Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG25_LEIMA

TriTrypDb:

LmjF.13.1290 , LMJLV39_130017200 , LMJSD75_130017200

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	621	625	PF00656	0.529
CLV_C14_Caspase3-7	822	826	PF00656	0.658
CLV_NRD_NRD_1	182	184	PF00675	0.657
CLV_NRD_NRD_1	264	266	PF00675	0.853
CLV_NRD_NRD_1	519	521	PF00675	0.599
CLV_NRD_NRD_1	576	578	PF00675	0.802
CLV_NRD_NRD_1	583	585	PF00675	0.723
CLV_NRD_NRD_1	849	851	PF00675	0.548
CLV_PCSK_FUR_1	180	184	PF00082	0.661
CLV_PCSK_FUR_1	262	266	PF00082	0.851
CLV_PCSK_KEX2_1	182	184	PF00082	0.657
CLV_PCSK_KEX2_1	261	263	PF00082	0.755
CLV_PCSK_KEX2_1	264	266	PF00082	0.751
CLV_PCSK_KEX2_1	519	521	PF00082	0.599
CLV_PCSK_KEX2_1	583	585	PF00082	0.797
CLV_PCSK_KEX2_1	848	850	PF00082	0.565
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.745
CLV_PCSK_SKI1_1	298	302	PF00082	0.713
CLV_PCSK_SKI1_1	449	453	PF00082	0.561
CLV_PCSK_SKI1_1	519	523	PF00082	0.471
CLV_PCSK_SKI1_1	620	624	PF00082	0.575
CLV_PCSK_SKI1_1	69	73	PF00082	0.787
CLV_PCSK_SKI1_1	7	11	PF00082	0.787
DEG_APCC_DBOX_1	448	456	PF00400	0.647
DEG_APCC_DBOX_1	619	627	PF00400	0.608
DEG_SCF_FBW7_1	33	39	PF00400	0.609
DEG_SPOP_SBC_1	100	104	PF00917	0.819
DEG_SPOP_SBC_1	218	222	PF00917	0.787
DEG_SPOP_SBC_1	305	309	PF00917	0.790
DEG_SPOP_SBC_1	415	419	PF00917	0.713
DOC_ANK_TNKS_1	768	775	PF00023	0.866
DOC_CKS1_1	33	38	PF01111	0.655
DOC_CKS1_1	371	376	PF01111	0.683
DOC_CKS1_1	765	770	PF01111	0.817
DOC_MAPK_gen_1	43	51	PF00069	0.792
DOC_MAPK_gen_1	446	456	PF00069	0.504
DOC_MAPK_MEF2A_6	449	456	PF00069	0.648
DOC_MAPK_NFAT4_5	449	457	PF00069	0.648
DOC_PP2B_LxvP_1	338	341	PF13499	0.610
DOC_PP2B_LxvP_1	644	647	PF13499	0.565
DOC_USP7_MATH_1	100	104	PF00917	0.819
DOC_USP7_MATH_1	12	16	PF00917	0.791
DOC_USP7_MATH_1	120	124	PF00917	0.567
DOC_USP7_MATH_1	132	136	PF00917	0.667
DOC_USP7_MATH_1	153	157	PF00917	0.685
DOC_USP7_MATH_1	165	169	PF00917	0.653
DOC_USP7_MATH_1	218	222	PF00917	0.817
DOC_USP7_MATH_1	303	307	PF00917	0.790
DOC_USP7_MATH_1	322	326	PF00917	0.767
DOC_USP7_MATH_1	354	358	PF00917	0.805
DOC_USP7_MATH_1	410	414	PF00917	0.800
DOC_USP7_MATH_1	415	419	PF00917	0.756
DOC_USP7_MATH_1	434	438	PF00917	0.771
DOC_USP7_MATH_1	439	443	PF00917	0.688
DOC_USP7_MATH_1	505	509	PF00917	0.770
DOC_USP7_MATH_1	600	604	PF00917	0.665
DOC_USP7_MATH_1	714	718	PF00917	0.703
DOC_USP7_MATH_1	732	736	PF00917	0.701
DOC_USP7_MATH_1	760	764	PF00917	0.797
DOC_USP7_MATH_1	776	780	PF00917	0.794
DOC_USP7_MATH_1	871	875	PF00917	0.614
DOC_WW_Pin1_4	145	150	PF00397	0.707
DOC_WW_Pin1_4	167	172	PF00397	0.771
DOC_WW_Pin1_4	24	29	PF00397	0.766
DOC_WW_Pin1_4	244	249	PF00397	0.678
DOC_WW_Pin1_4	299	304	PF00397	0.715
DOC_WW_Pin1_4	312	317	PF00397	0.761
DOC_WW_Pin1_4	32	37	PF00397	0.824
DOC_WW_Pin1_4	339	344	PF00397	0.723
DOC_WW_Pin1_4	370	375	PF00397	0.723
DOC_WW_Pin1_4	495	500	PF00397	0.709
DOC_WW_Pin1_4	568	573	PF00397	0.768
DOC_WW_Pin1_4	64	69	PF00397	0.823
DOC_WW_Pin1_4	685	690	PF00397	0.548
DOC_WW_Pin1_4	727	732	PF00397	0.799
DOC_WW_Pin1_4	758	763	PF00397	0.829
DOC_WW_Pin1_4	764	769	PF00397	0.855
DOC_WW_Pin1_4	772	777	PF00397	0.697
DOC_WW_Pin1_4	843	848	PF00397	0.770
DOC_WW_Pin1_4	89	94	PF00397	0.806
LIG_14-3-3_CanoR_1	268	277	PF00244	0.782
LIG_14-3-3_CanoR_1	298	303	PF00244	0.707
LIG_14-3-3_CanoR_1	331	339	PF00244	0.628
LIG_14-3-3_CanoR_1	446	456	PF00244	0.425
LIG_14-3-3_CanoR_1	492	496	PF00244	0.736
LIG_14-3-3_CanoR_1	648	657	PF00244	0.771
LIG_14-3-3_CanoR_1	836	845	PF00244	0.749
LIG_14-3-3_CanoR_1	857	863	PF00244	0.527
LIG_14-3-3_CanoR_1	868	874	PF00244	0.476
LIG_14-3-3_CanoR_1	899	903	PF00244	0.525
LIG_Actin_WH2_2	888	906	PF00022	0.628
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BIR_III_3	1	5	PF00653	0.701
LIG_BIR_III_4	825	829	PF00653	0.627
LIG_BRCT_BRCA1_1	341	345	PF00533	0.734
LIG_BRCT_BRCA1_1	478	482	PF00533	0.733
LIG_BRCT_BRCA1_1	493	497	PF00533	0.560
LIG_BRCT_BRCA1_1	507	511	PF00533	0.719
LIG_Clathr_ClatBox_1	453	457	PF01394	0.643
LIG_deltaCOP1_diTrp_1	543	551	PF00928	0.519
LIG_FHA_1	223	229	PF00498	0.783
LIG_FHA_1	319	325	PF00498	0.836
LIG_FHA_1	361	367	PF00498	0.642
LIG_FHA_1	371	377	PF00498	0.789
LIG_FHA_1	417	423	PF00498	0.751
LIG_FHA_1	550	556	PF00498	0.628
LIG_FHA_1	59	65	PF00498	0.631
LIG_FHA_1	639	645	PF00498	0.731
LIG_FHA_1	739	745	PF00498	0.751
LIG_FHA_1	786	792	PF00498	0.543
LIG_FHA_2	174	180	PF00498	0.580
LIG_FHA_2	585	591	PF00498	0.725
LIG_FHA_2	619	625	PF00498	0.614
LIG_FHA_2	721	727	PF00498	0.829
LIG_Integrin_RGD_1	139	141	PF01839	0.621
LIG_LIR_Apic_2	260	266	PF02991	0.739
LIG_LIR_Apic_2	683	689	PF02991	0.535
LIG_LIR_Gen_1	342	352	PF02991	0.705
LIG_LIR_Gen_1	522	533	PF02991	0.517
LIG_LIR_Gen_1	839	847	PF02991	0.778
LIG_LIR_Nem_3	141	146	PF02991	0.780
LIG_LIR_Nem_3	342	348	PF02991	0.706
LIG_LIR_Nem_3	423	428	PF02991	0.765
LIG_LIR_Nem_3	480	486	PF02991	0.713
LIG_LIR_Nem_3	508	514	PF02991	0.606
LIG_LIR_Nem_3	522	528	PF02991	0.420
LIG_LIR_Nem_3	543	547	PF02991	0.457
LIG_LIR_Nem_3	839	845	PF02991	0.784
LIG_MLH1_MIPbox_1	479	483	PF16413	0.700
LIG_NRBOX	677	683	PF00104	0.554
LIG_SH2_CRK	112	116	PF00017	0.666
LIG_SH2_CRK	800	804	PF00017	0.485
LIG_SH2_PTP2	686	689	PF00017	0.584
LIG_SH2_STAP1	913	917	PF00017	0.520
LIG_SH2_STAT5	541	544	PF00017	0.519
LIG_SH2_STAT5	686	689	PF00017	0.537
LIG_SH3_1	87	93	PF00018	0.810
LIG_SH3_3	158	164	PF00018	0.679
LIG_SH3_3	313	319	PF00018	0.774
LIG_SH3_3	338	344	PF00018	0.622
LIG_SH3_3	363	369	PF00018	0.645
LIG_SH3_3	371	377	PF00018	0.821
LIG_SH3_3	48	54	PF00018	0.867
LIG_SH3_3	496	502	PF00018	0.809
LIG_SH3_3	592	598	PF00018	0.874
LIG_SH3_3	640	646	PF00018	0.590
LIG_SH3_3	684	690	PF00018	0.644
LIG_SH3_3	728	734	PF00018	0.759
LIG_SH3_3	770	776	PF00018	0.794
LIG_SH3_3	87	93	PF00018	0.787
LIG_SH3_3	877	883	PF00018	0.591
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.562
LIG_SUMO_SIM_anti_2	674	680	PF11976	0.533
LIG_SUMO_SIM_par_1	247	253	PF11976	0.640
LIG_SUMO_SIM_par_1	450	457	PF11976	0.636
LIG_TRAF2_1	176	179	PF00917	0.808
LIG_TYR_ITIM	798	803	PF00017	0.483
LIG_Vh1_VBS_1	862	880	PF01044	0.612
LIG_WW_3	645	649	PF00397	0.589
LIG_WW_3	688	692	PF00397	0.548
MOD_CDC14_SPxK_1	27	30	PF00782	0.598
MOD_CDC14_SPxK_1	688	691	PF00782	0.556
MOD_CDC14_SPxK_1	846	849	PF00782	0.566
MOD_CDK_SPK_2	145	150	PF00069	0.610
MOD_CDK_SPK_2	64	69	PF00069	0.787
MOD_CDK_SPK_2	764	769	PF00069	0.819
MOD_CDK_SPK_2	843	848	PF00069	0.692
MOD_CDK_SPxK_1	24	30	PF00069	0.610
MOD_CDK_SPxK_1	32	38	PF00069	0.569
MOD_CDK_SPxK_1	685	691	PF00069	0.538
MOD_CDK_SPxK_1	843	849	PF00069	0.574
MOD_CDK_SPxxK_3	843	850	PF00069	0.765
MOD_CK1_1	123	129	PF00069	0.744
MOD_CK1_1	222	228	PF00069	0.777
MOD_CK1_1	282	288	PF00069	0.845
MOD_CK1_1	304	310	PF00069	0.734
MOD_CK1_1	315	321	PF00069	0.735
MOD_CK1_1	414	420	PF00069	0.843
MOD_CK1_1	437	443	PF00069	0.723
MOD_CK1_1	566	572	PF00069	0.762
MOD_CK1_1	63	69	PF00069	0.805
MOD_CK1_1	651	657	PF00069	0.742
MOD_CK1_1	730	736	PF00069	0.768
MOD_CK1_1	738	744	PF00069	0.787
MOD_CK1_1	761	767	PF00069	0.802
MOD_CK1_1	906	912	PF00069	0.570
MOD_CK1_1	92	98	PF00069	0.760
MOD_CK2_1	173	179	PF00069	0.582
MOD_CK2_1	720	726	PF00069	0.806
MOD_CK2_1	906	912	PF00069	0.524
MOD_Cter_Amidation	581	584	PF01082	0.813
MOD_GlcNHglycan	115	118	PF01048	0.763
MOD_GlcNHglycan	126	129	PF01048	0.700
MOD_GlcNHglycan	130	133	PF01048	0.646
MOD_GlcNHglycan	171	174	PF01048	0.706
MOD_GlcNHglycan	208	211	PF01048	0.833
MOD_GlcNHglycan	238	241	PF01048	0.764
MOD_GlcNHglycan	24	27	PF01048	0.739
MOD_GlcNHglycan	271	274	PF01048	0.782
MOD_GlcNHglycan	303	306	PF01048	0.695
MOD_GlcNHglycan	324	327	PF01048	0.855
MOD_GlcNHglycan	333	336	PF01048	0.775
MOD_GlcNHglycan	356	359	PF01048	0.799
MOD_GlcNHglycan	413	416	PF01048	0.754
MOD_GlcNHglycan	436	439	PF01048	0.750
MOD_GlcNHglycan	441	444	PF01048	0.686
MOD_GlcNHglycan	449	452	PF01048	0.527
MOD_GlcNHglycan	507	510	PF01048	0.721
MOD_GlcNHglycan	565	568	PF01048	0.735
MOD_GlcNHglycan	602	605	PF01048	0.512
MOD_GlcNHglycan	648	651	PF01048	0.756
MOD_GlcNHglycan	69	72	PF01048	0.747
MOD_GlcNHglycan	783	786	PF01048	0.739
MOD_GlcNHglycan	838	841	PF01048	0.739
MOD_GlcNHglycan	873	876	PF01048	0.616
MOD_GSK3_1	120	127	PF00069	0.792
MOD_GSK3_1	128	135	PF00069	0.806
MOD_GSK3_1	141	148	PF00069	0.642
MOD_GSK3_1	165	172	PF00069	0.684
MOD_GSK3_1	202	209	PF00069	0.763
MOD_GSK3_1	218	225	PF00069	0.805
MOD_GSK3_1	232	239	PF00069	0.715
MOD_GSK3_1	279	286	PF00069	0.802
MOD_GSK3_1	299	306	PF00069	0.786
MOD_GSK3_1	318	325	PF00069	0.793
MOD_GSK3_1	32	39	PF00069	0.694
MOD_GSK3_1	372	379	PF00069	0.780
MOD_GSK3_1	387	394	PF00069	0.487
MOD_GSK3_1	406	413	PF00069	0.792
MOD_GSK3_1	430	437	PF00069	0.742
MOD_GSK3_1	473	480	PF00069	0.678
MOD_GSK3_1	491	498	PF00069	0.538
MOD_GSK3_1	549	556	PF00069	0.569
MOD_GSK3_1	56	63	PF00069	0.766
MOD_GSK3_1	561	568	PF00069	0.687
MOD_GSK3_1	572	579	PF00069	0.822
MOD_GSK3_1	646	653	PF00069	0.830
MOD_GSK3_1	681	688	PF00069	0.600
MOD_GSK3_1	714	721	PF00069	0.823
MOD_GSK3_1	732	739	PF00069	0.754
MOD_GSK3_1	760	767	PF00069	0.795
MOD_GSK3_1	772	779	PF00069	0.770
MOD_GSK3_1	781	788	PF00069	0.643
MOD_GSK3_1	858	865	PF00069	0.620
MOD_GSK3_1	898	905	PF00069	0.549
MOD_GSK3_1	95	102	PF00069	0.791
MOD_N-GLC_1	206	211	PF02516	0.603
MOD_NEK2_1	101	106	PF00069	0.717
MOD_NEK2_1	187	192	PF00069	0.735
MOD_NEK2_1	281	286	PF00069	0.778
MOD_NEK2_1	393	398	PF00069	0.457
MOD_NEK2_1	565	570	PF00069	0.697
MOD_NEK2_1	60	65	PF00069	0.717
MOD_NEK2_1	637	642	PF00069	0.644
MOD_NEK2_1	681	686	PF00069	0.613
MOD_NEK2_1	73	78	PF00069	0.813
MOD_NEK2_1	786	791	PF00069	0.721
MOD_NEK2_1	862	867	PF00069	0.583
MOD_NEK2_1	869	874	PF00069	0.481
MOD_NEK2_1	902	907	PF00069	0.606
MOD_PIKK_1	416	422	PF00454	0.783
MOD_PIKK_1	527	533	PF00454	0.627
MOD_PIKK_1	648	654	PF00454	0.715
MOD_PIKK_1	786	792	PF00454	0.712
MOD_PKA_1	519	525	PF00069	0.474
MOD_PKA_1	577	583	PF00069	0.767
MOD_PKA_2	22	28	PF00069	0.732
MOD_PKA_2	232	238	PF00069	0.855
MOD_PKA_2	279	285	PF00069	0.822
MOD_PKA_2	491	497	PF00069	0.746
MOD_PKA_2	519	525	PF00069	0.474
MOD_PKA_2	56	62	PF00069	0.733
MOD_PKA_2	576	582	PF00069	0.758
MOD_PKA_2	835	841	PF00069	0.829
MOD_PKA_2	898	904	PF00069	0.606
MOD_PKB_1	137	145	PF00069	0.619
MOD_Plk_1	786	792	PF00069	0.683
MOD_Plk_4	196	202	PF00069	0.798
MOD_Plk_4	219	225	PF00069	0.705
MOD_Plk_4	681	687	PF00069	0.521
MOD_Plk_4	858	864	PF00069	0.616
MOD_Plk_4	898	904	PF00069	0.519
MOD_ProDKin_1	145	151	PF00069	0.706
MOD_ProDKin_1	167	173	PF00069	0.767
MOD_ProDKin_1	24	30	PF00069	0.765
MOD_ProDKin_1	244	250	PF00069	0.678
MOD_ProDKin_1	299	305	PF00069	0.713
MOD_ProDKin_1	312	318	PF00069	0.759
MOD_ProDKin_1	32	38	PF00069	0.827
MOD_ProDKin_1	339	345	PF00069	0.720
MOD_ProDKin_1	370	376	PF00069	0.723
MOD_ProDKin_1	495	501	PF00069	0.726
MOD_ProDKin_1	568	574	PF00069	0.770
MOD_ProDKin_1	64	70	PF00069	0.822
MOD_ProDKin_1	685	691	PF00069	0.555
MOD_ProDKin_1	727	733	PF00069	0.796
MOD_ProDKin_1	758	764	PF00069	0.832
MOD_ProDKin_1	772	778	PF00069	0.696
MOD_ProDKin_1	843	849	PF00069	0.768
MOD_ProDKin_1	89	95	PF00069	0.807
MOD_SUMO_for_1	71	74	PF00179	0.791
MOD_SUMO_rev_2	717	722	PF00179	0.792
TRG_DiLeu_BaEn_4	244	250	PF01217	0.646
TRG_ENDOCYTIC_2	800	803	PF00928	0.481
TRG_ENDOCYTIC_2	842	845	PF00928	0.819
TRG_ER_diArg_1	180	183	PF00400	0.662
TRG_ER_diArg_1	263	265	PF00400	0.841
TRG_ER_diArg_1	518	520	PF00400	0.602
TRG_ER_diArg_1	791	794	PF00400	0.540
TRG_ER_diArg_1	847	850	PF00400	0.681
TRG_NLS_MonoExtC_3	260	265	PF00514	0.815
TRG_NLS_MonoExtN_4	258	265	PF00514	0.812
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW5	Leptomonas seymouri	30%	97%
A0A3Q8I9N0	Leishmania donovani	87%	100%
A4H7B2	Leishmania braziliensis	62%	87%
A4HVQ7	Leishmania infantum	87%	100%
E9APF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%