AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4QG40_LEIMA

TriTrypDb:

LmjF.13.1140 , LMJLV39_130015600 , LMJSD75_130015600

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG40

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.378
CLV_C14_Caspase3-7	258	262	PF00656	0.377
CLV_C14_Caspase3-7	387	391	PF00656	0.396
CLV_NRD_NRD_1	133	135	PF00675	0.302
CLV_NRD_NRD_1	165	167	PF00675	0.418
CLV_NRD_NRD_1	61	63	PF00675	0.281
CLV_PCSK_KEX2_1	133	135	PF00082	0.302
CLV_PCSK_KEX2_1	165	167	PF00082	0.393
CLV_PCSK_KEX2_1	61	63	PF00082	0.281
CLV_PCSK_SKI1_1	260	264	PF00082	0.368
CLV_PCSK_SKI1_1	386	390	PF00082	0.460
CLV_PCSK_SKI1_1	8	12	PF00082	0.562
DEG_Nend_UBRbox_3	1	3	PF02207	0.629
DEG_SPOP_SBC_1	151	155	PF00917	0.192
DOC_MAPK_DCC_7	3	12	PF00069	0.396
DOC_MAPK_gen_1	57	66	PF00069	0.415
DOC_MAPK_HePTP_8	213	225	PF00069	0.252
DOC_MAPK_HePTP_8	56	68	PF00069	0.281
DOC_MAPK_MEF2A_6	216	225	PF00069	0.310
DOC_MAPK_MEF2A_6	336	344	PF00069	0.287
DOC_MAPK_MEF2A_6	59	68	PF00069	0.281
DOC_PP4_FxxP_1	104	107	PF00568	0.415
DOC_USP7_MATH_1	197	201	PF00917	0.329
DOC_USP7_MATH_1	328	332	PF00917	0.438
DOC_USP7_MATH_1	44	48	PF00917	0.371
DOC_USP7_MATH_1	84	88	PF00917	0.453
DOC_USP7_UBL2_3	11	15	PF12436	0.401
DOC_USP7_UBL2_3	289	293	PF12436	0.429
DOC_WW_Pin1_4	223	228	PF00397	0.298
DOC_WW_Pin1_4	347	352	PF00397	0.312
LIG_14-3-3_CanoR_1	196	202	PF00244	0.413
LIG_14-3-3_CanoR_1	247	253	PF00244	0.305
LIG_14-3-3_CanoR_1	336	341	PF00244	0.400
LIG_Actin_WH2_2	118	135	PF00022	0.327
LIG_BRCT_BRCA1_1	361	365	PF00533	0.281
LIG_eIF4E_1	31	37	PF01652	0.281
LIG_FHA_1	140	146	PF00498	0.339
LIG_FHA_1	17	23	PF00498	0.414
LIG_FHA_1	226	232	PF00498	0.301
LIG_FHA_1	261	267	PF00498	0.406
LIG_FHA_1	337	343	PF00498	0.375
LIG_FHA_1	387	393	PF00498	0.440
LIG_FHA_2	367	373	PF00498	0.303
LIG_LIR_Apic_2	101	107	PF02991	0.232
LIG_LIR_Apic_2	349	355	PF02991	0.282
LIG_LIR_Nem_3	307	311	PF02991	0.325
LIG_MLH1_MIPbox_1	361	365	PF16413	0.281
LIG_SH2_NCK_1	352	356	PF00017	0.280
LIG_SH2_STAT5	31	34	PF00017	0.281
LIG_SUMO_SIM_par_1	221	226	PF11976	0.324
LIG_SxIP_EBH_1	204	216	PF03271	0.383
LIG_TRAF2_1	272	275	PF00917	0.475
LIG_WRC_WIRS_1	308	313	PF05994	0.415
MOD_CDK_SPxxK_3	223	230	PF00069	0.362
MOD_CK1_1	108	114	PF00069	0.342
MOD_CK1_1	153	159	PF00069	0.407
MOD_CK1_1	18	24	PF00069	0.545
MOD_CK1_1	199	205	PF00069	0.392
MOD_CK1_1	314	320	PF00069	0.388
MOD_CK1_1	321	327	PF00069	0.376
MOD_CK1_1	366	372	PF00069	0.308
MOD_CK1_1	74	80	PF00069	0.371
MOD_CK2_1	366	372	PF00069	0.270
MOD_CK2_1	84	90	PF00069	0.302
MOD_GlcNHglycan	204	207	PF01048	0.379
MOD_GlcNHglycan	321	324	PF01048	0.401
MOD_GlcNHglycan	330	333	PF01048	0.415
MOD_GlcNHglycan	39	42	PF01048	0.424
MOD_GlcNHglycan	52	56	PF01048	0.389
MOD_GSK3_1	105	112	PF00069	0.331
MOD_GSK3_1	18	25	PF00069	0.560
MOD_GSK3_1	195	202	PF00069	0.400
MOD_GSK3_1	307	314	PF00069	0.381
MOD_GSK3_1	317	324	PF00069	0.274
MOD_GSK3_1	359	366	PF00069	0.281
MOD_GSK3_1	70	77	PF00069	0.358
MOD_N-GLC_1	206	211	PF02516	0.359
MOD_N-GLC_1	366	371	PF02516	0.367
MOD_N-GLC_2	193	195	PF02516	0.192
MOD_NEK2_1	140	145	PF00069	0.404
MOD_NEK2_1	181	186	PF00069	0.379
MOD_NEK2_1	279	284	PF00069	0.327
MOD_NEK2_1	319	324	PF00069	0.394
MOD_NEK2_1	37	42	PF00069	0.313
MOD_NEK2_1	395	400	PF00069	0.464
MOD_OFUCOSY	105	110	PF10250	0.192
MOD_PIKK_1	181	187	PF00454	0.362
MOD_PIKK_1	246	252	PF00454	0.446
MOD_PIKK_1	25	31	PF00454	0.403
MOD_PIKK_1	366	372	PF00454	0.305
MOD_PKA_2	195	201	PF00069	0.357
MOD_PKA_2	246	252	PF00069	0.380
MOD_Plk_1	206	212	PF00069	0.252
MOD_Plk_1	366	372	PF00069	0.380
MOD_Plk_1	51	57	PF00069	0.319
MOD_Plk_2-3	255	261	PF00069	0.375
MOD_Plk_4	123	129	PF00069	0.293
MOD_Plk_4	140	146	PF00069	0.215
MOD_Plk_4	314	320	PF00069	0.447
MOD_Plk_4	395	401	PF00069	0.511
MOD_ProDKin_1	223	229	PF00069	0.298
MOD_ProDKin_1	347	353	PF00069	0.312
TRG_DiLeu_BaEn_3	274	280	PF01217	0.192
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.252
TRG_ENDOCYTIC_2	308	311	PF00928	0.283
TRG_ER_diArg_1	132	134	PF00400	0.301
TRG_ER_diArg_1	60	62	PF00400	0.429
TRG_NES_CRM1_1	243	255	PF08389	0.311
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L5	Leptomonas seymouri	65%	100%
A0A0N1I6V6	Leptomonas seymouri	23%	100%
A0A0S4JJG1	Bodo saltans	23%	100%
A0A0S4JUT3	Bodo saltans	24%	100%
A0A1X0NNK2	Trypanosomatidae	41%	100%
A0A3Q8I9M0	Leishmania donovani	92%	100%
A0A3Q8IDU3	Leishmania donovani	24%	90%
A0A3R7LZE9	Trypanosoma rangeli	45%	100%
A4H7A0	Leishmania braziliensis	78%	98%
A4HF07	Leishmania braziliensis	25%	100%
A4HVP2	Leishmania infantum	92%	100%
A4I286	Leishmania infantum	24%	90%
D0A6K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9APD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AYD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q942	Leishmania major	25%	92%
V5ARR6	Trypanosoma cruzi	44%	94%