LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania major
UniProt:
Q4QG33_LEIMA
TriTrypDb:
LmjF.13.1210 , LMJLV39_130016300 * , LMJSD75_130016300
Length:
501

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 6
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54

Expansion

Sequence features

Q4QG33
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG33

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0015851 nucleobase transport 5 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015205 nucleobase transmembrane transporter activity 3 3
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 317 321 PF00656 0.538
CLV_NRD_NRD_1 86 88 PF00675 0.322
CLV_PCSK_KEX2_1 230 232 PF00082 0.288
CLV_PCSK_KEX2_1 261 263 PF00082 0.381
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.248
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.381
CLV_PCSK_SKI1_1 227 231 PF00082 0.270
CLV_PCSK_SKI1_1 326 330 PF00082 0.388
CLV_PCSK_SKI1_1 416 420 PF00082 0.332
CLV_PCSK_SKI1_1 43 47 PF00082 0.494
DEG_Nend_Nbox_1 1 3 PF02207 0.622
DEG_SPOP_SBC_1 168 172 PF00917 0.339
DEG_SPOP_SBC_1 255 259 PF00917 0.559
DOC_ANK_TNKS_1 288 295 PF00023 0.608
DOC_CDC14_PxL_1 361 369 PF14671 0.456
DOC_CKS1_1 81 86 PF01111 0.371
DOC_MAPK_gen_1 373 383 PF00069 0.371
DOC_MAPK_gen_1 87 93 PF00069 0.531
DOC_MAPK_HePTP_8 91 103 PF00069 0.509
DOC_MAPK_MEF2A_6 376 385 PF00069 0.385
DOC_MAPK_MEF2A_6 416 424 PF00069 0.355
DOC_MAPK_MEF2A_6 94 103 PF00069 0.337
DOC_MAPK_NFAT4_5 94 102 PF00069 0.415
DOC_PP1_RVXF_1 398 404 PF00149 0.545
DOC_PP2B_LxvP_1 110 113 PF13499 0.331
DOC_PP2B_LxvP_1 362 365 PF13499 0.336
DOC_PP2B_LxvP_1 367 370 PF13499 0.255
DOC_PP4_FxxP_1 345 348 PF00568 0.574
DOC_USP7_MATH_1 255 259 PF00917 0.766
DOC_USP7_MATH_1 271 275 PF00917 0.574
DOC_USP7_MATH_1 295 299 PF00917 0.793
DOC_USP7_MATH_1 30 34 PF00917 0.382
DOC_USP7_MATH_1 484 488 PF00917 0.382
DOC_USP7_UBL2_3 287 291 PF12436 0.787
DOC_WW_Pin1_4 52 57 PF00397 0.452
DOC_WW_Pin1_4 80 85 PF00397 0.411
LIG_14-3-3_CanoR_1 214 219 PF00244 0.506
LIG_14-3-3_CanoR_1 262 270 PF00244 0.618
LIG_14-3-3_CanoR_1 326 334 PF00244 0.575
LIG_14-3-3_CanoR_1 394 400 PF00244 0.332
LIG_14-3-3_CanoR_1 464 473 PF00244 0.526
LIG_14-3-3_CanoR_1 87 92 PF00244 0.497
LIG_Actin_WH2_2 174 192 PF00022 0.488
LIG_BIR_III_4 390 394 PF00653 0.304
LIG_BRCT_BRCA1_1 211 215 PF00533 0.464
LIG_BRCT_BRCA1_1 454 458 PF00533 0.438
LIG_BRCT_BRCA1_1 54 58 PF00533 0.423
LIG_BRCT_BRCA1_1 89 93 PF00533 0.526
LIG_Clathr_ClatBox_1 101 105 PF01394 0.378
LIG_EH1_1 356 364 PF00400 0.425
LIG_eIF4E_1 14 20 PF01652 0.346
LIG_FHA_1 13 19 PF00498 0.342
LIG_FHA_1 265 271 PF00498 0.711
LIG_FHA_1 378 384 PF00498 0.360
LIG_FHA_1 71 77 PF00498 0.341
LIG_FHA_2 315 321 PF00498 0.496
LIG_FHA_2 327 333 PF00498 0.507
LIG_IRF3_LxIS_1 407 412 PF10401 0.444
LIG_LIR_Gen_1 105 114 PF02991 0.353
LIG_LIR_Gen_1 143 153 PF02991 0.488
LIG_LIR_Gen_1 182 193 PF02991 0.297
LIG_LIR_Gen_1 352 362 PF02991 0.280
LIG_LIR_Gen_1 375 386 PF02991 0.344
LIG_LIR_Gen_1 423 432 PF02991 0.397
LIG_LIR_Nem_3 105 110 PF02991 0.289
LIG_LIR_Nem_3 143 148 PF02991 0.498
LIG_LIR_Nem_3 182 188 PF02991 0.302
LIG_LIR_Nem_3 212 218 PF02991 0.375
LIG_LIR_Nem_3 225 229 PF02991 0.403
LIG_LIR_Nem_3 274 280 PF02991 0.771
LIG_LIR_Nem_3 352 357 PF02991 0.283
LIG_LIR_Nem_3 375 381 PF02991 0.303
LIG_LIR_Nem_3 40 44 PF02991 0.332
LIG_LIR_Nem_3 423 427 PF02991 0.374
LIG_LIR_Nem_3 455 461 PF02991 0.290
LIG_LIR_Nem_3 64 68 PF02991 0.296
LIG_LIR_Nem_3 90 96 PF02991 0.522
LIG_NRBOX 439 445 PF00104 0.192
LIG_NRBOX 487 493 PF00104 0.265
LIG_Pex14_2 161 165 PF04695 0.347
LIG_Pex14_2 354 358 PF04695 0.284
LIG_Pex14_2 424 428 PF04695 0.359
LIG_PTB_Apo_2 445 452 PF02174 0.334
LIG_SH2_CRK 145 149 PF00017 0.484
LIG_SH2_CRK 185 189 PF00017 0.323
LIG_SH2_CRK 226 230 PF00017 0.427
LIG_SH2_NCK_1 145 149 PF00017 0.522
LIG_SH2_NCK_1 66 70 PF00017 0.402
LIG_SH2_SRC 139 142 PF00017 0.388
LIG_SH2_SRC 430 433 PF00017 0.321
LIG_SH2_STAP1 14 18 PF00017 0.356
LIG_SH2_STAP1 185 189 PF00017 0.285
LIG_SH2_STAT5 12 15 PF00017 0.340
LIG_SH2_STAT5 139 142 PF00017 0.364
LIG_SH2_STAT5 193 196 PF00017 0.300
LIG_SH2_STAT5 430 433 PF00017 0.299
LIG_SH3_3 454 460 PF00018 0.406
LIG_SH3_3 495 501 PF00018 0.518
LIG_SH3_3 50 56 PF00018 0.319
LIG_SH3_3 78 84 PF00018 0.334
LIG_SUMO_SIM_anti_2 360 366 PF11976 0.456
LIG_SUMO_SIM_anti_2 380 385 PF11976 0.319
LIG_SUMO_SIM_par_1 360 366 PF11976 0.385
LIG_TRAF2_1 248 251 PF00917 0.512
LIG_TYR_ITSM 141 148 PF00017 0.480
LIG_WRC_WIRS_1 62 67 PF05994 0.285
MOD_CDK_SPxxK_3 80 87 PF00069 0.406
MOD_CK1_1 257 263 PF00069 0.753
MOD_CK1_1 70 76 PF00069 0.318
MOD_CK2_1 135 141 PF00069 0.392
MOD_CK2_1 326 332 PF00069 0.524
MOD_CK2_1 4 10 PF00069 0.536
MOD_GlcNHglycan 156 159 PF01048 0.312
MOD_GlcNHglycan 165 168 PF01048 0.334
MOD_GlcNHglycan 32 35 PF01048 0.557
MOD_GlcNHglycan 488 491 PF01048 0.320
MOD_GSK3_1 163 170 PF00069 0.316
MOD_GSK3_1 177 184 PF00069 0.288
MOD_GSK3_1 295 302 PF00069 0.788
MOD_GSK3_1 314 321 PF00069 0.461
MOD_GSK3_1 460 467 PF00069 0.437
MOD_N-GLC_1 3 8 PF02516 0.289
MOD_N-GLC_1 326 331 PF02516 0.294
MOD_NEK2_1 127 132 PF00069 0.386
MOD_NEK2_1 140 145 PF00069 0.482
MOD_NEK2_1 147 152 PF00069 0.465
MOD_NEK2_1 169 174 PF00069 0.339
MOD_NEK2_1 194 199 PF00069 0.350
MOD_NEK2_1 20 25 PF00069 0.319
MOD_NEK2_1 209 214 PF00069 0.234
MOD_NEK2_1 256 261 PF00069 0.760
MOD_NEK2_1 3 8 PF00069 0.553
MOD_NEK2_1 334 339 PF00069 0.499
MOD_NEK2_1 349 354 PF00069 0.301
MOD_NEK2_1 357 362 PF00069 0.364
MOD_NEK2_1 409 414 PF00069 0.321
MOD_NEK2_1 444 449 PF00069 0.403
MOD_NEK2_1 478 483 PF00069 0.346
MOD_NEK2_1 89 94 PF00069 0.508
MOD_NEK2_1 97 102 PF00069 0.301
MOD_NEK2_2 395 400 PF00069 0.227
MOD_PIKK_1 115 121 PF00454 0.375
MOD_PIKK_1 70 76 PF00454 0.272
MOD_PKA_1 87 93 PF00069 0.498
MOD_Plk_1 140 146 PF00069 0.506
MOD_Plk_1 181 187 PF00069 0.224
MOD_Plk_1 3 9 PF00069 0.655
MOD_Plk_2-3 299 305 PF00069 0.553
MOD_Plk_2-3 320 326 PF00069 0.505
MOD_Plk_4 135 141 PF00069 0.384
MOD_Plk_4 184 190 PF00069 0.284
MOD_Plk_4 20 26 PF00069 0.347
MOD_Plk_4 357 363 PF00069 0.312
MOD_Plk_4 420 426 PF00069 0.331
MOD_Plk_4 478 484 PF00069 0.339
MOD_Plk_4 61 67 PF00069 0.300
MOD_Plk_4 77 83 PF00069 0.306
MOD_Plk_4 97 103 PF00069 0.232
MOD_ProDKin_1 52 58 PF00069 0.446
MOD_ProDKin_1 80 86 PF00069 0.405
TRG_ENDOCYTIC_2 145 148 PF00928 0.493
TRG_ENDOCYTIC_2 185 188 PF00928 0.307
TRG_ENDOCYTIC_2 193 196 PF00928 0.288
TRG_ENDOCYTIC_2 226 229 PF00928 0.477
TRG_ENDOCYTIC_2 277 280 PF00928 0.770

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 36% 100%
A0A0N0P6Z5 Leptomonas seymouri 32% 100%
A0A0N1I1J0 Leptomonas seymouri 33% 100%
A0A0N1I8E8 Leptomonas seymouri 27% 100%
A0A0N1PBQ1 Leptomonas seymouri 67% 99%
A0A0S4JBS4 Bodo saltans 33% 100%
A0A1X0NN91 Trypanosomatidae 52% 100%
A0A1X0NPL0 Trypanosomatidae 56% 100%
A0A1X0NV38 Trypanosomatidae 35% 100%
A0A1X0NWJ5 Trypanosomatidae 36% 100%
A0A3Q8ICX7 Leishmania donovani 92% 100%
A0A3R7NQR3 Trypanosoma rangeli 53% 100%
A0A3S7WTL0 Leishmania donovani 33% 100%
A0A3S7XAS5 Leishmania donovani 33% 100%
A0A422MQ08 Trypanosoma rangeli 34% 100%
A0A422N8M2 Trypanosoma rangeli 29% 100%
A0A422NHH9 Trypanosoma rangeli 30% 100%
A0A422NR81 Trypanosoma rangeli 30% 100%
A1L272 Danio rerio 23% 97%
A4H6I0 Leishmania braziliensis 34% 91%
A4H7A5 Leishmania braziliensis 80% 100%
A4HG96 Leishmania braziliensis 26% 99%
A4HP60 Leishmania braziliensis 33% 100%
A4HUW2 Leishmania infantum 36% 91%
A4HVP9 Leishmania infantum 92% 100%
A4HWK9 Leishmania infantum 33% 100%
A4IDG6 Leishmania infantum 32% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AGM5 Leishmania infantum 33% 100%
E9AGM6 Leishmania infantum 33% 100%
E9AGM7 Leishmania infantum 33% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 91%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O76343 Leishmania donovani 34% 100%
Q4Q1M9 Leishmania major 31% 100%
Q4QF58 Leishmania major 33% 100%
Q4QF59 Leishmania major 33% 76%
Q4QH25 Leishmania major 34% 91%
Q7RTT9 Homo sapiens 22% 95%
Q8R139 Mus musculus 22% 95%
V5BGB1 Trypanosoma cruzi 56% 100%
V5BRM5 Trypanosoma cruzi 35% 100%
V5DSF4 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS