Doublecortin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG69_LEIMA

TriTrypDb:

LmjF.13.0850 , LMJLV39_130012600 , LMJSD75_130012700

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.607
CLV_C14_Caspase3-7	190	194	PF00656	0.629
CLV_C14_Caspase3-7	224	228	PF00656	0.610
CLV_C14_Caspase3-7	528	532	PF00656	0.618
CLV_NRD_NRD_1	351	353	PF00675	0.680
CLV_NRD_NRD_1	422	424	PF00675	0.608
CLV_NRD_NRD_1	496	498	PF00675	0.648
CLV_NRD_NRD_1	512	514	PF00675	0.537
CLV_NRD_NRD_1	544	546	PF00675	0.603
CLV_NRD_NRD_1	566	568	PF00675	0.755
CLV_NRD_NRD_1	678	680	PF00675	0.655
CLV_NRD_NRD_1	7	9	PF00675	0.581
CLV_NRD_NRD_1	793	795	PF00675	0.650
CLV_NRD_NRD_1	814	816	PF00675	0.608
CLV_NRD_NRD_1	890	892	PF00675	0.677
CLV_PCSK_KEX2_1	351	353	PF00082	0.680
CLV_PCSK_KEX2_1	422	424	PF00082	0.608
CLV_PCSK_KEX2_1	512	514	PF00082	0.610
CLV_PCSK_KEX2_1	544	546	PF00082	0.603
CLV_PCSK_KEX2_1	565	567	PF00082	0.768
CLV_PCSK_KEX2_1	678	680	PF00082	0.655
CLV_PCSK_KEX2_1	814	816	PF00082	0.608
CLV_PCSK_KEX2_1	890	892	PF00082	0.677
CLV_PCSK_KEX2_1	917	919	PF00082	0.634
CLV_PCSK_PC1ET2_1	917	919	PF00082	0.634
CLV_PCSK_PC7_1	562	568	PF00082	0.775
CLV_PCSK_SKI1_1	440	444	PF00082	0.600
CLV_PCSK_SKI1_1	519	523	PF00082	0.619
CLV_PCSK_SKI1_1	712	716	PF00082	0.682
CLV_PCSK_SKI1_1	752	756	PF00082	0.661
CLV_PCSK_SKI1_1	890	894	PF00082	0.563
DEG_SCF_FBW7_1	380	385	PF00400	0.609
DEG_SCF_FBW7_1	909	916	PF00400	0.664
DEG_SPOP_SBC_1	537	541	PF00917	0.630
DEG_SPOP_SBC_1	688	692	PF00917	0.657
DEG_SPOP_SBC_1	804	808	PF00917	0.609
DEG_SPOP_SBC_1	885	889	PF00917	0.661
DOC_CKS1_1	411	416	PF01111	0.458
DOC_CKS1_1	796	801	PF01111	0.568
DOC_CYCLIN_RxL_1	435	446	PF00134	0.609
DOC_MAPK_gen_1	8	15	PF00069	0.587
DOC_MAPK_MEF2A_6	794	803	PF00069	0.622
DOC_MAPK_RevD_3	410	423	PF00069	0.494
DOC_PP1_RVXF_1	765	771	PF00149	0.552
DOC_PP4_FxxP_1	591	594	PF00568	0.571
DOC_USP7_MATH_1	189	193	PF00917	0.622
DOC_USP7_MATH_1	246	250	PF00917	0.633
DOC_USP7_MATH_1	306	310	PF00917	0.623
DOC_USP7_MATH_1	406	410	PF00917	0.572
DOC_USP7_MATH_1	503	507	PF00917	0.681
DOC_USP7_MATH_1	511	515	PF00917	0.632
DOC_USP7_MATH_1	537	541	PF00917	0.693
DOC_USP7_MATH_1	688	692	PF00917	0.657
DOC_USP7_MATH_1	780	784	PF00917	0.628
DOC_USP7_MATH_1	804	808	PF00917	0.686
DOC_USP7_MATH_1	886	890	PF00917	0.793
DOC_USP7_MATH_1	899	903	PF00917	0.591
DOC_WW_Pin1_4	179	184	PF00397	0.674
DOC_WW_Pin1_4	191	196	PF00397	0.612
DOC_WW_Pin1_4	329	334	PF00397	0.699
DOC_WW_Pin1_4	340	345	PF00397	0.605
DOC_WW_Pin1_4	378	383	PF00397	0.678
DOC_WW_Pin1_4	410	415	PF00397	0.592
DOC_WW_Pin1_4	446	451	PF00397	0.595
DOC_WW_Pin1_4	497	502	PF00397	0.655
DOC_WW_Pin1_4	795	800	PF00397	0.565
DOC_WW_Pin1_4	864	869	PF00397	0.665
DOC_WW_Pin1_4	874	879	PF00397	0.609
DOC_WW_Pin1_4	909	914	PF00397	0.667
LIG_14-3-3_CanoR_1	329	333	PF00244	0.645
LIG_14-3-3_CanoR_1	440	450	PF00244	0.594
LIG_14-3-3_CanoR_1	469	473	PF00244	0.598
LIG_14-3-3_CanoR_1	477	483	PF00244	0.595
LIG_14-3-3_CanoR_1	492	501	PF00244	0.575
LIG_14-3-3_CanoR_1	512	516	PF00244	0.578
LIG_14-3-3_CanoR_1	519	529	PF00244	0.646
LIG_14-3-3_CanoR_1	668	673	PF00244	0.632
LIG_14-3-3_CanoR_1	679	689	PF00244	0.588
LIG_14-3-3_CanoR_1	8	16	PF00244	0.578
LIG_14-3-3_CanoR_1	874	878	PF00244	0.701
LIG_14-3-3_CanoR_1	890	895	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BRCT_BRCA1_1	529	533	PF00533	0.819
LIG_BRCT_BRCA1_1	587	591	PF00533	0.621
LIG_EVH1_2	649	653	PF00568	0.672
LIG_FHA_1	180	186	PF00498	0.644
LIG_FHA_1	334	340	PF00498	0.677
LIG_FHA_1	388	394	PF00498	0.625
LIG_FHA_1	414	420	PF00498	0.499
LIG_FHA_1	443	449	PF00498	0.479
LIG_FHA_1	599	605	PF00498	0.643
LIG_FHA_1	796	802	PF00498	0.597
LIG_FHA_1	8	14	PF00498	0.616
LIG_FHA_2	19	25	PF00498	0.575
LIG_FHA_2	250	256	PF00498	0.620
LIG_FHA_2	320	326	PF00498	0.625
LIG_FHA_2	491	497	PF00498	0.621
LIG_FHA_2	526	532	PF00498	0.728
LIG_FHA_2	650	656	PF00498	0.655
LIG_FHA_2	730	736	PF00498	0.608
LIG_FHA_2	874	880	PF00498	0.611
LIG_LIR_Apic_2	108	113	PF02991	0.611
LIG_LIR_Apic_2	129	134	PF02991	0.615
LIG_LIR_Apic_2	150	155	PF02991	0.610
LIG_LIR_Apic_2	24	29	PF02991	0.587
LIG_LIR_Apic_2	394	400	PF02991	0.619
LIG_LIR_Apic_2	45	50	PF02991	0.632
LIG_LIR_Apic_2	514	518	PF02991	0.688
LIG_LIR_Apic_2	588	594	PF02991	0.592
LIG_LIR_Apic_2	66	71	PF02991	0.630
LIG_LIR_Apic_2	87	92	PF02991	0.610
LIG_LIR_LC3C_4	415	420	PF02991	0.480
LIG_LIR_Nem_3	20	26	PF02991	0.580
LIG_LIR_Nem_3	437	441	PF02991	0.620
LIG_LIR_Nem_3	580	584	PF02991	0.611
LIG_LIR_Nem_3	616	621	PF02991	0.690
LIG_PCNA_yPIPBox_3	727	737	PF02747	0.531
LIG_SH2_CRK	110	114	PF00017	0.610
LIG_SH2_CRK	131	135	PF00017	0.617
LIG_SH2_CRK	152	156	PF00017	0.624
LIG_SH2_CRK	26	30	PF00017	0.592
LIG_SH2_CRK	47	51	PF00017	0.632
LIG_SH2_CRK	515	519	PF00017	0.693
LIG_SH2_CRK	68	72	PF00017	0.619
LIG_SH2_CRK	89	93	PF00017	0.610
LIG_SH2_GRB2like	583	586	PF00017	0.600
LIG_SH2_NCK_1	110	114	PF00017	0.610
LIG_SH2_NCK_1	131	135	PF00017	0.617
LIG_SH2_NCK_1	152	156	PF00017	0.624
LIG_SH2_NCK_1	26	30	PF00017	0.592
LIG_SH2_NCK_1	397	401	PF00017	0.567
LIG_SH2_NCK_1	47	51	PF00017	0.632
LIG_SH2_NCK_1	68	72	PF00017	0.619
LIG_SH2_NCK_1	89	93	PF00017	0.610
LIG_SH2_SRC	515	518	PF00017	0.579
LIG_SH2_SRC	592	595	PF00017	0.519
LIG_SH2_STAP1	438	442	PF00017	0.621
LIG_SH2_STAT3	911	914	PF00017	0.641
LIG_SH2_STAT5	441	444	PF00017	0.600
LIG_SH2_STAT5	484	487	PF00017	0.605
LIG_SH2_STAT5	581	584	PF00017	0.635
LIG_SH2_STAT5	592	595	PF00017	0.518
LIG_SH2_STAT5	744	747	PF00017	0.563
LIG_SH2_STAT5	911	914	PF00017	0.697
LIG_SH3_1	617	623	PF00018	0.641
LIG_SH3_3	10	16	PF00018	0.604
LIG_SH3_3	298	304	PF00018	0.637
LIG_SH3_3	339	345	PF00018	0.707
LIG_SH3_3	355	361	PF00018	0.563
LIG_SH3_3	477	483	PF00018	0.594
LIG_SH3_3	591	597	PF00018	0.648
LIG_SH3_3	617	623	PF00018	0.807
LIG_SH3_3	798	804	PF00018	0.812
LIG_SH3_3	862	868	PF00018	0.669
LIG_SUMO_SIM_par_1	449	456	PF11976	0.525
LIG_TRAF2_1	113	116	PF00917	0.562
LIG_TRAF2_1	119	122	PF00917	0.603
LIG_TRAF2_1	134	137	PF00917	0.562
LIG_TRAF2_1	140	143	PF00917	0.608
LIG_TRAF2_1	155	158	PF00917	0.586
LIG_TRAF2_1	161	164	PF00917	0.612
LIG_TRAF2_1	200	203	PF00917	0.621
LIG_TRAF2_1	29	32	PF00917	0.623
LIG_TRAF2_1	35	38	PF00917	0.603
LIG_TRAF2_1	50	53	PF00917	0.553
LIG_TRAF2_1	56	59	PF00917	0.588
LIG_TRAF2_1	71	74	PF00917	0.564
LIG_TRAF2_1	732	735	PF00917	0.601
LIG_TRAF2_1	77	80	PF00917	0.600
LIG_TRAF2_1	92	95	PF00917	0.559
LIG_TRAF2_1	98	101	PF00917	0.594
LIG_TYR_ITIM	604	609	PF00017	0.652
LIG_WW_3	516	520	PF00397	0.577
LIG_WW_3	648	652	PF00397	0.674
MOD_CK1_1	249	255	PF00069	0.622
MOD_CK1_1	332	338	PF00069	0.623
MOD_CK1_1	376	382	PF00069	0.625
MOD_CK1_1	506	512	PF00069	0.652
MOD_CK1_1	520	526	PF00069	0.592
MOD_CK1_1	626	632	PF00069	0.646
MOD_CK1_1	680	686	PF00069	0.688
MOD_CK1_1	690	696	PF00069	0.625
MOD_CK1_1	710	716	PF00069	0.529
MOD_CK1_1	783	789	PF00069	0.657
MOD_CK1_1	807	813	PF00069	0.671
MOD_CK1_1	884	890	PF00069	0.692
MOD_CK1_1	919	925	PF00069	0.690
MOD_CK2_1	205	211	PF00069	0.645
MOD_CK2_1	328	334	PF00069	0.635
MOD_CK2_1	490	496	PF00069	0.696
MOD_CK2_1	571	577	PF00069	0.646
MOD_CK2_1	649	655	PF00069	0.662
MOD_CK2_1	690	696	PF00069	0.702
MOD_CK2_1	729	735	PF00069	0.654
MOD_CK2_1	824	830	PF00069	0.638
MOD_CK2_1	843	849	PF00069	0.630
MOD_CK2_1	873	879	PF00069	0.617
MOD_Cter_Amidation	812	815	PF01082	0.672
MOD_DYRK1A_RPxSP_1	329	333	PF00069	0.645
MOD_DYRK1A_RPxSP_1	874	878	PF00069	0.645
MOD_GlcNHglycan	291	295	PF01048	0.668
MOD_GlcNHglycan	307	311	PF01048	0.572
MOD_GlcNHglycan	375	378	PF01048	0.623
MOD_GlcNHglycan	408	411	PF01048	0.519
MOD_GlcNHglycan	505	508	PF01048	0.667
MOD_GlcNHglycan	509	512	PF01048	0.646
MOD_GlcNHglycan	522	525	PF01048	0.659
MOD_GlcNHglycan	628	631	PF01048	0.644
MOD_GlcNHglycan	692	695	PF01048	0.631
MOD_GlcNHglycan	782	785	PF01048	0.718
MOD_GlcNHglycan	809	812	PF01048	0.656
MOD_GlcNHglycan	826	829	PF01048	0.505
MOD_GlcNHglycan	845	848	PF01048	0.570
MOD_GlcNHglycan	883	886	PF01048	0.687
MOD_GlcNHglycan	921	924	PF01048	0.702
MOD_GSK3_1	246	253	PF00069	0.590
MOD_GSK3_1	328	335	PF00069	0.619
MOD_GSK3_1	376	383	PF00069	0.635
MOD_GSK3_1	406	413	PF00069	0.513
MOD_GSK3_1	442	449	PF00069	0.588
MOD_GSK3_1	453	460	PF00069	0.494
MOD_GSK3_1	503	510	PF00069	0.670
MOD_GSK3_1	525	532	PF00069	0.730
MOD_GSK3_1	533	540	PF00069	0.698
MOD_GSK3_1	649	656	PF00069	0.658
MOD_GSK3_1	668	675	PF00069	0.631
MOD_GSK3_1	683	690	PF00069	0.637
MOD_GSK3_1	701	708	PF00069	0.664
MOD_GSK3_1	725	732	PF00069	0.614
MOD_GSK3_1	780	787	PF00069	0.603
MOD_GSK3_1	803	810	PF00069	0.680
MOD_GSK3_1	860	867	PF00069	0.679
MOD_GSK3_1	881	888	PF00069	0.654
MOD_GSK3_1	909	916	PF00069	0.692
MOD_N-GLC_1	205	210	PF02516	0.600
MOD_N-GLC_1	264	269	PF02516	0.684
MOD_N-GLC_1	478	483	PF02516	0.646
MOD_N-GLC_1	909	914	PF02516	0.695
MOD_NEK2_1	225	230	PF00069	0.608
MOD_NEK2_1	373	378	PF00069	0.630
MOD_NEK2_1	453	458	PF00069	0.592
MOD_NEK2_1	522	527	PF00069	0.725
MOD_NEK2_1	529	534	PF00069	0.759
MOD_NEK2_1	653	658	PF00069	0.624
MOD_NEK2_1	663	668	PF00069	0.519
MOD_NEK2_1	689	694	PF00069	0.678
MOD_NEK2_1	722	727	PF00069	0.655
MOD_NEK2_1	809	814	PF00069	0.634
MOD_NEK2_2	636	641	PF00069	0.644
MOD_NEK2_2	707	712	PF00069	0.691
MOD_PIKK_1	213	219	PF00454	0.600
MOD_PIKK_1	360	366	PF00454	0.648
MOD_PIKK_1	663	669	PF00454	0.673
MOD_PIKK_1	701	707	PF00454	0.690
MOD_PIKK_1	722	728	PF00454	0.655
MOD_PKA_1	890	896	PF00069	0.560
MOD_PKA_2	328	334	PF00069	0.648
MOD_PKA_2	434	440	PF00069	0.531
MOD_PKA_2	468	474	PF00069	0.622
MOD_PKA_2	511	517	PF00069	0.646
MOD_PKA_2	525	531	PF00069	0.575
MOD_PKA_2	626	632	PF00069	0.646
MOD_PKA_2	677	683	PF00069	0.679
MOD_PKA_2	7	13	PF00069	0.611
MOD_PKA_2	873	879	PF00069	0.701
MOD_PKA_2	890	896	PF00069	0.517
MOD_PKB_1	727	735	PF00069	0.566
MOD_Plk_1	425	431	PF00069	0.655
MOD_Plk_1	453	459	PF00069	0.587
MOD_Plk_1	485	491	PF00069	0.636
MOD_Plk_2-3	18	24	PF00069	0.574
MOD_Plk_2-3	232	238	PF00069	0.618
MOD_Plk_4	598	604	PF00069	0.627
MOD_ProDKin_1	179	185	PF00069	0.675
MOD_ProDKin_1	191	197	PF00069	0.614
MOD_ProDKin_1	329	335	PF00069	0.698
MOD_ProDKin_1	340	346	PF00069	0.601
MOD_ProDKin_1	378	384	PF00069	0.678
MOD_ProDKin_1	410	416	PF00069	0.585
MOD_ProDKin_1	446	452	PF00069	0.588
MOD_ProDKin_1	497	503	PF00069	0.657
MOD_ProDKin_1	795	801	PF00069	0.565
MOD_ProDKin_1	864	870	PF00069	0.669
MOD_ProDKin_1	874	880	PF00069	0.604
MOD_ProDKin_1	909	915	PF00069	0.665
MOD_SUMO_for_1	261	264	PF00179	0.643
MOD_SUMO_rev_2	212	222	PF00179	0.642
MOD_SUMO_rev_2	254	263	PF00179	0.645
MOD_SUMO_rev_2	495	500	PF00179	0.638
MOD_SUMO_rev_2	760	768	PF00179	0.537
TRG_ENDOCYTIC_2	606	609	PF00928	0.651
TRG_ER_diArg_1	350	352	PF00400	0.684
TRG_ER_diArg_1	421	423	PF00400	0.607
TRG_ER_diArg_1	543	545	PF00400	0.611
TRG_ER_diArg_1	565	567	PF00400	0.751
TRG_ER_diArg_1	677	679	PF00400	0.700
TRG_ER_diArg_1	814	816	PF00400	0.664
TRG_ER_diArg_1	890	892	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	761	765	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSK5	Leishmania donovani	82%	85%
A4H773	Leishmania braziliensis	60%	100%
A4HVL3	Leishmania infantum	81%	89%
E9APA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%