Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG71_LEIMA

TriTrypDb:

LmjF.13.0830 , LMJLV39_130012400 , LMJSD75_130012500

Length:

1236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QG71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	506	510	PF00656	0.599
CLV_C14_Caspase3-7	515	519	PF00656	0.770
CLV_NRD_NRD_1	127	129	PF00675	0.503
CLV_NRD_NRD_1	206	208	PF00675	0.593
CLV_NRD_NRD_1	935	937	PF00675	0.511
CLV_PCSK_KEX2_1	1079	1081	PF00082	0.507
CLV_PCSK_KEX2_1	127	129	PF00082	0.503
CLV_PCSK_KEX2_1	206	208	PF00082	0.593
CLV_PCSK_KEX2_1	611	613	PF00082	0.517
CLV_PCSK_KEX2_1	842	844	PF00082	0.566
CLV_PCSK_KEX2_1	935	937	PF00082	0.511
CLV_PCSK_PC1ET2_1	1079	1081	PF00082	0.496
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.517
CLV_PCSK_PC1ET2_1	842	844	PF00082	0.514
CLV_PCSK_SKI1_1	1131	1135	PF00082	0.447
CLV_PCSK_SKI1_1	1176	1180	PF00082	0.647
CLV_PCSK_SKI1_1	211	215	PF00082	0.691
CLV_PCSK_SKI1_1	341	345	PF00082	0.474
CLV_PCSK_SKI1_1	346	350	PF00082	0.470
CLV_PCSK_SKI1_1	384	388	PF00082	0.672
CLV_PCSK_SKI1_1	593	597	PF00082	0.440
CLV_PCSK_SKI1_1	611	615	PF00082	0.573
CLV_PCSK_SKI1_1	712	716	PF00082	0.614
CLV_PCSK_SKI1_1	738	742	PF00082	0.672
CLV_PCSK_SKI1_1	894	898	PF00082	0.500
CLV_PCSK_SKI1_1	936	940	PF00082	0.599
DEG_APCC_DBOX_1	1082	1090	PF00400	0.460
DEG_APCC_DBOX_1	1173	1181	PF00400	0.578
DEG_APCC_DBOX_1	340	348	PF00400	0.452
DEG_APCC_DBOX_1	735	743	PF00400	0.623
DEG_APCC_DBOX_1	904	912	PF00400	0.435
DEG_COP1_1	219	228	PF00400	0.650
DEG_SPOP_SBC_1	50	54	PF00917	0.683
DOC_CKS1_1	1167	1172	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	710	716	PF00134	0.519
DOC_MAPK_DCC_7	977	987	PF00069	0.482
DOC_MAPK_gen_1	1009	1016	PF00069	0.417
DOC_MAPK_gen_1	1079	1088	PF00069	0.439
DOC_MAPK_gen_1	380	388	PF00069	0.601
DOC_MAPK_MEF2A_6	578	586	PF00069	0.469
DOC_PIKK_1	840	848	PF02985	0.506
DOC_PP1_RVXF_1	1085	1091	PF00149	0.443
DOC_PP1_RVXF_1	248	255	PF00149	0.659
DOC_PP2B_LxvP_1	967	970	PF13499	0.371
DOC_PP4_FxxP_1	1110	1113	PF00568	0.350
DOC_USP7_MATH_1	1185	1189	PF00917	0.597
DOC_USP7_MATH_1	136	140	PF00917	0.578
DOC_USP7_MATH_1	169	173	PF00917	0.582
DOC_USP7_MATH_1	197	201	PF00917	0.752
DOC_USP7_MATH_1	30	34	PF00917	0.693
DOC_USP7_MATH_1	411	415	PF00917	0.641
DOC_USP7_MATH_1	428	432	PF00917	0.668
DOC_USP7_MATH_1	438	442	PF00917	0.742
DOC_USP7_MATH_1	50	54	PF00917	0.751
DOC_USP7_MATH_1	522	526	PF00917	0.737
DOC_USP7_MATH_1	533	537	PF00917	0.533
DOC_USP7_MATH_1	670	674	PF00917	0.691
DOC_USP7_MATH_1	769	773	PF00917	0.599
DOC_USP7_MATH_1	797	801	PF00917	0.486
DOC_USP7_UBL2_3	380	384	PF12436	0.548
DOC_WW_Pin1_4	1166	1171	PF00397	0.591
DOC_WW_Pin1_4	177	182	PF00397	0.757
DOC_WW_Pin1_4	185	190	PF00397	0.679
DOC_WW_Pin1_4	35	40	PF00397	0.709
DOC_WW_Pin1_4	422	427	PF00397	0.530
DOC_WW_Pin1_4	64	69	PF00397	0.674
DOC_WW_Pin1_4	645	650	PF00397	0.631
DOC_WW_Pin1_4	688	693	PF00397	0.750
DOC_WW_Pin1_4	93	98	PF00397	0.566
LIG_14-3-3_CanoR_1	140	144	PF00244	0.589
LIG_14-3-3_CanoR_1	176	181	PF00244	0.812
LIG_14-3-3_CanoR_1	183	189	PF00244	0.688
LIG_14-3-3_CanoR_1	246	254	PF00244	0.627
LIG_14-3-3_CanoR_1	37	43	PF00244	0.710
LIG_14-3-3_CanoR_1	551	556	PF00244	0.657
LIG_14-3-3_CanoR_1	712	720	PF00244	0.585
LIG_14-3-3_CanoR_1	738	743	PF00244	0.683
LIG_14-3-3_CanoR_1	912	922	PF00244	0.452
LIG_14-3-3_CanoR_1	935	939	PF00244	0.474
LIG_14-3-3_CanoR_1	988	993	PF00244	0.471
LIG_Actin_WH2_2	919	937	PF00022	0.480
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_4	1183	1187	PF00653	0.597
LIG_BIR_III_4	279	283	PF00653	0.623
LIG_BRCT_BRCA1_1	1	5	PF00533	0.644
LIG_BRCT_BRCA1_1	438	442	PF00533	0.673
LIG_CaM_IQ_9	1132	1147	PF13499	0.419
LIG_CaM_IQ_9	601	617	PF13499	0.481
LIG_Clathr_ClatBox_1	806	810	PF01394	0.439
LIG_eIF4E_1	616	622	PF01652	0.497
LIG_EVH1_2	449	453	PF00568	0.577
LIG_EVH1_2	539	543	PF00568	0.571
LIG_FHA_1	1059	1065	PF00498	0.404
LIG_FHA_1	1150	1156	PF00498	0.485
LIG_FHA_1	220	226	PF00498	0.657
LIG_FHA_1	29	35	PF00498	0.611
LIG_FHA_1	361	367	PF00498	0.618
LIG_FHA_1	397	403	PF00498	0.561
LIG_FHA_1	425	431	PF00498	0.597
LIG_FHA_1	548	554	PF00498	0.675
LIG_FHA_1	692	698	PF00498	0.621
LIG_FHA_1	888	894	PF00498	0.657
LIG_FHA_1	914	920	PF00498	0.450
LIG_FHA_1	949	955	PF00498	0.486
LIG_FHA_1	989	995	PF00498	0.594
LIG_FHA_2	161	167	PF00498	0.541
LIG_FHA_2	2	8	PF00498	0.610
LIG_FHA_2	555	561	PF00498	0.633
LIG_FHA_2	941	947	PF00498	0.514
LIG_GBD_Chelix_1	596	604	PF00786	0.588
LIG_HCF-1_HBM_1	869	872	PF13415	0.496
LIG_LIR_Apic_2	1108	1113	PF02991	0.349
LIG_LIR_Apic_2	1165	1170	PF02991	0.535
LIG_LIR_Gen_1	38	44	PF02991	0.628
LIG_LIR_Gen_1	571	579	PF02991	0.452
LIG_LIR_Nem_3	38	43	PF02991	0.627
LIG_LIR_Nem_3	571	575	PF02991	0.462
LIG_LIR_Nem_3	679	685	PF02991	0.624
LIG_MYND_1	385	389	PF01753	0.593
LIG_NRBOX	343	349	PF00104	0.455
LIG_PCNA_yPIPBox_3	942	954	PF02747	0.521
LIG_PDZ_Class_2	1231	1236	PF00595	0.518
LIG_REV1ctd_RIR_1	919	927	PF16727	0.475
LIG_SH2_CRK	1021	1025	PF00017	0.461
LIG_SH2_CRK	122	126	PF00017	0.479
LIG_SH2_CRK	378	382	PF00017	0.541
LIG_SH2_CRK	572	576	PF00017	0.529
LIG_SH2_CRK	682	686	PF00017	0.594
LIG_SH2_GRB2like	1098	1101	PF00017	0.462
LIG_SH2_GRB2like	21	24	PF00017	0.684
LIG_SH2_NCK_1	135	139	PF00017	0.578
LIG_SH2_SRC	135	138	PF00017	0.583
LIG_SH2_STAP1	1071	1075	PF00017	0.489
LIG_SH2_STAT5	1027	1030	PF00017	0.469
LIG_SH2_STAT5	1093	1096	PF00017	0.433
LIG_SH2_STAT5	1098	1101	PF00017	0.451
LIG_SH2_STAT5	21	24	PF00017	0.684
LIG_SH2_STAT5	393	396	PF00017	0.494
LIG_SH2_STAT5	57	60	PF00017	0.690
LIG_SH2_STAT5	606	609	PF00017	0.441
LIG_SH2_STAT5	616	619	PF00017	0.451
LIG_SH2_STAT5	709	712	PF00017	0.534
LIG_SH2_STAT5	872	875	PF00017	0.447
LIG_SH2_STAT5	914	917	PF00017	0.473
LIG_SH3_3	186	192	PF00018	0.717
LIG_SH3_3	202	208	PF00018	0.551
LIG_SH3_3	383	389	PF00018	0.633
LIG_SH3_3	391	397	PF00018	0.524
LIG_SH3_3	427	433	PF00018	0.669
LIG_SH3_3	460	466	PF00018	0.595
LIG_SH3_3	534	540	PF00018	0.582
LIG_SH3_3	761	767	PF00018	0.642
LIG_SH3_3	810	816	PF00018	0.470
LIG_SH3_5	568	572	PF00018	0.517
LIG_Sin3_3	964	971	PF02671	0.402
LIG_SUMO_SIM_anti_2	1160	1165	PF11976	0.539
LIG_SUMO_SIM_anti_2	772	779	PF11976	0.496
LIG_SUMO_SIM_anti_2	800	806	PF11976	0.443
LIG_SUMO_SIM_par_1	550	557	PF11976	0.651
LIG_SUMO_SIM_par_1	693	698	PF11976	0.629
LIG_SUMO_SIM_par_1	805	812	PF11976	0.455
LIG_TRAF2_1	287	290	PF00917	0.605
LIG_TRAF2_1	808	811	PF00917	0.524
LIG_TYR_ITIM	133	138	PF00017	0.466
LIG_TYR_ITIM	376	381	PF00017	0.527
LIG_UBA3_1	343	349	PF00899	0.455
LIG_WRC_WIRS_1	335	340	PF05994	0.479
MOD_CDC14_SPxK_1	180	183	PF00782	0.779
MOD_CDK_SPK_2	64	69	PF00069	0.623
MOD_CDK_SPxK_1	177	183	PF00069	0.783
MOD_CK1_1	139	145	PF00069	0.577
MOD_CK1_1	187	193	PF00069	0.672
MOD_CK1_1	219	225	PF00069	0.667
MOD_CK1_1	259	265	PF00069	0.754
MOD_CK1_1	278	284	PF00069	0.497
MOD_CK1_1	337	343	PF00069	0.492
MOD_CK1_1	355	361	PF00069	0.693
MOD_CK1_1	512	518	PF00069	0.671
MOD_CK1_1	554	560	PF00069	0.637
MOD_CK1_1	688	694	PF00069	0.631
MOD_CK1_1	723	729	PF00069	0.643
MOD_CK1_1	84	90	PF00069	0.716
MOD_CK2_1	1056	1062	PF00069	0.494
MOD_CK2_1	139	145	PF00069	0.576
MOD_CK2_1	289	295	PF00069	0.572
MOD_CK2_1	30	36	PF00069	0.653
MOD_CK2_1	320	326	PF00069	0.537
MOD_CK2_1	38	44	PF00069	0.682
MOD_CK2_1	554	560	PF00069	0.607
MOD_CK2_1	57	63	PF00069	0.540
MOD_CK2_1	716	722	PF00069	0.655
MOD_CK2_1	835	841	PF00069	0.547
MOD_CK2_1	93	99	PF00069	0.637
MOD_CK2_1	940	946	PF00069	0.640
MOD_GlcNHglycan	1040	1043	PF01048	0.477
MOD_GlcNHglycan	14	17	PF01048	0.714
MOD_GlcNHglycan	262	265	PF01048	0.739
MOD_GlcNHglycan	279	283	PF01048	0.573
MOD_GlcNHglycan	357	360	PF01048	0.569
MOD_GlcNHglycan	466	469	PF01048	0.711
MOD_GlcNHglycan	505	508	PF01048	0.653
MOD_GlcNHglycan	520	523	PF01048	0.645
MOD_GlcNHglycan	531	534	PF01048	0.630
MOD_GlcNHglycan	593	596	PF01048	0.468
MOD_GlcNHglycan	635	638	PF01048	0.491
MOD_GlcNHglycan	659	662	PF01048	0.683
MOD_GlcNHglycan	697	700	PF01048	0.689
MOD_GlcNHglycan	731	734	PF01048	0.709
MOD_GlcNHglycan	746	749	PF01048	0.758
MOD_GlcNHglycan	757	760	PF01048	0.623
MOD_GlcNHglycan	824	827	PF01048	0.563
MOD_GlcNHglycan	93	96	PF01048	0.711
MOD_GlcNHglycan	954	957	PF01048	0.395
MOD_GlcNHglycan	962	965	PF01048	0.404
MOD_GSK3_1	1034	1041	PF00069	0.528
MOD_GSK3_1	1205	1212	PF00069	0.585
MOD_GSK3_1	1221	1228	PF00069	0.677
MOD_GSK3_1	160	167	PF00069	0.529
MOD_GSK3_1	179	186	PF00069	0.623
MOD_GSK3_1	197	204	PF00069	0.665
MOD_GSK3_1	216	223	PF00069	0.698
MOD_GSK3_1	24	31	PF00069	0.602
MOD_GSK3_1	256	263	PF00069	0.601
MOD_GSK3_1	424	431	PF00069	0.710
MOD_GSK3_1	454	461	PF00069	0.689
MOD_GSK3_1	510	517	PF00069	0.676
MOD_GSK3_1	518	525	PF00069	0.577
MOD_GSK3_1	529	536	PF00069	0.577
MOD_GSK3_1	547	554	PF00069	0.620
MOD_GSK3_1	623	630	PF00069	0.546
MOD_GSK3_1	645	652	PF00069	0.542
MOD_GSK3_1	686	693	PF00069	0.581
MOD_GSK3_1	712	719	PF00069	0.663
MOD_GSK3_1	744	751	PF00069	0.677
MOD_GSK3_1	776	783	PF00069	0.546
MOD_GSK3_1	899	906	PF00069	0.481
MOD_GSK3_1	948	955	PF00069	0.417
MOD_LATS_1	501	507	PF00433	0.650
MOD_N-GLC_1	1099	1104	PF02516	0.565
MOD_N-GLC_1	220	225	PF02516	0.626
MOD_N-GLC_1	436	441	PF02516	0.671
MOD_N-GLC_1	562	567	PF02516	0.623
MOD_N-GLC_1	670	675	PF02516	0.628
MOD_N-GLC_1	988	993	PF02516	0.518
MOD_N-GLC_2	8	10	PF02516	0.615
MOD_NEK2_1	1010	1015	PF00069	0.440
MOD_NEK2_1	1200	1205	PF00069	0.594
MOD_NEK2_1	1213	1218	PF00069	0.629
MOD_NEK2_1	28	33	PF00069	0.690
MOD_NEK2_1	529	534	PF00069	0.653
MOD_NEK2_1	591	596	PF00069	0.503
MOD_NEK2_1	617	622	PF00069	0.434
MOD_NEK2_1	627	632	PF00069	0.441
MOD_NEK2_1	657	662	PF00069	0.784
MOD_NEK2_1	675	680	PF00069	0.523
MOD_NEK2_1	685	690	PF00069	0.640
MOD_NEK2_1	720	725	PF00069	0.655
MOD_NEK2_1	753	758	PF00069	0.627
MOD_NEK2_1	81	86	PF00069	0.723
MOD_NEK2_1	822	827	PF00069	0.584
MOD_NEK2_1	887	892	PF00069	0.574
MOD_NEK2_1	91	96	PF00069	0.798
MOD_NEK2_1	921	926	PF00069	0.427
MOD_NEK2_1	934	939	PF00069	0.440
MOD_NEK2_1	948	953	PF00069	0.360
MOD_NEK2_1	960	965	PF00069	0.369
MOD_NEK2_2	670	675	PF00069	0.688
MOD_PIKK_1	1169	1175	PF00454	0.615
MOD_PIKK_1	352	358	PF00454	0.502
MOD_PIKK_1	627	633	PF00454	0.525
MOD_PIKK_1	84	90	PF00454	0.752
MOD_PK_1	551	557	PF00069	0.672
MOD_PKA_1	320	326	PF00069	0.537
MOD_PKA_2	1010	1016	PF00069	0.444
MOD_PKA_2	1038	1044	PF00069	0.533
MOD_PKA_2	1214	1220	PF00069	0.591
MOD_PKA_2	1221	1227	PF00069	0.608
MOD_PKA_2	139	145	PF00069	0.598
MOD_PKA_2	170	176	PF00069	0.778
MOD_PKA_2	245	251	PF00069	0.649
MOD_PKA_2	260	266	PF00069	0.463
MOD_PKA_2	44	50	PF00069	0.652
MOD_PKA_2	547	553	PF00069	0.660
MOD_PKA_2	617	623	PF00069	0.436
MOD_PKA_2	716	722	PF00069	0.593
MOD_PKA_2	84	90	PF00069	0.559
MOD_PKA_2	934	940	PF00069	0.626
MOD_PKA_2	987	993	PF00069	0.441
MOD_PKB_1	174	182	PF00069	0.636
MOD_PKB_1	736	744	PF00069	0.654
MOD_Plk_1	1099	1105	PF00069	0.444
MOD_Plk_1	289	295	PF00069	0.572
MOD_Plk_1	476	482	PF00069	0.622
MOD_Plk_1	562	568	PF00069	0.553
MOD_Plk_1	623	629	PF00069	0.475
MOD_Plk_1	670	676	PF00069	0.629
MOD_Plk_1	888	894	PF00069	0.513
MOD_Plk_1	940	946	PF00069	0.481
MOD_Plk_2-3	326	332	PF00069	0.470
MOD_Plk_4	38	44	PF00069	0.653
MOD_Plk_4	617	623	PF00069	0.436
MOD_Plk_4	670	676	PF00069	0.687
MOD_Plk_4	723	729	PF00069	0.619
MOD_Plk_4	797	803	PF00069	0.467
MOD_Plk_4	921	927	PF00069	0.511
MOD_Plk_4	929	935	PF00069	0.440
MOD_ProDKin_1	1166	1172	PF00069	0.590
MOD_ProDKin_1	177	183	PF00069	0.759
MOD_ProDKin_1	185	191	PF00069	0.681
MOD_ProDKin_1	35	41	PF00069	0.709
MOD_ProDKin_1	422	428	PF00069	0.530
MOD_ProDKin_1	64	70	PF00069	0.676
MOD_ProDKin_1	645	651	PF00069	0.637
MOD_ProDKin_1	688	694	PF00069	0.753
MOD_ProDKin_1	93	99	PF00069	0.566
TRG_DiLeu_BaEn_1	1130	1135	PF01217	0.483
TRG_DiLeu_BaEn_1	339	344	PF01217	0.513
TRG_DiLeu_BaEn_1	869	874	PF01217	0.510
TRG_DiLeu_BaEn_4	289	295	PF01217	0.508
TRG_DiLeu_BaEn_4	810	816	PF01217	0.543
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.651
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.456
TRG_ENDOCYTIC_2	1021	1024	PF00928	0.377
TRG_ENDOCYTIC_2	122	125	PF00928	0.484
TRG_ENDOCYTIC_2	135	138	PF00928	0.590
TRG_ENDOCYTIC_2	378	381	PF00928	0.501
TRG_ENDOCYTIC_2	40	43	PF00928	0.658
TRG_ENDOCYTIC_2	572	575	PF00928	0.453
TRG_ENDOCYTIC_2	682	685	PF00928	0.595
TRG_ER_diArg_1	1008	1011	PF00400	0.429
TRG_ER_diArg_1	1174	1177	PF00400	0.657
TRG_ER_diArg_1	126	128	PF00400	0.494
TRG_ER_diArg_1	175	178	PF00400	0.681
TRG_ER_diArg_1	205	207	PF00400	0.553
TRG_ER_diArg_1	736	739	PF00400	0.676
TRG_ER_diArg_1	934	936	PF00400	0.521
TRG_NES_CRM1_1	799	812	PF08389	0.510
TRG_NES_CRM1_1	903	917	PF08389	0.464
TRG_NLS_MonoExtN_4	609	614	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	843	847	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	894	898	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	942	946	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9G9	Leptomonas seymouri	44%	99%
A0A1X0NN34	Trypanosomatidae	30%	100%
A0A3Q8ICV6	Leishmania donovani	92%	100%
A4H771	Leishmania braziliensis	66%	99%
A4HVL1	Leishmania infantum	92%	100%
E9APA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%