	6	2
GO:0043933	protein-containing complex organization	4	7
GO:0044237	cellular metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0065003	protein-containing complex assembly	5	7
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.511
CLV_C14_Caspase3-7	186	190	PF00656	0.423
CLV_NRD_NRD_1	117	119	PF00675	0.271
CLV_PCSK_KEX2_1	117	119	PF00082	0.271
CLV_PCSK_KEX2_1	221	223	PF00082	0.509
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.497
CLV_PCSK_SKI1_1	163	167	PF00082	0.298
CLV_PCSK_SKI1_1	214	218	PF00082	0.279
CLV_PCSK_SKI1_1	221	225	PF00082	0.482
CLV_PCSK_SKI1_1	236	240	PF00082	0.472
CLV_PCSK_SKI1_1	91	95	PF00082	0.383
CLV_PCSK_SKI1_1	99	103	PF00082	0.268
DEG_APCC_DBOX_1	67	75	PF00400	0.427
DEG_MDM2_SWIB_1	196	204	PF02201	0.468
DOC_CKS1_1	165	170	PF01111	0.457
DOC_CYCLIN_RxL_1	157	169	PF00134	0.477
DOC_MAPK_gen_1	96	104	PF00069	0.468
DOC_PP1_RVXF_1	89	95	PF00149	0.381
DOC_USP7_MATH_1	149	153	PF00917	0.444
DOC_USP7_MATH_1	49	53	PF00917	0.565
DOC_USP7_MATH_1	75	79	PF00917	0.405
DOC_WW_Pin1_4	164	169	PF00397	0.606
DOC_WW_Pin1_4	84	89	PF00397	0.473
LIG_14-3-3_CanoR_1	132	139	PF00244	0.423
LIG_14-3-3_CanoR_1	184	191	PF00244	0.423
LIG_14-3-3_CanoR_1	243	251	PF00244	0.523
LIG_14-3-3_CanoR_1	68	72	PF00244	0.550
LIG_Actin_WH2_2	228	245	PF00022	0.469
LIG_Actin_WH2_2	52	70	PF00022	0.466
LIG_deltaCOP1_diTrp_1	82	90	PF00928	0.406
LIG_eIF4E_1	160	166	PF01652	0.457
LIG_FHA_2	145	151	PF00498	0.477
LIG_FHA_2	184	190	PF00498	0.476
LIG_FHA_2	210	216	PF00498	0.468
LIG_FHA_2	84	90	PF00498	0.362
LIG_LIR_Apic_2	82	88	PF02991	0.481
LIG_LIR_Gen_1	199	208	PF02991	0.468
LIG_LIR_Gen_1	63	74	PF02991	0.553
LIG_LIR_Nem_3	158	164	PF02991	0.592
LIG_LIR_Nem_3	199	204	PF02991	0.468
LIG_LIR_Nem_3	237	242	PF02991	0.411
LIG_LIR_Nem_3	63	69	PF02991	0.563
LIG_NRBOX	161	167	PF00104	0.468
LIG_Pex14_1	90	94	PF04695	0.372
LIG_Pex14_2	173	177	PF04695	0.468
LIG_Pex14_2	196	200	PF04695	0.468
LIG_RPA_C_Fungi	29	41	PF08784	0.487
LIG_SH2_CRK	98	102	PF00017	0.302
LIG_SH2_NCK_1	85	89	PF00017	0.400
LIG_SH2_SRC	201	204	PF00017	0.320
LIG_SH2_STAP1	197	201	PF00017	0.302
LIG_SH2_STAT3	203	206	PF00017	0.302
LIG_SH2_STAT5	160	163	PF00017	0.299
LIG_SH2_STAT5	164	167	PF00017	0.305
LIG_SH2_STAT5	203	206	PF00017	0.348
LIG_SH2_STAT5	66	69	PF00017	0.571
LIG_SH2_STAT5	85	88	PF00017	0.302
LIG_SH3_3	12	18	PF00018	0.527
LIG_TRFH_1	164	168	PF08558	0.286
LIG_UBA3_1	101	107	PF00899	0.302
MOD_CDK_SPxxK_3	84	91	PF00069	0.466
MOD_CK1_1	112	118	PF00069	0.302
MOD_CK1_1	126	132	PF00069	0.302
MOD_CK1_1	135	141	PF00069	0.302
MOD_CK1_1	209	215	PF00069	0.302
MOD_CK1_1	234	240	PF00069	0.406
MOD_CK1_1	60	66	PF00069	0.404
MOD_CK2_1	149	155	PF00069	0.276
MOD_CK2_1	196	202	PF00069	0.496
MOD_CK2_1	209	215	PF00069	0.220
MOD_CK2_1	83	89	PF00069	0.372
MOD_GlcNHglycan	125	128	PF01048	0.302
MOD_GlcNHglycan	208	211	PF01048	0.454
MOD_GlcNHglycan	236	239	PF01048	0.410
MOD_GlcNHglycan	24	27	PF01048	0.510
MOD_GlcNHglycan	45	48	PF01048	0.582
MOD_GlcNHglycan	51	54	PF01048	0.491
MOD_GlcNHglycan	7	10	PF01048	0.552
MOD_GSK3_1	131	138	PF00069	0.363
MOD_N-GLC_1	57	62	PF02516	0.521
MOD_NEK2_1	131	136	PF00069	0.241
MOD_NEK2_1	196	201	PF00069	0.302
MOD_NEK2_1	242	247	PF00069	0.530
MOD_NEK2_1	67	72	PF00069	0.446
MOD_NEK2_1	97	102	PF00069	0.347
MOD_NMyristoyl	1	7	PF02799	0.545
MOD_PIKK_1	132	138	PF00454	0.363
MOD_PIKK_1	242	248	PF00454	0.533
MOD_PIKK_1	75	81	PF00454	0.447
MOD_PKA_2	131	137	PF00069	0.239
MOD_PKA_2	183	189	PF00069	0.239
MOD_PKA_2	242	248	PF00069	0.505
MOD_PKA_2	67	73	PF00069	0.469
MOD_Plk_1	149	155	PF00069	0.307
MOD_Plk_1	57	63	PF00069	0.510
MOD_Plk_4	191	197	PF00069	0.294
MOD_Plk_4	51	57	PF00069	0.508
MOD_ProDKin_1	164	170	PF00069	0.495
MOD_ProDKin_1	84	90	PF00069	0.464
MOD_SUMO_rev_2	226	231	PF00179	0.528
TRG_ENDOCYTIC_2	201	204	PF00928	0.302
TRG_ENDOCYTIC_2	21	24	PF00928	0.502
TRG_ENDOCYTIC_2	66	69	PF00928	0.571
TRG_ENDOCYTIC_2	98	101	PF00928	0.302
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R0	Leptomonas seymouri	64%	80%
A0A3S5H6N9	Leishmania donovani	91%	100%
A4H770	Leishmania braziliensis	79%	100%
A4HVL0	Leishmania infantum	92%	100%
E9APA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%