DNA/RNA non-specific endonuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA/RNA non-specific endonuclease-like protein

Species:

Leishmania major

UniProt:

Q4QG27_LEIMA

TriTrypDb:

LmjF.13.1270 , LMJLV39_130017000 , LMJSD75_130017000

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	3
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QG27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG27

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	2
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	6
GO:0004520	DNA endonuclease activity	5	2
GO:0004521	RNA endonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	816	820	PF00656	0.478
CLV_NRD_NRD_1	108	110	PF00675	0.449
CLV_NRD_NRD_1	122	124	PF00675	0.432
CLV_NRD_NRD_1	173	175	PF00675	0.699
CLV_NRD_NRD_1	208	210	PF00675	0.691
CLV_NRD_NRD_1	223	225	PF00675	0.735
CLV_NRD_NRD_1	347	349	PF00675	0.646
CLV_NRD_NRD_1	393	395	PF00675	0.579
CLV_NRD_NRD_1	4	6	PF00675	0.389
CLV_NRD_NRD_1	412	414	PF00675	0.433
CLV_NRD_NRD_1	493	495	PF00675	0.700
CLV_NRD_NRD_1	533	535	PF00675	0.722
CLV_NRD_NRD_1	568	570	PF00675	0.632
CLV_NRD_NRD_1	59	61	PF00675	0.462
CLV_NRD_NRD_1	694	696	PF00675	0.734
CLV_NRD_NRD_1	761	763	PF00675	0.709
CLV_PCSK_FUR_1	391	395	PF00082	0.548
CLV_PCSK_FUR_1	491	495	PF00082	0.636
CLV_PCSK_KEX2_1	108	110	PF00082	0.449
CLV_PCSK_KEX2_1	122	124	PF00082	0.432
CLV_PCSK_KEX2_1	173	175	PF00082	0.699
CLV_PCSK_KEX2_1	208	210	PF00082	0.691
CLV_PCSK_KEX2_1	223	225	PF00082	0.735
CLV_PCSK_KEX2_1	291	293	PF00082	0.700
CLV_PCSK_KEX2_1	347	349	PF00082	0.646
CLV_PCSK_KEX2_1	393	395	PF00082	0.579
CLV_PCSK_KEX2_1	4	6	PF00082	0.389
CLV_PCSK_KEX2_1	412	414	PF00082	0.433
CLV_PCSK_KEX2_1	493	495	PF00082	0.641
CLV_PCSK_KEX2_1	531	533	PF00082	0.727
CLV_PCSK_KEX2_1	560	562	PF00082	0.761
CLV_PCSK_KEX2_1	568	570	PF00082	0.672
CLV_PCSK_KEX2_1	59	61	PF00082	0.467
CLV_PCSK_KEX2_1	694	696	PF00082	0.750
CLV_PCSK_KEX2_1	761	763	PF00082	0.709
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.700
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.684
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.761
CLV_PCSK_PC7_1	564	570	PF00082	0.661
CLV_PCSK_SKI1_1	108	112	PF00082	0.450
CLV_PCSK_SKI1_1	182	186	PF00082	0.695
CLV_PCSK_SKI1_1	348	352	PF00082	0.684
CLV_PCSK_SKI1_1	397	401	PF00082	0.517
CLV_PCSK_SKI1_1	405	409	PF00082	0.470
CLV_PCSK_SKI1_1	5	9	PF00082	0.391
CLV_PCSK_SKI1_1	752	756	PF00082	0.591
DEG_APCC_DBOX_1	186	194	PF00400	0.522
DEG_APCC_DBOX_1	248	256	PF00400	0.489
DEG_APCC_DBOX_1	25	33	PF00400	0.389
DEG_APCC_DBOX_1	4	12	PF00400	0.423
DEG_SCF_FBW7_1	129	134	PF00400	0.713
DEG_SPOP_SBC_1	511	515	PF00917	0.528
DOC_ANK_TNKS_1	595	602	PF00023	0.493
DOC_CKS1_1	128	133	PF01111	0.717
DOC_CYCLIN_RxL_1	105	115	PF00134	0.647
DOC_CYCLIN_RxL_1	470	480	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.510
DOC_MAPK_DCC_7	26	34	PF00069	0.390
DOC_MAPK_FxFP_2	97	100	PF00069	0.592
DOC_MAPK_gen_1	182	192	PF00069	0.517
DOC_MAPK_gen_1	246	255	PF00069	0.481
DOC_MAPK_gen_1	391	401	PF00069	0.317
DOC_MAPK_gen_1	631	639	PF00069	0.401
DOC_MAPK_HePTP_8	39	51	PF00069	0.265
DOC_MAPK_JIP1_4	249	255	PF00069	0.490
DOC_MAPK_MEF2A_6	26	34	PF00069	0.395
DOC_MAPK_MEF2A_6	42	51	PF00069	0.239
DOC_MAPK_MEF2A_6	633	641	PF00069	0.373
DOC_PP1_RVXF_1	35	42	PF00149	0.246
DOC_PP1_RVXF_1	395	402	PF00149	0.317
DOC_PP2B_LxvP_1	359	362	PF13499	0.382
DOC_PP2B_LxvP_1	582	585	PF13499	0.444
DOC_PP2B_LxvP_1	719	722	PF13499	0.393
DOC_PP2B_LxvP_1	740	743	PF13499	0.385
DOC_PP4_FxxP_1	545	548	PF00568	0.510
DOC_PP4_FxxP_1	97	100	PF00568	0.624
DOC_USP7_MATH_1	131	135	PF00917	0.744
DOC_USP7_MATH_1	138	142	PF00917	0.677
DOC_USP7_MATH_1	259	263	PF00917	0.511
DOC_USP7_MATH_1	290	294	PF00917	0.505
DOC_USP7_MATH_1	296	300	PF00917	0.471
DOC_USP7_MATH_1	430	434	PF00917	0.358
DOC_USP7_MATH_1	511	515	PF00917	0.604
DOC_USP7_MATH_1	549	553	PF00917	0.498
DOC_USP7_MATH_1	559	563	PF00917	0.517
DOC_USP7_MATH_1	572	576	PF00917	0.346
DOC_USP7_MATH_1	622	626	PF00917	0.456
DOC_USP7_MATH_1	671	675	PF00917	0.501
DOC_USP7_MATH_1	715	719	PF00917	0.453
DOC_USP7_MATH_1	760	764	PF00917	0.505
DOC_USP7_MATH_1	768	772	PF00917	0.465
DOC_USP7_MATH_1	781	785	PF00917	0.357
DOC_USP7_MATH_1	827	831	PF00917	0.475
DOC_USP7_MATH_1	88	92	PF00917	0.680
DOC_WW_Pin1_4	127	132	PF00397	0.748
DOC_WW_Pin1_4	134	139	PF00397	0.750
DOC_WW_Pin1_4	165	170	PF00397	0.597
DOC_WW_Pin1_4	192	197	PF00397	0.520
DOC_WW_Pin1_4	254	259	PF00397	0.578
DOC_WW_Pin1_4	32	37	PF00397	0.412
DOC_WW_Pin1_4	353	358	PF00397	0.469
DOC_WW_Pin1_4	434	439	PF00397	0.301
DOC_WW_Pin1_4	517	522	PF00397	0.500
DOC_WW_Pin1_4	539	544	PF00397	0.518
DOC_WW_Pin1_4	664	669	PF00397	0.552
DOC_WW_Pin1_4	699	704	PF00397	0.563
DOC_WW_Pin1_4	705	710	PF00397	0.520
LIG_14-3-3_CanoR_1	177	186	PF00244	0.500
LIG_14-3-3_CanoR_1	209	219	PF00244	0.495
LIG_14-3-3_CanoR_1	269	277	PF00244	0.453
LIG_14-3-3_CanoR_1	347	353	PF00244	0.515
LIG_14-3-3_CanoR_1	397	402	PF00244	0.332
LIG_14-3-3_CanoR_1	536	545	PF00244	0.543
LIG_14-3-3_CanoR_1	59	67	PF00244	0.672
LIG_14-3-3_CanoR_1	752	760	PF00244	0.335
LIG_14-3-3_CanoR_1	826	832	PF00244	0.414
LIG_14-3-3_CanoR_1	834	840	PF00244	0.407
LIG_Actin_WH2_2	43	61	PF00022	0.265
LIG_BRCT_BRCA1_1	16	20	PF00533	0.260
LIG_BRCT_BRCA1_1	308	312	PF00533	0.484
LIG_BRCT_BRCA1_1	541	545	PF00533	0.514
LIG_BRCT_BRCA1_1	93	97	PF00533	0.643
LIG_CSL_BTD_1	619	622	PF09270	0.448
LIG_deltaCOP1_diTrp_1	615	621	PF00928	0.460
LIG_FHA_1	130	136	PF00498	0.675
LIG_FHA_1	150	156	PF00498	0.474
LIG_FHA_1	220	226	PF00498	0.536
LIG_FHA_1	277	283	PF00498	0.546
LIG_FHA_1	284	290	PF00498	0.492
LIG_FHA_1	301	307	PF00498	0.422
LIG_FHA_1	409	415	PF00498	0.239
LIG_FHA_1	496	502	PF00498	0.514
LIG_FHA_1	647	653	PF00498	0.472
LIG_FHA_1	665	671	PF00498	0.466
LIG_FHA_1	753	759	PF00498	0.422
LIG_FHA_1	787	793	PF00498	0.400
LIG_FHA_2	178	184	PF00498	0.474
LIG_FHA_2	269	275	PF00498	0.539
LIG_FHA_2	60	66	PF00498	0.649
LIG_FHA_2	814	820	PF00498	0.478
LIG_LIR_Apic_2	183	189	PF02991	0.497
LIG_LIR_Apic_2	542	548	PF02991	0.510
LIG_LIR_Apic_2	94	100	PF02991	0.625
LIG_LIR_Gen_1	17	25	PF02991	0.232
LIG_LIR_Gen_1	309	320	PF02991	0.439
LIG_LIR_Gen_1	835	843	PF02991	0.446
LIG_LIR_LC3C_4	784	787	PF02991	0.389
LIG_LIR_Nem_3	17	23	PF02991	0.232
LIG_LIR_Nem_3	204	210	PF02991	0.520
LIG_LIR_Nem_3	309	315	PF02991	0.436
LIG_LIR_Nem_3	600	606	PF02991	0.405
LIG_LIR_Nem_3	723	729	PF02991	0.357
LIG_LIR_Nem_3	835	840	PF02991	0.446
LIG_LIR_Nem_3	94	99	PF02991	0.643
LIG_MLH1_MIPbox_1	93	97	PF16413	0.597
LIG_NRBOX	17	23	PF00104	0.265
LIG_PAM2_1	192	204	PF00658	0.482
LIG_PCNA_yPIPBox_3	455	465	PF02747	0.327
LIG_Pex14_1	379	383	PF04695	0.332
LIG_Pex14_2	726	730	PF04695	0.357
LIG_PROFILIN_1	709	715	PF00235	0.461
LIG_REV1ctd_RIR_1	399	409	PF16727	0.332
LIG_SH2_CRK	186	190	PF00017	0.504
LIG_SH2_CRK	370	374	PF00017	0.332
LIG_SH2_NCK_1	370	374	PF00017	0.332
LIG_SH2_SRC	370	373	PF00017	0.332
LIG_SH2_STAT3	645	648	PF00017	0.379
LIG_SH2_STAT5	116	119	PF00017	0.680
LIG_SH2_STAT5	179	182	PF00017	0.476
LIG_SH2_STAT5	383	386	PF00017	0.332
LIG_SH2_STAT5	472	475	PF00017	0.332
LIG_SH3_1	706	712	PF00018	0.475
LIG_SH3_2	140	145	PF14604	0.708
LIG_SH3_3	137	143	PF00018	0.710
LIG_SH3_3	518	524	PF00018	0.477
LIG_SH3_3	65	71	PF00018	0.737
LIG_SH3_3	675	681	PF00018	0.471
LIG_SH3_3	701	707	PF00018	0.547
LIG_SH3_3	708	714	PF00018	0.514
LIG_SH3_3	740	746	PF00018	0.390
LIG_SH3_3	754	760	PF00018	0.336
LIG_SH3_3	87	93	PF00018	0.650
LIG_SUMO_SIM_par_1	30	35	PF11976	0.431
LIG_SUMO_SIM_par_1	788	793	PF11976	0.388
LIG_SUMO_SIM_par_1	798	805	PF11976	0.339
LIG_TRFH_1	837	841	PF08558	0.433
LIG_TRFH_1	96	100	PF08558	0.640
LIG_TYR_ITIM	368	373	PF00017	0.332
LIG_WW_3	522	526	PF00397	0.523
MOD_CDC14_SPxK_1	257	260	PF00782	0.493
MOD_CDC14_SPxK_1	547	550	PF00782	0.505
MOD_CDK_SPK_2	32	37	PF00069	0.412
MOD_CDK_SPxK_1	254	260	PF00069	0.492
MOD_CDK_SPxK_1	544	550	PF00069	0.533
MOD_CDK_SPxxK_3	699	706	PF00069	0.474
MOD_CK1_1	133	139	PF00069	0.748
MOD_CK1_1	14	20	PF00069	0.232
MOD_CK1_1	248	254	PF00069	0.532
MOD_CK1_1	262	268	PF00069	0.450
MOD_CK1_1	299	305	PF00069	0.485
MOD_CK1_1	702	708	PF00069	0.563
MOD_CK1_1	817	823	PF00069	0.507
MOD_CK1_1	91	97	PF00069	0.640
MOD_CK2_1	177	183	PF00069	0.507
MOD_CK2_1	215	221	PF00069	0.484
MOD_CK2_1	268	274	PF00069	0.545
MOD_CK2_1	59	65	PF00069	0.670
MOD_CK2_1	785	791	PF00069	0.381
MOD_CK2_1	796	802	PF00069	0.331
MOD_CMANNOS	616	619	PF00535	0.689
MOD_GlcNHglycan	265	268	PF01048	0.713
MOD_GlcNHglycan	292	295	PF01048	0.701
MOD_GlcNHglycan	308	311	PF01048	0.610
MOD_GlcNHglycan	337	340	PF01048	0.727
MOD_GlcNHglycan	348	351	PF01048	0.714
MOD_GlcNHglycan	539	542	PF01048	0.723
MOD_GlcNHglycan	588	591	PF01048	0.700
MOD_GlcNHglycan	624	627	PF01048	0.705
MOD_GlcNHglycan	659	662	PF01048	0.681
MOD_GlcNHglycan	808	811	PF01048	0.641
MOD_GlcNHglycan	853	856	PF01048	0.674
MOD_GSK3_1	127	134	PF00069	0.800
MOD_GSK3_1	165	172	PF00069	0.686
MOD_GSK3_1	21	28	PF00069	0.476
MOD_GSK3_1	211	218	PF00069	0.495
MOD_GSK3_1	259	266	PF00069	0.535
MOD_GSK3_1	296	303	PF00069	0.505
MOD_GSK3_1	306	313	PF00069	0.434
MOD_GSK3_1	337	344	PF00069	0.603
MOD_GSK3_1	403	410	PF00069	0.309
MOD_GSK3_1	430	437	PF00069	0.332
MOD_GSK3_1	506	513	PF00069	0.536
MOD_GSK3_1	560	567	PF00069	0.482
MOD_GSK3_1	586	593	PF00069	0.471
MOD_GSK3_1	59	66	PF00069	0.668
MOD_GSK3_1	653	660	PF00069	0.542
MOD_GSK3_1	74	81	PF00069	0.678
MOD_GSK3_1	768	775	PF00069	0.436
MOD_GSK3_1	777	784	PF00069	0.349
MOD_GSK3_1	802	809	PF00069	0.403
MOD_GSK3_1	810	817	PF00069	0.436
MOD_GSK3_1	851	858	PF00069	0.474
MOD_LATS_1	261	267	PF00433	0.543
MOD_LATS_1	57	63	PF00433	0.642
MOD_N-GLC_2	396	398	PF02516	0.485
MOD_NEK2_1	146	151	PF00069	0.557
MOD_NEK2_1	21	26	PF00069	0.505
MOD_NEK2_1	210	215	PF00069	0.490
MOD_NEK2_1	306	311	PF00069	0.585
MOD_NEK2_1	407	412	PF00069	0.332
MOD_NEK2_1	58	63	PF00069	0.650
MOD_NEK2_1	683	688	PF00069	0.441
MOD_NEK2_1	725	730	PF00069	0.356
MOD_NEK2_1	785	790	PF00069	0.385
MOD_NEK2_1	796	801	PF00069	0.305
MOD_PIKK_1	138	144	PF00454	0.685
MOD_PIKK_1	177	183	PF00454	0.507
MOD_PIKK_1	512	518	PF00454	0.579
MOD_PK_1	63	69	PF00069	0.628
MOD_PKA_1	408	414	PF00069	0.250
MOD_PKA_1	560	566	PF00069	0.531
MOD_PKA_1	59	65	PF00069	0.667
MOD_PKA_1	761	767	PF00069	0.486
MOD_PKA_2	211	217	PF00069	0.433
MOD_PKA_2	245	251	PF00069	0.505
MOD_PKA_2	25	31	PF00069	0.389
MOD_PKA_2	259	265	PF00069	0.490
MOD_PKA_2	268	274	PF00069	0.574
MOD_PKA_2	346	352	PF00069	0.440
MOD_PKA_2	385	391	PF00069	0.304
MOD_PKA_2	495	501	PF00069	0.446
MOD_PKA_2	549	555	PF00069	0.481
MOD_PKA_2	560	566	PF00069	0.513
MOD_PKA_2	572	578	PF00069	0.368
MOD_PKA_2	58	64	PF00069	0.672
MOD_PKA_2	657	663	PF00069	0.512
MOD_PKA_2	760	766	PF00069	0.510
MOD_PKA_2	817	823	PF00069	0.507
MOD_PKB_1	804	812	PF00069	0.429
MOD_Plk_1	112	118	PF00069	0.602
MOD_Plk_1	403	409	PF00069	0.332
MOD_Plk_4	112	118	PF00069	0.587
MOD_Plk_4	201	207	PF00069	0.481
MOD_Plk_4	248	254	PF00069	0.515
MOD_Plk_4	25	31	PF00069	0.412
MOD_Plk_4	715	721	PF00069	0.457
MOD_Plk_4	796	802	PF00069	0.388
MOD_Plk_4	91	97	PF00069	0.661
MOD_ProDKin_1	127	133	PF00069	0.750
MOD_ProDKin_1	134	140	PF00069	0.747
MOD_ProDKin_1	165	171	PF00069	0.596
MOD_ProDKin_1	192	198	PF00069	0.519
MOD_ProDKin_1	254	260	PF00069	0.579
MOD_ProDKin_1	32	38	PF00069	0.413
MOD_ProDKin_1	353	359	PF00069	0.458
MOD_ProDKin_1	434	440	PF00069	0.301
MOD_ProDKin_1	517	523	PF00069	0.495
MOD_ProDKin_1	539	545	PF00069	0.518
MOD_ProDKin_1	664	670	PF00069	0.552
MOD_ProDKin_1	699	705	PF00069	0.564
TRG_DiLeu_BaEn_1	736	741	PF01217	0.388
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.675
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.439
TRG_DiLeu_BaLyEn_6	577	582	PF01217	0.403
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.464
TRG_ENDOCYTIC_2	370	373	PF00928	0.332
TRG_ER_diArg_1	108	110	PF00400	0.649
TRG_ER_diArg_1	121	123	PF00400	0.635
TRG_ER_diArg_1	207	209	PF00400	0.493
TRG_ER_diArg_1	223	225	PF00400	0.535
TRG_ER_diArg_1	3	5	PF00400	0.571
TRG_ER_diArg_1	391	394	PF00400	0.377
TRG_ER_diArg_1	412	414	PF00400	0.353
TRG_ER_diArg_1	491	494	PF00400	0.438
TRG_ER_diArg_1	532	534	PF00400	0.540
TRG_ER_diArg_1	58	60	PF00400	0.661
TRG_ER_diArg_1	760	762	PF00400	0.440
TRG_ER_diArg_1	803	806	PF00400	0.391
TRG_ER_diArg_1	843	846	PF00400	0.480
TRG_NES_CRM1_1	776	791	PF08389	0.373
TRG_NLS_MonoCore_2	530	535	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9Q8	Leishmania donovani	87%	100%
A4H7B0	Leishmania braziliensis	63%	98%
A4HVQ5	Leishmania infantum	86%	98%
E9APF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%