Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG53_LEIMA

TriTrypDb:

LmjF.13.1010 , LMJLV39_130014200 , LMJSD75_130014300

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QG53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.558
CLV_NRD_NRD_1	130	132	PF00675	0.596
CLV_NRD_NRD_1	140	142	PF00675	0.603
CLV_NRD_NRD_1	201	203	PF00675	0.440
CLV_NRD_NRD_1	225	227	PF00675	0.461
CLV_PCSK_KEX2_1	140	142	PF00082	0.588
CLV_PCSK_KEX2_1	200	202	PF00082	0.444
CLV_PCSK_KEX2_1	224	226	PF00082	0.460
CLV_PCSK_PC7_1	221	227	PF00082	0.450
CLV_PCSK_SKI1_1	181	185	PF00082	0.445
CLV_PCSK_SKI1_1	217	221	PF00082	0.441
CLV_PCSK_SKI1_1	225	229	PF00082	0.347
CLV_PCSK_SKI1_1	305	309	PF00082	0.327
DEG_APCC_DBOX_1	216	224	PF00400	0.624
DEG_APCC_DBOX_1	310	318	PF00400	0.589
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DEG_SPOP_SBC_1	26	30	PF00917	0.557
DOC_MAPK_gen_1	140	148	PF00069	0.465
DOC_MAPK_gen_1	224	235	PF00069	0.634
DOC_MAPK_HePTP_8	223	235	PF00069	0.633
DOC_MAPK_MEF2A_6	226	235	PF00069	0.618
DOC_PP2B_LxvP_1	269	272	PF13499	0.433
DOC_USP7_MATH_1	109	113	PF00917	0.404
DOC_USP7_MATH_1	240	244	PF00917	0.302
DOC_USP7_MATH_1	83	87	PF00917	0.421
DOC_WW_Pin1_4	95	100	PF00397	0.446
LIG_14-3-3_CanoR_1	140	148	PF00244	0.482
LIG_14-3-3_CanoR_1	181	186	PF00244	0.571
LIG_14-3-3_CanoR_1	256	264	PF00244	0.390
LIG_Actin_WH2_2	36	53	PF00022	0.525
LIG_EH1_1	163	171	PF00400	0.312
LIG_EH1_1	247	255	PF00400	0.388
LIG_eIF4E_1	164	170	PF01652	0.312
LIG_FHA_1	157	163	PF00498	0.252
LIG_FHA_1	182	188	PF00498	0.577
LIG_FHA_1	249	255	PF00498	0.352
LIG_FHA_1	82	88	PF00498	0.319
LIG_FHA_2	189	195	PF00498	0.613
LIG_FHA_2	9	15	PF00498	0.598
LIG_LIR_LC3C_4	158	162	PF02991	0.315
LIG_MYND_1	104	108	PF01753	0.415
LIG_PCNA_PIPBox_1	32	41	PF02747	0.523
LIG_PCNA_yPIPBox_3	32	44	PF02747	0.531
LIG_PDZ_Class_3	322	327	PF00595	0.576
LIG_Pex14_1	292	296	PF04695	0.352
LIG_RPA_C_Fungi	251	263	PF08784	0.381
LIG_SH2_CRK	64	68	PF00017	0.472
LIG_SH2_GRB2like	137	140	PF00017	0.656
LIG_SH2_NCK_1	236	240	PF00017	0.294
LIG_SH2_STAP1	164	168	PF00017	0.352
LIG_SH2_STAP1	174	178	PF00017	0.401
LIG_SH2_STAP1	236	240	PF00017	0.338
LIG_SH2_STAT5	133	136	PF00017	0.532
LIG_SH2_STAT5	177	180	PF00017	0.442
LIG_SH2_STAT5	287	290	PF00017	0.327
LIG_SH2_STAT5	322	325	PF00017	0.380
LIG_SH2_STAT5	38	41	PF00017	0.387
LIG_SH3_3	105	111	PF00018	0.488
LIG_SH3_3	288	294	PF00018	0.388
LIG_SH3_CIN85_PxpxPR_1	212	217	PF14604	0.563
LIG_SUMO_SIM_anti_2	158	165	PF11976	0.362
LIG_SUMO_SIM_par_1	153	159	PF11976	0.314
LIG_SUMO_SIM_par_1	312	318	PF11976	0.396
LIG_SUMO_SIM_par_1	64	70	PF11976	0.312
LIG_SUMO_SIM_par_1	72	78	PF11976	0.453
LIG_TRAF2_1	30	33	PF00917	0.462
LIG_TYR_ITIM	62	67	PF00017	0.331
MOD_CK1_1	243	249	PF00069	0.302
MOD_CK1_1	273	279	PF00069	0.603
MOD_CK1_1	98	104	PF00069	0.528
MOD_CK2_1	188	194	PF00069	0.493
MOD_CK2_1	25	31	PF00069	0.400
MOD_GlcNHglycan	100	103	PF01048	0.515
MOD_GlcNHglycan	149	152	PF01048	0.510
MOD_GlcNHglycan	207	210	PF01048	0.663
MOD_GlcNHglycan	45	48	PF01048	0.360
MOD_GlcNHglycan	69	72	PF01048	0.312
MOD_GSK3_1	303	310	PF00069	0.375
MOD_GSK3_1	39	46	PF00069	0.367
MOD_NEK2_1	156	161	PF00069	0.327
MOD_NEK2_1	248	253	PF00069	0.315
MOD_NEK2_1	303	308	PF00069	0.391
MOD_NEK2_1	39	44	PF00069	0.397
MOD_NEK2_1	67	72	PF00069	0.307
MOD_NEK2_1	81	86	PF00069	0.456
MOD_NEK2_2	172	177	PF00069	0.441
MOD_PIKK_1	109	115	PF00454	0.536
MOD_PIKK_1	257	263	PF00454	0.514
MOD_PKA_2	139	145	PF00069	0.509
MOD_PKA_2	257	263	PF00069	0.514
MOD_PKA_2	43	49	PF00069	0.436
MOD_Plk_1	75	81	PF00069	0.538
MOD_Plk_4	156	162	PF00069	0.330
MOD_Plk_4	243	249	PF00069	0.321
MOD_Plk_4	270	276	PF00069	0.502
MOD_Plk_4	69	75	PF00069	0.290
MOD_Plk_4	83	89	PF00069	0.488
MOD_ProDKin_1	95	101	PF00069	0.558
TRG_ENDOCYTIC_2	264	267	PF00928	0.536
TRG_ENDOCYTIC_2	64	67	PF00928	0.341
TRG_ER_diArg_1	200	202	PF00400	0.548
TRG_ER_diArg_1	223	226	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT7	Leptomonas seymouri	52%	94%
A0A3S7WSJ9	Leishmania donovani	91%	100%
A4H789	Leishmania braziliensis	74%	100%
A4HVM9	Leishmania infantum	91%	100%
E9APC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%