C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG66_LEIMA

TriTrypDb:

LmjF.13.0880 , LMJLV39_130012900 , LMJSD75_130013000

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG66

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	609	613	PF00656	0.803
CLV_C14_Caspase3-7	642	646	PF00656	0.766
CLV_NRD_NRD_1	225	227	PF00675	0.801
CLV_NRD_NRD_1	290	292	PF00675	0.715
CLV_NRD_NRD_1	312	314	PF00675	0.762
CLV_NRD_NRD_1	502	504	PF00675	0.658
CLV_NRD_NRD_1	81	83	PF00675	0.578
CLV_PCSK_KEX2_1	225	227	PF00082	0.801
CLV_PCSK_KEX2_1	290	292	PF00082	0.721
CLV_PCSK_KEX2_1	312	314	PF00082	0.762
CLV_PCSK_KEX2_1	491	493	PF00082	0.611
CLV_PCSK_KEX2_1	502	504	PF00082	0.551
CLV_PCSK_KEX2_1	681	683	PF00082	0.777
CLV_PCSK_KEX2_1	693	695	PF00082	0.756
CLV_PCSK_KEX2_1	81	83	PF00082	0.578
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.639
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.777
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.756
CLV_PCSK_SKI1_1	387	391	PF00082	0.522
CLV_PCSK_SKI1_1	456	460	PF00082	0.596
CLV_PCSK_SKI1_1	693	697	PF00082	0.754
DEG_SCF_FBW7_1	130	135	PF00400	0.766
DEG_SPOP_SBC_1	132	136	PF00917	0.756
DOC_AGCK_PIF_2	45	50	PF00069	0.551
DOC_CKS1_1	129	134	PF01111	0.775
DOC_CKS1_1	35	40	PF01111	0.552
DOC_MAPK_DCC_7	332	340	PF00069	0.631
DOC_MAPK_gen_1	392	399	PF00069	0.609
DOC_MAPK_MEF2A_6	392	399	PF00069	0.507
DOC_MAPK_NFAT4_5	392	400	PF00069	0.617
DOC_PP2B_LxvP_1	15	18	PF13499	0.535
DOC_USP7_MATH_1	132	136	PF00917	0.760
DOC_USP7_MATH_1	148	152	PF00917	0.516
DOC_USP7_MATH_1	527	531	PF00917	0.757
DOC_USP7_MATH_1	548	552	PF00917	0.897
DOC_USP7_MATH_1	557	561	PF00917	0.735
DOC_USP7_MATH_1	585	589	PF00917	0.862
DOC_USP7_MATH_1	591	595	PF00917	0.792
DOC_USP7_MATH_1	618	622	PF00917	0.799
DOC_USP7_UBL2_3	456	460	PF12436	0.596
DOC_USP7_UBL2_3	589	593	PF12436	0.758
DOC_USP7_UBL2_3	671	675	PF12436	0.781
DOC_USP7_UBL2_3	676	680	PF12436	0.763
DOC_USP7_UBL2_3	689	693	PF12436	0.558
DOC_WW_Pin1_4	128	133	PF00397	0.856
DOC_WW_Pin1_4	20	25	PF00397	0.614
DOC_WW_Pin1_4	34	39	PF00397	0.595
DOC_WW_Pin1_4	565	570	PF00397	0.785
DOC_WW_Pin1_4	587	592	PF00397	0.778
DOC_WW_Pin1_4	66	71	PF00397	0.572
DOC_WW_Pin1_4	95	100	PF00397	0.807
LIG_14-3-3_CanoR_1	326	332	PF00244	0.744
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	41	45	PF00533	0.555
LIG_CSL_BTD_1	15	18	PF09270	0.535
LIG_CtBP_PxDLS_1	38	42	PF00389	0.560
LIG_EH1_1	264	272	PF00400	0.691
LIG_FHA_1	12	18	PF00498	0.536
LIG_FHA_1	171	177	PF00498	0.751
LIG_FHA_1	25	31	PF00498	0.583
LIG_FHA_1	369	375	PF00498	0.535
LIG_FHA_2	342	348	PF00498	0.698
LIG_FHA_2	35	41	PF00498	0.624
LIG_FHA_2	601	607	PF00498	0.746
LIG_FHA_2	67	73	PF00498	0.563
LIG_IBAR_NPY_1	263	265	PF08397	0.807
LIG_Integrin_isoDGR_2	11	13	PF01839	0.676
LIG_Integrin_RGD_1	222	224	PF01839	0.852
LIG_IRF3_LxIS_1	5	10	PF10401	0.602
LIG_LIR_Apic_2	292	298	PF02991	0.763
LIG_LIR_Apic_2	351	356	PF02991	0.542
LIG_LIR_Gen_1	402	411	PF02991	0.574
LIG_LIR_Nem_3	402	406	PF02991	0.529
LIG_LIR_Nem_3	42	48	PF02991	0.548
LIG_LIR_Nem_3	421	426	PF02991	0.311
LIG_LIR_Nem_3	79	83	PF02991	0.575
LIG_NRBOX	171	177	PF00104	0.649
LIG_SH2_CRK	353	357	PF00017	0.565
LIG_SH2_CRK	96	100	PF00017	0.810
LIG_SH2_GRB2like	353	356	PF00017	0.556
LIG_SH2_NCK_1	96	100	PF00017	0.810
LIG_SH2_PTP2	35	38	PF00017	0.556
LIG_SH2_STAP1	238	242	PF00017	0.831
LIG_SH2_STAP1	50	54	PF00017	0.645
LIG_SH2_STAT3	50	53	PF00017	0.547
LIG_SH2_STAT5	35	38	PF00017	0.556
LIG_SH2_STAT5	428	431	PF00017	0.542
LIG_SH2_STAT5	46	49	PF00017	0.543
LIG_SH2_STAT5	517	520	PF00017	0.777
LIG_SH2_STAT5	8	11	PF00017	0.542
LIG_SH3_2	688	693	PF14604	0.658
LIG_SH3_3	248	254	PF00018	0.712
LIG_SH3_3	340	346	PF00018	0.594
LIG_SH3_3	685	691	PF00018	0.665
LIG_SH3_4	676	683	PF00018	0.863
LIG_TRAF2_1	402	405	PF00917	0.644
LIG_TRAF2_1	646	649	PF00917	0.885
LIG_UBA3_1	466	475	PF00899	0.582
MOD_CDK_SPxK_1	587	593	PF00069	0.760
MOD_CK1_1	146	152	PF00069	0.822
MOD_CK1_1	614	620	PF00069	0.749
MOD_CK1_1	621	627	PF00069	0.691
MOD_CK2_1	20	26	PF00069	0.600
MOD_CK2_1	34	40	PF00069	0.562
MOD_CK2_1	341	347	PF00069	0.704
MOD_CK2_1	399	405	PF00069	0.639
MOD_CK2_1	532	538	PF00069	0.779
MOD_CK2_1	66	72	PF00069	0.575
MOD_Cter_Amidation	288	291	PF01082	0.752
MOD_Cter_Amidation	390	393	PF01082	0.644
MOD_GlcNHglycan	1	4	PF01048	0.609
MOD_GlcNHglycan	146	149	PF01048	0.824
MOD_GlcNHglycan	150	153	PF01048	0.801
MOD_GlcNHglycan	167	170	PF01048	0.500
MOD_GlcNHglycan	191	194	PF01048	0.789
MOD_GlcNHglycan	287	290	PF01048	0.791
MOD_GlcNHglycan	520	523	PF01048	0.861
MOD_GlcNHglycan	555	558	PF01048	0.875
MOD_GlcNHglycan	576	579	PF01048	0.776
MOD_GlcNHglycan	616	619	PF01048	0.746
MOD_GlcNHglycan	635	639	PF01048	0.837
MOD_GSK3_1	128	135	PF00069	0.797
MOD_GSK3_1	144	151	PF00069	0.511
MOD_GSK3_1	18	25	PF00069	0.540
MOD_GSK3_1	180	187	PF00069	0.781
MOD_GSK3_1	285	292	PF00069	0.791
MOD_GSK3_1	314	321	PF00069	0.852
MOD_GSK3_1	518	525	PF00069	0.759
MOD_GSK3_1	553	560	PF00069	0.791
MOD_GSK3_1	581	588	PF00069	0.808
MOD_GSK3_1	612	619	PF00069	0.778
MOD_GSK3_1	620	627	PF00069	0.761
MOD_GSK3_1	7	14	PF00069	0.585
MOD_N-GLC_1	189	194	PF02516	0.825
MOD_N-GLC_1	557	562	PF02516	0.849
MOD_NEK2_1	143	148	PF00069	0.759
MOD_NEK2_1	236	241	PF00069	0.827
MOD_NEK2_1	308	313	PF00069	0.749
MOD_NEK2_1	327	332	PF00069	0.494
MOD_NEK2_1	39	44	PF00069	0.551
MOD_NEK2_1	516	521	PF00069	0.775
MOD_NEK2_1	7	12	PF00069	0.538
MOD_PIKK_1	170	176	PF00454	0.753
MOD_PIKK_1	236	242	PF00454	0.829
MOD_PIKK_1	316	322	PF00454	0.865
MOD_PIKK_1	508	514	PF00454	0.796
MOD_PIKK_1	522	528	PF00454	0.764
MOD_PIKK_1	541	547	PF00454	0.797
MOD_PIKK_1	548	554	PF00454	0.782
MOD_PIKK_1	567	573	PF00454	0.586
MOD_PKA_1	689	695	PF00069	0.856
MOD_PKA_2	18	24	PF00069	0.630
MOD_PKA_2	289	295	PF00069	0.855
MOD_Plk_1	557	563	PF00069	0.693
MOD_Plk_2-3	341	347	PF00069	0.624
MOD_Plk_2-3	532	538	PF00069	0.779
MOD_Plk_4	348	354	PF00069	0.537
MOD_Plk_4	368	374	PF00069	0.530
MOD_ProDKin_1	128	134	PF00069	0.856
MOD_ProDKin_1	20	26	PF00069	0.607
MOD_ProDKin_1	34	40	PF00069	0.586
MOD_ProDKin_1	565	571	PF00069	0.785
MOD_ProDKin_1	587	593	PF00069	0.779
MOD_ProDKin_1	66	72	PF00069	0.575
MOD_ProDKin_1	95	101	PF00069	0.811
MOD_SUMO_rev_2	23	30	PF00179	0.698
MOD_SUMO_rev_2	347	352	PF00179	0.599
MOD_SUMO_rev_2	382	389	PF00179	0.571
MOD_SUMO_rev_2	402	409	PF00179	0.556
MOD_SUMO_rev_2	486	493	PF00179	0.734
MOD_SUMO_rev_2	660	669	PF00179	0.784
TRG_DiLeu_BaEn_2	85	91	PF01217	0.626
TRG_ENDOCYTIC_2	259	262	PF00928	0.828
TRG_ER_diArg_1	225	227	PF00400	0.860
TRG_ER_diArg_1	80	82	PF00400	0.572
TRG_NLS_Bipartite_1	670	685	PF00514	0.815
TRG_NLS_MonoExtC_3	679	684	PF00514	0.769
TRG_NLS_MonoExtC_3	692	697	PF00514	0.752
TRG_NLS_MonoExtN_4	668	674	PF00514	0.774
TRG_NLS_MonoExtN_4	677	684	PF00514	0.755
TRG_NLS_MonoExtN_4	690	697	PF00514	0.751

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX4	Leptomonas seymouri	55%	100%
A0A3S5H6P0	Leishmania donovani	95%	100%
A4H776	Leishmania braziliensis	86%	100%
A4HVL6	Leishmania infantum	95%	100%
E9APB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%