Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QG23_LEIMA

TriTrypDb:

LmjF.13.1310 , LMJLV39_130017400 , LMJSD75_130017400

Length:

420

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 6
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QG23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.325
CLV_PCSK_SKI1_1	209	213	PF00082	0.408
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DOC_MAPK_gen_1	16	25	PF00069	0.552
DOC_MAPK_MEF2A_6	16	25	PF00069	0.522
DOC_PP4_FxxP_1	170	173	PF00568	0.283
DOC_PP4_FxxP_1	394	397	PF00568	0.688
DOC_PP4_FxxP_1	52	55	PF00568	0.382
DOC_USP7_MATH_1	129	133	PF00917	0.238
DOC_USP7_MATH_1	196	200	PF00917	0.283
DOC_USP7_MATH_1	55	59	PF00917	0.401
DOC_USP7_MATH_1	6	10	PF00917	0.492
DOC_WW_Pin1_4	108	113	PF00397	0.245
DOC_WW_Pin1_4	172	177	PF00397	0.372
LIG_14-3-3_CanoR_1	143	151	PF00244	0.349
LIG_14-3-3_CanoR_1	202	207	PF00244	0.254
LIG_14-3-3_CanoR_1	253	260	PF00244	0.297
LIG_ActinCP_TwfCPI_2	52	61	PF01115	0.357
LIG_BIR_III_2	109	113	PF00653	0.245
LIG_BRCT_BRCA1_1	203	207	PF00533	0.283
LIG_BRCT_BRCA1_1	254	258	PF00533	0.379
LIG_deltaCOP1_diTrp_1	361	367	PF00928	0.614
LIG_EH_1	391	395	PF12763	0.637
LIG_FHA_1	119	125	PF00498	0.322
LIG_FHA_1	161	167	PF00498	0.373
LIG_FHA_1	400	406	PF00498	0.633
LIG_FHA_1	83	89	PF00498	0.296
LIG_FHA_2	143	149	PF00498	0.316
LIG_FHA_2	219	225	PF00498	0.325
LIG_IRF3_LxIS_1	151	158	PF10401	0.283
LIG_LIR_Apic_2	51	55	PF02991	0.421
LIG_LIR_Gen_1	98	106	PF02991	0.301
LIG_LIR_Nem_3	131	136	PF02991	0.317
LIG_LIR_Nem_3	232	236	PF02991	0.391
LIG_LIR_Nem_3	98	104	PF02991	0.289
LIG_Pex14_1	286	290	PF04695	0.382
LIG_Pex14_1	363	367	PF04695	0.612
LIG_Pex14_2	133	137	PF04695	0.283
LIG_Pex14_2	187	191	PF04695	0.316
LIG_SH2_CRK	101	105	PF00017	0.356
LIG_SH2_STAT3	181	184	PF00017	0.304
LIG_SH2_STAT5	103	106	PF00017	0.308
LIG_SH2_STAT5	165	168	PF00017	0.271
LIG_SH2_STAT5	169	172	PF00017	0.401
LIG_SH2_STAT5	231	234	PF00017	0.361
LIG_SH2_STAT5	74	77	PF00017	0.353
LIG_SH3_3	148	154	PF00018	0.291
LIG_SH3_3	170	176	PF00018	0.288
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.555
LIG_SUMO_SIM_anti_2	292	298	PF11976	0.372
LIG_SUMO_SIM_par_1	19	24	PF11976	0.592
LIG_SUMO_SIM_par_1	28	34	PF11976	0.492
LIG_TRAF2_1	325	328	PF00917	0.698
LIG_WRC_WIRS_1	49	54	PF05994	0.352
MOD_CK1_1	111	117	PF00069	0.209
MOD_CK1_1	131	137	PF00069	0.353
MOD_CK1_1	220	226	PF00069	0.338
MOD_CK1_1	337	343	PF00069	0.698
MOD_CK1_1	395	401	PF00069	0.724
MOD_GlcNHglycan	126	129	PF01048	0.528
MOD_GlcNHglycan	227	230	PF01048	0.657
MOD_GlcNHglycan	352	355	PF01048	0.520
MOD_GlcNHglycan	398	401	PF01048	0.467
MOD_GlcNHglycan	56	60	PF01048	0.567
MOD_GSK3_1	104	111	PF00069	0.366
MOD_GSK3_1	124	131	PF00069	0.369
MOD_GSK3_1	216	223	PF00069	0.338
MOD_GSK3_1	225	232	PF00069	0.384
MOD_GSK3_1	237	244	PF00069	0.401
MOD_GSK3_1	248	255	PF00069	0.386
MOD_GSK3_1	262	269	PF00069	0.352
MOD_GSK3_1	330	337	PF00069	0.722
MOD_GSK3_1	346	353	PF00069	0.768
MOD_GSK3_1	366	373	PF00069	0.805
MOD_GSK3_1	392	399	PF00069	0.673
MOD_N-GLC_1	191	196	PF02516	0.483
MOD_N-GLC_1	242	247	PF02516	0.653
MOD_N-GLC_1	275	280	PF02516	0.673
MOD_NEK2_1	155	160	PF00069	0.283
MOD_NEK2_1	191	196	PF00069	0.258
MOD_NEK2_1	236	241	PF00069	0.393
MOD_NEK2_1	275	280	PF00069	0.570
MOD_NEK2_1	302	307	PF00069	0.290
MOD_NEK2_1	338	343	PF00069	0.693
MOD_NEK2_2	160	165	PF00069	0.215
MOD_PIKK_1	196	202	PF00454	0.270
MOD_PIKK_1	248	254	PF00454	0.388
MOD_PIKK_1	262	268	PF00454	0.303
MOD_PIKK_1	346	352	PF00454	0.781
MOD_PKA_1	413	419	PF00069	0.667
MOD_PKA_2	142	148	PF00069	0.349
MOD_PKA_2	201	207	PF00069	0.279
MOD_PKA_2	252	258	PF00069	0.342
MOD_Plk_1	217	223	PF00069	0.316
MOD_Plk_1	242	248	PF00069	0.377
MOD_Plk_2-3	218	224	PF00069	0.283
MOD_Plk_4	160	166	PF00069	0.295
MOD_Plk_4	186	192	PF00069	0.262
MOD_Plk_4	202	208	PF00069	0.274
MOD_Plk_4	237	243	PF00069	0.429
MOD_Plk_4	334	340	PF00069	0.694
MOD_ProDKin_1	108	114	PF00069	0.245
MOD_ProDKin_1	172	178	PF00069	0.372
MOD_SUMO_rev_2	218	228	PF00179	0.270
TRG_ENDOCYTIC_2	101	104	PF00928	0.352
TRG_ENDOCYTIC_2	233	236	PF00928	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY91	Leptomonas seymouri	34%	100%
A0A0N1PG18	Leptomonas seymouri	47%	94%
A0A1X0NVE8	Trypanosomatidae	22%	100%
A0A3S5H587	Leishmania donovani	33%	100%
A0A3S5H6P8	Leishmania donovani	87%	100%
A4H3U3	Leishmania braziliensis	32%	100%
A4H7B4	Leishmania braziliensis	67%	100%
A4HS17	Leishmania infantum	33%	100%
A4HVQ9	Leishmania infantum	87%	100%
E9AK04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9APF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q9XZY2	Leishmania major	33%	100%