Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG57_LEIMA

TriTrypDb:

LmjF.13.0970 , LMJLV39_130013800 , LMJSD75_130013900

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.785
CLV_C14_Caspase3-7	416	420	PF00656	0.696
CLV_NRD_NRD_1	313	315	PF00675	0.585
CLV_NRD_NRD_1	34	36	PF00675	0.677
CLV_NRD_NRD_1	401	403	PF00675	0.577
CLV_NRD_NRD_1	441	443	PF00675	0.567
CLV_NRD_NRD_1	589	591	PF00675	0.422
CLV_PCSK_KEX2_1	34	36	PF00082	0.677
CLV_PCSK_KEX2_1	401	403	PF00082	0.577
CLV_PCSK_KEX2_1	522	524	PF00082	0.419
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.419
CLV_PCSK_SKI1_1	191	195	PF00082	0.660
CLV_PCSK_SKI1_1	376	380	PF00082	0.577
CLV_PCSK_SKI1_1	557	561	PF00082	0.451
CLV_PCSK_SKI1_1	602	606	PF00082	0.382
CLV_Separin_Metazoa	124	128	PF03568	0.462
DEG_Kelch_Keap1_1	467	472	PF01344	0.577
DEG_SCF_FBW7_1	378	383	PF00400	0.576
DEG_SCF_FBW7_1	582	589	PF00400	0.472
DEG_SPOP_SBC_1	58	62	PF00917	0.752
DOC_CYCLIN_yCln2_LP_2	22	25	PF00134	0.625
DOC_MAPK_gen_1	287	295	PF00069	0.508
DOC_PP1_RVXF_1	279	286	PF00149	0.410
DOC_PP1_RVXF_1	560	567	PF00149	0.442
DOC_PP2B_LxvP_1	22	25	PF13499	0.656
DOC_PP4_MxPP_1	488	491	PF00568	0.595
DOC_PP4_MxPP_1	8	11	PF00568	0.559
DOC_USP7_MATH_1	107	111	PF00917	0.648
DOC_USP7_MATH_1	14	18	PF00917	0.683
DOC_USP7_MATH_1	202	206	PF00917	0.668
DOC_USP7_MATH_1	326	330	PF00917	0.715
DOC_USP7_MATH_1	38	42	PF00917	0.664
DOC_USP7_MATH_1	380	384	PF00917	0.618
DOC_USP7_MATH_1	393	397	PF00917	0.632
DOC_USP7_MATH_1	400	404	PF00917	0.616
DOC_USP7_MATH_1	417	421	PF00917	0.641
DOC_USP7_MATH_1	466	470	PF00917	0.714
DOC_USP7_MATH_1	547	551	PF00917	0.544
DOC_USP7_MATH_1	57	61	PF00917	0.807
DOC_USP7_MATH_1	87	91	PF00917	0.628
DOC_USP7_UBL2_3	187	191	PF12436	0.621
DOC_WW_Pin1_4	269	274	PF00397	0.439
DOC_WW_Pin1_4	376	381	PF00397	0.576
DOC_WW_Pin1_4	541	546	PF00397	0.469
DOC_WW_Pin1_4	582	587	PF00397	0.505
DOC_WW_Pin1_4	59	64	PF00397	0.740
LIG_14-3-3_CanoR_1	233	243	PF00244	0.489
LIG_14-3-3_CanoR_1	361	369	PF00244	0.715
LIG_14-3-3_CanoR_1	442	450	PF00244	0.664
LIG_Actin_WH2_2	428	444	PF00022	0.528
LIG_AP2alpha_1	551	555	PF02296	0.499
LIG_APCC_ABBA_1	349	354	PF00400	0.752
LIG_APCC_ABBA_1	593	598	PF00400	0.379
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BIR_III_4	334	338	PF00653	0.718
LIG_Clathr_ClatBox_1	501	505	PF01394	0.396
LIG_EVH1_1	489	493	PF00568	0.455
LIG_FHA_1	107	113	PF00498	0.655
LIG_FHA_1	14	20	PF00498	0.605
LIG_FHA_1	174	180	PF00498	0.596
LIG_FHA_1	344	350	PF00498	0.749
LIG_FHA_1	366	372	PF00498	0.618
LIG_FHA_1	373	379	PF00498	0.619
LIG_FHA_1	436	442	PF00498	0.765
LIG_FHA_1	501	507	PF00498	0.520
LIG_FHA_1	587	593	PF00498	0.420
LIG_FHA_2	118	124	PF00498	0.672
LIG_FHA_2	138	144	PF00498	0.280
LIG_FHA_2	351	357	PF00498	0.754
LIG_FHA_2	360	366	PF00498	0.640
LIG_GBD_Chelix_1	155	163	PF00786	0.423
LIG_GBD_Chelix_1	548	556	PF00786	0.564
LIG_LIR_Gen_1	479	489	PF02991	0.522
LIG_LIR_Gen_1	528	539	PF02991	0.451
LIG_LIR_Gen_1	550	559	PF02991	0.435
LIG_LIR_Nem_3	479	484	PF02991	0.519
LIG_LIR_Nem_3	518	524	PF02991	0.431
LIG_LIR_Nem_3	528	534	PF02991	0.462
LIG_LIR_Nem_3	550	554	PF02991	0.413
LIG_LIR_Nem_3	598	604	PF02991	0.376
LIG_Pex14_2	551	555	PF04695	0.515
LIG_REV1ctd_RIR_1	552	561	PF16727	0.501
LIG_SH2_CRK	521	525	PF00017	0.424
LIG_SH2_GRB2like	294	297	PF00017	0.498
LIG_SH2_GRB2like	527	530	PF00017	0.461
LIG_SH2_NCK_1	531	535	PF00017	0.438
LIG_SH2_PTP2	481	484	PF00017	0.629
LIG_SH2_STAP1	153	157	PF00017	0.418
LIG_SH2_STAP1	513	517	PF00017	0.424
LIG_SH2_STAP1	527	531	PF00017	0.578
LIG_SH2_STAT3	596	599	PF00017	0.515
LIG_SH2_STAT5	276	279	PF00017	0.450
LIG_SH2_STAT5	294	297	PF00017	0.498
LIG_SH2_STAT5	312	315	PF00017	0.676
LIG_SH2_STAT5	481	484	PF00017	0.629
LIG_SH2_STAT5	73	76	PF00017	0.717
LIG_SH3_3	487	493	PF00018	0.479
LIG_SH3_3	503	509	PF00018	0.413
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.390
LIG_SUMO_SIM_anti_2	237	244	PF11976	0.552
LIG_SUMO_SIM_anti_2	503	508	PF11976	0.406
LIG_SUMO_SIM_par_1	500	505	PF11976	0.395
LIG_SxIP_EBH_1	236	247	PF03271	0.422
LIG_TRAF2_1	140	143	PF00917	0.443
LIG_TRAF2_1	363	366	PF00917	0.694
LIG_TRAF2_1	41	44	PF00917	0.769
LIG_TRAF2_1	470	473	PF00917	0.766
LIG_TYR_ITAM	518	534	PF00017	0.440
LIG_UBA3_1	253	261	PF00899	0.401
LIG_UBA3_1	284	290	PF00899	0.449
LIG_WRC_WIRS_1	548	553	PF05994	0.433
MOD_CDK_SPK_2	541	546	PF00069	0.469
MOD_CK1_1	12	18	PF00069	0.719
MOD_CK1_1	205	211	PF00069	0.717
MOD_CK1_1	218	224	PF00069	0.598
MOD_CK1_1	269	275	PF00069	0.434
MOD_CK1_1	420	426	PF00069	0.791
MOD_CK1_1	446	452	PF00069	0.662
MOD_CK2_1	137	143	PF00069	0.448
MOD_CK2_1	205	211	PF00069	0.734
MOD_CK2_1	359	365	PF00069	0.760
MOD_CK2_1	38	44	PF00069	0.647
MOD_CK2_1	466	472	PF00069	0.705
MOD_GlcNHglycan	109	112	PF01048	0.564
MOD_GlcNHglycan	159	162	PF01048	0.406
MOD_GlcNHglycan	16	19	PF01048	0.578
MOD_GlcNHglycan	323	326	PF01048	0.645
MOD_GlcNHglycan	40	43	PF01048	0.803
MOD_GlcNHglycan	402	405	PF01048	0.612
MOD_GlcNHglycan	406	409	PF01048	0.609
MOD_GlcNHglycan	415	418	PF01048	0.648
MOD_GlcNHglycan	419	422	PF01048	0.642
MOD_GlcNHglycan	423	426	PF01048	0.515
MOD_GlcNHglycan	443	446	PF01048	0.569
MOD_GlcNHglycan	468	472	PF01048	0.602
MOD_GlcNHglycan	494	497	PF01048	0.592
MOD_GlcNHglycan	5	8	PF01048	0.693
MOD_GlcNHglycan	97	100	PF01048	0.707
MOD_GSK3_1	107	114	PF00069	0.649
MOD_GSK3_1	201	208	PF00069	0.579
MOD_GSK3_1	212	219	PF00069	0.795
MOD_GSK3_1	234	241	PF00069	0.429
MOD_GSK3_1	265	272	PF00069	0.447
MOD_GSK3_1	317	324	PF00069	0.535
MOD_GSK3_1	372	379	PF00069	0.615
MOD_GSK3_1	380	387	PF00069	0.634
MOD_GSK3_1	400	407	PF00069	0.709
MOD_GSK3_1	413	420	PF00069	0.585
MOD_GSK3_1	421	428	PF00069	0.608
MOD_GSK3_1	430	437	PF00069	0.533
MOD_GSK3_1	446	453	PF00069	0.550
MOD_GSK3_1	58	65	PF00069	0.660
MOD_GSK3_1	582	589	PF00069	0.472
MOD_GSK3_1	9	16	PF00069	0.620
MOD_N-GLC_1	130	135	PF02516	0.414
MOD_N-GLC_1	265	270	PF02516	0.441
MOD_N-GLC_1	466	471	PF02516	0.592
MOD_N-GLC_2	137	139	PF02516	0.457
MOD_NEK2_1	132	137	PF00069	0.425
MOD_NEK2_1	227	232	PF00069	0.495
MOD_NEK2_1	249	254	PF00069	0.384
MOD_NEK2_1	441	446	PF00069	0.626
MOD_NEK2_1	566	571	PF00069	0.467
MOD_NEK2_1	597	602	PF00069	0.417
MOD_NEK2_2	87	92	PF00069	0.562
MOD_PIKK_1	137	143	PF00454	0.426
MOD_PIKK_1	327	333	PF00454	0.560
MOD_PIKK_1	49	55	PF00454	0.578
MOD_PIKK_1	580	586	PF00454	0.620
MOD_PKA_2	360	366	PF00069	0.698
MOD_PKA_2	400	406	PF00069	0.735
MOD_PKA_2	441	447	PF00069	0.569
MOD_Plk_1	265	271	PF00069	0.450
MOD_Plk_1	304	310	PF00069	0.556
MOD_Plk_1	365	371	PF00069	0.624
MOD_Plk_1	597	603	PF00069	0.393
MOD_Plk_4	18	24	PF00069	0.653
MOD_Plk_4	227	233	PF00069	0.493
MOD_Plk_4	235	241	PF00069	0.432
MOD_Plk_4	249	255	PF00069	0.360
MOD_Plk_4	365	371	PF00069	0.625
MOD_Plk_4	476	482	PF00069	0.553
MOD_Plk_4	547	553	PF00069	0.439
MOD_ProDKin_1	269	275	PF00069	0.434
MOD_ProDKin_1	376	382	PF00069	0.577
MOD_ProDKin_1	541	547	PF00069	0.472
MOD_ProDKin_1	582	588	PF00069	0.497
MOD_ProDKin_1	59	65	PF00069	0.737
MOD_SUMO_for_1	193	196	PF00179	0.557
MOD_SUMO_rev_2	190	195	PF00179	0.512
MOD_SUMO_rev_2	275	283	PF00179	0.424
TRG_DiLeu_BaEn_1	121	126	PF01217	0.491
TRG_DiLeu_BaEn_1	184	189	PF01217	0.487
TRG_DiLeu_BaEn_2	364	370	PF01217	0.628
TRG_ENDOCYTIC_2	152	155	PF00928	0.398
TRG_ENDOCYTIC_2	481	484	PF00928	0.629
TRG_ENDOCYTIC_2	521	524	PF00928	0.423
TRG_ENDOCYTIC_2	531	534	PF00928	0.440
TRG_ENDOCYTIC_2	601	604	PF00928	0.384
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM83	Leptomonas seymouri	65%	97%
A0A3S7WSI1	Leishmania donovani	92%	97%
A4H785	Leishmania braziliensis	78%	95%
A4HVM5	Leishmania infantum	91%	97%
E9APC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%