Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG37_LEIMA

TriTrypDb:

LmjF.13.1170 , LMJLV39_130015900 , LMJSD75_130015900

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	10
GO:0031974	membrane-enclosed lumen	2	10
GO:0043233	organelle lumen	3	10
GO:0070013	intracellular organelle lumen	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QG37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.464
CLV_C14_Caspase3-7	190	194	PF00656	0.594
CLV_C14_Caspase3-7	259	263	PF00656	0.641
CLV_C14_Caspase3-7	50	54	PF00656	0.777
CLV_C14_Caspase3-7	56	60	PF00656	0.504
CLV_NRD_NRD_1	117	119	PF00675	0.519
CLV_NRD_NRD_1	186	188	PF00675	0.700
CLV_NRD_NRD_1	271	273	PF00675	0.685
CLV_NRD_NRD_1	28	30	PF00675	0.666
CLV_NRD_NRD_1	314	316	PF00675	0.343
CLV_NRD_NRD_1	396	398	PF00675	0.398
CLV_NRD_NRD_1	410	412	PF00675	0.515
CLV_NRD_NRD_1	417	419	PF00675	0.637
CLV_PCSK_KEX2_1	116	118	PF00082	0.490
CLV_PCSK_KEX2_1	186	188	PF00082	0.696
CLV_PCSK_KEX2_1	223	225	PF00082	0.630
CLV_PCSK_KEX2_1	270	272	PF00082	0.651
CLV_PCSK_KEX2_1	28	30	PF00082	0.662
CLV_PCSK_KEX2_1	396	398	PF00082	0.392
CLV_PCSK_KEX2_1	410	412	PF00082	0.524
CLV_PCSK_KEX2_1	46	48	PF00082	0.699
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.630
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.699
CLV_PCSK_PC7_1	182	188	PF00082	0.570
CLV_PCSK_SKI1_1	110	114	PF00082	0.528
CLV_PCSK_SKI1_1	117	121	PF00082	0.432
CLV_PCSK_SKI1_1	220	224	PF00082	0.677
CLV_PCSK_SKI1_1	320	324	PF00082	0.518
CLV_PCSK_SKI1_1	349	353	PF00082	0.431
CLV_PCSK_SKI1_1	459	463	PF00082	0.388
CLV_PCSK_SKI1_1	490	494	PF00082	0.318
CLV_Separin_Metazoa	393	397	PF03568	0.364
DEG_SPOP_SBC_1	82	86	PF00917	0.558
DOC_CKS1_1	441	446	PF01111	0.567
DOC_CYCLIN_RxL_1	114	124	PF00134	0.503
DOC_CYCLIN_RxL_1	288	296	PF00134	0.450
DOC_CYCLIN_RxL_1	362	371	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.502
DOC_MAPK_gen_1	276	286	PF00069	0.374
DOC_MAPK_gen_1	396	404	PF00069	0.569
DOC_MAPK_MEF2A_6	279	286	PF00069	0.338
DOC_MAPK_MEF2A_6	386	394	PF00069	0.460
DOC_MAPK_MEF2A_6	396	404	PF00069	0.569
DOC_PP1_RVXF_1	363	370	PF00149	0.364
DOC_PP2B_LxvP_1	286	289	PF13499	0.419
DOC_PP2B_LxvP_1	3	6	PF13499	0.505
DOC_PP4_FxxP_1	404	407	PF00568	0.725
DOC_PP4_FxxP_1	434	437	PF00568	0.642
DOC_USP7_MATH_1	121	125	PF00917	0.312
DOC_USP7_MATH_1	289	293	PF00917	0.508
DOC_USP7_MATH_1	325	329	PF00917	0.600
DOC_USP7_MATH_1	420	424	PF00917	0.657
DOC_USP7_MATH_1	65	69	PF00917	0.764
DOC_USP7_MATH_1	83	87	PF00917	0.486
DOC_USP7_UBL2_3	316	320	PF12436	0.456
DOC_WW_Pin1_4	191	196	PF00397	0.593
DOC_WW_Pin1_4	252	257	PF00397	0.767
DOC_WW_Pin1_4	328	333	PF00397	0.641
DOC_WW_Pin1_4	426	431	PF00397	0.633
DOC_WW_Pin1_4	437	442	PF00397	0.545
DOC_WW_Pin1_4	91	96	PF00397	0.771
LIG_14-3-3_CanoR_1	158	168	PF00244	0.411
LIG_14-3-3_CanoR_1	204	209	PF00244	0.437
LIG_14-3-3_CanoR_1	276	286	PF00244	0.469
LIG_14-3-3_CanoR_1	363	368	PF00244	0.365
LIG_14-3-3_CanoR_1	411	417	PF00244	0.598
LIG_14-3-3_CanoR_1	450	456	PF00244	0.486
LIG_APCC_ABBA_1	71	76	PF00400	0.710
LIG_BIR_III_2	80	84	PF00653	0.561
LIG_BIR_III_4	59	63	PF00653	0.502
LIG_BRCT_BRCA1_1	164	168	PF00533	0.349
LIG_BRCT_BRCA1_1	365	369	PF00533	0.454
LIG_BRCT_BRCA1_1	67	71	PF00533	0.663
LIG_BRCT_BRCA1_1	85	89	PF00533	0.663
LIG_CaM_IQ_9	127	142	PF13499	0.424
LIG_deltaCOP1_diTrp_1	306	310	PF00928	0.291
LIG_deltaCOP1_diTrp_1	343	352	PF00928	0.460
LIG_FHA_1	502	508	PF00498	0.520
LIG_FHA_2	306	312	PF00498	0.428
LIG_GBD_Chelix_1	533	541	PF00786	0.464
LIG_IRF3_LxIS_1	3	8	PF10401	0.553
LIG_KLC1_Yacidic_2	388	393	PF13176	0.378
LIG_LIR_Apic_2	401	407	PF02991	0.617
LIG_LIR_Apic_2	474	480	PF02991	0.443
LIG_LIR_Apic_2	76	82	PF02991	0.572
LIG_LIR_Gen_1	306	314	PF02991	0.289
LIG_LIR_Gen_1	388	399	PF02991	0.361
LIG_LIR_Gen_1	494	503	PF02991	0.543
LIG_LIR_Nem_3	155	160	PF02991	0.477
LIG_LIR_Nem_3	285	290	PF02991	0.295
LIG_LIR_Nem_3	306	310	PF02991	0.291
LIG_LIR_Nem_3	68	74	PF02991	0.558
LIG_MLH1_MIPbox_1	164	168	PF16413	0.349
LIG_MYND_1	150	154	PF01753	0.395
LIG_SH2_CRK	205	209	PF00017	0.434
LIG_SH2_CRK	477	481	PF00017	0.475
LIG_SH2_GRB2like	357	360	PF00017	0.358
LIG_SH2_NCK_1	241	245	PF00017	0.599
LIG_SH2_SRC	178	181	PF00017	0.518
LIG_SH2_SRC	357	360	PF00017	0.358
LIG_SH2_STAP1	471	475	PF00017	0.431
LIG_SH2_STAT3	510	513	PF00017	0.423
LIG_SH2_STAT5	167	170	PF00017	0.315
LIG_SH2_STAT5	178	181	PF00017	0.466
LIG_SH2_STAT5	241	244	PF00017	0.597
LIG_SH2_STAT5	391	394	PF00017	0.365
LIG_SH2_STAT5	496	499	PF00017	0.423
LIG_SH2_STAT5	510	513	PF00017	0.493
LIG_SH2_STAT5	523	526	PF00017	0.489
LIG_SH3_3	148	154	PF00018	0.394
LIG_SH3_3	438	444	PF00018	0.711
LIG_SH3_3	92	98	PF00018	0.567
LIG_TRAF2_1	377	380	PF00917	0.345
LIG_UBA3_1	309	316	PF00899	0.252
LIG_WRPW_2	71	74	PF00400	0.486
LIG_WW_3	217	221	PF00397	0.576
MOD_CK1_1	102	108	PF00069	0.499
MOD_CK1_1	166	172	PF00069	0.381
MOD_CK1_1	31	37	PF00069	0.582
MOD_CK1_1	327	333	PF00069	0.613
MOD_CK1_1	423	429	PF00069	0.720
MOD_CK1_1	454	460	PF00069	0.463
MOD_CK1_1	8	14	PF00069	0.685
MOD_CK1_1	84	90	PF00069	0.652
MOD_CK2_1	411	417	PF00069	0.726
MOD_Cter_Amidation	184	187	PF01082	0.554
MOD_GlcNHglycan	154	157	PF01048	0.431
MOD_GlcNHglycan	18	21	PF01048	0.499
MOD_GlcNHglycan	182	185	PF01048	0.526
MOD_GlcNHglycan	220	223	PF01048	0.765
MOD_GlcNHglycan	31	34	PF01048	0.633
MOD_GlcNHglycan	334	337	PF01048	0.470
MOD_GlcNHglycan	425	428	PF01048	0.765
MOD_GlcNHglycan	456	459	PF01048	0.390
MOD_GlcNHglycan	466	470	PF01048	0.225
MOD_GlcNHglycan	7	10	PF01048	0.575
MOD_GlcNHglycan	86	89	PF01048	0.620
MOD_GSK3_1	11	18	PF00069	0.675
MOD_GSK3_1	159	166	PF00069	0.512
MOD_GSK3_1	27	34	PF00069	0.640
MOD_GSK3_1	289	296	PF00069	0.448
MOD_GSK3_1	320	327	PF00069	0.420
MOD_GSK3_1	328	335	PF00069	0.439
MOD_GSK3_1	450	457	PF00069	0.516
MOD_GSK3_1	533	540	PF00069	0.381
MOD_GSK3_1	83	90	PF00069	0.588
MOD_NEK2_1	160	165	PF00069	0.416
MOD_NEK2_1	168	173	PF00069	0.292
MOD_NEK2_1	282	287	PF00069	0.505
MOD_NEK2_1	293	298	PF00069	0.431
MOD_NEK2_1	400	405	PF00069	0.632
MOD_NEK2_1	533	538	PF00069	0.451
MOD_NEK2_1	89	94	PF00069	0.736
MOD_NEK2_2	305	310	PF00069	0.249
MOD_PIKK_1	405	411	PF00454	0.579
MOD_PIKK_1	460	466	PF00454	0.445
MOD_PK_1	204	210	PF00069	0.436
MOD_PKA_1	28	34	PF00069	0.564
MOD_PKA_1	46	52	PF00069	0.699
MOD_PKA_2	239	245	PF00069	0.762
MOD_PKA_2	27	33	PF00069	0.640
MOD_PKA_2	46	52	PF00069	0.681
MOD_PKA_2	65	71	PF00069	0.621
MOD_Plk_1	293	299	PF00069	0.385
MOD_Plk_1	305	311	PF00069	0.248
MOD_Plk_1	400	406	PF00069	0.515
MOD_Plk_4	163	169	PF00069	0.514
MOD_Plk_4	293	299	PF00069	0.379
MOD_ProDKin_1	191	197	PF00069	0.589
MOD_ProDKin_1	252	258	PF00069	0.766
MOD_ProDKin_1	328	334	PF00069	0.642
MOD_ProDKin_1	426	432	PF00069	0.631
MOD_ProDKin_1	437	443	PF00069	0.546
MOD_ProDKin_1	91	97	PF00069	0.766
MOD_SUMO_rev_2	414	420	PF00179	0.708
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.535
TRG_ENDOCYTIC_2	167	170	PF00928	0.315
TRG_ENDOCYTIC_2	205	208	PF00928	0.428
TRG_ENDOCYTIC_2	391	394	PF00928	0.447
TRG_ENDOCYTIC_2	496	499	PF00928	0.388
TRG_ER_diArg_1	116	118	PF00400	0.526
TRG_ER_diArg_1	238	241	PF00400	0.586
TRG_ER_diArg_1	27	29	PF00400	0.668
TRG_ER_diArg_1	270	272	PF00400	0.677
TRG_ER_diArg_1	362	365	PF00400	0.319
TRG_ER_diArg_1	395	397	PF00400	0.382
TRG_NES_CRM1_1	388	401	PF08389	0.385
TRG_NES_CRM1_1	491	506	PF08389	0.332
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	459	464	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J1	Leptomonas seymouri	52%	100%
A0A1X0NMY2	Trypanosomatidae	33%	100%
A0A3R7KEA8	Trypanosoma rangeli	34%	100%
A0A3S7WSK1	Leishmania donovani	92%	100%
A4HVP5	Leishmania infantum	92%	100%
D0A6K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5D7N8	Trypanosoma cruzi	35%	100%