Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG39_LEIMA

TriTrypDb:

LmjF.13.1150 , LMJLV39_130015700 , LMJSD75_130015700

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005811	lipid droplet	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QG39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG39

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006638	neutral lipid metabolic process	4	2
GO:0006639	acylglycerol metabolic process	5	2
GO:0006641	triglyceride metabolic process	6	2
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	12
GO:0019433	triglyceride catabolic process	7	2
GO:0042592	homeostatic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	12
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046461	neutral lipid catabolic process	5	2
GO:0046464	acylglycerol catabolic process	6	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0046503	glycerolipid catabolic process	5	2
GO:0048878	chemical homeostasis	4	2
GO:0055088	lipid homeostasis	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004806	triglyceride lipase activity	5	2
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0052689	carboxylic ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.522
CLV_NRD_NRD_1	276	278	PF00675	0.521
CLV_PCSK_KEX2_1	105	107	PF00082	0.510
CLV_PCSK_KEX2_1	276	278	PF00082	0.521
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.516
CLV_PCSK_SKI1_1	129	133	PF00082	0.460
CLV_PCSK_SKI1_1	245	249	PF00082	0.585
CLV_PCSK_SKI1_1	29	33	PF00082	0.271
CLV_PCSK_SKI1_1	55	59	PF00082	0.303
DEG_APCC_KENBOX_2	147	151	PF00400	0.372
DOC_CYCLIN_yClb5_NLxxxL_5	299	308	PF00134	0.494
DOC_MAPK_FxFP_2	241	244	PF00069	0.402
DOC_MAPK_gen_1	127	136	PF00069	0.379
DOC_MAPK_gen_1	14	23	PF00069	0.349
DOC_MAPK_MEF2A_6	127	136	PF00069	0.282
DOC_MAPK_NFAT4_5	127	135	PF00069	0.378
DOC_PP4_FxxP_1	241	244	PF00568	0.402
DOC_SPAK_OSR1_1	97	101	PF12202	0.335
DOC_USP7_UBL2_3	12	16	PF12436	0.331
DOC_USP7_UBL2_3	25	29	PF12436	0.349
DOC_WW_Pin1_4	14	19	PF00397	0.330
DOC_WW_Pin1_4	291	296	PF00397	0.395
LIG_14-3-3_CanoR_1	97	107	PF00244	0.324
LIG_BRCT_BRCA1_1	295	299	PF00533	0.412
LIG_BRCT_BRCA1_1	314	318	PF00533	0.415
LIG_deltaCOP1_diTrp_1	279	288	PF00928	0.369
LIG_FHA_1	15	21	PF00498	0.328
LIG_FHA_1	40	46	PF00498	0.281
LIG_FHA_2	159	165	PF00498	0.382
LIG_FHA_2	99	105	PF00498	0.325
LIG_LIR_Apic_2	239	244	PF02991	0.413
LIG_LIR_Gen_1	161	171	PF02991	0.341
LIG_LIR_Nem_3	161	166	PF02991	0.339
LIG_LIR_Nem_3	298	304	PF02991	0.393
LIG_PDZ_Class_2	315	320	PF00595	0.405
LIG_PTB_Apo_2	235	242	PF02174	0.325
LIG_PTB_Apo_2	92	99	PF02174	0.357
LIG_SH2_SRC	210	213	PF00017	0.285
LIG_SH2_STAT3	143	146	PF00017	0.327
LIG_SH2_STAT3	50	53	PF00017	0.337
LIG_SH2_STAT5	152	155	PF00017	0.414
LIG_SH2_STAT5	205	208	PF00017	0.294
LIG_SH2_STAT5	210	213	PF00017	0.277
LIG_SH2_STAT5	235	238	PF00017	0.383
LIG_SH2_STAT5	287	290	PF00017	0.496
LIG_SH2_STAT5	50	53	PF00017	0.357
LIG_SH3_3	20	26	PF00018	0.364
LIG_SH3_4	25	32	PF00018	0.323
LIG_WRC_WIRS_1	31	36	PF05994	0.273
MOD_CK1_1	197	203	PF00069	0.340
MOD_CK2_1	158	164	PF00069	0.233
MOD_CK2_1	310	316	PF00069	0.490
MOD_DYRK1A_RPxSP_1	14	18	PF00069	0.336
MOD_GlcNHglycan	312	315	PF01048	0.690
MOD_GlcNHglycan	68	71	PF01048	0.368
MOD_GSK3_1	130	137	PF00069	0.268
MOD_GSK3_1	171	178	PF00069	0.328
MOD_NEK2_1	130	135	PF00069	0.268
MOD_NEK2_1	191	196	PF00069	0.403
MOD_NEK2_1	39	44	PF00069	0.290
MOD_NEK2_1	59	64	PF00069	0.292
MOD_PIKK_1	142	148	PF00454	0.410
MOD_PIKK_1	175	181	PF00454	0.446
MOD_PKA_2	191	197	PF00069	0.313
MOD_Plk_4	191	197	PF00069	0.339
MOD_Plk_4	59	65	PF00069	0.292
MOD_ProDKin_1	14	20	PF00069	0.325
MOD_ProDKin_1	291	297	PF00069	0.393
MOD_SUMO_rev_2	102	107	PF00179	0.325
TRG_DiLeu_BaEn_1	54	59	PF01217	0.547
TRG_ER_diArg_1	276	278	PF00400	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P891	Leptomonas seymouri	90%	100%
A0A0S4ISG1	Bodo saltans	70%	100%
A0A1X0NN13	Trypanosomatidae	78%	100%
A0A3S7WSN3	Leishmania donovani	98%	100%
A0A422MYV8	Trypanosoma rangeli	80%	100%
A4H7A1	Leishmania braziliensis	93%	100%
A4HVP3	Leishmania infantum	98%	100%
D0A6N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9APD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BB21	Trypanosoma cruzi	79%	100%