Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QG28_LEIMA

TriTrypDb:

LmjF.13.1260 , LMJLV39_130016800 , LMJSD75_130016800

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QG28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.656
CLV_NRD_NRD_1	127	129	PF00675	0.408
CLV_NRD_NRD_1	135	137	PF00675	0.479
CLV_PCSK_KEX2_1	126	128	PF00082	0.401
CLV_PCSK_KEX2_1	135	137	PF00082	0.477
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.501
CLV_PCSK_SKI1_1	27	31	PF00082	0.433
CLV_PCSK_SKI1_1	56	60	PF00082	0.435
CLV_PCSK_SKI1_1	61	65	PF00082	0.318
DEG_APCC_DBOX_1	55	63	PF00400	0.527
DEG_APCC_DBOX_1	8	16	PF00400	0.590
DOC_CYCLIN_yCln2_LP_2	30	33	PF00134	0.593
DOC_MAPK_MEF2A_6	98	107	PF00069	0.346
DOC_MAPK_RevD_3	112	127	PF00069	0.260
DOC_PP2B_LxvP_1	29	32	PF13499	0.687
DOC_USP7_MATH_1	19	23	PF00917	0.660
DOC_USP7_UBL2_3	133	137	PF12436	0.675
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_deltaCOP1_diTrp_1	91	99	PF00928	0.458
LIG_EH1_1	111	119	PF00400	0.332
LIG_LIR_Gen_1	170	180	PF02991	0.659
LIG_LIR_Nem_3	170	176	PF02991	0.678
LIG_PDZ_Class_3	187	192	PF00595	0.701
LIG_Pex14_1	93	97	PF04695	0.458
LIG_SH2_CRK	65	69	PF00017	0.356
LIG_SH2_STAT3	57	60	PF00017	0.619
LIG_SH2_STAT5	121	124	PF00017	0.375
LIG_SH3_3	11	17	PF00018	0.663
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.667
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.636
LIG_SUMO_SIM_par_1	102	108	PF11976	0.397
LIG_SUMO_SIM_par_1	44	49	PF11976	0.578
LIG_TRAF2_1	164	167	PF00917	0.696
LIG_WRC_WIRS_1	173	178	PF05994	0.657
LIG_WW_3	31	35	PF00397	0.594
MOD_CK1_1	168	174	PF00069	0.748
MOD_CK1_1	186	192	PF00069	0.762
MOD_CK2_1	145	151	PF00069	0.792
MOD_CK2_1	185	191	PF00069	0.700
MOD_GlcNHglycan	23	26	PF01048	0.500
MOD_GSK3_1	165	172	PF00069	0.713
MOD_N-GLC_1	89	94	PF02516	0.634
MOD_NEK2_1	82	87	PF00069	0.495
MOD_NEK2_1	89	94	PF00069	0.426
MOD_PIKK_1	127	133	PF00454	0.583
MOD_PKA_1	127	133	PF00069	0.618
MOD_PKA_2	127	133	PF00069	0.631
MOD_Plk_1	169	175	PF00069	0.727
MOD_Plk_1	46	52	PF00069	0.637
MOD_Plk_1	89	95	PF00069	0.424
MOD_Plk_4	46	52	PF00069	0.637
TRG_ENDOCYTIC_2	121	124	PF00928	0.260
TRG_ENDOCYTIC_2	173	176	PF00928	0.661
TRG_ER_diArg_1	126	128	PF00400	0.570
TRG_NLS_MonoExtN_4	133	139	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II27	Leishmania donovani	83%	100%
A4H7A9	Leishmania braziliensis	47%	96%
A4HVQ4	Leishmania infantum	83%	100%
E9APF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%