Metallo-peptidase, Clan ME, Family M16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase alpha subunit, putative

Species:

Leishmania major

UniProt:

Q4QG67_LEIMA

TriTrypDb:

LmjF.13.0870 , LMJLV39_130012800 , LMJSD75_130012900

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QG67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	22
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.384
CLV_C14_Caspase3-7	434	438	PF00656	0.566
CLV_C14_Caspase3-7	484	488	PF00656	0.455
CLV_NRD_NRD_1	165	167	PF00675	0.636
CLV_NRD_NRD_1	3	5	PF00675	0.597
CLV_NRD_NRD_1	354	356	PF00675	0.498
CLV_PCSK_KEX2_1	165	167	PF00082	0.621
CLV_PCSK_KEX2_1	3	5	PF00082	0.597
CLV_PCSK_KEX2_1	498	500	PF00082	0.424
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.424
CLV_PCSK_SKI1_1	225	229	PF00082	0.423
CLV_PCSK_SKI1_1	356	360	PF00082	0.379
CLV_PCSK_SKI1_1	419	423	PF00082	0.413
CLV_PCSK_SKI1_1	445	449	PF00082	0.475
CLV_PCSK_SKI1_1	70	74	PF00082	0.363
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DEG_SPOP_SBC_1	108	112	PF00917	0.332
DEG_SPOP_SBC_1	156	160	PF00917	0.441
DOC_MAPK_gen_1	137	146	PF00069	0.309
DOC_MAPK_MEF2A_6	137	146	PF00069	0.321
DOC_PP4_FxxP_1	196	199	PF00568	0.355
DOC_PP4_FxxP_1	396	399	PF00568	0.324
DOC_USP7_MATH_1	130	134	PF00917	0.419
DOC_USP7_MATH_1	157	161	PF00917	0.625
DOC_USP7_MATH_1	245	249	PF00917	0.410
DOC_USP7_MATH_1	46	50	PF00917	0.631
DOC_USP7_MATH_1	471	475	PF00917	0.450
DOC_USP7_MATH_1	488	492	PF00917	0.397
DOC_USP7_MATH_1	79	83	PF00917	0.385
DOC_USP7_UBL2_3	444	448	PF12436	0.328
DOC_WW_Pin1_4	286	291	PF00397	0.415
DOC_WW_Pin1_4	29	34	PF00397	0.533
LIG_14-3-3_CanoR_1	123	129	PF00244	0.402
LIG_14-3-3_CanoR_1	419	428	PF00244	0.484
LIG_14-3-3_CanoR_1	429	435	PF00244	0.507
LIG_14-3-3_CanoR_1	70	79	PF00244	0.482
LIG_Clathr_ClatBox_1	118	122	PF01394	0.369
LIG_eIF4E_1	400	406	PF01652	0.308
LIG_FHA_1	39	45	PF00498	0.471
LIG_FHA_1	400	406	PF00498	0.399
LIG_FHA_1	420	426	PF00498	0.204
LIG_FHA_1	71	77	PF00498	0.466
LIG_FHA_2	316	322	PF00498	0.396
LIG_FHA_2	332	338	PF00498	0.515
LIG_FHA_2	456	462	PF00498	0.411
LIG_FHA_2	478	484	PF00498	0.431
LIG_IBAR_NPY_1	398	400	PF08397	0.207
LIG_LIR_Apic_2	214	220	PF02991	0.374
LIG_LIR_Apic_2	262	267	PF02991	0.319
LIG_LIR_Gen_1	185	196	PF02991	0.324
LIG_LIR_Nem_3	185	191	PF02991	0.310
LIG_LIR_Nem_3	259	264	PF02991	0.288
LIG_LIR_Nem_3	461	465	PF02991	0.325
LIG_PTAP_UEV_1	95	100	PF05743	0.335
LIG_PTB_Apo_2	113	120	PF02174	0.352
LIG_PTB_Apo_2	237	244	PF02174	0.469
LIG_PTB_Apo_2	285	292	PF02174	0.397
LIG_SH2_CRK	93	97	PF00017	0.378
LIG_SH2_GRB2like	286	289	PF00017	0.388
LIG_SH2_NCK_1	93	97	PF00017	0.398
LIG_SH2_PTP2	141	144	PF00017	0.382
LIG_SH2_PTP2	264	267	PF00017	0.296
LIG_SH2_SRC	93	96	PF00017	0.358
LIG_SH2_STAP1	223	227	PF00017	0.445
LIG_SH2_STAP1	25	29	PF00017	0.661
LIG_SH2_STAP1	261	265	PF00017	0.288
LIG_SH2_STAP1	501	505	PF00017	0.306
LIG_SH2_STAT3	223	226	PF00017	0.320
LIG_SH2_STAT5	141	144	PF00017	0.359
LIG_SH2_STAT5	264	267	PF00017	0.273
LIG_SH2_STAT5	317	320	PF00017	0.446
LIG_SH2_STAT5	462	465	PF00017	0.313
LIG_SH2_STAT5	86	89	PF00017	0.291
LIG_SH3_1	93	99	PF00018	0.499
LIG_SH3_2	54	59	PF14604	0.563
LIG_SH3_3	2	8	PF00018	0.482
LIG_SH3_3	42	48	PF00018	0.614
LIG_SH3_3	51	57	PF00018	0.536
LIG_SH3_3	93	99	PF00018	0.375
LIG_TRAF2_1	481	484	PF00917	0.522
MOD_CK1_1	155	161	PF00069	0.499
MOD_CK1_1	250	256	PF00069	0.440
MOD_CK1_1	315	321	PF00069	0.435
MOD_CK1_1	431	437	PF00069	0.419
MOD_CK1_1	438	444	PF00069	0.406
MOD_CK1_1	474	480	PF00069	0.518
MOD_CK1_1	506	512	PF00069	0.339
MOD_CK2_1	130	136	PF00069	0.366
MOD_CK2_1	20	26	PF00069	0.580
MOD_CK2_1	315	321	PF00069	0.379
MOD_CK2_1	477	483	PF00069	0.443
MOD_GlcNHglycan	11	14	PF01048	0.553
MOD_GlcNHglycan	154	157	PF01048	0.511
MOD_GlcNHglycan	293	296	PF01048	0.469
MOD_GlcNHglycan	375	378	PF01048	0.527
MOD_GlcNHglycan	96	99	PF01048	0.582
MOD_GSK3_1	152	159	PF00069	0.480
MOD_GSK3_1	247	254	PF00069	0.387
MOD_GSK3_1	431	438	PF00069	0.490
MOD_GSK3_1	473	480	PF00069	0.467
MOD_GSK3_1	503	510	PF00069	0.333
MOD_N-GLC_1	114	119	PF02516	0.446
MOD_N-GLC_1	506	511	PF02516	0.287
MOD_NEK2_1	107	112	PF00069	0.350
MOD_NEK2_1	227	232	PF00069	0.447
MOD_NEK2_1	247	252	PF00069	0.531
MOD_NEK2_1	38	43	PF00069	0.618
MOD_NEK2_1	446	451	PF00069	0.390
MOD_NEK2_2	114	119	PF00069	0.382
MOD_OFUCOSY	463	469	PF10250	0.274
MOD_PIKK_1	160	166	PF00454	0.635
MOD_PIKK_1	312	318	PF00454	0.334
MOD_PIKK_1	32	38	PF00454	0.512
MOD_PIKK_1	428	434	PF00454	0.348
MOD_PIKK_1	446	452	PF00454	0.418
MOD_PKA_2	204	210	PF00069	0.380
MOD_PKA_2	428	434	PF00069	0.464
MOD_Plk_1	114	120	PF00069	0.387
MOD_Plk_1	312	318	PF00069	0.315
MOD_Plk_1	474	480	PF00069	0.442
MOD_Plk_1	506	512	PF00069	0.281
MOD_Plk_4	114	120	PF00069	0.396
MOD_Plk_4	247	253	PF00069	0.455
MOD_Plk_4	339	345	PF00069	0.373
MOD_Plk_4	361	367	PF00069	0.314
MOD_Plk_4	435	441	PF00069	0.503
MOD_Plk_4	507	513	PF00069	0.302
MOD_ProDKin_1	286	292	PF00069	0.424
MOD_ProDKin_1	29	35	PF00069	0.533
MOD_SUMO_for_1	410	413	PF00179	0.332
MOD_SUMO_rev_2	23	29	PF00179	0.524
MOD_SUMO_rev_2	491	500	PF00179	0.318
TRG_ENDOCYTIC_2	141	144	PF00928	0.382
TRG_ENDOCYTIC_2	501	504	PF00928	0.303
TRG_ER_diArg_1	2	4	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM61	Leptomonas seymouri	40%	100%
A0A0N1PFG1	Leptomonas seymouri	76%	100%
A0A0S4IY11	Bodo saltans	41%	100%
A0A0S4JST8	Bodo saltans	45%	100%
A0A1X0NPP7	Trypanosomatidae	53%	100%
A0A1X0NXN6	Trypanosomatidae	38%	100%
A0A3Q8IBQ6	Leishmania donovani	96%	100%
A0A3R7JXS6	Trypanosoma rangeli	37%	100%
A0A3R7MEV0	Trypanosoma rangeli	52%	100%
A0A3S7WWC3	Leishmania donovani	40%	100%
A4H775	Leishmania braziliensis	83%	100%
A4HBN2	Leishmania braziliensis	39%	100%
A4HVL5	Leishmania infantum	96%	100%
A4HZ33	Leishmania infantum	40%	100%
D0A6P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9APB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AV01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
P29677	Solanum tuberosum	21%	100%
P43265	Euglena gracilis	23%	100%
Q10713	Homo sapiens	22%	100%
Q4QCI1	Leishmania major	40%	93%
Q5R513	Pongo abelii	22%	100%
Q9DC61	Mus musculus	23%	100%
Q9ZU25	Arabidopsis thaliana	20%	100%
V5BB16	Trypanosoma cruzi	53%	95%
V5BQ54	Trypanosoma cruzi	38%	100%