NDK domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania major

UniProt:

Q4QG49_LEIMA

TriTrypDb:

LmjF.13.1050 , LMJLV39_130014700 , LMJSD75_130014700

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG49

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.512
CLV_C14_Caspase3-7	3	7	PF00656	0.727
CLV_C14_Caspase3-7	86	90	PF00656	0.519
CLV_NRD_NRD_1	153	155	PF00675	0.613
CLV_NRD_NRD_1	32	34	PF00675	0.400
CLV_PCSK_KEX2_1	32	34	PF00082	0.400
CLV_PCSK_SKI1_1	198	202	PF00082	0.261
CLV_PCSK_SKI1_1	21	25	PF00082	0.308
DEG_APCC_DBOX_1	52	60	PF00400	0.564
DEG_SIAH_1	76	84	PF03145	0.533
DEG_SPOP_SBC_1	5	9	PF00917	0.459
DOC_CKS1_1	25	30	PF01111	0.394
DOC_CYCLIN_RxL_1	149	161	PF00134	0.579
DOC_CYCLIN_RxL_1	18	27	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	75	78	PF00134	0.584
DOC_MAPK_gen_1	168	175	PF00069	0.485
DOC_MAPK_MEF2A_6	168	175	PF00069	0.410
DOC_PP2B_LxvP_1	75	78	PF13499	0.588
DOC_USP7_MATH_1	167	171	PF00917	0.486
DOC_USP7_MATH_1	4	8	PF00917	0.557
DOC_WW_Pin1_4	24	29	PF00397	0.460
DOC_WW_Pin1_4	91	96	PF00397	0.519
LIG_14-3-3_CanoR_1	57	67	PF00244	0.340
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_BIR_III_3	1	5	PF00653	0.707
LIG_BRCT_BRCA1_1	93	97	PF00533	0.654
LIG_FHA_1	109	115	PF00498	0.508
LIG_FHA_1	183	189	PF00498	0.518
LIG_FHA_1	97	103	PF00498	0.599
LIG_FHA_2	84	90	PF00498	0.652
LIG_GBD_Chelix_1	67	75	PF00786	0.400
LIG_LIR_Gen_1	111	118	PF02991	0.373
LIG_LIR_Gen_1	46	56	PF02991	0.393
LIG_LIR_Nem_3	111	116	PF02991	0.375
LIG_LIR_Nem_3	35	39	PF02991	0.432
LIG_LIR_Nem_3	46	52	PF02991	0.346
LIG_SH2_PTP2	113	116	PF00017	0.325
LIG_SH2_STAT5	113	116	PF00017	0.323
LIG_SH2_STAT5	192	195	PF00017	0.437
LIG_SH2_STAT5	39	42	PF00017	0.458
LIG_SH3_1	210	216	PF00018	0.467
LIG_SH3_2	213	218	PF14604	0.448
LIG_SH3_3	210	216	PF00018	0.464
LIG_SH3_3	77	83	PF00018	0.680
LIG_SH3_3	89	95	PF00018	0.697
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.491
LIG_SUMO_SIM_par_1	22	27	PF11976	0.445
LIG_TYR_ITSM	109	116	PF00017	0.439
LIG_UBA3_1	114	121	PF00899	0.248
LIG_WRC_WIRS_1	126	131	PF05994	0.437
MOD_CK1_1	186	192	PF00069	0.573
MOD_CK1_1	8	14	PF00069	0.502
MOD_Cter_Amidation	152	155	PF01082	0.521
MOD_GlcNHglycan	185	188	PF01048	0.575
MOD_GlcNHglycan	2	5	PF01048	0.651
MOD_GSK3_1	125	132	PF00069	0.543
MOD_GSK3_1	182	189	PF00069	0.504
MOD_GSK3_1	4	11	PF00069	0.671
MOD_N-GLC_1	226	231	PF02516	0.426
MOD_NEK2_1	108	113	PF00069	0.472
MOD_NEK2_1	117	122	PF00069	0.489
MOD_NEK2_1	125	130	PF00069	0.452
MOD_NEK2_1	15	20	PF00069	0.528
MOD_NEK2_1	158	163	PF00069	0.463
MOD_NEK2_1	71	76	PF00069	0.519
MOD_PIKK_1	129	135	PF00454	0.520
MOD_PIKK_1	226	232	PF00454	0.631
MOD_Plk_1	71	77	PF00069	0.550
MOD_Plk_4	125	131	PF00069	0.446
MOD_Plk_4	97	103	PF00069	0.588
MOD_ProDKin_1	24	30	PF00069	0.459
MOD_ProDKin_1	91	97	PF00069	0.504
TRG_DiLeu_BaEn_1	54	59	PF01217	0.490
TRG_DiLeu_BaEn_4	54	60	PF01217	0.445
TRG_DiLeu_LyEn_5	54	59	PF01217	0.490
TRG_ENDOCYTIC_2	113	116	PF00928	0.277
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P894	Leptomonas seymouri	61%	97%
A0A0S4JTH8	Bodo saltans	35%	100%
A0A1X0NPH5	Trypanosomatidae	36%	82%
A0A3S7WSM5	Leishmania donovani	94%	100%
A0A422NGD0	Trypanosoma rangeli	40%	92%
A4H793	Leishmania braziliensis	78%	100%
A4HVN3	Leishmania infantum	93%	100%
D0A6L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	91%
E9APC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DBS4	Trypanosoma cruzi	41%	92%