Putative DNA-directed RNA polymerase ii 8.2 Kdpolypeptide

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase I subunit, putative

Species:

Leishmania major

UniProt:

Q4QG42_LEIMA

TriTrypDb:

LmjF.13.1120 , LMJLV39_130015400 , LMJSD75_130015400

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	8
GO:0005665	RNA polymerase II, core complex	4	2
GO:0005666	RNA polymerase III complex	4	2
GO:0005736	RNA polymerase I complex	4	2
GO:0030880	RNA polymerase complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	8
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	8
GO:1902494	catalytic complex	2	8
GO:1990234	transferase complex	3	8

Expansion

Sequence features

Q4QG42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG42

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006351	DNA-templated transcription	7	8
GO:0006360	transcription by RNA polymerase I	8	2
GO:0006366	transcription by RNA polymerase II	8	2
GO:0006383	transcription by RNA polymerase III	8	2
GO:0006399	tRNA metabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009059	macromolecule biosynthetic process	4	8
GO:0009304	tRNA transcription	8	2
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0018130	heterocycle biosynthetic process	4	8
GO:0019438	aromatic compound biosynthetic process	4	8
GO:0032774	RNA biosynthetic process	5	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034654	nucleobase-containing compound biosynthetic process	4	8
GO:0034660	ncRNA metabolic process	6	2
GO:0042797	tRNA transcription by RNA polymerase III	9	2
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:0097659	nucleic acid-templated transcription	6	8
GO:0098781	ncRNA transcription	8	2
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	8
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034062	5'-3' RNA polymerase activity	5	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097747	RNA polymerase activity	4	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.241
CLV_PCSK_KEX2_1	46	48	PF00082	0.241
CLV_PCSK_PC7_1	42	48	PF00082	0.227
CLV_PCSK_SKI1_1	17	21	PF00082	0.269
CLV_PCSK_SKI1_1	47	51	PF00082	0.241
CLV_PCSK_SKI1_1	6	10	PF00082	0.239
DEG_APCC_DBOX_1	46	54	PF00400	0.427
DEG_Nend_Nbox_1	1	3	PF02207	0.262
DOC_MAPK_MEF2A_6	17	24	PF00069	0.469
DOC_MAPK_NFAT4_5	17	25	PF00069	0.469
LIG_14-3-3_CanoR_1	47	55	PF00244	0.427
LIG_14-3-3_CanoR_1	6	14	PF00244	0.460
LIG_APCC_ABBAyCdc20_2	17	23	PF00400	0.469
LIG_Clathr_ClatBox_1	19	23	PF01394	0.469
LIG_FHA_1	54	60	PF00498	0.469
LIG_FHA_1	65	71	PF00498	0.489
LIG_FHA_2	49	55	PF00498	0.427
LIG_LIR_Nem_3	16	21	PF02991	0.460
LIG_SH2_STAT5	18	21	PF00017	0.469
LIG_SH3_3	83	89	PF00018	0.524
LIG_TYR_ITIM	19	24	PF00017	0.504
MOD_GSK3_1	23	30	PF00069	0.475
MOD_NEK2_1	48	53	PF00069	0.479
MOD_PIKK_1	23	29	PF00454	0.469
TRG_ENDOCYTIC_2	21	24	PF00928	0.461
TRG_ER_diArg_1	46	48	PF00400	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P890	Leptomonas seymouri	88%	100%
A0A0N1IKV3	Leptomonas seymouri	47%	100%
A0A0S4JEQ2	Bodo saltans	70%	100%
A0A0S4KJV1	Bodo saltans	43%	92%
A0A3Q8I9P7	Leishmania donovani	99%	100%
A0A3Q8IGL4	Leishmania donovani	48%	100%
A0A3R7RS40	Trypanosoma rangeli	49%	70%
A0B6E7	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	37%	100%
A1RSD9	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	35%	100%
A2BK83	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	35%	100%
A2SSV3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	39%	100%
A3CWI3	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	40%	100%
A3DMR0	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	35%	100%
A3MXZ9	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	38%	100%
A4H798	Leishmania braziliensis	94%	100%
A4HE74	Leishmania braziliensis	47%	100%
A4HVP0	Leishmania infantum	99%	100%
A4WNA8	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	38%	100%
A4YIM8	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	43%	100%
A7IAH1	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	39%	100%
A8M9S4	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	32%	100%
A8Y1E9	Caenorhabditis briggsae	52%	100%
B0R4Y6	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	30%	100%
B1YC34	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	38%	100%
B6YSQ7	Thermococcus onnurineus (strain NA1)	44%	100%
B8GEG1	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	37%	100%
B8YB63	Saccharolobus shibatae	38%	100%
B9LPW4	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	38%	100%
C3MJQ1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	38%	100%
C3MZ09	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	38%	100%
C3N058	Sulfolobus islandicus (strain M.16.27)	38%	100%
C3N8S2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	38%	100%
C3NMP6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	38%	100%
C4KJ97	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	38%	100%
C9ZJZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ACT0	Leishmania major	48%	100%
E9AH97	Leishmania infantum	48%	100%
E9APD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AXL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
O13877	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
O29135	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	41%	100%
O59298	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	49%	100%
P22139	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P29199	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
P39472	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	41%	100%
P60291	Pyrococcus abyssi (strain GE5 / Orsay)	48%	100%
P60292	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	48%	100%
P62875	Homo sapiens	49%	100%
P62876	Mus musculus	49%	100%
Q0W8C7	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	38%	100%
Q12TI4	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	39%	100%
Q18G60	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	36%	100%
Q2FTN7	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	40%	100%
Q32P78	Bos taurus	49%	100%
Q39290	Brassica napus	53%	100%
Q3IQT2	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	33%	100%
Q46CK8	Methanosarcina barkeri (strain Fusaro / DSM 804)	40%	100%
Q55AB6	Dictyostelium discoideum	54%	100%
Q5JJC9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	43%	100%
Q6L292	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	39%	100%
Q6QN04	Chinchilla lanigera	49%	100%
Q75BV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	45%	100%
Q8LFJ6	Arabidopsis thaliana	53%	100%
Q8PW43	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	39%	100%
Q8SRS6	Encephalitozoon cuniculi (strain GB-M1)	48%	100%
Q8TT41	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	39%	100%
Q8TVB4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	42%	100%
Q8ZYP9	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	35%	100%
Q96YW4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	41%	100%
Q979K0	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	42%	100%
Q980Z8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	40%	100%
Q9GR61	Caenorhabditis elegans	52%	100%
Q9HL09	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	40%	100%
Q9HQJ1	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	30%	100%
Q9SYA6	Arabidopsis thaliana	50%	100%
Q9VC49	Drosophila melanogaster	51%	100%
Q9YB47	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	33%	100%