LeishMANIAdb
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Katanin p60 ATPase-containing subunit A-like 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A-like 2
Gene product:
katanin-like protein
Species:
Leishmania major
UniProt:
Q4QG58_LEIMA
TriTrypDb:
LmjF.13.0960 , LMJLV39_130013700 * , LMJSD75_130013800 *
Length:
565

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 11
GO:0005737 cytoplasm 2 11
GO:0005815 microtubule organizing center 2 2
GO:0005874 microtubule 6 11
GO:0036064 ciliary basal body 3 2
GO:0099080 supramolecular complex 2 11
GO:0099081 supramolecular polymer 3 11
GO:0099512 supramolecular fiber 4 11
GO:0099513 polymeric cytoskeletal fiber 5 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4QG58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG58

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 11
GO:0006996 organelle organization 4 11
GO:0007010 cytoskeleton organization 5 11
GO:0007017 microtubule-based process 2 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0051013 microtubule severing 4 11
GO:0071840 cellular component organization or biogenesis 2 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0005524 ATP binding 5 11
GO:0008017 microtubule binding 5 11
GO:0008092 cytoskeletal protein binding 3 11
GO:0008568 microtubule severing ATPase activity 2 11
GO:0015631 tubulin binding 4 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016853 isomerase activity 2 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0140657 ATP-dependent activity 1 11
GO:0140776 protein-containing complex destabilizing activity 1 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 112 116 PF00656 0.700
CLV_C14_Caspase3-7 378 382 PF00656 0.297
CLV_C14_Caspase3-7 405 409 PF00656 0.408
CLV_C14_Caspase3-7 75 79 PF00656 0.600
CLV_NRD_NRD_1 132 134 PF00675 0.640
CLV_NRD_NRD_1 220 222 PF00675 0.797
CLV_NRD_NRD_1 244 246 PF00675 0.681
CLV_NRD_NRD_1 38 40 PF00675 0.510
CLV_NRD_NRD_1 397 399 PF00675 0.297
CLV_NRD_NRD_1 413 415 PF00675 0.297
CLV_NRD_NRD_1 437 439 PF00675 0.297
CLV_NRD_NRD_1 458 460 PF00675 0.511
CLV_NRD_NRD_1 498 500 PF00675 0.408
CLV_PCSK_FUR_1 36 40 PF00082 0.443
CLV_PCSK_KEX2_1 186 188 PF00082 0.739
CLV_PCSK_KEX2_1 220 222 PF00082 0.797
CLV_PCSK_KEX2_1 244 246 PF00082 0.611
CLV_PCSK_KEX2_1 38 40 PF00082 0.437
CLV_PCSK_KEX2_1 397 399 PF00082 0.297
CLV_PCSK_KEX2_1 412 414 PF00082 0.262
CLV_PCSK_KEX2_1 437 439 PF00082 0.294
CLV_PCSK_KEX2_1 441 443 PF00082 0.297
CLV_PCSK_KEX2_1 458 460 PF00082 0.418
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.652
CLV_PCSK_PC1ET2_1 412 414 PF00082 0.304
CLV_PCSK_PC1ET2_1 441 443 PF00082 0.297
CLV_PCSK_PC7_1 437 443 PF00082 0.297
CLV_PCSK_SKI1_1 140 144 PF00082 0.765
CLV_PCSK_SKI1_1 244 248 PF00082 0.492
CLV_PCSK_SKI1_1 267 271 PF00082 0.377
CLV_PCSK_SKI1_1 288 292 PF00082 0.369
CLV_PCSK_SKI1_1 313 317 PF00082 0.308
CLV_PCSK_SKI1_1 325 329 PF00082 0.274
CLV_PCSK_SKI1_1 361 365 PF00082 0.297
CLV_PCSK_SKI1_1 38 42 PF00082 0.441
CLV_PCSK_SKI1_1 397 401 PF00082 0.297
CLV_PCSK_SKI1_1 441 445 PF00082 0.296
CLV_PCSK_SKI1_1 458 462 PF00082 0.339
CLV_Separin_Metazoa 521 525 PF03568 0.208
DEG_APCC_DBOX_1 243 251 PF00400 0.569
DEG_Nend_UBRbox_1 1 4 PF02207 0.724
DEG_SPOP_SBC_1 141 145 PF00917 0.769
DOC_CYCLIN_RxL_1 358 365 PF00134 0.297
DOC_CYCLIN_RxL_1 453 464 PF00134 0.473
DOC_CYCLIN_yClb5_NLxxxL_5 161 170 PF00134 0.721
DOC_MAPK_gen_1 310 318 PF00069 0.359
DOC_MAPK_gen_1 358 368 PF00069 0.316
DOC_MAPK_gen_1 36 46 PF00069 0.409
DOC_MAPK_gen_1 412 421 PF00069 0.346
DOC_MAPK_gen_1 437 447 PF00069 0.297
DOC_MAPK_HePTP_8 35 47 PF00069 0.483
DOC_MAPK_MEF2A_6 38 47 PF00069 0.401
DOC_MAPK_MEF2A_6 438 447 PF00069 0.297
DOC_MAPK_RevD_3 443 459 PF00069 0.482
DOC_PP1_RVXF_1 451 458 PF00149 0.443
DOC_PP1_SILK_1 306 311 PF00149 0.493
DOC_PP2B_LxvP_1 523 526 PF13499 0.386
DOC_PP4_FxxP_1 318 321 PF00568 0.297
DOC_USP7_MATH_1 141 145 PF00917 0.764
DOC_USP7_MATH_1 15 19 PF00917 0.502
DOC_USP7_MATH_1 209 213 PF00917 0.734
DOC_USP7_MATH_1 237 241 PF00917 0.659
DOC_USP7_MATH_1 344 348 PF00917 0.364
DOC_USP7_MATH_1 386 390 PF00917 0.411
DOC_WW_Pin1_4 144 149 PF00397 0.743
LIG_14-3-3_CanoR_1 107 117 PF00244 0.643
LIG_14-3-3_CanoR_1 140 149 PF00244 0.750
LIG_14-3-3_CanoR_1 337 341 PF00244 0.316
LIG_14-3-3_CanoR_1 397 407 PF00244 0.297
LIG_14-3-3_CanoR_1 442 448 PF00244 0.354
LIG_14-3-3_CanoR_1 541 545 PF00244 0.358
LIG_14-3-3_CanoR_1 68 72 PF00244 0.532
LIG_Actin_WH2_2 147 164 PF00022 0.768
LIG_Actin_WH2_2 254 269 PF00022 0.532
LIG_BIR_III_4 113 117 PF00653 0.746
LIG_BRCT_BRCA1_1 372 376 PF00533 0.297
LIG_CaM_IQ_9 60 75 PF13499 0.603
LIG_CtBP_PxDLS_1 148 152 PF00389 0.656
LIG_EVH1_1 250 254 PF00568 0.560
LIG_FHA_1 193 199 PF00498 0.703
LIG_FHA_1 22 28 PF00498 0.438
LIG_FHA_1 253 259 PF00498 0.516
LIG_FHA_1 372 378 PF00498 0.297
LIG_FHA_1 399 405 PF00498 0.297
LIG_FHA_1 431 437 PF00498 0.339
LIG_FHA_2 403 409 PF00498 0.452
LIG_FHA_2 527 533 PF00498 0.316
LIG_Integrin_isoDGR_2 223 225 PF01839 0.558
LIG_Integrin_RGD_1 353 355 PF01839 0.297
LIG_LIR_Nem_3 275 281 PF02991 0.512
LIG_LIR_Nem_3 338 343 PF02991 0.297
LIG_LIR_Nem_3 88 92 PF02991 0.416
LIG_LYPXL_yS_3 301 304 PF13949 0.415
LIG_MYND_1 159 163 PF01753 0.712
LIG_Rb_pABgroove_1 358 366 PF01858 0.339
LIG_SH2_SRC 370 373 PF00017 0.316
LIG_SH2_STAP1 471 475 PF00017 0.408
LIG_SH2_STAP1 89 93 PF00017 0.440
LIG_SH3_1 248 254 PF00018 0.464
LIG_SH3_2 519 524 PF14604 0.440
LIG_SH3_3 151 157 PF00018 0.669
LIG_SH3_3 246 252 PF00018 0.436
LIG_SH3_3 292 298 PF00018 0.376
LIG_SH3_3 442 448 PF00018 0.297
LIG_SH3_3 516 522 PF00018 0.366
LIG_SUMO_SIM_anti_2 485 490 PF11976 0.297
LIG_SUMO_SIM_anti_2 78 84 PF11976 0.450
LIG_SUMO_SIM_par_1 268 273 PF11976 0.481
LIG_SUMO_SIM_par_1 42 48 PF11976 0.371
LIG_SUMO_SIM_par_1 443 449 PF11976 0.408
LIG_TRAF2_1 28 31 PF00917 0.507
LIG_TYR_ITIM 299 304 PF00017 0.413
LIG_UBA3_1 304 313 PF00899 0.409
LIG_UBA3_1 403 412 PF00899 0.316
LIG_UBA3_1 435 441 PF00899 0.297
MOD_CK1_1 144 150 PF00069 0.770
MOD_CK1_1 240 246 PF00069 0.611
MOD_CK1_1 256 262 PF00069 0.288
MOD_CK1_1 347 353 PF00069 0.308
MOD_CK1_1 382 388 PF00069 0.297
MOD_CK1_1 446 452 PF00069 0.529
MOD_CK1_1 464 470 PF00069 0.486
MOD_CK1_1 67 73 PF00069 0.458
MOD_CK2_1 209 215 PF00069 0.764
MOD_CK2_1 386 392 PF00069 0.374
MOD_CK2_1 500 506 PF00069 0.418
MOD_Cter_Amidation 218 221 PF01082 0.793
MOD_GlcNHglycan 123 126 PF01048 0.656
MOD_GlcNHglycan 178 181 PF01048 0.710
MOD_GlcNHglycan 194 198 PF01048 0.680
MOD_GlcNHglycan 205 208 PF01048 0.766
MOD_GlcNHglycan 211 214 PF01048 0.632
MOD_GlcNHglycan 384 387 PF01048 0.302
MOD_GlcNHglycan 481 484 PF01048 0.337
MOD_GlcNHglycan 560 563 PF01048 0.437
MOD_GlcNHglycan 74 77 PF01048 0.572
MOD_GSK3_1 140 147 PF00069 0.722
MOD_GSK3_1 252 259 PF00069 0.484
MOD_GSK3_1 331 338 PF00069 0.297
MOD_GSK3_1 343 350 PF00069 0.297
MOD_GSK3_1 382 389 PF00069 0.322
MOD_GSK3_1 398 405 PF00069 0.291
MOD_GSK3_1 475 482 PF00069 0.310
MOD_GSK3_1 533 540 PF00069 0.281
MOD_GSK3_1 558 565 PF00069 0.495
MOD_LATS_1 515 521 PF00433 0.364
MOD_NEK2_1 198 203 PF00069 0.762
MOD_NEK2_1 261 266 PF00069 0.392
MOD_NEK2_1 422 427 PF00069 0.297
MOD_NEK2_1 7 12 PF00069 0.663
MOD_NEK2_2 336 341 PF00069 0.290
MOD_NEK2_2 56 61 PF00069 0.208
MOD_PIKK_1 21 27 PF00454 0.555
MOD_PIKK_1 402 408 PF00454 0.408
MOD_PIKK_1 500 506 PF00454 0.364
MOD_PIKK_1 69 75 PF00454 0.540
MOD_PKA_2 161 167 PF00069 0.733
MOD_PKA_2 336 342 PF00069 0.316
MOD_PKA_2 386 392 PF00069 0.370
MOD_PKA_2 540 546 PF00069 0.358
MOD_PKA_2 67 73 PF00069 0.531
MOD_PKB_1 105 113 PF00069 0.611
MOD_Plk_1 193 199 PF00069 0.507
MOD_Plk_4 237 243 PF00069 0.587
MOD_Plk_4 261 267 PF00069 0.487
MOD_Plk_4 323 329 PF00069 0.307
MOD_Plk_4 336 342 PF00069 0.279
MOD_Plk_4 344 350 PF00069 0.294
MOD_Plk_4 371 377 PF00069 0.297
MOD_Plk_4 379 385 PF00069 0.297
MOD_Plk_4 81 87 PF00069 0.405
MOD_ProDKin_1 144 150 PF00069 0.744
MOD_SUMO_for_1 399 402 PF00179 0.297
MOD_SUMO_rev_2 30 35 PF00179 0.523
TRG_DiLeu_BaEn_1 379 384 PF01217 0.297
TRG_DiLeu_BaEn_1 440 445 PF01217 0.297
TRG_DiLeu_BaEn_4 30 36 PF01217 0.537
TRG_DiLeu_BaLyEn_6 456 461 PF01217 0.458
TRG_ENDOCYTIC_2 301 304 PF00928 0.399
TRG_ENDOCYTIC_2 92 95 PF00928 0.413
TRG_ER_diArg_1 104 107 PF00400 0.537
TRG_ER_diArg_1 244 246 PF00400 0.611
TRG_ER_diArg_1 35 38 PF00400 0.473
TRG_ER_diArg_1 397 399 PF00400 0.297
TRG_ER_diArg_1 436 438 PF00400 0.297
TRG_ER_diArg_1 457 459 PF00400 0.471
TRG_NLS_Bipartite_1 397 416 PF00514 0.316
TRG_NLS_MonoExtC_3 411 417 PF00514 0.316
TRG_Pf-PMV_PEXEL_1 267 271 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 279 283 PF00026 0.396
TRG_Pf-PMV_PEXEL_1 361 365 PF00026 0.297
TRG_Pf-PMV_PEXEL_1 499 504 PF00026 0.370

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P897 Leptomonas seymouri 68% 98%
A0A0S4IR32 Bodo saltans 54% 100%
A0A1X0NPJ1 Trypanosomatidae 58% 98%
A0A3Q8I9I1 Leishmania donovani 95% 100%
A0JMA9 Xenopus tropicalis 44% 100%
A4H784 Leishmania braziliensis 80% 96%
A4HVM4 Leishmania infantum 96% 100%
D0A6N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9APC0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O75351 Homo sapiens 39% 100%
Q3B8D5 Xenopus laevis 39% 100%
Q5R658 Pongo abelii 39% 100%
Q793F9 Rattus norvegicus 39% 100%
Q8IYT4 Homo sapiens 42% 100%
Q8VEJ9 Mus musculus 39% 100%
Q9D3R6 Mus musculus 41% 100%
Q9UN37 Homo sapiens 39% 100%
V5DBR1 Trypanosoma cruzi 57% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS