Protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG63_LEIMA

TriTrypDb:

LmjF.13.0910 , LMJLV39_130013200 , LMJSD75_130013300

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4QG63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	702	706	PF00656	0.474
CLV_NRD_NRD_1	191	193	PF00675	0.512
CLV_NRD_NRD_1	311	313	PF00675	0.650
CLV_NRD_NRD_1	338	340	PF00675	0.732
CLV_NRD_NRD_1	44	46	PF00675	0.646
CLV_NRD_NRD_1	828	830	PF00675	0.798
CLV_PCSK_KEX2_1	191	193	PF00082	0.651
CLV_PCSK_KEX2_1	311	313	PF00082	0.650
CLV_PCSK_KEX2_1	337	339	PF00082	0.745
CLV_PCSK_KEX2_1	36	38	PF00082	0.630
CLV_PCSK_KEX2_1	43	45	PF00082	0.571
CLV_PCSK_KEX2_1	437	439	PF00082	0.668
CLV_PCSK_KEX2_1	802	804	PF00082	0.644
CLV_PCSK_KEX2_1	828	830	PF00082	0.798
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.630
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.668
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.644
CLV_PCSK_SKI1_1	177	181	PF00082	0.652
CLV_PCSK_SKI1_1	184	188	PF00082	0.604
CLV_PCSK_SKI1_1	191	195	PF00082	0.526
CLV_PCSK_SKI1_1	244	248	PF00082	0.638
CLV_PCSK_SKI1_1	487	491	PF00082	0.658
CLV_PCSK_SKI1_1	598	602	PF00082	0.643
CLV_PCSK_SKI1_1	760	764	PF00082	0.471
CLV_PCSK_SKI1_1	802	806	PF00082	0.625
DEG_SCF_FBW7_1	453	458	PF00400	0.632
DEG_SCF_FBW7_1	48	53	PF00400	0.685
DEG_SPOP_SBC_1	381	385	PF00917	0.688
DEG_SPOP_SBC_1	395	399	PF00917	0.549
DEG_SPOP_SBC_1	522	526	PF00917	0.642
DOC_CKS1_1	283	288	PF01111	0.642
DOC_CKS1_1	463	468	PF01111	0.658
DOC_CKS1_1	497	502	PF01111	0.668
DOC_CYCLIN_RxL_1	181	190	PF00134	0.684
DOC_CYCLIN_RxL_1	689	702	PF00134	0.445
DOC_CYCLIN_yClb1_LxF_4	733	739	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	60	63	PF00134	0.613
DOC_MAPK_DCC_7	741	751	PF00069	0.439
DOC_MAPK_gen_1	689	698	PF00069	0.471
DOC_MAPK_gen_1	741	751	PF00069	0.342
DOC_MAPK_MEF2A_6	147	155	PF00069	0.580
DOC_MAPK_MEF2A_6	157	164	PF00069	0.474
DOC_MAPK_MEF2A_6	311	318	PF00069	0.571
DOC_MAPK_MEF2A_6	619	626	PF00069	0.465
DOC_MAPK_MEF2A_6	744	753	PF00069	0.343
DOC_MAPK_MEF2A_6	793	801	PF00069	0.632
DOC_MAPK_NFAT4_5	157	165	PF00069	0.530
DOC_MAPK_NFAT4_5	619	627	PF00069	0.465
DOC_PIKK_1	648	655	PF02985	0.364
DOC_PP1_RVXF_1	690	696	PF00149	0.430
DOC_PP2B_LxvP_1	60	63	PF13499	0.637
DOC_PP2B_LxvP_1	821	824	PF13499	0.806
DOC_PP4_FxxP_1	283	286	PF00568	0.652
DOC_PP4_FxxP_1	51	54	PF00568	0.698
DOC_PP4_FxxP_1	548	551	PF00568	0.652
DOC_PP4_MxPP_1	342	345	PF00568	0.659
DOC_USP7_MATH_1	101	105	PF00917	0.695
DOC_USP7_MATH_1	213	217	PF00917	0.556
DOC_USP7_MATH_1	238	242	PF00917	0.760
DOC_USP7_MATH_1	250	254	PF00917	0.642
DOC_USP7_MATH_1	262	266	PF00917	0.669
DOC_USP7_MATH_1	290	294	PF00917	0.672
DOC_USP7_MATH_1	380	384	PF00917	0.719
DOC_USP7_MATH_1	395	399	PF00917	0.576
DOC_USP7_MATH_1	455	459	PF00917	0.564
DOC_USP7_MATH_1	631	635	PF00917	0.570
DOC_USP7_MATH_1	64	68	PF00917	0.612
DOC_USP7_MATH_1	92	96	PF00917	0.739
DOC_WW_Pin1_4	199	204	PF00397	0.571
DOC_WW_Pin1_4	245	250	PF00397	0.739
DOC_WW_Pin1_4	258	263	PF00397	0.630
DOC_WW_Pin1_4	282	287	PF00397	0.682
DOC_WW_Pin1_4	349	354	PF00397	0.705
DOC_WW_Pin1_4	396	401	PF00397	0.700
DOC_WW_Pin1_4	451	456	PF00397	0.690
DOC_WW_Pin1_4	459	464	PF00397	0.693
DOC_WW_Pin1_4	46	51	PF00397	0.782
DOC_WW_Pin1_4	491	496	PF00397	0.711
DOC_WW_Pin1_4	97	102	PF00397	0.783
LIG_14-3-3_CanoR_1	161	171	PF00244	0.540
LIG_14-3-3_CanoR_1	244	249	PF00244	0.716
LIG_14-3-3_CanoR_1	43	51	PF00244	0.729
LIG_14-3-3_CanoR_1	487	496	PF00244	0.663
LIG_14-3-3_CanoR_1	633	637	PF00244	0.509
LIG_14-3-3_CanoR_1	646	652	PF00244	0.458
LIG_14-3-3_CanoR_1	728	738	PF00244	0.356
LIG_14-3-3_CanoR_1	741	747	PF00244	0.496
LIG_14-3-3_CanoR_1	748	752	PF00244	0.409
LIG_14-3-3_CanoR_1	785	794	PF00244	0.642
LIG_14-3-3_CanoR_1	803	811	PF00244	0.636
LIG_APCC_ABBA_1	1	6	PF00400	0.628
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BIR_III_4	543	547	PF00653	0.627
LIG_BIR_III_4	579	583	PF00653	0.588
LIG_BRCT_BRCA1_1	103	107	PF00533	0.710
LIG_BRCT_BRCA1_1	252	256	PF00533	0.653
LIG_BRCT_BRCA1_1	383	387	PF00533	0.688
LIG_EVH1_1	811	815	PF00568	0.654
LIG_FHA_1	397	403	PF00498	0.678
LIG_FHA_1	491	497	PF00498	0.736
LIG_FHA_1	664	670	PF00498	0.526
LIG_FHA_1	774	780	PF00498	0.531
LIG_FHA_2	205	211	PF00498	0.490
LIG_FHA_2	486	492	PF00498	0.660
LIG_FHA_2	648	654	PF00498	0.517
LIG_GBD_Chelix_1	124	132	PF00786	0.578
LIG_Integrin_isoDGR_2	269	271	PF01839	0.680
LIG_LIR_Apic_2	280	286	PF02991	0.659
LIG_LIR_Apic_2	49	54	PF02991	0.691
LIG_LIR_Apic_2	547	551	PF02991	0.648
LIG_LIR_Gen_1	298	308	PF02991	0.553
LIG_LIR_Gen_1	354	363	PF02991	0.715
LIG_LIR_Nem_3	298	303	PF02991	0.614
LIG_LIR_Nem_3	354	360	PF02991	0.720
LIG_LIR_Nem_3	384	390	PF02991	0.728
LIG_LIR_Nem_3	562	568	PF02991	0.654
LIG_MYND_1	477	481	PF01753	0.674
LIG_MYND_1	819	823	PF01753	0.786
LIG_NRBOX	148	154	PF00104	0.578
LIG_NRBOX	748	754	PF00104	0.476
LIG_NRP_CendR_1	828	831	PF00754	0.687
LIG_Pex14_2	179	183	PF04695	0.420
LIG_SH2_CRK	138	142	PF00017	0.589
LIG_SH2_CRK	300	304	PF00017	0.624
LIG_SH2_CRK	310	314	PF00017	0.606
LIG_SH2_STAP1	300	304	PF00017	0.630
LIG_SH2_STAP1	512	516	PF00017	0.653
LIG_SH2_STAT5	122	125	PF00017	0.575
LIG_SH2_STAT5	357	360	PF00017	0.711
LIG_SH2_STAT5	636	639	PF00017	0.456
LIG_SH3_1	338	344	PF00018	0.728
LIG_SH3_1	460	466	PF00018	0.673
LIG_SH3_3	338	344	PF00018	0.728
LIG_SH3_3	403	409	PF00018	0.665
LIG_SH3_3	460	466	PF00018	0.673
LIG_SH3_3	494	500	PF00018	0.770
LIG_SH3_3	51	57	PF00018	0.779
LIG_SH3_3	809	815	PF00018	0.773
LIG_SUMO_SIM_anti_2	750	756	PF11976	0.442
LIG_SUMO_SIM_par_1	750	756	PF11976	0.442
LIG_TYR_ITIM	136	141	PF00017	0.581
LIG_UBA3_1	30	36	PF00899	0.615
LIG_WW_3	822	826	PF00397	0.658
MOD_CDK_SPK_2	199	204	PF00069	0.571
MOD_CDK_SPK_2	451	456	PF00069	0.625
MOD_CDK_SPK_2	97	102	PF00069	0.699
MOD_CDK_SPxxK_3	462	469	PF00069	0.661
MOD_CK1_1	217	223	PF00069	0.726
MOD_CK1_1	226	232	PF00069	0.742
MOD_CK1_1	26	32	PF00069	0.629
MOD_CK1_1	265	271	PF00069	0.671
MOD_CK1_1	383	389	PF00069	0.684
MOD_CK1_1	446	452	PF00069	0.721
MOD_CK1_1	462	468	PF00069	0.622
MOD_CK1_1	618	624	PF00069	0.609
MOD_CK1_1	663	669	PF00069	0.515
MOD_CK1_1	76	82	PF00069	0.765
MOD_CK2_1	163	169	PF00069	0.546
MOD_CK2_1	204	210	PF00069	0.466
MOD_CK2_1	425	431	PF00069	0.757
MOD_CK2_1	485	491	PF00069	0.661
MOD_CK2_1	703	709	PF00069	0.596
MOD_CK2_1	97	103	PF00069	0.702
MOD_GlcNHglycan	15	18	PF01048	0.632
MOD_GlcNHglycan	219	222	PF01048	0.710
MOD_GlcNHglycan	275	278	PF01048	0.729
MOD_GlcNHglycan	292	295	PF01048	0.638
MOD_GlcNHglycan	366	369	PF01048	0.581
MOD_GlcNHglycan	391	394	PF01048	0.700
MOD_GlcNHglycan	414	417	PF01048	0.755
MOD_GlcNHglycan	421	424	PF01048	0.693
MOD_GlcNHglycan	448	451	PF01048	0.664
MOD_GlcNHglycan	457	460	PF01048	0.561
MOD_GlcNHglycan	525	528	PF01048	0.666
MOD_GlcNHglycan	705	708	PF01048	0.406
MOD_GlcNHglycan	75	78	PF01048	0.758
MOD_GlcNHglycan	773	776	PF01048	0.542
MOD_GlcNHglycan	815	818	PF01048	0.749
MOD_GlcNHglycan	86	89	PF01048	0.601
MOD_GSK3_1	19	26	PF00069	0.753
MOD_GSK3_1	213	220	PF00069	0.654
MOD_GSK3_1	245	252	PF00069	0.698
MOD_GSK3_1	258	265	PF00069	0.607
MOD_GSK3_1	278	285	PF00069	0.596
MOD_GSK3_1	451	458	PF00069	0.628
MOD_GSK3_1	46	53	PF00069	0.785
MOD_GSK3_1	485	492	PF00069	0.727
MOD_GSK3_1	632	639	PF00069	0.599
MOD_GSK3_1	69	76	PF00069	0.688
MOD_GSK3_1	771	778	PF00069	0.495
MOD_GSK3_1	97	104	PF00069	0.718
MOD_N-GLC_1	199	204	PF02516	0.571
MOD_N-GLC_1	213	218	PF02516	0.487
MOD_N-GLC_1	262	267	PF02516	0.622
MOD_N-GLC_1	290	295	PF02516	0.704
MOD_N-GLC_1	544	549	PF02516	0.647
MOD_N-GLC_1	647	652	PF02516	0.570
MOD_N-GLC_1	703	708	PF02516	0.446
MOD_N-GLC_1	724	729	PF02516	0.417
MOD_NEK2_1	175	180	PF00069	0.538
MOD_NEK2_1	187	192	PF00069	0.562
MOD_NEK2_1	303	308	PF00069	0.548
MOD_NEK2_1	632	637	PF00069	0.478
MOD_NEK2_1	682	687	PF00069	0.457
MOD_NEK2_1	69	74	PF00069	0.680
MOD_NEK2_1	696	701	PF00069	0.301
MOD_NEK2_1	711	716	PF00069	0.433
MOD_NEK2_1	724	729	PF00069	0.298
MOD_NEK2_1	753	758	PF00069	0.499
MOD_NEK2_2	278	283	PF00069	0.713
MOD_PIKK_1	785	791	PF00454	0.526
MOD_PIKK_1	92	98	PF00454	0.667
MOD_PK_1	312	318	PF00069	0.572
MOD_PK_1	793	799	PF00069	0.631
MOD_PKA_1	43	49	PF00069	0.652
MOD_PKA_1	802	808	PF00069	0.626
MOD_PKA_2	270	276	PF00069	0.719
MOD_PKA_2	412	418	PF00069	0.622
MOD_PKA_2	426	432	PF00069	0.661
MOD_PKA_2	43	49	PF00069	0.724
MOD_PKA_2	455	461	PF00069	0.572
MOD_PKA_2	618	624	PF00069	0.486
MOD_PKA_2	632	638	PF00069	0.457
MOD_PKA_2	747	753	PF00069	0.489
MOD_PKA_2	784	790	PF00069	0.615
MOD_PKA_2	792	798	PF00069	0.575
MOD_PKA_2	802	808	PF00069	0.526
MOD_Plk_1	262	268	PF00069	0.591
MOD_Plk_1	647	653	PF00069	0.473
MOD_Plk_1	660	666	PF00069	0.451
MOD_Plk_1	69	75	PF00069	0.558
MOD_Plk_1	703	709	PF00069	0.523
MOD_Plk_4	101	107	PF00069	0.701
MOD_Plk_4	151	157	PF00069	0.571
MOD_Plk_4	175	181	PF00069	0.525
MOD_Plk_4	204	210	PF00069	0.569
MOD_Plk_4	214	220	PF00069	0.536
MOD_Plk_4	26	32	PF00069	0.629
MOD_Plk_4	262	268	PF00069	0.658
MOD_Plk_4	278	284	PF00069	0.626
MOD_Plk_4	295	301	PF00069	0.637
MOD_Plk_4	443	449	PF00069	0.686
MOD_Plk_4	55	61	PF00069	0.634
MOD_Plk_4	632	638	PF00069	0.487
MOD_Plk_4	64	70	PF00069	0.574
MOD_Plk_4	647	653	PF00069	0.466
MOD_Plk_4	682	688	PF00069	0.421
MOD_Plk_4	747	753	PF00069	0.482
MOD_ProDKin_1	199	205	PF00069	0.566
MOD_ProDKin_1	245	251	PF00069	0.738
MOD_ProDKin_1	258	264	PF00069	0.630
MOD_ProDKin_1	282	288	PF00069	0.681
MOD_ProDKin_1	349	355	PF00069	0.704
MOD_ProDKin_1	396	402	PF00069	0.703
MOD_ProDKin_1	451	457	PF00069	0.692
MOD_ProDKin_1	459	465	PF00069	0.694
MOD_ProDKin_1	46	52	PF00069	0.783
MOD_ProDKin_1	491	497	PF00069	0.707
MOD_ProDKin_1	97	103	PF00069	0.786
MOD_SUMO_rev_2	653	658	PF00179	0.476
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.581
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.480
TRG_ENDOCYTIC_2	138	141	PF00928	0.588
TRG_ENDOCYTIC_2	300	303	PF00928	0.616
TRG_ENDOCYTIC_2	304	307	PF00928	0.618
TRG_ENDOCYTIC_2	357	360	PF00928	0.721
TRG_ENDOCYTIC_2	565	568	PF00928	0.655
TRG_ER_diArg_1	191	193	PF00400	0.506
TRG_ER_diArg_1	310	312	PF00400	0.660
TRG_ER_diArg_1	337	339	PF00400	0.745
TRG_ER_diArg_1	43	45	PF00400	0.642
TRG_ER_diArg_1	691	694	PF00400	0.496
TRG_ER_diArg_1	828	831	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSJ0	Leishmania donovani	89%	100%
A4H779	Leishmania braziliensis	64%	92%
A4HVL9	Leishmania infantum	89%	100%
E9APB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%