Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG54_LEIMA

TriTrypDb:

LmjF.13.1000 , LMJLV39_130014100 , LMJSD75_130014200

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.639
CLV_C14_Caspase3-7	267	271	PF00656	0.582
CLV_C14_Caspase3-7	311	315	PF00656	0.706
CLV_NRD_NRD_1	114	116	PF00675	0.644
CLV_NRD_NRD_1	158	160	PF00675	0.694
CLV_NRD_NRD_1	213	215	PF00675	0.658
CLV_NRD_NRD_1	230	232	PF00675	0.514
CLV_NRD_NRD_1	273	275	PF00675	0.650
CLV_NRD_NRD_1	340	342	PF00675	0.703
CLV_NRD_NRD_1	347	349	PF00675	0.646
CLV_NRD_NRD_1	350	352	PF00675	0.621
CLV_NRD_NRD_1	366	368	PF00675	0.567
CLV_PCSK_FUR_1	211	215	PF00082	0.501
CLV_PCSK_FUR_1	287	291	PF00082	0.653
CLV_PCSK_FUR_1	348	352	PF00082	0.616
CLV_PCSK_KEX2_1	114	116	PF00082	0.644
CLV_PCSK_KEX2_1	158	160	PF00082	0.694
CLV_PCSK_KEX2_1	213	215	PF00082	0.558
CLV_PCSK_KEX2_1	273	275	PF00082	0.747
CLV_PCSK_KEX2_1	289	291	PF00082	0.607
CLV_PCSK_KEX2_1	340	342	PF00082	0.706
CLV_PCSK_KEX2_1	347	349	PF00082	0.649
CLV_PCSK_KEX2_1	350	352	PF00082	0.623
CLV_PCSK_KEX2_1	366	368	PF00082	0.491
CLV_PCSK_KEX2_1	51	53	PF00082	0.600
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.622
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.600
CLV_PCSK_SKI1_1	350	354	PF00082	0.764
CLV_PCSK_SKI1_1	356	360	PF00082	0.622
CLV_PCSK_SKI1_1	409	413	PF00082	0.385
CLV_PCSK_SKI1_1	422	426	PF00082	0.417
DEG_APCC_DBOX_1	380	388	PF00400	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SPOP_SBC_1	172	176	PF00917	0.584
DOC_CKS1_1	160	165	PF01111	0.704
DOC_CYCLIN_RxL_1	419	429	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.585
DOC_MAPK_gen_1	231	238	PF00069	0.621
DOC_MAPK_MEF2A_6	231	240	PF00069	0.605
DOC_MAPK_RevD_3	200	214	PF00069	0.508
DOC_PP1_RVXF_1	407	413	PF00149	0.384
DOC_PP4_FxxP_1	440	443	PF00568	0.499
DOC_USP7_MATH_1	13	17	PF00917	0.719
DOC_USP7_MATH_1	173	177	PF00917	0.628
DOC_USP7_MATH_1	24	28	PF00917	0.596
DOC_USP7_MATH_1	283	287	PF00917	0.568
DOC_USP7_MATH_1	30	34	PF00917	0.549
DOC_USP7_MATH_1	377	381	PF00917	0.440
DOC_USP7_MATH_1	59	63	PF00917	0.600
DOC_USP7_MATH_2	189	195	PF00917	0.693
DOC_USP7_UBL2_3	180	184	PF12436	0.697
DOC_USP7_UBL2_3	47	51	PF12436	0.601
DOC_WW_Pin1_4	159	164	PF00397	0.788
DOC_WW_Pin1_4	276	281	PF00397	0.683
DOC_WW_Pin1_4	9	14	PF00397	0.669
LIG_14-3-3_CanoR_1	121	126	PF00244	0.580
LIG_14-3-3_CanoR_1	330	338	PF00244	0.674
LIG_14-3-3_CanoR_1	435	439	PF00244	0.389
LIG_BIR_III_4	248	252	PF00653	0.575
LIG_BRCT_BRCA1_1	436	440	PF00533	0.457
LIG_Clathr_ClatBox_1	237	241	PF01394	0.588
LIG_FHA_1	66	72	PF00498	0.538
LIG_FHA_1	97	103	PF00498	0.577
LIG_FHA_2	318	324	PF00498	0.648
LIG_FHA_2	332	338	PF00498	0.631
LIG_FHA_2	445	451	PF00498	0.445
LIG_FHA_2	58	64	PF00498	0.564
LIG_FHA_2	70	76	PF00498	0.581
LIG_LIR_Apic_2	437	443	PF02991	0.487
LIG_LIR_Nem_3	399	404	PF02991	0.412
LIG_LIR_Nem_3	75	81	PF02991	0.509
LIG_Pex14_2	397	401	PF04695	0.424
LIG_SH2_CRK	67	71	PF00017	0.448
LIG_SH2_CRK	89	93	PF00017	0.522
LIG_SH2_STAP1	404	408	PF00017	0.415
LIG_SH2_STAP1	67	71	PF00017	0.448
LIG_SH2_STAT5	217	220	PF00017	0.585
LIG_SH2_STAT5	451	454	PF00017	0.510
LIG_SH2_STAT5	67	70	PF00017	0.487
LIG_SH2_STAT5	89	92	PF00017	0.522
LIG_SH3_3	154	160	PF00018	0.693
LIG_SH3_3	223	229	PF00018	0.525
LIG_SH3_3	34	40	PF00018	0.650
LIG_SUMO_SIM_par_1	67	72	PF11976	0.555
LIG_SUMO_SIM_par_1	97	103	PF11976	0.577
LIG_TRFH_1	428	432	PF08558	0.494
LIG_TYR_ITIM	65	70	PF00017	0.466
LIG_UBA3_1	237	242	PF00899	0.572
MOD_CK1_1	12	18	PF00069	0.632
MOD_CK1_1	194	200	PF00069	0.619
MOD_CK1_1	244	250	PF00069	0.586
MOD_CK1_1	276	282	PF00069	0.709
MOD_CK1_1	399	405	PF00069	0.387
MOD_CK1_1	4	10	PF00069	0.703
MOD_CK2_1	173	179	PF00069	0.646
MOD_CK2_1	323	329	PF00069	0.678
MOD_CK2_1	399	405	PF00069	0.384
MOD_CK2_1	444	450	PF00069	0.440
MOD_CK2_1	456	462	PF00069	0.439
MOD_CK2_1	69	75	PF00069	0.562
MOD_CK2_1	91	97	PF00069	0.727
MOD_Cter_Amidation	229	232	PF01082	0.530
MOD_Cter_Amidation	345	348	PF01082	0.653
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.691
MOD_GlcNHglycan	134	137	PF01048	0.644
MOD_GlcNHglycan	243	246	PF01048	0.782
MOD_GlcNHglycan	26	29	PF01048	0.719
MOD_GlcNHglycan	275	278	PF01048	0.712
MOD_GlcNHglycan	283	286	PF01048	0.632
MOD_GlcNHglycan	3	6	PF01048	0.709
MOD_GlcNHglycan	32	35	PF01048	0.666
MOD_GlcNHglycan	321	326	PF01048	0.630
MOD_GlcNHglycan	356	359	PF01048	0.586
MOD_GSK3_1	128	135	PF00069	0.497
MOD_GSK3_1	171	178	PF00069	0.623
MOD_GSK3_1	24	31	PF00069	0.595
MOD_GSK3_1	279	286	PF00069	0.661
MOD_GSK3_1	317	324	PF00069	0.577
MOD_GSK3_1	346	353	PF00069	0.666
MOD_GSK3_1	434	441	PF00069	0.425
MOD_GSK3_1	65	72	PF00069	0.501
MOD_GSK3_1	9	16	PF00069	0.669
MOD_LATS_1	328	334	PF00433	0.670
MOD_N-GLC_1	24	29	PF02516	0.713
MOD_N-GLC_1	252	257	PF02516	0.583
MOD_N-GLC_1	456	461	PF02516	0.520
MOD_NEK2_1	1	6	PF00069	0.713
MOD_NEK2_1	151	156	PF00069	0.701
MOD_NEK2_1	352	357	PF00069	0.667
MOD_NEK2_1	434	439	PF00069	0.420
MOD_NEK2_1	444	449	PF00069	0.453
MOD_NEK2_2	136	141	PF00069	0.472
MOD_PKA_1	158	164	PF00069	0.646
MOD_PKA_1	273	279	PF00069	0.654
MOD_PKA_1	350	356	PF00069	0.603
MOD_PKA_2	158	164	PF00069	0.646
MOD_PKA_2	273	279	PF00069	0.654
MOD_PKA_2	346	352	PF00069	0.675
MOD_PKA_2	434	440	PF00069	0.381
MOD_PKB_1	128	136	PF00069	0.493
MOD_PKB_1	348	356	PF00069	0.685
MOD_Plk_1	136	142	PF00069	0.513
MOD_Plk_1	194	200	PF00069	0.619
MOD_Plk_1	456	462	PF00069	0.534
MOD_Plk_2-3	191	197	PF00069	0.642
MOD_Plk_2-3	317	323	PF00069	0.586
MOD_Plk_2-3	456	462	PF00069	0.534
MOD_Plk_4	356	362	PF00069	0.662
MOD_Plk_4	414	420	PF00069	0.380
MOD_Plk_4	434	440	PF00069	0.252
MOD_Plk_4	65	71	PF00069	0.571
MOD_ProDKin_1	159	165	PF00069	0.788
MOD_ProDKin_1	276	282	PF00069	0.684
MOD_ProDKin_1	9	15	PF00069	0.669
MOD_SUMO_for_1	257	260	PF00179	0.719
MOD_SUMO_for_1	308	311	PF00179	0.725
MOD_SUMO_rev_2	161	170	PF00179	0.664
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.609
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.567
TRG_ENDOCYTIC_2	67	70	PF00928	0.451
TRG_ENDOCYTIC_2	89	92	PF00928	0.513
TRG_ER_diArg_1	114	116	PF00400	0.699
TRG_ER_diArg_1	127	130	PF00400	0.395
TRG_ER_diArg_1	157	159	PF00400	0.692
TRG_ER_diArg_1	210	213	PF00400	0.496
TRG_ER_diArg_1	290	293	PF00400	0.777
TRG_ER_diArg_1	347	350	PF00400	0.654
TRG_ER_diArg_1	365	367	PF00400	0.587
TRG_ER_diArg_1	387	390	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7S2	Leptomonas seymouri	50%	100%
A0A3S5H6P2	Leishmania donovani	89%	100%
A4H788	Leishmania braziliensis	71%	100%
A4HVM8	Leishmania infantum	89%	100%
E9APC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%