LeishMANIAdb
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DUF155 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF155 domain-containing protein
Gene product:
Uncharacterised ACR, YagE family COG1723, putative
Species:
Leishmania major
UniProt:
Q4QG41_LEIMA
TriTrypDb:
LmjF.13.1130 , LMJLV39_130015500 * , LMJSD75_130015500 *
Length:
592

Annotations

LeishMANIAdb annotations

Distantly homologous to the mammalian RMND1 mitochondrial protein (DUF155 domain protein).. Might have a mitochondrial transit sequence.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 10
GO:0016020 membrane 2 9
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QG41
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG41

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 532 536 PF00656 0.445
CLV_NRD_NRD_1 154 156 PF00675 0.629
CLV_NRD_NRD_1 423 425 PF00675 0.288
CLV_NRD_NRD_1 479 481 PF00675 0.242
CLV_PCSK_KEX2_1 153 155 PF00082 0.651
CLV_PCSK_KEX2_1 423 425 PF00082 0.288
CLV_PCSK_KEX2_1 479 481 PF00082 0.242
CLV_PCSK_SKI1_1 13 17 PF00082 0.554
CLV_PCSK_SKI1_1 356 360 PF00082 0.259
CLV_PCSK_SKI1_1 479 483 PF00082 0.252
CLV_PCSK_SKI1_1 492 496 PF00082 0.242
CLV_PCSK_SKI1_1 515 519 PF00082 0.242
CLV_PCSK_SKI1_1 68 72 PF00082 0.669
CLV_Separin_Metazoa 17 21 PF03568 0.443
DEG_APCC_DBOX_1 12 20 PF00400 0.380
DEG_Nend_UBRbox_2 1 3 PF02207 0.528
DEG_SCF_TRCP1_1 138 143 PF00400 0.483
DEG_SPOP_SBC_1 328 332 PF00917 0.472
DOC_CYCLIN_RxL_1 10 17 PF00134 0.369
DOC_CYCLIN_RxL_1 65 75 PF00134 0.429
DOC_MAPK_FxFP_2 341 344 PF00069 0.431
DOC_MAPK_gen_1 10 18 PF00069 0.479
DOC_MAPK_gen_1 466 476 PF00069 0.442
DOC_MAPK_MEF2A_6 446 454 PF00069 0.442
DOC_MAPK_MEF2A_6 559 567 PF00069 0.442
DOC_PP1_RVXF_1 410 416 PF00149 0.442
DOC_PP1_RVXF_1 557 563 PF00149 0.506
DOC_PP2B_LxvP_1 70 73 PF13499 0.432
DOC_PP4_FxxP_1 217 220 PF00568 0.432
DOC_PP4_FxxP_1 341 344 PF00568 0.431
DOC_PP4_FxxP_1 418 421 PF00568 0.442
DOC_USP7_MATH_1 130 134 PF00917 0.501
DOC_USP7_MATH_1 144 148 PF00917 0.344
DOC_USP7_MATH_1 218 222 PF00917 0.513
DOC_USP7_MATH_1 251 255 PF00917 0.516
DOC_USP7_MATH_1 299 303 PF00917 0.517
DOC_USP7_MATH_1 309 313 PF00917 0.485
DOC_USP7_MATH_1 328 332 PF00917 0.464
DOC_USP7_MATH_1 428 432 PF00917 0.525
DOC_WW_Pin1_4 103 108 PF00397 0.537
DOC_WW_Pin1_4 264 269 PF00397 0.506
DOC_WW_Pin1_4 324 329 PF00397 0.564
DOC_WW_Pin1_4 459 464 PF00397 0.459
LIG_14-3-3_CanoR_1 120 124 PF00244 0.497
LIG_14-3-3_CanoR_1 24 29 PF00244 0.410
LIG_14-3-3_CanoR_1 379 385 PF00244 0.484
LIG_Actin_WH2_2 481 498 PF00022 0.442
LIG_APCC_ABBA_1 257 262 PF00400 0.470
LIG_Clathr_ClatBox_1 567 571 PF01394 0.335
LIG_deltaCOP1_diTrp_1 561 569 PF00928 0.300
LIG_FHA_1 25 31 PF00498 0.419
LIG_FHA_1 379 385 PF00498 0.444
LIG_FHA_1 392 398 PF00498 0.436
LIG_FHA_1 400 406 PF00498 0.442
LIG_FHA_1 427 433 PF00498 0.459
LIG_FHA_2 204 210 PF00498 0.341
LIG_FHA_2 519 525 PF00498 0.512
LIG_LIR_Apic_2 159 163 PF02991 0.486
LIG_LIR_Apic_2 173 177 PF02991 0.368
LIG_LIR_Apic_2 339 344 PF02991 0.431
LIG_LIR_Apic_2 362 368 PF02991 0.442
LIG_LIR_Apic_2 416 421 PF02991 0.442
LIG_LIR_Apic_2 510 516 PF02991 0.459
LIG_LIR_Gen_1 209 218 PF02991 0.332
LIG_LIR_Gen_1 221 229 PF02991 0.467
LIG_LIR_Gen_1 394 403 PF02991 0.525
LIG_LIR_Gen_1 42 53 PF02991 0.373
LIG_LIR_Gen_1 448 457 PF02991 0.442
LIG_LIR_Gen_1 561 570 PF02991 0.276
LIG_LIR_LC3C_4 254 259 PF02991 0.466
LIG_LIR_Nem_3 209 213 PF02991 0.337
LIG_LIR_Nem_3 221 225 PF02991 0.459
LIG_LIR_Nem_3 294 300 PF02991 0.501
LIG_LIR_Nem_3 354 360 PF02991 0.434
LIG_LIR_Nem_3 394 398 PF02991 0.534
LIG_LIR_Nem_3 42 48 PF02991 0.442
LIG_LIR_Nem_3 448 452 PF02991 0.442
LIG_LIR_Nem_3 55 60 PF02991 0.284
LIG_LIR_Nem_3 561 565 PF02991 0.276
LIG_NRBOX 14 20 PF00104 0.377
LIG_NRBOX 47 53 PF00104 0.397
LIG_OCRL_FandH_1 209 221 PF00620 0.343
LIG_PCNA_yPIPBox_3 10 19 PF02747 0.400
LIG_PCNA_yPIPBox_3 64 74 PF02747 0.377
LIG_Pex14_1 509 513 PF04695 0.442
LIG_PTB_Apo_2 383 390 PF02174 0.525
LIG_PTB_Phospho_1 383 389 PF10480 0.525
LIG_SH2_CRK 297 301 PF00017 0.475
LIG_SH2_CRK 345 349 PF00017 0.276
LIG_SH2_CRK 365 369 PF00017 0.355
LIG_SH2_PTP2 183 186 PF00017 0.267
LIG_SH2_PTP2 449 452 PF00017 0.525
LIG_SH2_STAP1 380 384 PF00017 0.525
LIG_SH2_STAT3 199 202 PF00017 0.323
LIG_SH2_STAT3 380 383 PF00017 0.427
LIG_SH2_STAT5 183 186 PF00017 0.290
LIG_SH2_STAT5 205 208 PF00017 0.350
LIG_SH2_STAT5 337 340 PF00017 0.469
LIG_SH2_STAT5 357 360 PF00017 0.355
LIG_SH2_STAT5 380 383 PF00017 0.490
LIG_SH2_STAT5 449 452 PF00017 0.442
LIG_SH2_STAT5 513 516 PF00017 0.442
LIG_SH3_3 265 271 PF00018 0.573
LIG_SH3_4 515 522 PF00018 0.442
LIG_SUMO_SIM_anti_2 147 152 PF11976 0.442
LIG_SUMO_SIM_anti_2 89 95 PF11976 0.472
LIG_SUMO_SIM_par_1 401 407 PF11976 0.525
LIG_SUMO_SIM_par_1 84 90 PF11976 0.497
LIG_TRAF2_1 521 524 PF00917 0.525
LIG_TYR_ITIM 181 186 PF00017 0.283
LIG_TYR_ITIM 447 452 PF00017 0.442
MOD_CDK_SPxxK_3 459 466 PF00069 0.459
MOD_CK1_1 119 125 PF00069 0.543
MOD_CK1_1 291 297 PF00069 0.557
MOD_CK1_1 330 336 PF00069 0.445
MOD_CK2_1 472 478 PF00069 0.442
MOD_CK2_1 518 524 PF00069 0.525
MOD_GlcNHglycan 108 111 PF01048 0.670
MOD_GlcNHglycan 132 135 PF01048 0.732
MOD_GlcNHglycan 138 141 PF01048 0.644
MOD_GlcNHglycan 21 24 PF01048 0.620
MOD_GlcNHglycan 253 256 PF01048 0.792
MOD_GlcNHglycan 290 293 PF01048 0.800
MOD_GlcNHglycan 369 372 PF01048 0.259
MOD_GlcNHglycan 443 446 PF01048 0.246
MOD_GlcNHglycan 496 499 PF01048 0.242
MOD_GSK3_1 102 109 PF00069 0.515
MOD_GSK3_1 130 137 PF00069 0.501
MOD_GSK3_1 140 147 PF00069 0.402
MOD_GSK3_1 19 26 PF00069 0.397
MOD_GSK3_1 2 9 PF00069 0.445
MOD_GSK3_1 28 35 PF00069 0.363
MOD_GSK3_1 286 293 PF00069 0.494
MOD_GSK3_1 299 306 PF00069 0.365
MOD_GSK3_1 324 331 PF00069 0.489
MOD_GSK3_1 374 381 PF00069 0.468
MOD_N-GLC_1 144 149 PF02516 0.682
MOD_N-GLC_1 310 315 PF02516 0.710
MOD_N-GLC_1 328 333 PF02516 0.690
MOD_NEK2_1 28 33 PF00069 0.384
MOD_NEK2_1 286 291 PF00069 0.556
MOD_NEK2_1 435 440 PF00069 0.455
MOD_NEK2_1 441 446 PF00069 0.462
MOD_NEK2_1 457 462 PF00069 0.442
MOD_NEK2_1 494 499 PF00069 0.442
MOD_PIKK_1 28 34 PF00454 0.364
MOD_PIKK_1 291 297 PF00454 0.571
MOD_PIKK_1 379 385 PF00454 0.427
MOD_PIKK_1 550 556 PF00454 0.530
MOD_PKA_2 119 125 PF00069 0.518
MOD_PKA_2 19 25 PF00069 0.451
MOD_PKA_2 275 281 PF00069 0.560
MOD_PKA_2 28 34 PF00069 0.362
MOD_PKA_2 378 384 PF00069 0.525
MOD_PKA_2 399 405 PF00069 0.525
MOD_PKB_1 240 248 PF00069 0.553
MOD_Plk_1 144 150 PF00069 0.430
MOD_Plk_1 310 316 PF00069 0.524
MOD_Plk_1 509 515 PF00069 0.488
MOD_Plk_4 218 224 PF00069 0.526
MOD_Plk_4 32 38 PF00069 0.421
MOD_Plk_4 330 336 PF00069 0.488
MOD_Plk_4 428 434 PF00069 0.463
MOD_Plk_4 509 515 PF00069 0.488
MOD_Plk_4 543 549 PF00069 0.497
MOD_ProDKin_1 103 109 PF00069 0.538
MOD_ProDKin_1 264 270 PF00069 0.504
MOD_ProDKin_1 324 330 PF00069 0.560
MOD_ProDKin_1 459 465 PF00069 0.459
MOD_SUMO_rev_2 529 538 PF00179 0.442
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.488
TRG_DiLeu_BaLyEn_6 477 482 PF01217 0.442
TRG_ENDOCYTIC_2 183 186 PF00928 0.282
TRG_ENDOCYTIC_2 205 208 PF00928 0.329
TRG_ENDOCYTIC_2 297 300 PF00928 0.510
TRG_ENDOCYTIC_2 337 340 PF00928 0.319
TRG_ENDOCYTIC_2 345 348 PF00928 0.239
TRG_ENDOCYTIC_2 357 360 PF00928 0.355
TRG_ENDOCYTIC_2 449 452 PF00928 0.442
TRG_ENDOCYTIC_2 45 48 PF00928 0.366
TRG_ENDOCYTIC_2 491 494 PF00928 0.459
TRG_ER_diArg_1 153 155 PF00400 0.451
TRG_ER_diArg_1 412 415 PF00400 0.475
TRG_ER_diArg_1 422 424 PF00400 0.459
TRG_ER_diArg_1 479 481 PF00400 0.442
TRG_Pf-PMV_PEXEL_1 13 17 PF00026 0.640
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.704
TRG_Pf-PMV_PEXEL_1 466 470 PF00026 0.242
TRG_Pf-PMV_PEXEL_1 479 483 PF00026 0.242

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7R5 Leptomonas seymouri 64% 98%
A0A0S4JBA8 Bodo saltans 55% 100%
A0A3S5IRE7 Trypanosoma rangeli 50% 100%
A0A3S7WSK6 Leishmania donovani 97% 100%
A4H799 Leishmania braziliensis 84% 100%
A4HVP1 Leishmania infantum 97% 100%
E9APD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5B779 Trypanosoma cruzi 48% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS