Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG68_LEIMA

TriTrypDb:

LmjF.13.0860 , LMJLV39_130012700 , LMJSD75_130012800

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.682
CLV_NRD_NRD_1	157	159	PF00675	0.788
CLV_NRD_NRD_1	161	163	PF00675	0.742
CLV_NRD_NRD_1	261	263	PF00675	0.694
CLV_NRD_NRD_1	284	286	PF00675	0.646
CLV_PCSK_FUR_1	155	159	PF00082	0.725
CLV_PCSK_FUR_1	411	415	PF00082	0.631
CLV_PCSK_KEX2_1	157	159	PF00082	0.788
CLV_PCSK_KEX2_1	161	163	PF00082	0.742
CLV_PCSK_KEX2_1	225	227	PF00082	0.688
CLV_PCSK_KEX2_1	244	246	PF00082	0.684
CLV_PCSK_KEX2_1	261	263	PF00082	0.694
CLV_PCSK_KEX2_1	284	286	PF00082	0.641
CLV_PCSK_KEX2_1	348	350	PF00082	0.827
CLV_PCSK_KEX2_1	413	415	PF00082	0.644
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.688
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.684
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.827
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.668
CLV_PCSK_PC7_1	157	163	PF00082	0.757
CLV_PCSK_PC7_1	409	415	PF00082	0.594
CLV_PCSK_SKI1_1	121	125	PF00082	0.640
CLV_PCSK_SKI1_1	245	249	PF00082	0.697
CLV_PCSK_SKI1_1	349	353	PF00082	0.826
CLV_PCSK_SKI1_1	60	64	PF00082	0.464
DEG_Nend_Nbox_1	1	3	PF02207	0.466
DOC_CKS1_1	138	143	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.537
DOC_MAPK_DCC_7	16	25	PF00069	0.450
DOC_MAPK_MEF2A_6	16	25	PF00069	0.466
DOC_MAPK_MEF2A_6	32	39	PF00069	0.385
DOC_MAPK_MEF2A_6	60	69	PF00069	0.532
DOC_PP4_FxxP_1	228	231	PF00568	0.734
DOC_USP7_MATH_1	103	107	PF00917	0.682
DOC_USP7_MATH_1	110	114	PF00917	0.623
DOC_USP7_MATH_1	179	183	PF00917	0.572
DOC_USP7_MATH_1	187	191	PF00917	0.515
DOC_USP7_MATH_1	28	32	PF00917	0.462
DOC_USP7_MATH_1	327	331	PF00917	0.710
DOC_USP7_MATH_1	360	364	PF00917	0.629
DOC_USP7_MATH_1	426	430	PF00917	0.592
DOC_USP7_MATH_1	91	95	PF00917	0.489
DOC_USP7_MATH_2	125	131	PF00917	0.629
DOC_USP7_UBL2_3	221	225	PF12436	0.677
DOC_WW_Pin1_4	121	126	PF00397	0.742
DOC_WW_Pin1_4	137	142	PF00397	0.584
DOC_WW_Pin1_4	148	153	PF00397	0.674
DOC_WW_Pin1_4	16	21	PF00397	0.444
DOC_WW_Pin1_4	31	36	PF00397	0.415
DOC_WW_Pin1_4	356	361	PF00397	0.702
DOC_WW_Pin1_4	42	47	PF00397	0.402
LIG_14-3-3_CanoR_1	170	178	PF00244	0.531
LIG_14-3-3_CanoR_1	90	98	PF00244	0.406
LIG_Actin_WH2_2	62	77	PF00022	0.519
LIG_AP2alpha_2	200	202	PF02296	0.693
LIG_BRCT_BRCA1_1	112	116	PF00533	0.796
LIG_BRCT_BRCA1_1	129	133	PF00533	0.452
LIG_CSL_BTD_1	239	242	PF09270	0.683
LIG_FHA_1	126	132	PF00498	0.742
LIG_FHA_1	230	236	PF00498	0.552
LIG_FHA_1	32	38	PF00498	0.421
LIG_FHA_1	357	363	PF00498	0.723
LIG_FHA_1	6	12	PF00498	0.453
LIG_FHA_2	122	128	PF00498	0.671
LIG_FHA_2	306	312	PF00498	0.630
LIG_FHA_2	397	403	PF00498	0.559
LIG_Integrin_isoDGR_2	343	345	PF01839	0.758
LIG_LIR_Apic_2	136	141	PF02991	0.615
LIG_LIR_Apic_2	270	276	PF02991	0.655
LIG_LIR_Gen_1	34	43	PF02991	0.393
LIG_LIR_Nem_3	190	196	PF02991	0.563
LIG_LIR_Nem_3	34	39	PF02991	0.394
LIG_MYND_1	20	24	PF01753	0.453
LIG_SH2_CRK	138	142	PF00017	0.728
LIG_SH2_STAT5	196	199	PF00017	0.531
LIG_SH2_STAT5	216	219	PF00017	0.552
LIG_SH2_STAT5	98	101	PF00017	0.456
LIG_SH3_3	11	17	PF00018	0.437
LIG_SH3_3	18	24	PF00018	0.443
LIG_SH3_3	236	242	PF00018	0.657
LIG_SH3_3	243	249	PF00018	0.682
LIG_SH3_3	298	304	PF00018	0.693
LIG_SH3_3	368	374	PF00018	0.780
LIG_TRAF2_1	249	252	PF00917	0.585
LIG_TRAF2_1	308	311	PF00917	0.737
LIG_UBA3_1	418	423	PF00899	0.432
MOD_CDK_SPxxK_3	148	155	PF00069	0.683
MOD_CK1_1	182	188	PF00069	0.532
MOD_CK1_1	31	37	PF00069	0.427
MOD_CK2_1	103	109	PF00069	0.699
MOD_CK2_1	121	127	PF00069	0.477
MOD_CK2_1	305	311	PF00069	0.624
MOD_CK2_1	328	334	PF00069	0.668
MOD_CK2_1	396	402	PF00069	0.585
MOD_Cter_Amidation	159	162	PF01082	0.749
MOD_Cter_Amidation	223	226	PF01082	0.678
MOD_Cter_Amidation	346	349	PF01082	0.703
MOD_DYRK1A_RPxSP_1	16	20	PF00069	0.437
MOD_GlcNHglycan	105	108	PF01048	0.743
MOD_GlcNHglycan	116	119	PF01048	0.643
MOD_GlcNHglycan	189	192	PF01048	0.639
MOD_GlcNHglycan	321	324	PF01048	0.817
MOD_GlcNHglycan	362	365	PF01048	0.751
MOD_GSK3_1	110	117	PF00069	0.797
MOD_GSK3_1	121	128	PF00069	0.612
MOD_GSK3_1	133	140	PF00069	0.632
MOD_GSK3_1	143	150	PF00069	0.737
MOD_GSK3_1	178	185	PF00069	0.699
MOD_GSK3_1	229	236	PF00069	0.674
MOD_GSK3_1	315	322	PF00069	0.782
MOD_GSK3_1	356	363	PF00069	0.822
MOD_GSK3_1	42	49	PF00069	0.522
MOD_N-GLC_1	267	272	PF02516	0.761
MOD_N-GLC_1	380	385	PF02516	0.761
MOD_NEK2_1	116	121	PF00069	0.786
MOD_NEK2_1	133	138	PF00069	0.560
MOD_NEK2_1	418	423	PF00069	0.668
MOD_NEK2_1	74	79	PF00069	0.540
MOD_PIKK_1	133	139	PF00454	0.605
MOD_PIKK_1	256	262	PF00454	0.678
MOD_PIKK_1	380	386	PF00454	0.756
MOD_PIKK_1	54	60	PF00454	0.485
MOD_PKA_2	396	402	PF00069	0.585
MOD_PKA_2	91	97	PF00069	0.398
MOD_PKB_1	90	98	PF00069	0.406
MOD_Plk_1	143	149	PF00069	0.769
MOD_Plk_1	305	311	PF00069	0.604
MOD_Plk_1	380	386	PF00069	0.756
MOD_Plk_4	179	185	PF00069	0.544
MOD_Plk_4	310	316	PF00069	0.751
MOD_Plk_4	92	98	PF00069	0.502
MOD_ProDKin_1	121	127	PF00069	0.739
MOD_ProDKin_1	137	143	PF00069	0.584
MOD_ProDKin_1	148	154	PF00069	0.678
MOD_ProDKin_1	16	22	PF00069	0.448
MOD_ProDKin_1	31	37	PF00069	0.412
MOD_ProDKin_1	356	362	PF00069	0.704
MOD_ProDKin_1	42	48	PF00069	0.409
MOD_SUMO_rev_2	71	77	PF00179	0.522
TRG_DiLeu_BaEn_2	229	235	PF01217	0.554
TRG_ER_diArg_1	155	158	PF00400	0.733
TRG_ER_diArg_1	261	264	PF00400	0.698
TRG_ER_diArg_1	64	67	PF00400	0.517
TRG_ER_diArg_1	89	92	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I155	Leptomonas seymouri	47%	100%
A0A3Q8I8I3	Leishmania donovani	91%	100%
A4H774	Leishmania braziliensis	71%	100%
A4HVL4	Leishmania infantum	91%	100%
E9APB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%