TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG43_LEIMA

TriTrypDb:

LmjF.13.1110 , LMJLV39_130015300 , LMJSD75_130015300

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.580
CLV_C14_Caspase3-7	394	398	PF00656	0.792
CLV_C14_Caspase3-7	94	98	PF00656	0.591
CLV_NRD_NRD_1	12	14	PF00675	0.535
CLV_NRD_NRD_1	151	153	PF00675	0.614
CLV_NRD_NRD_1	217	219	PF00675	0.491
CLV_NRD_NRD_1	227	229	PF00675	0.539
CLV_NRD_NRD_1	249	251	PF00675	0.633
CLV_NRD_NRD_1	315	317	PF00675	0.562
CLV_NRD_NRD_1	322	324	PF00675	0.610
CLV_NRD_NRD_1	402	404	PF00675	0.643
CLV_NRD_NRD_1	427	429	PF00675	0.588
CLV_NRD_NRD_1	444	446	PF00675	0.378
CLV_NRD_NRD_1	467	469	PF00675	0.505
CLV_NRD_NRD_1	473	475	PF00675	0.539
CLV_NRD_NRD_1	508	510	PF00675	0.589
CLV_NRD_NRD_1	58	60	PF00675	0.569
CLV_NRD_NRD_1	6	8	PF00675	0.595
CLV_NRD_NRD_1	66	68	PF00675	0.494
CLV_PCSK_KEX2_1	12	14	PF00082	0.587
CLV_PCSK_KEX2_1	217	219	PF00082	0.545
CLV_PCSK_KEX2_1	249	251	PF00082	0.660
CLV_PCSK_KEX2_1	299	301	PF00082	0.583
CLV_PCSK_KEX2_1	322	324	PF00082	0.614
CLV_PCSK_KEX2_1	402	404	PF00082	0.664
CLV_PCSK_KEX2_1	427	429	PF00082	0.613
CLV_PCSK_KEX2_1	444	446	PF00082	0.367
CLV_PCSK_KEX2_1	462	464	PF00082	0.505
CLV_PCSK_KEX2_1	467	469	PF00082	0.498
CLV_PCSK_KEX2_1	473	475	PF00082	0.491
CLV_PCSK_KEX2_1	65	67	PF00082	0.550
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.583
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.634
CLV_PCSK_PC7_1	463	469	PF00082	0.588
CLV_PCSK_SKI1_1	124	128	PF00082	0.452
CLV_PCSK_SKI1_1	159	163	PF00082	0.637
CLV_PCSK_SKI1_1	191	195	PF00082	0.559
CLV_PCSK_SKI1_1	265	269	PF00082	0.721
CLV_PCSK_SKI1_1	509	513	PF00082	0.541
DEG_APCC_DBOX_1	123	131	PF00400	0.598
DOC_CYCLIN_yClb5_NLxxxL_5	203	211	PF00134	0.584
DOC_MAPK_gen_1	444	451	PF00069	0.629
DOC_PP1_RVXF_1	33	40	PF00149	0.601
DOC_USP7_MATH_1	396	400	PF00917	0.762
DOC_USP7_UBL2_3	358	362	PF12436	0.611
LIG_14-3-3_CanoR_1	137	143	PF00244	0.502
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_CaM_IQ_9	454	470	PF13499	0.517
LIG_Clathr_ClatBox_1	211	215	PF01394	0.502
LIG_FHA_1	336	342	PF00498	0.630
LIG_FHA_1	76	82	PF00498	0.568
LIG_FHA_2	267	273	PF00498	0.638
LIG_Integrin_RGD_1	386	388	PF01839	0.794
LIG_LIR_Nem_3	488	494	PF02991	0.464
LIG_PCNA_PIPBox_1	103	112	PF02747	0.577
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.543
LIG_PCNA_yPIPBox_3	96	110	PF02747	0.583
LIG_PTB_Apo_2	253	260	PF02174	0.658
LIG_PTB_Phospho_1	253	259	PF10480	0.690
LIG_Rb_pABgroove_1	347	355	PF01858	0.647
LIG_REV1ctd_RIR_1	37	46	PF16727	0.621
LIG_SH2_SRC	494	497	PF00017	0.493
LIG_SH2_STAP1	110	114	PF00017	0.568
LIG_SH2_STAP1	422	426	PF00017	0.616
LIG_SH2_STAT3	110	113	PF00017	0.571
LIG_SH2_STAT3	336	339	PF00017	0.712
LIG_SH2_STAT3	429	432	PF00017	0.655
LIG_SH2_STAT5	324	327	PF00017	0.636
LIG_SH2_STAT5	45	48	PF00017	0.613
LIG_SH2_STAT5	494	497	PF00017	0.445
LIG_TRAF2_1	235	238	PF00917	0.531
LIG_TRAF2_1	290	293	PF00917	0.562
LIG_TRAF2_1	312	315	PF00917	0.657
LIG_TRAF2_1	328	331	PF00917	0.440
LIG_TRAF2_1	482	485	PF00917	0.581
MOD_CK2_1	266	272	PF00069	0.701
MOD_CK2_1	30	36	PF00069	0.538
MOD_CK2_1	479	485	PF00069	0.416
MOD_GlcNHglycan	391	394	PF01048	0.786
MOD_GSK3_1	67	74	PF00069	0.457
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	24	29	PF00069	0.636
MOD_NEK2_1	43	48	PF00069	0.441
MOD_NEK2_1	69	74	PF00069	0.581
MOD_PIKK_1	335	341	PF00454	0.612
MOD_PIKK_1	45	51	PF00454	0.686
MOD_PIKK_1	479	485	PF00454	0.538
MOD_PIKK_1	509	515	PF00454	0.595
MOD_PK_1	294	300	PF00069	0.573
MOD_PKA_1	509	515	PF00069	0.628
MOD_PKB_1	65	73	PF00069	0.539
MOD_Plk_1	24	30	PF00069	0.631
MOD_Plk_4	206	212	PF00069	0.544
MOD_Plk_4	344	350	PF00069	0.581
MOD_Plk_4	494	500	PF00069	0.552
MOD_SUMO_for_1	282	285	PF00179	0.641
MOD_SUMO_for_1	328	331	PF00179	0.627
MOD_SUMO_rev_2	115	121	PF00179	0.595
MOD_SUMO_rev_2	291	295	PF00179	0.568
MOD_SUMO_rev_2	314	319	PF00179	0.636
MOD_SUMO_rev_2	376	383	PF00179	0.691
TRG_ENDOCYTIC_2	158	161	PF00928	0.597
TRG_ER_diArg_1	11	13	PF00400	0.598
TRG_ER_diArg_1	134	137	PF00400	0.531
TRG_ER_diArg_1	249	252	PF00400	0.685
TRG_ER_diArg_1	321	323	PF00400	0.647
TRG_ER_diArg_1	426	428	PF00400	0.611
TRG_ER_diArg_1	65	67	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD47	Leptomonas seymouri	64%	96%
A0A1X0NPL9	Trypanosomatidae	38%	100%
A0A3R7MPR3	Trypanosoma rangeli	38%	100%
A0A3S5H6P4	Leishmania donovani	96%	100%
A4H797	Leishmania braziliensis	83%	100%
A4HVN9	Leishmania infantum	96%	100%
D0A6K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9APD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BBN8	Trypanosoma cruzi	37%	100%