Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG55_LEIMA

TriTrypDb:

LmjF.13.0990 , LMJLV39_130014000 , LMJSD75_130014100

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.791
CLV_C14_Caspase3-7	309	313	PF00656	0.768
CLV_C14_Caspase3-7	440	444	PF00656	0.752
CLV_NRD_NRD_1	183	185	PF00675	0.531
CLV_NRD_NRD_1	187	189	PF00675	0.535
CLV_NRD_NRD_1	191	193	PF00675	0.533
CLV_NRD_NRD_1	197	199	PF00675	0.540
CLV_NRD_NRD_1	226	228	PF00675	0.689
CLV_NRD_NRD_1	253	255	PF00675	0.576
CLV_NRD_NRD_1	260	262	PF00675	0.580
CLV_NRD_NRD_1	269	271	PF00675	0.516
CLV_NRD_NRD_1	289	291	PF00675	0.745
CLV_NRD_NRD_1	293	295	PF00675	0.808
CLV_NRD_NRD_1	3	5	PF00675	0.636
CLV_NRD_NRD_1	324	326	PF00675	0.632
CLV_NRD_NRD_1	352	354	PF00675	0.698
CLV_NRD_NRD_1	400	402	PF00675	0.677
CLV_NRD_NRD_1	470	472	PF00675	0.557
CLV_NRD_NRD_1	476	478	PF00675	0.603
CLV_NRD_NRD_1	72	74	PF00675	0.608
CLV_PCSK_FUR_1	290	294	PF00082	0.809
CLV_PCSK_FUR_1	468	472	PF00082	0.552
CLV_PCSK_KEX2_1	16	18	PF00082	0.575
CLV_PCSK_KEX2_1	191	193	PF00082	0.560
CLV_PCSK_KEX2_1	197	199	PF00082	0.503
CLV_PCSK_KEX2_1	224	226	PF00082	0.625
CLV_PCSK_KEX2_1	260	262	PF00082	0.648
CLV_PCSK_KEX2_1	291	293	PF00082	0.735
CLV_PCSK_KEX2_1	3	5	PF00082	0.636
CLV_PCSK_KEX2_1	31	33	PF00082	0.551
CLV_PCSK_KEX2_1	348	350	PF00082	0.737
CLV_PCSK_KEX2_1	400	402	PF00082	0.647
CLV_PCSK_KEX2_1	425	427	PF00082	0.487
CLV_PCSK_KEX2_1	470	472	PF00082	0.589
CLV_PCSK_KEX2_1	65	67	PF00082	0.538
CLV_PCSK_KEX2_1	72	74	PF00082	0.528
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.667
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.593
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.604
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.651
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.752
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.528
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.779
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.586
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.556
CLV_PCSK_PC7_1	396	402	PF00082	0.659
CLV_PCSK_PC7_1	68	74	PF00082	0.567
CLV_PCSK_SKI1_1	19	23	PF00082	0.699
CLV_PCSK_SKI1_1	214	218	PF00082	0.674
CLV_PCSK_SKI1_1	31	35	PF00082	0.610
CLV_PCSK_SKI1_1	472	476	PF00082	0.553
CLV_PCSK_SKI1_1	56	60	PF00082	0.621
CLV_PCSK_SKI1_1	72	76	PF00082	0.647
DOC_ANK_TNKS_1	309	316	PF00023	0.699
DOC_CKS1_1	120	125	PF01111	0.789
DOC_MAPK_gen_1	323	330	PF00069	0.631
DOC_MAPK_gen_1	425	432	PF00069	0.498
DOC_PP1_RVXF_1	245	251	PF00149	0.452
DOC_PP1_RVXF_1	324	331	PF00149	0.648
DOC_PP2B_LxvP_1	152	155	PF13499	0.710
DOC_USP7_MATH_1	136	140	PF00917	0.681
DOC_USP7_MATH_1	341	345	PF00917	0.737
DOC_USP7_MATH_1	87	91	PF00917	0.684
DOC_USP7_UBL2_3	129	133	PF12436	0.643
DOC_USP7_UBL2_3	185	189	PF12436	0.532
DOC_USP7_UBL2_3	224	228	PF12436	0.651
DOC_WW_Pin1_4	119	124	PF00397	0.797
DOC_WW_Pin1_4	21	26	PF00397	0.572
LIG_14-3-3_CanoR_1	254	260	PF00244	0.652
LIG_14-3-3_CanoR_1	325	331	PF00244	0.649
LIG_14-3-3_CanoR_1	383	390	PF00244	0.615
LIG_14-3-3_CanoR_1	461	467	PF00244	0.541
LIG_14-3-3_CanoR_1	72	77	PF00244	0.526
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_FHA_1	80	86	PF00498	0.624
LIG_FHA_2	164	170	PF00498	0.701
LIG_FHA_2	238	244	PF00498	0.635
LIG_FHA_2	294	300	PF00498	0.584
LIG_FHA_2	438	444	PF00498	0.743
LIG_Integrin_RGD_1	310	312	PF01839	0.701
LIG_LIR_Gen_1	357	367	PF02991	0.568
LIG_LIR_Nem_3	357	362	PF02991	0.544
LIG_LIR_Nem_3	452	458	PF02991	0.550
LIG_LIR_Nem_3	485	489	PF02991	0.639
LIG_PDZ_Class_2	485	490	PF00595	0.620
LIG_SH2_NCK_1	359	363	PF00017	0.650
LIG_SH2_STAP1	215	219	PF00017	0.700
LIG_SH2_STAT5	61	64	PF00017	0.533
LIG_SH3_2	128	133	PF14604	0.708
LIG_SH3_3	117	123	PF00018	0.718
LIG_SH3_3	125	131	PF00018	0.733
LIG_SH3_3	148	154	PF00018	0.773
LIG_SH3_3	368	374	PF00018	0.564
LIG_SUMO_SIM_anti_2	360	366	PF11976	0.564
LIG_TRAF2_1	177	180	PF00917	0.646
LIG_TRAF2_1	207	210	PF00917	0.566
LIG_TRAF2_1	450	453	PF00917	0.447
LIG_UBA3_1	58	65	PF00899	0.669
MOD_CDK_SPxxK_3	21	28	PF00069	0.564
MOD_CK1_1	316	322	PF00069	0.687
MOD_CK1_1	47	53	PF00069	0.644
MOD_CK1_1	90	96	PF00069	0.809
MOD_CK2_1	136	142	PF00069	0.693
MOD_CK2_1	174	180	PF00069	0.690
MOD_CK2_1	293	299	PF00069	0.582
MOD_CK2_1	389	395	PF00069	0.601
MOD_CK2_1	447	453	PF00069	0.474
MOD_Cter_Amidation	222	225	PF01082	0.642
MOD_GlcNHglycan	142	147	PF01048	0.682
MOD_GlcNHglycan	176	179	PF01048	0.629
MOD_GlcNHglycan	283	286	PF01048	0.780
MOD_GlcNHglycan	391	394	PF01048	0.569
MOD_GlcNHglycan	403	406	PF01048	0.540
MOD_GlcNHglycan	89	92	PF01048	0.725
MOD_GlcNHglycan	93	96	PF01048	0.713
MOD_GSK3_1	111	118	PF00069	0.714
MOD_GSK3_1	163	170	PF00069	0.727
MOD_GSK3_1	277	284	PF00069	0.644
MOD_GSK3_1	385	392	PF00069	0.570
MOD_GSK3_1	47	54	PF00069	0.645
MOD_GSK3_1	87	94	PF00069	0.694
MOD_N-GLC_1	265	270	PF02516	0.688
MOD_NEK2_1	144	149	PF00069	0.649
MOD_PIKK_1	265	271	PF00454	0.609
MOD_PIKK_1	51	57	PF00454	0.543
MOD_PKA_1	293	299	PF00069	0.714
MOD_PKA_1	72	78	PF00069	0.457
MOD_PKA_2	160	166	PF00069	0.758
MOD_PKA_2	281	287	PF00069	0.636
MOD_PKA_2	293	299	PF00069	0.656
MOD_PKA_2	382	388	PF00069	0.619
MOD_PKA_2	447	453	PF00069	0.576
MOD_PKA_2	72	78	PF00069	0.651
MOD_PKA_2	79	85	PF00069	0.635
MOD_PKB_1	292	300	PF00069	0.765
MOD_Plk_1	341	347	PF00069	0.627
MOD_Plk_4	115	121	PF00069	0.564
MOD_ProDKin_1	119	125	PF00069	0.796
MOD_ProDKin_1	21	27	PF00069	0.567
MOD_SUMO_for_1	482	485	PF00179	0.626
MOD_SUMO_rev_2	24	33	PF00179	0.653
MOD_SUMO_rev_2	450	458	PF00179	0.532
MOD_SUMO_rev_2	473	480	PF00179	0.694
TRG_DiLeu_BaEn_1	410	415	PF01217	0.594
TRG_DiLeu_BaEn_4	453	459	PF01217	0.432
TRG_DiLeu_LyEn_5	410	415	PF01217	0.626
TRG_ENDOCYTIC_2	359	362	PF00928	0.645
TRG_ER_diArg_1	197	200	PF00400	0.603
TRG_ER_diArg_1	290	293	PF00400	0.734
TRG_ER_diArg_1	400	402	PF00400	0.650
TRG_ER_diArg_1	411	414	PF00400	0.580
TRG_ER_diArg_1	468	471	PF00400	0.597
TRG_NLS_Bipartite_1	3	20	PF00514	0.672
TRG_NLS_MonoCore_2	128	133	PF00514	0.708
TRG_NLS_MonoCore_2	289	294	PF00514	0.807
TRG_NLS_MonoExtC_3	128	133	PF00514	0.735
TRG_NLS_MonoExtC_3	223	228	PF00514	0.630
TRG_NLS_MonoExtC_3	289	294	PF00514	0.749
TRG_NLS_MonoExtC_3	346	352	PF00514	0.664
TRG_NLS_MonoExtN_4	128	133	PF00514	0.729
TRG_NLS_MonoExtN_4	224	231	PF00514	0.654
TRG_NLS_MonoExtN_4	28	35	PF00514	0.612
TRG_NLS_MonoExtN_4	345	351	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE43	Leptomonas seymouri	54%	97%
A0A3S7WSJ6	Leishmania donovani	90%	100%
A0A422NGB0	Trypanosoma rangeli	37%	100%
A4H787	Leishmania braziliensis	69%	98%
A4HVM7	Leishmania infantum	90%	100%
D0A6M7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AVQ1	Trypanosoma cruzi	34%	100%