Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania major

UniProt:

Q4QG59_LEIMA

TriTrypDb:

LmjF.13.0950 , LMJLV39_130013600 , LMJSD75_130013700

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005884	actin filament	6	2
GO:0005930	axoneme	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	10
GO:0043226	organelle	2	8

Expansion

Sequence features

Q4QG59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG59

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	2
GO:0005200	structural constituent of cytoskeleton	2	2
GO:0098918	structural constituent of synapse	2	2
GO:0098973	structural constituent of postsynaptic actin cytoskeleton	3	2
GO:0099186	structural constituent of postsynapse	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.308
CLV_NRD_NRD_1	466	468	PF00675	0.309
CLV_PCSK_KEX2_1	256	258	PF00082	0.308
CLV_PCSK_SKI1_1	159	163	PF00082	0.309
CLV_PCSK_SKI1_1	175	179	PF00082	0.243
DEG_MDM2_SWIB_1	77	84	PF02201	0.509
DEG_Nend_UBRbox_2	1	3	PF02207	0.618
DEG_SCF_TRCP1_1	156	162	PF00400	0.426
DOC_CKS1_1	111	116	PF01111	0.402
DOC_CKS1_1	235	240	PF01111	0.509
DOC_MAPK_MEF2A_6	118	126	PF00069	0.426
DOC_PP1_RVXF_1	372	379	PF00149	0.509
DOC_PP2B_LxvP_1	31	34	PF13499	0.443
DOC_PP4_FxxP_1	314	317	PF00568	0.426
DOC_USP7_MATH_1	249	253	PF00917	0.527
DOC_USP7_MATH_1	283	287	PF00917	0.478
DOC_USP7_MATH_1	402	406	PF00917	0.515
DOC_WW_Pin1_4	110	115	PF00397	0.401
DOC_WW_Pin1_4	177	182	PF00397	0.480
DOC_WW_Pin1_4	234	239	PF00397	0.499
DOC_WW_Pin1_4	244	249	PF00397	0.525
DOC_WW_Pin1_4	300	305	PF00397	0.450
DOC_WW_Pin1_4	96	101	PF00397	0.437
LIG_14-3-3_CanoR_1	175	182	PF00244	0.443
LIG_14-3-3_CanoR_1	229	238	PF00244	0.390
LIG_14-3-3_CanoR_1	256	265	PF00244	0.446
LIG_14-3-3_CanoR_1	443	449	PF00244	0.538
LIG_Actin_WH2_2	84	99	PF00022	0.468
LIG_BRCT_BRCA1_1	404	408	PF00533	0.509
LIG_BRCT_BRCA1_1	88	92	PF00533	0.494
LIG_deltaCOP1_diTrp_1	80	88	PF00928	0.454
LIG_eIF4E_1	338	344	PF01652	0.480
LIG_FHA_1	106	112	PF00498	0.509
LIG_FHA_1	119	125	PF00498	0.426
LIG_FHA_1	136	142	PF00498	0.452
LIG_FHA_1	148	154	PF00498	0.420
LIG_FHA_1	160	166	PF00498	0.416
LIG_FHA_1	186	192	PF00498	0.453
LIG_FHA_1	260	266	PF00498	0.446
LIG_FHA_1	276	282	PF00498	0.482
LIG_FHA_1	329	335	PF00498	0.448
LIG_FHA_1	5	11	PF00498	0.405
LIG_FHA_2	202	208	PF00498	0.448
LIG_FHA_2	280	286	PF00498	0.500
LIG_LIR_Apic_2	217	223	PF02991	0.502
LIG_LIR_Apic_2	311	317	PF02991	0.426
LIG_LIR_Gen_1	169	177	PF02991	0.446
LIG_LIR_Gen_1	457	465	PF02991	0.509
LIG_LIR_Gen_1	85	96	PF02991	0.424
LIG_LIR_LC3C_4	150	155	PF02991	0.509
LIG_LIR_Nem_3	169	174	PF02991	0.446
LIG_LIR_Nem_3	377	381	PF02991	0.454
LIG_LIR_Nem_3	405	411	PF02991	0.500
LIG_LIR_Nem_3	457	463	PF02991	0.432
LIG_LIR_Nem_3	80	84	PF02991	0.438
LIG_LIR_Nem_3	85	91	PF02991	0.413
LIG_NRBOX	190	196	PF00104	0.443
LIG_PCNA_PIPBox_1	456	465	PF02747	0.509
LIG_PCNA_yPIPBox_3	337	349	PF02747	0.411
LIG_Pex14_1	88	92	PF04695	0.494
LIG_Pex14_2	368	372	PF04695	0.436
LIG_Pex14_2	77	81	PF04695	0.509
LIG_SH2_CRK	171	175	PF00017	0.446
LIG_SH2_CRK	338	342	PF00017	0.480
LIG_SH2_GRB2like	396	399	PF00017	0.509
LIG_SH2_NCK_1	236	240	PF00017	0.446
LIG_SH2_NCK_1	329	333	PF00017	0.463
LIG_SH2_PTP2	220	223	PF00017	0.441
LIG_SH2_STAP1	338	342	PF00017	0.463
LIG_SH2_STAP1	396	400	PF00017	0.468
LIG_SH2_STAP1	445	449	PF00017	0.426
LIG_SH2_STAT5	135	138	PF00017	0.519
LIG_SH2_STAT5	190	193	PF00017	0.426
LIG_SH2_STAT5	220	223	PF00017	0.411
LIG_SH2_STAT5	236	239	PF00017	0.411
LIG_SH3_3	108	114	PF00018	0.432
LIG_SH3_3	34	40	PF00018	0.443
LIG_SH3_3	66	72	PF00018	0.443
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.439
LIG_SUMO_SIM_anti_2	339	346	PF11976	0.542
LIG_SUMO_SIM_par_1	138	146	PF11976	0.469
LIG_SUMO_SIM_par_1	339	346	PF11976	0.511
LIG_TRAF2_1	206	209	PF00917	0.515
LIG_TRAF2_2	434	439	PF00917	0.463
LIG_TYR_ITIM	478	483	PF00017	0.509
LIG_UBA3_1	340	349	PF00899	0.377
LIG_WRC_WIRS_1	126	131	PF05994	0.426
MOD_CK1_1	143	149	PF00069	0.493
MOD_CK1_1	16	22	PF00069	0.496
MOD_CK1_1	240	246	PF00069	0.446
MOD_CK1_1	252	258	PF00069	0.415
MOD_CK1_1	268	274	PF00069	0.528
MOD_CK1_1	426	432	PF00069	0.509
MOD_CK1_1	99	105	PF00069	0.494
MOD_CK2_1	201	207	PF00069	0.435
MOD_CK2_1	279	285	PF00069	0.508
MOD_CK2_1	287	293	PF00069	0.572
MOD_CK2_1	349	355	PF00069	0.522
MOD_CK2_1	463	469	PF00069	0.426
MOD_GlcNHglycan	156	159	PF01048	0.226
MOD_GlcNHglycan	239	242	PF01048	0.279
MOD_GlcNHglycan	251	254	PF01048	0.334
MOD_GlcNHglycan	267	270	PF01048	0.322
MOD_GlcNHglycan	273	276	PF01048	0.313
MOD_GlcNHglycan	289	292	PF01048	0.371
MOD_GSK3_1	136	143	PF00069	0.454
MOD_GSK3_1	230	237	PF00069	0.432
MOD_GSK3_1	240	247	PF00069	0.462
MOD_GSK3_1	252	259	PF00069	0.516
MOD_GSK3_1	271	278	PF00069	0.497
MOD_GSK3_1	279	286	PF00069	0.449
MOD_N-GLC_1	3	8	PF02516	0.555
MOD_N-GLC_1	336	341	PF02516	0.309
MOD_N-GLC_2	385	387	PF02516	0.226
MOD_NEK2_1	105	110	PF00069	0.504
MOD_NEK2_1	125	130	PF00069	0.449
MOD_NEK2_1	136	141	PF00069	0.441
MOD_NEK2_1	287	292	PF00069	0.465
MOD_NEK2_1	336	341	PF00069	0.468
MOD_NEK2_1	343	348	PF00069	0.468
MOD_NEK2_1	449	454	PF00069	0.449
MOD_NEK2_1	463	468	PF00069	0.415
MOD_PIKK_1	105	111	PF00454	0.533
MOD_PIKK_1	136	142	PF00454	0.426
MOD_PIKK_1	175	181	PF00454	0.476
MOD_PIKK_1	256	262	PF00454	0.446
MOD_PK_1	41	47	PF00069	0.480
MOD_PKA_1	256	262	PF00069	0.480
MOD_PKA_2	255	261	PF00069	0.533
MOD_PKA_2	368	374	PF00069	0.529
MOD_PKA_2	423	429	PF00069	0.426
MOD_Plk_1	118	124	PF00069	0.426
MOD_Plk_1	336	342	PF00069	0.468
MOD_Plk_1	349	355	PF00069	0.468
MOD_Plk_2-3	350	356	PF00069	0.446
MOD_Plk_4	130	136	PF00069	0.443
MOD_Plk_4	140	146	PF00069	0.426
MOD_Plk_4	283	289	PF00069	0.428
MOD_Plk_4	32	38	PF00069	0.509
MOD_Plk_4	336	342	PF00069	0.480
MOD_Plk_4	444	450	PF00069	0.451
MOD_ProDKin_1	110	116	PF00069	0.401
MOD_ProDKin_1	177	183	PF00069	0.480
MOD_ProDKin_1	234	240	PF00069	0.499
MOD_ProDKin_1	244	250	PF00069	0.525
MOD_ProDKin_1	300	306	PF00069	0.450
MOD_ProDKin_1	96	102	PF00069	0.437
TRG_DiLeu_BaEn_1	169	174	PF01217	0.446
TRG_DiLeu_BaEn_2	100	106	PF01217	0.426
TRG_ENDOCYTIC_2	171	174	PF00928	0.446
TRG_ENDOCYTIC_2	338	341	PF00928	0.465
TRG_ENDOCYTIC_2	396	399	PF00928	0.468
TRG_ENDOCYTIC_2	480	483	PF00928	0.556
TRG_ER_diArg_1	221	224	PF00400	0.377
TRG_ER_diArg_1	40	43	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P696	Leptomonas seymouri	27%	100%
A0A0N0P8M2	Leptomonas seymouri	73%	100%
A0A0N1I659	Leptomonas seymouri	26%	97%
A0A0N1IM09	Leptomonas seymouri	24%	100%
A0A1X0NJ12	Trypanosomatidae	23%	100%
A0A3Q8I9L1	Leishmania donovani	97%	100%
A0A3Q8IJ53	Leishmania donovani	26%	93%
A0A422NGD7	Trypanosoma rangeli	53%	100%
A0A422NI92	Trypanosoma rangeli	26%	100%
A0A422NRB8	Trypanosoma rangeli	26%	100%
A2WNB0	Oryza sativa subsp. indica	26%	100%
A4FUX8	Bos taurus	24%	100%
A4H783	Leishmania braziliensis	83%	100%
A4HA61	Leishmania braziliensis	24%	100%
A4HMB0	Leishmania braziliensis	25%	94%
A4HVM3	Leishmania infantum	97%	100%
A4IAX6	Leishmania infantum	26%	93%
C9ZXR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A6N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9APB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AQC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B5V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	93%
O94805	Homo sapiens	24%	100%
O96019	Homo sapiens	23%	100%
P80428	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P86173	Rattus norvegicus	24%	100%
Q09849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4FX37	Leishmania major	26%	97%
Q4P2E8	Ustilago maydis (strain 521 / FGSC 9021)	25%	90%
Q4QD95	Leishmania major	24%	100%
Q4R333	Macaca fascicularis	23%	100%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q4WHA3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54KZ7	Dictyostelium discoideum	22%	99%
Q55CU2	Dictyostelium discoideum	29%	100%
Q5AW89	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	21%	100%
Q5NBI2	Oryza sativa subsp. japonica	26%	100%
Q6BXN0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	98%
Q6C061	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	100%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q7SHR0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q84M92	Arabidopsis thaliana	27%	100%
Q8LGE3	Arabidopsis thaliana	28%	100%
Q8RYC2	Arabidopsis thaliana	32%	100%
Q99MR0	Mus musculus	24%	100%
Q9GZN1	Homo sapiens	22%	100%
Q9P7X7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9Z2N8	Mus musculus	23%	100%
V5AVP6	Trypanosoma cruzi	50%	100%
V5DJL3	Trypanosoma cruzi	27%	100%