LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QG22_LEIMA
TriTrypDb:
LmjF.13.1320 , LMJLV39_130017500 , LMJSD75_130017500
Length:
464

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 12, no: 2
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

Q4QG22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 300 306 PF00089 0.421
CLV_NRD_NRD_1 157 159 PF00675 0.428
CLV_NRD_NRD_1 342 344 PF00675 0.509
CLV_NRD_NRD_1 375 377 PF00675 0.548
CLV_NRD_NRD_1 431 433 PF00675 0.544
CLV_NRD_NRD_1 435 437 PF00675 0.542
CLV_PCSK_KEX2_1 157 159 PF00082 0.428
CLV_PCSK_KEX2_1 342 344 PF00082 0.510
CLV_PCSK_KEX2_1 375 377 PF00082 0.552
CLV_PCSK_KEX2_1 431 433 PF00082 0.543
CLV_PCSK_KEX2_1 435 437 PF00082 0.541
CLV_PCSK_PC7_1 431 437 PF00082 0.562
CLV_PCSK_SKI1_1 251 255 PF00082 0.668
DEG_Nend_UBRbox_1 1 4 PF02207 0.594
DOC_MAPK_gen_1 288 295 PF00069 0.657
DOC_PP1_RVXF_1 249 256 PF00149 0.484
DOC_USP7_MATH_1 105 109 PF00917 0.332
DOC_WW_Pin1_4 332 337 PF00397 0.750
LIG_14-3-3_CanoR_1 234 244 PF00244 0.440
LIG_14-3-3_CanoR_1 440 449 PF00244 0.803
LIG_BIR_III_4 67 71 PF00653 0.263
LIG_BRCT_BRCA1_1 442 446 PF00533 0.755
LIG_Clathr_ClatBox_1 202 206 PF01394 0.302
LIG_FHA_1 197 203 PF00498 0.452
LIG_FHA_1 59 65 PF00498 0.323
LIG_FHA_2 380 386 PF00498 0.654
LIG_FHA_2 443 449 PF00498 0.702
LIG_FHA_2 58 64 PF00498 0.258
LIG_LIR_Apic_2 418 424 PF02991 0.685
LIG_LIR_Gen_1 219 230 PF02991 0.337
LIG_LIR_Gen_1 252 263 PF02991 0.412
LIG_LIR_Nem_3 149 155 PF02991 0.302
LIG_LIR_Nem_3 219 225 PF02991 0.370
LIG_LIR_Nem_3 227 231 PF02991 0.368
LIG_LIR_Nem_3 252 258 PF02991 0.427
LIG_LIR_Nem_3 443 449 PF02991 0.756
LIG_MYND_1 325 329 PF01753 0.637
LIG_NRBOX 11 17 PF00104 0.461
LIG_PDZ_Class_2 459 464 PF00595 0.733
LIG_Pex14_1 133 137 PF04695 0.330
LIG_Pex14_1 152 156 PF04695 0.316
LIG_Pex14_1 260 264 PF04695 0.358
LIG_Pex14_2 246 250 PF04695 0.500
LIG_SH2_CRK 222 226 PF00017 0.298
LIG_SH2_CRK 322 326 PF00017 0.667
LIG_SH2_NCK_1 195 199 PF00017 0.326
LIG_SH2_NCK_1 322 326 PF00017 0.667
LIG_SH2_SRC 421 424 PF00017 0.685
LIG_SH2_STAT5 100 103 PF00017 0.341
LIG_SH2_STAT5 188 191 PF00017 0.364
LIG_SH2_STAT5 281 284 PF00017 0.394
LIG_SH2_STAT5 308 311 PF00017 0.730
LIG_SH2_STAT5 58 61 PF00017 0.339
LIG_SH3_3 104 110 PF00018 0.317
LIG_SH3_3 173 179 PF00018 0.343
LIG_SH3_3 205 211 PF00018 0.357
LIG_SH3_3 229 235 PF00018 0.513
LIG_SH3_3 402 408 PF00018 0.686
LIG_SH3_3 446 452 PF00018 0.755
LIG_SUMO_SIM_par_1 11 17 PF11976 0.491
LIG_TRAF2_1 289 292 PF00917 0.669
LIG_TRAF2_1 336 339 PF00917 0.756
LIG_TRAF2_1 420 423 PF00917 0.708
LIG_TRAF2_1 60 63 PF00917 0.239
LIG_TRAF2_2 353 358 PF00917 0.675
LIG_TRFH_1 228 232 PF08558 0.328
LIG_UBA3_1 33 39 PF00899 0.448
LIG_Vh1_VBS_1 7 25 PF01044 0.401
MOD_CK1_1 194 200 PF00069 0.323
MOD_CK1_1 45 51 PF00069 0.338
MOD_CK2_1 368 374 PF00069 0.699
MOD_CK2_1 379 385 PF00069 0.643
MOD_CK2_1 407 413 PF00069 0.689
MOD_CK2_1 49 55 PF00069 0.437
MOD_CK2_1 57 63 PF00069 0.295
MOD_GlcNHglycan 103 106 PF01048 0.559
MOD_GlcNHglycan 18 21 PF01048 0.574
MOD_GlcNHglycan 409 412 PF01048 0.632
MOD_GlcNHglycan 423 427 PF01048 0.614
MOD_GlcNHglycan 44 47 PF01048 0.573
MOD_GlcNHglycan 51 54 PF01048 0.588
MOD_GSK3_1 105 112 PF00069 0.281
MOD_GSK3_1 119 126 PF00069 0.366
MOD_GSK3_1 356 363 PF00069 0.721
MOD_GSK3_1 364 371 PF00069 0.666
MOD_GSK3_1 40 47 PF00069 0.309
MOD_GSK3_1 422 429 PF00069 0.779
MOD_GSK3_1 438 445 PF00069 0.735
MOD_GSK3_1 54 61 PF00069 0.202
MOD_GSK3_1 71 78 PF00069 0.285
MOD_GSK3_1 94 101 PF00069 0.293
MOD_NEK2_1 16 21 PF00069 0.516
MOD_NEK2_1 364 369 PF00069 0.652
MOD_NEK2_1 42 47 PF00069 0.358
MOD_NEK2_1 49 54 PF00069 0.379
MOD_NEK2_2 283 288 PF00069 0.530
MOD_PIKK_1 160 166 PF00454 0.339
MOD_PIKK_1 315 321 PF00454 0.703
MOD_PIKK_1 379 385 PF00454 0.631
MOD_PIKK_1 440 446 PF00454 0.755
MOD_PK_1 438 444 PF00069 0.810
MOD_PKA_1 157 163 PF00069 0.228
MOD_PKA_1 431 437 PF00069 0.764
MOD_PKA_2 157 163 PF00069 0.238
MOD_PKA_2 430 436 PF00069 0.792
MOD_PKA_2 94 100 PF00069 0.209
MOD_PKB_1 436 444 PF00069 0.761
MOD_Plk_1 360 366 PF00069 0.722
MOD_Plk_1 399 405 PF00069 0.812
MOD_Plk_1 54 60 PF00069 0.325
MOD_Plk_1 95 101 PF00069 0.352
MOD_Plk_4 54 60 PF00069 0.367
MOD_Plk_4 75 81 PF00069 0.333
MOD_Plk_4 95 101 PF00069 0.221
MOD_ProDKin_1 332 338 PF00069 0.748
MOD_SUMO_for_1 289 292 PF00179 0.630
TRG_DiLeu_BaLyEn_6 198 203 PF01217 0.313
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.300
TRG_ENDOCYTIC_2 222 225 PF00928 0.287
TRG_ER_diArg_1 156 158 PF00400 0.228
TRG_ER_diArg_1 435 438 PF00400 0.741
TRG_Pf-PMV_PEXEL_1 201 206 PF00026 0.538
TRG_Pf-PMV_PEXEL_1 440 444 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 47% 98%
A0A1X0NN75 Trypanosomatidae 24% 100%
A0A1X0NVE8 Trypanosomatidae 26% 100%
A0A3S7WSM6 Leishmania donovani 90% 100%
A0A3S7X9E7 Leishmania donovani 35% 100%
A0A422MPN3 Trypanosoma rangeli 22% 100%
A4H7B5 Leishmania braziliensis 67% 98%
A4HVR0 Leishmania infantum 90% 100%
C9ZJM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AFA3 Leishmania major 35% 100%
E9AHW4 Leishmania infantum 36% 100%
E9APF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B6F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS