Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG64_LEIMA

TriTrypDb:

LmjF.13.0900 , LMJLV39_130013100 , LMJSD75_130013200

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.563
CLV_NRD_NRD_1	117	119	PF00675	0.480
CLV_NRD_NRD_1	131	133	PF00675	0.582
CLV_NRD_NRD_1	170	172	PF00675	0.491
CLV_NRD_NRD_1	174	176	PF00675	0.475
CLV_NRD_NRD_1	186	188	PF00675	0.489
CLV_NRD_NRD_1	225	227	PF00675	0.488
CLV_NRD_NRD_1	256	258	PF00675	0.512
CLV_NRD_NRD_1	373	375	PF00675	0.677
CLV_NRD_NRD_1	531	533	PF00675	0.618
CLV_NRD_NRD_1	546	548	PF00675	0.747
CLV_NRD_NRD_1	549	551	PF00675	0.831
CLV_PCSK_FUR_1	528	532	PF00082	0.590
CLV_PCSK_FUR_1	547	551	PF00082	0.665
CLV_PCSK_KEX2_1	117	119	PF00082	0.507
CLV_PCSK_KEX2_1	131	133	PF00082	0.526
CLV_PCSK_KEX2_1	136	138	PF00082	0.488
CLV_PCSK_KEX2_1	16	18	PF00082	0.600
CLV_PCSK_KEX2_1	174	176	PF00082	0.475
CLV_PCSK_KEX2_1	225	227	PF00082	0.488
CLV_PCSK_KEX2_1	251	253	PF00082	0.507
CLV_PCSK_KEX2_1	255	257	PF00082	0.518
CLV_PCSK_KEX2_1	266	268	PF00082	0.483
CLV_PCSK_KEX2_1	33	35	PF00082	0.511
CLV_PCSK_KEX2_1	397	399	PF00082	0.632
CLV_PCSK_KEX2_1	46	48	PF00082	0.523
CLV_PCSK_KEX2_1	530	532	PF00082	0.630
CLV_PCSK_KEX2_1	545	547	PF00082	0.769
CLV_PCSK_KEX2_1	549	551	PF00082	0.845
CLV_PCSK_KEX2_1	610	612	PF00082	0.560
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.488
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.600
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.507
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.483
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.511
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.572
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.523
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.560
CLV_PCSK_PC7_1	132	138	PF00082	0.484
CLV_PCSK_PC7_1	252	258	PF00082	0.508
CLV_PCSK_PC7_1	545	551	PF00082	0.678
CLV_PCSK_SKI1_1	175	179	PF00082	0.487
CLV_PCSK_SKI1_1	194	198	PF00082	0.510
CLV_PCSK_SKI1_1	267	271	PF00082	0.478
CLV_PCSK_SKI1_1	428	432	PF00082	0.531
CLV_PCSK_SKI1_1	588	592	PF00082	0.775
DEG_SPOP_SBC_1	336	340	PF00917	0.606
DEG_SPOP_SBC_1	516	520	PF00917	0.576
DEG_SPOP_SBC_1	73	77	PF00917	0.653
DOC_CYCLIN_RxL_1	263	272	PF00134	0.490
DOC_MAPK_gen_1	142	148	PF00069	0.560
DOC_MAPK_gen_1	171	182	PF00069	0.496
DOC_MAPK_gen_1	225	237	PF00069	0.482
DOC_MAPK_gen_1	251	262	PF00069	0.508
DOC_MAPK_gen_1	439	447	PF00069	0.514
DOC_MAPK_gen_1	528	535	PF00069	0.674
DOC_MAPK_MEF2A_6	174	182	PF00069	0.497
DOC_MAPK_MEF2A_6	255	264	PF00069	0.511
DOC_MAPK_NFAT4_5	175	183	PF00069	0.501
DOC_PP1_RVXF_1	203	209	PF00149	0.491
DOC_PP1_RVXF_1	264	271	PF00149	0.488
DOC_PP2B_LxvP_1	299	302	PF13499	0.524
DOC_PP4_FxxP_1	111	114	PF00568	0.462
DOC_USP7_MATH_1	100	104	PF00917	0.486
DOC_USP7_MATH_1	244	248	PF00917	0.507
DOC_USP7_MATH_1	335	339	PF00917	0.645
DOC_USP7_MATH_1	383	387	PF00917	0.768
DOC_USP7_MATH_1	496	500	PF00917	0.630
DOC_USP7_MATH_1	509	513	PF00917	0.643
DOC_USP7_MATH_1	517	521	PF00917	0.625
DOC_USP7_MATH_1	552	556	PF00917	0.734
DOC_USP7_MATH_1	596	600	PF00917	0.594
DOC_USP7_MATH_1	72	76	PF00917	0.612
DOC_USP7_UBL2_3	227	231	PF12436	0.475
DOC_WW_Pin1_4	110	115	PF00397	0.468
DOC_WW_Pin1_4	391	396	PF00397	0.751
DOC_WW_Pin1_4	476	481	PF00397	0.710
DOC_WW_Pin1_4	490	495	PF00397	0.614
DOC_WW_Pin1_4	566	571	PF00397	0.707
LIG_14-3-3_CanoR_1	174	178	PF00244	0.476
LIG_14-3-3_CanoR_1	428	434	PF00244	0.624
LIG_14-3-3_CanoR_1	441	447	PF00244	0.440
LIG_Actin_WH2_2	36	51	PF00022	0.517
LIG_APCC_ABBAyCdc20_2	266	272	PF00400	0.479
LIG_BIR_III_2	471	475	PF00653	0.648
LIG_BRCT_BRCA1_1	107	111	PF00533	0.531
LIG_BRCT_BRCA1_1	192	196	PF00533	0.514
LIG_Clathr_ClatBox_1	268	272	PF01394	0.403
LIG_deltaCOP1_diTrp_1	29	39	PF00928	0.500
LIG_DLG_GKlike_1	256	264	PF00625	0.587
LIG_FHA_1	291	297	PF00498	0.507
LIG_FHA_1	298	304	PF00498	0.554
LIG_FHA_1	429	435	PF00498	0.701
LIG_FHA_1	440	446	PF00498	0.510
LIG_FHA_1	452	458	PF00498	0.492
LIG_FHA_1	50	56	PF00498	0.537
LIG_FHA_1	582	588	PF00498	0.670
LIG_FHA_2	168	174	PF00498	0.551
LIG_FHA_2	179	185	PF00498	0.461
LIG_FHA_2	273	279	PF00498	0.560
LIG_Integrin_RGD_1	367	369	PF01839	0.642
LIG_LIR_Apic_2	108	114	PF02991	0.522
LIG_LIR_Gen_1	106	115	PF02991	0.504
LIG_LIR_Gen_1	176	185	PF02991	0.505
LIG_LIR_Gen_1	35	43	PF02991	0.503
LIG_LIR_Nem_3	106	110	PF02991	0.517
LIG_LIR_Nem_3	176	180	PF02991	0.498
LIG_LIR_Nem_3	35	39	PF02991	0.501
LIG_MYND_1	465	469	PF01753	0.597
LIG_Pex14_2	107	111	PF04695	0.513
LIG_SH2_CRK	21	25	PF00017	0.581
LIG_SH2_CRK	239	243	PF00017	0.513
LIG_SH2_STAP1	21	25	PF00017	0.657
LIG_SH2_STAT5	109	112	PF00017	0.497
LIG_SH2_STAT5	241	244	PF00017	0.516
LIG_SH3_3	289	295	PF00018	0.459
LIG_SH3_3	459	465	PF00018	0.603
LIG_SH3_CIN85_PxpxPR_1	570	575	PF14604	0.643
LIG_Sin3_3	328	335	PF02671	0.598
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.485
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.651
LIG_SUMO_SIM_par_1	144	150	PF11976	0.485
LIG_SUMO_SIM_par_1	419	425	PF11976	0.651
LIG_TRAF2_1	350	353	PF00917	0.647
LIG_TYR_ITIM	237	242	PF00017	0.516
LIG_UBA3_1	260	266	PF00899	0.508
MOD_CDC14_SPxK_1	394	397	PF00782	0.657
MOD_CDK_SPK_2	476	481	PF00069	0.574
MOD_CDK_SPK_2	492	497	PF00069	0.621
MOD_CDK_SPK_2	568	573	PF00069	0.685
MOD_CDK_SPxK_1	391	397	PF00069	0.656
MOD_CDK_SPxxK_3	110	117	PF00069	0.460
MOD_CDK_SPxxK_3	391	398	PF00069	0.562
MOD_CDK_SPxxK_3	490	497	PF00069	0.654
MOD_CDK_SPxxK_3	566	573	PF00069	0.767
MOD_CK1_1	103	109	PF00069	0.692
MOD_CK1_1	147	153	PF00069	0.502
MOD_CK1_1	379	385	PF00069	0.665
MOD_CK1_1	38	44	PF00069	0.482
MOD_CK1_1	391	397	PF00069	0.659
MOD_CK1_1	495	501	PF00069	0.614
MOD_CK1_1	53	59	PF00069	0.524
MOD_CK1_1	564	570	PF00069	0.748
MOD_CK1_1	594	600	PF00069	0.580
MOD_CK1_1	606	612	PF00069	0.559
MOD_CK1_1	75	81	PF00069	0.604
MOD_CK2_1	110	116	PF00069	0.484
MOD_CK2_1	167	173	PF00069	0.563
MOD_CK2_1	178	184	PF00069	0.453
MOD_CK2_1	552	558	PF00069	0.718
MOD_Cter_Amidation	14	17	PF01082	0.640
MOD_Cter_Amidation	264	267	PF01082	0.504
MOD_Cter_Amidation	395	398	PF01082	0.567
MOD_Cter_Amidation	528	531	PF01082	0.604
MOD_GlcNHglycan	314	317	PF01048	0.641
MOD_GlcNHglycan	318	321	PF01048	0.602
MOD_GlcNHglycan	339	342	PF01048	0.631
MOD_GlcNHglycan	378	381	PF01048	0.732
MOD_GlcNHglycan	385	388	PF01048	0.635
MOD_GlcNHglycan	391	394	PF01048	0.598
MOD_GlcNHglycan	399	402	PF01048	0.634
MOD_GlcNHglycan	40	43	PF01048	0.506
MOD_GlcNHglycan	458	461	PF01048	0.650
MOD_GlcNHglycan	507	510	PF01048	0.691
MOD_GlcNHglycan	52	55	PF01048	0.529
MOD_GlcNHglycan	523	526	PF01048	0.615
MOD_GlcNHglycan	553	557	PF01048	0.767
MOD_GlcNHglycan	59	62	PF01048	0.526
MOD_GlcNHglycan	593	596	PF01048	0.591
MOD_GlcNHglycan	6	9	PF01048	0.611
MOD_GSK3_1	105	112	PF00069	0.613
MOD_GSK3_1	280	287	PF00069	0.506
MOD_GSK3_1	297	304	PF00069	0.523
MOD_GSK3_1	312	319	PF00069	0.523
MOD_GSK3_1	34	41	PF00069	0.503
MOD_GSK3_1	378	385	PF00069	0.676
MOD_GSK3_1	424	431	PF00069	0.549
MOD_GSK3_1	451	458	PF00069	0.552
MOD_GSK3_1	49	56	PF00069	0.539
MOD_GSK3_1	492	499	PF00069	0.745
MOD_GSK3_1	501	508	PF00069	0.621
MOD_GSK3_1	517	524	PF00069	0.637
MOD_GSK3_1	552	559	PF00069	0.749
MOD_GSK3_1	560	567	PF00069	0.693
MOD_GSK3_1	602	609	PF00069	0.568
MOD_N-GLC_1	3	8	PF02516	0.593
MOD_N-GLC_1	450	455	PF02516	0.534
MOD_N-GLC_1	510	515	PF02516	0.568
MOD_NEK2_1	178	183	PF00069	0.507
MOD_NEK2_1	433	438	PF00069	0.558
MOD_NEK2_1	456	461	PF00069	0.580
MOD_NEK2_1	505	510	PF00069	0.552
MOD_PIKK_1	556	562	PF00454	0.675
MOD_PIKK_1	596	602	PF00454	0.566
MOD_PKA_1	256	262	PF00069	0.585
MOD_PKA_1	397	403	PF00069	0.628
MOD_PKA_2	173	179	PF00069	0.482
MOD_PKA_2	256	262	PF00069	0.585
MOD_PKA_2	272	278	PF00069	0.391
MOD_PKA_2	397	403	PF00069	0.674
MOD_PKA_2	4	10	PF00069	0.648
MOD_PKA_2	440	446	PF00069	0.510
MOD_PKA_2	451	457	PF00069	0.551
MOD_PKB_1	47	55	PF00069	0.531
MOD_PKB_1	611	619	PF00069	0.554
MOD_Plk_1	280	286	PF00069	0.650
MOD_Plk_1	34	40	PF00069	0.502
MOD_Plk_4	144	150	PF00069	0.517
MOD_Plk_4	244	250	PF00069	0.504
MOD_Plk_4	256	262	PF00069	0.509
MOD_Plk_4	35	41	PF00069	0.482
MOD_Plk_4	429	435	PF00069	0.560
MOD_Plk_4	496	502	PF00069	0.568
MOD_ProDKin_1	110	116	PF00069	0.467
MOD_ProDKin_1	391	397	PF00069	0.753
MOD_ProDKin_1	476	482	PF00069	0.707
MOD_ProDKin_1	490	496	PF00069	0.609
MOD_ProDKin_1	566	572	PF00069	0.706
MOD_SUMO_rev_2	190	198	PF00179	0.559
MOD_SUMO_rev_2	200	207	PF00179	0.429
MOD_SUMO_rev_2	340	350	PF00179	0.619
TRG_DiLeu_BaEn_1	305	310	PF01217	0.520
TRG_DiLeu_BaEn_2	172	178	PF01217	0.552
TRG_DiLeu_BaEn_2	34	40	PF01217	0.502
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.615
TRG_DiLeu_LyEn_5	305	310	PF01217	0.520
TRG_ENDOCYTIC_2	21	24	PF00928	0.588
TRG_ENDOCYTIC_2	239	242	PF00928	0.515
TRG_ER_diArg_1	2	5	PF00400	0.675
TRG_ER_diArg_1	224	226	PF00400	0.494
TRG_ER_diArg_1	255	257	PF00400	0.524
TRG_ER_diArg_1	528	531	PF00400	0.664
TRG_ER_diArg_1	532	535	PF00400	0.676
TRG_ER_diArg_1	545	547	PF00400	0.607
TRG_ER_diArg_1	572	575	PF00400	0.646
TRG_NLS_MonoExtN_4	608	614	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I995	Leptomonas seymouri	58%	100%
A0A3Q8II04	Leishmania donovani	90%	98%
A4H778	Leishmania braziliensis	69%	100%
A4HVL8	Leishmania infantum	90%	100%
E9APB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%