Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG65_LEIMA

TriTrypDb:

LmjF.13.0890 , LMJLV39_130013000 , LMJSD75_130013100

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.592
CLV_NRD_NRD_1	103	105	PF00675	0.530
CLV_NRD_NRD_1	141	143	PF00675	0.549
CLV_NRD_NRD_1	236	238	PF00675	0.506
CLV_NRD_NRD_1	257	259	PF00675	0.497
CLV_NRD_NRD_1	51	53	PF00675	0.585
CLV_NRD_NRD_1	75	77	PF00675	0.559
CLV_PCSK_FUR_1	234	238	PF00082	0.502
CLV_PCSK_KEX2_1	140	142	PF00082	0.605
CLV_PCSK_KEX2_1	236	238	PF00082	0.498
CLV_PCSK_KEX2_1	257	259	PF00082	0.502
CLV_PCSK_KEX2_1	53	55	PF00082	0.533
CLV_PCSK_KEX2_1	75	77	PF00082	0.559
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.533
CLV_PCSK_SKI1_1	113	117	PF00082	0.655
CLV_PCSK_SKI1_1	304	308	PF00082	0.570
CLV_Separin_Metazoa	155	159	PF03568	0.596
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.623
DOC_MAPK_MEF2A_6	276	284	PF00069	0.618
DOC_PP4_MxPP_1	88	91	PF00568	0.474
DOC_USP7_MATH_1	166	170	PF00917	0.602
DOC_WW_Pin1_4	321	326	PF00397	0.584
DOC_WW_Pin1_4	36	41	PF00397	0.615
LIG_14-3-3_CanoR_1	158	168	PF00244	0.620
LIG_APCC_ABBAyCdc20_2	65	71	PF00400	0.430
LIG_BRCT_BRCA1_1	312	316	PF00533	0.568
LIG_FHA_1	209	215	PF00498	0.436
LIG_FHA_2	149	155	PF00498	0.699
LIG_LIR_Apic_2	6	12	PF02991	0.649
LIG_LIR_Gen_1	131	139	PF02991	0.535
LIG_LIR_Gen_1	189	198	PF02991	0.442
LIG_LIR_Gen_1	202	208	PF02991	0.332
LIG_LIR_Gen_1	313	321	PF02991	0.670
LIG_LIR_Nem_3	131	137	PF02991	0.540
LIG_LIR_Nem_3	189	194	PF02991	0.439
LIG_LIR_Nem_3	202	206	PF02991	0.341
LIG_LIR_Nem_3	313	319	PF02991	0.666
LIG_LIR_Nem_3	62	67	PF02991	0.419
LIG_LIR_Nem_3	71	77	PF02991	0.426
LIG_SH2_CRK	9	13	PF00017	0.566
LIG_SH2_STAP1	229	233	PF00017	0.503
LIG_SH2_STAT3	229	232	PF00017	0.540
LIG_SH2_STAT5	191	194	PF00017	0.471
LIG_SH3_3	154	160	PF00018	0.756
LIG_SH3_3	201	207	PF00018	0.459
LIG_SH3_3	34	40	PF00018	0.618
LIG_TRAF2_1	253	256	PF00917	0.546
LIG_TRAF2_1	324	327	PF00917	0.652
MOD_CK1_1	170	176	PF00069	0.632
MOD_CK1_1	310	316	PF00069	0.620
MOD_CK2_1	148	154	PF00069	0.696
MOD_CK2_1	295	301	PF00069	0.591
MOD_CK2_1	321	327	PF00069	0.595
MOD_GlcNHglycan	113	116	PF01048	0.626
MOD_GlcNHglycan	16	20	PF01048	0.613
MOD_GlcNHglycan	24	27	PF01048	0.589
MOD_GlcNHglycan	271	274	PF01048	0.435
MOD_GlcNHglycan	295	300	PF01048	0.671
MOD_GSK3_1	107	114	PF00069	0.583
MOD_GSK3_1	11	18	PF00069	0.638
MOD_GSK3_1	166	173	PF00069	0.637
MOD_GSK3_1	306	313	PF00069	0.691
MOD_NEK2_1	208	213	PF00069	0.452
MOD_NEK2_1	307	312	PF00069	0.614
MOD_PIKK_1	107	113	PF00454	0.474
MOD_PIKK_1	228	234	PF00454	0.547
MOD_PKA_1	236	242	PF00069	0.552
MOD_PKA_2	236	242	PF00069	0.470
MOD_PKB_1	140	148	PF00069	0.585
MOD_PKB_1	234	242	PF00069	0.551
MOD_Plk_1	208	214	PF00069	0.501
MOD_Plk_2-3	57	63	PF00069	0.368
MOD_Plk_4	187	193	PF00069	0.455
MOD_Plk_4	199	205	PF00069	0.428
MOD_ProDKin_1	321	327	PF00069	0.583
MOD_ProDKin_1	36	42	PF00069	0.617
MOD_SUMO_for_1	289	292	PF00179	0.580
MOD_SUMO_rev_2	296	306	PF00179	0.731
TRG_AP2beta_CARGO_1	131	141	PF09066	0.594
TRG_DiLeu_BaEn_1	265	270	PF01217	0.521
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.471
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.334
TRG_ENDOCYTIC_2	191	194	PF00928	0.458
TRG_ER_diArg_1	140	142	PF00400	0.522
TRG_ER_diArg_1	233	236	PF00400	0.546
TRG_ER_diArg_1	257	259	PF00400	0.547
TRG_ER_diArg_1	74	76	PF00400	0.546
TRG_ER_diArg_1	98	101	PF00400	0.507
TRG_NLS_MonoExtC_3	51	56	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K8	Leptomonas seymouri	55%	90%
A0A0S4IK25	Bodo saltans	28%	83%
A0A1X0NN31	Trypanosomatidae	42%	100%
A0A3S7WSI8	Leishmania donovani	91%	100%
A4H777	Leishmania braziliensis	74%	100%
A4HVL7	Leishmania infantum	91%	100%
D0A6N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9APB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BK51	Trypanosoma cruzi	43%	100%