Glycosyltransferase family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosyltransferase family-like protein

Species:

Leishmania major

UniProt:

Q4QG61_LEIMA

TriTrypDb:

LmjF.13.0930 , LMJLV39_130013400 , LMJSD75_130013500

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QG61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG61

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0016740	transferase activity	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.429
CLV_C14_Caspase3-7	53	57	PF00656	0.259
CLV_NRD_NRD_1	22	24	PF00675	0.457
CLV_NRD_NRD_1	262	264	PF00675	0.529
CLV_NRD_NRD_1	6	8	PF00675	0.527
CLV_PCSK_KEX2_1	22	24	PF00082	0.455
CLV_PCSK_KEX2_1	262	264	PF00082	0.529
CLV_PCSK_KEX2_1	35	37	PF00082	0.458
CLV_PCSK_KEX2_1	6	8	PF00082	0.527
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.513
CLV_PCSK_SKI1_1	179	183	PF00082	0.361
CLV_PCSK_SKI1_1	41	45	PF00082	0.499
DEG_MDM2_SWIB_1	135	142	PF02201	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.583
DOC_CKS1_1	248	253	PF01111	0.440
DOC_CYCLIN_RxL_1	187	198	PF00134	0.377
DOC_MAPK_gen_1	41	49	PF00069	0.266
DOC_MAPK_MEF2A_6	193	201	PF00069	0.361
DOC_MAPK_MEF2A_6	41	49	PF00069	0.265
DOC_PP2B_LxvP_1	197	200	PF13499	0.362
DOC_PP4_FxxP_1	42	45	PF00568	0.294
DOC_WW_Pin1_4	247	252	PF00397	0.700
LIG_BRCT_BRCA1_1	131	135	PF00533	0.375
LIG_CtBP_PxDLS_1	89	94	PF00389	0.265
LIG_FHA_1	180	186	PF00498	0.349
LIG_FHA_1	200	206	PF00498	0.375
LIG_FHA_1	242	248	PF00498	0.652
LIG_FHA_2	248	254	PF00498	0.611
LIG_LIR_Gen_1	25	34	PF02991	0.314
LIG_LIR_Nem_3	145	149	PF02991	0.368
LIG_LIR_Nem_3	25	30	PF02991	0.324
LIG_LIR_Nem_3	73	79	PF02991	0.269
LIG_Pex14_1	8	12	PF04695	0.496
LIG_Pex14_2	127	131	PF04695	0.237
LIG_Pex14_2	135	139	PF04695	0.360
LIG_RPA_C_Plants	104	115	PF08784	0.237
LIG_SH2_CRK	79	83	PF00017	0.360
LIG_SH2_STAT3	230	233	PF00017	0.346
LIG_SH2_STAT5	16	19	PF00017	0.246
LIG_SH2_STAT5	166	169	PF00017	0.518
LIG_SH2_STAT5	184	187	PF00017	0.308
LIG_SH2_STAT5	223	226	PF00017	0.372
LIG_SH2_STAT5	230	233	PF00017	0.354
LIG_SH3_3	228	234	PF00018	0.346
LIG_WRC_WIRS_1	240	245	PF05994	0.541
MOD_CK1_1	242	248	PF00069	0.513
MOD_GlcNHglycan	158	161	PF01048	0.520
MOD_GlcNHglycan	189	192	PF01048	0.378
MOD_GlcNHglycan	52	55	PF01048	0.470
MOD_GSK3_1	195	202	PF00069	0.353
MOD_GSK3_1	204	211	PF00069	0.327
MOD_GSK3_1	249	256	PF00069	0.494
MOD_NEK2_1	156	161	PF00069	0.492
MOD_NEK2_1	195	200	PF00069	0.419
MOD_NEK2_1	90	95	PF00069	0.342
MOD_NEK2_2	270	275	PF00069	0.577
MOD_PKA_2	137	143	PF00069	0.482
MOD_PKA_2	50	56	PF00069	0.249
MOD_Plk_1	179	185	PF00069	0.354
MOD_Plk_1	195	201	PF00069	0.369
MOD_Plk_1	47	53	PF00069	0.360
MOD_Plk_2-3	253	259	PF00069	0.613
MOD_Plk_4	232	238	PF00069	0.410
MOD_ProDKin_1	247	253	PF00069	0.709
MOD_SUMO_rev_2	221	229	PF00179	0.404
TRG_ER_diArg_1	22	24	PF00400	0.256
TRG_ER_diArg_1	262	265	PF00400	0.535
TRG_ER_diArg_1	36	39	PF00400	0.256
TRG_ER_diArg_1	6	8	PF00400	0.556
TRG_NLS_Bipartite_1	22	39	PF00514	0.332
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P896	Leptomonas seymouri	79%	100%
A0A0N1PCD6	Leptomonas seymouri	33%	95%
A0A0S4IK22	Bodo saltans	63%	98%
A0A1X0NN04	Trypanosomatidae	67%	100%
A0A1X0P3F1	Trypanosomatidae	39%	80%
A0A3Q8I9N9	Leishmania donovani	96%	100%
A0A3R7K9Z6	Trypanosoma rangeli	36%	91%
A0A3R7MES7	Trypanosoma rangeli	71%	100%
A0A3S7XB94	Leishmania donovani	32%	96%
A4H781	Leishmania braziliensis	91%	100%
A4HPL2	Leishmania braziliensis	32%	96%
A4HVM1	Leishmania infantum	96%	100%
A4ID52	Leishmania infantum	32%	96%
D0A6N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	77%
D0A8K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	90%
E9APB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ATC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	96%
Q4Q173	Leishmania major	32%	100%
V5BK55	Trypanosoma cruzi	70%	100%
V5BS52	Trypanosoma cruzi	33%	91%