RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG21_LEIMA

TriTrypDb:

LmjF.13.1330 , LMJLV39_130017600 , LMJSD75_130017600

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QG21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.496
CLV_C14_Caspase3-7	299	303	PF00656	0.747
CLV_MEL_PAP_1	275	281	PF00089	0.423
CLV_NRD_NRD_1	147	149	PF00675	0.450
CLV_NRD_NRD_1	362	364	PF00675	0.426
CLV_NRD_NRD_1	415	417	PF00675	0.502
CLV_PCSK_FUR_1	412	416	PF00082	0.497
CLV_PCSK_KEX2_1	147	149	PF00082	0.450
CLV_PCSK_KEX2_1	362	364	PF00082	0.426
CLV_PCSK_KEX2_1	411	413	PF00082	0.527
CLV_PCSK_KEX2_1	414	416	PF00082	0.503
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.522
CLV_PCSK_SKI1_1	189	193	PF00082	0.388
CLV_PCSK_SKI1_1	233	237	PF00082	0.634
CLV_PCSK_SKI1_1	30	34	PF00082	0.636
DEG_APCC_DBOX_1	64	72	PF00400	0.627
DEG_SCF_FBW7_1	387	393	PF00400	0.638
DEG_SCF_FBW7_1	404	410	PF00400	0.703
DEG_SPOP_SBC_1	190	194	PF00917	0.388
DEG_SPOP_SBC_1	450	454	PF00917	0.459
DOC_CKS1_1	387	392	PF01111	0.635
DOC_CKS1_1	404	409	PF01111	0.702
DOC_MAPK_gen_1	63	71	PF00069	0.627
DOC_MAPK_MEF2A_6	420	429	PF00069	0.587
DOC_MAPK_RevD_3	400	413	PF00069	0.714
DOC_PP4_FxxP_1	292	295	PF00568	0.707
DOC_USP7_MATH_1	108	112	PF00917	0.631
DOC_USP7_MATH_1	127	131	PF00917	0.688
DOC_USP7_MATH_1	191	195	PF00917	0.393
DOC_USP7_MATH_1	240	244	PF00917	0.459
DOC_USP7_MATH_1	254	258	PF00917	0.420
DOC_USP7_MATH_1	312	316	PF00917	0.651
DOC_USP7_MATH_1	388	392	PF00917	0.722
DOC_USP7_MATH_1	450	454	PF00917	0.463
DOC_USP7_MATH_1	481	485	PF00917	0.477
DOC_USP7_UBL2_3	105	109	PF12436	0.701
DOC_WW_Pin1_4	131	136	PF00397	0.647
DOC_WW_Pin1_4	228	233	PF00397	0.489
DOC_WW_Pin1_4	249	254	PF00397	0.440
DOC_WW_Pin1_4	325	330	PF00397	0.660
DOC_WW_Pin1_4	366	371	PF00397	0.683
DOC_WW_Pin1_4	386	391	PF00397	0.726
DOC_WW_Pin1_4	403	408	PF00397	0.711
DOC_WW_Pin1_4	421	426	PF00397	0.576
DOC_WW_Pin1_4	451	456	PF00397	0.506
LIG_14-3-3_CanoR_1	128	137	PF00244	0.804
LIG_14-3-3_CanoR_1	147	152	PF00244	0.599
LIG_14-3-3_CanoR_1	189	199	PF00244	0.355
LIG_14-3-3_CanoR_1	237	245	PF00244	0.374
LIG_14-3-3_CanoR_1	483	489	PF00244	0.382
LIG_BRCT_BRCA1_1	272	276	PF00533	0.597
LIG_EH1_1	331	339	PF00400	0.628
LIG_EH1_1	53	61	PF00400	0.430
LIG_eIF4E_1	332	338	PF01652	0.626
LIG_FHA_1	191	197	PF00498	0.307
LIG_FHA_1	239	245	PF00498	0.445
LIG_FHA_1	256	262	PF00498	0.237
LIG_FHA_1	404	410	PF00498	0.759
LIG_FHA_1	417	423	PF00498	0.698
LIG_FHA_1	483	489	PF00498	0.485
LIG_FHA_2	469	475	PF00498	0.455
LIG_LIR_Apic_2	123	129	PF02991	0.690
LIG_LIR_Apic_2	211	217	PF02991	0.429
LIG_LIR_Gen_1	155	166	PF02991	0.641
LIG_LIR_Gen_1	201	207	PF02991	0.369
LIG_LIR_Gen_1	284	293	PF02991	0.728
LIG_LIR_Gen_1	321	332	PF02991	0.636
LIG_LIR_Gen_1	484	491	PF02991	0.420
LIG_LIR_Nem_3	155	161	PF02991	0.636
LIG_LIR_Nem_3	201	205	PF02991	0.369
LIG_LIR_Nem_3	257	262	PF02991	0.391
LIG_LIR_Nem_3	273	279	PF02991	0.581
LIG_LIR_Nem_3	284	289	PF02991	0.691
LIG_LIR_Nem_3	321	327	PF02991	0.641
LIG_LIR_Nem_3	436	442	PF02991	0.312
LIG_LIR_Nem_3	459	465	PF02991	0.497
LIG_LIR_Nem_3	471	476	PF02991	0.419
LIG_LIR_Nem_3	484	489	PF02991	0.432
LIG_MYND_1	339	343	PF01753	0.635
LIG_PDZ_Class_2	486	491	PF00595	0.492
LIG_Pex14_1	272	276	PF04695	0.597
LIG_SH2_CRK	183	187	PF00017	0.475
LIG_SH2_CRK	214	218	PF00017	0.395
LIG_SH2_GRB2like	449	452	PF00017	0.405
LIG_SH2_NCK_1	214	218	PF00017	0.395
LIG_SH2_SRC	449	452	PF00017	0.439
LIG_SH2_STAP1	158	162	PF00017	0.583
LIG_SH2_STAT5	332	335	PF00017	0.630
LIG_SH2_STAT5	476	479	PF00017	0.485
LIG_SH3_2	339	344	PF14604	0.655
LIG_SH3_3	247	253	PF00018	0.469
LIG_SH3_3	336	342	PF00018	0.706
LIG_SH3_3	367	373	PF00018	0.767
LIG_SH3_3	384	390	PF00018	0.647
LIG_SH3_3	401	407	PF00018	0.707
LIG_SH3_3	457	463	PF00018	0.520
LIG_SUMO_SIM_par_1	192	201	PF11976	0.267
LIG_TRAF2_1	94	97	PF00917	0.717
LIG_WRC_WIRS_1	153	158	PF05994	0.504
LIG_WRC_WIRS_1	199	204	PF05994	0.340
LIG_WRC_WIRS_1	261	266	PF05994	0.388
LIG_WW_3	341	345	PF00397	0.532
MOD_CDK_SPK_2	228	233	PF00069	0.563
MOD_CDK_SPK_2	325	330	PF00069	0.531
MOD_CDK_SPK_2	369	374	PF00069	0.588
MOD_CDK_SPK_2	456	461	PF00069	0.589
MOD_CDK_SPxxK_3	369	376	PF00069	0.640
MOD_CK1_1	103	109	PF00069	0.567
MOD_CK1_1	130	136	PF00069	0.605
MOD_CK1_1	198	204	PF00069	0.379
MOD_CK1_1	231	237	PF00069	0.713
MOD_CK1_1	243	249	PF00069	0.511
MOD_CK1_1	369	375	PF00069	0.704
MOD_CK1_1	393	399	PF00069	0.701
MOD_CK1_1	453	459	PF00069	0.559
MOD_CK1_1	484	490	PF00069	0.561
MOD_Cter_Amidation	145	148	PF01082	0.611
MOD_DYRK1A_RPxSP_1	131	135	PF00069	0.515
MOD_GlcNHglycan	119	125	PF01048	0.608
MOD_GlcNHglycan	266	269	PF01048	0.356
MOD_GlcNHglycan	302	306	PF01048	0.715
MOD_GlcNHglycan	392	395	PF01048	0.737
MOD_GlcNHglycan	455	458	PF01048	0.682
MOD_GSK3_1	127	134	PF00069	0.622
MOD_GSK3_1	147	154	PF00069	0.602
MOD_GSK3_1	191	198	PF00069	0.384
MOD_GSK3_1	240	247	PF00069	0.560
MOD_GSK3_1	260	267	PF00069	0.293
MOD_GSK3_1	301	308	PF00069	0.637
MOD_GSK3_1	319	326	PF00069	0.707
MOD_GSK3_1	365	372	PF00069	0.600
MOD_GSK3_1	386	393	PF00069	0.629
MOD_GSK3_1	403	410	PF00069	0.647
MOD_GSK3_1	445	452	PF00069	0.572
MOD_N-GLC_1	255	260	PF02516	0.388
MOD_N-GLC_1	450	455	PF02516	0.538
MOD_NEK2_1	171	176	PF00069	0.588
MOD_NEK2_1	244	249	PF00069	0.656
MOD_NEK2_1	264	269	PF00069	0.183
MOD_NEK2_1	307	312	PF00069	0.583
MOD_NEK2_1	319	324	PF00069	0.602
MOD_NEK2_1	333	338	PF00069	0.442
MOD_NEK2_1	444	449	PF00069	0.525
MOD_NEK2_2	240	245	PF00069	0.561
MOD_PIKK_1	312	318	PF00454	0.593
MOD_PKA_1	147	153	PF00069	0.550
MOD_PKA_2	127	133	PF00069	0.625
MOD_PKA_2	147	153	PF00069	0.475
MOD_PKA_2	353	359	PF00069	0.633
MOD_PKA_2	482	488	PF00069	0.457
MOD_PKB_1	414	422	PF00069	0.628
MOD_Plk_1	120	126	PF00069	0.610
MOD_Plk_1	255	261	PF00069	0.388
MOD_Plk_1	435	441	PF00069	0.340
MOD_Plk_4	10	16	PF00069	0.609
MOD_Plk_4	136	142	PF00069	0.587
MOD_Plk_4	147	153	PF00069	0.557
MOD_Plk_4	198	204	PF00069	0.340
MOD_Plk_4	23	29	PF00069	0.536
MOD_Plk_4	240	246	PF00069	0.585
MOD_Plk_4	281	287	PF00069	0.561
MOD_Plk_4	319	325	PF00069	0.651
MOD_Plk_4	333	339	PF00069	0.446
MOD_Plk_4	347	353	PF00069	0.530
MOD_ProDKin_1	131	137	PF00069	0.553
MOD_ProDKin_1	228	234	PF00069	0.605
MOD_ProDKin_1	249	255	PF00069	0.544
MOD_ProDKin_1	325	331	PF00069	0.570
MOD_ProDKin_1	366	372	PF00069	0.604
MOD_ProDKin_1	386	392	PF00069	0.666
MOD_ProDKin_1	403	409	PF00069	0.646
MOD_ProDKin_1	421	427	PF00069	0.447
MOD_ProDKin_1	451	457	PF00069	0.637
MOD_SUMO_rev_2	26	35	PF00179	0.602
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.683
TRG_ENDOCYTIC_2	158	161	PF00928	0.607
TRG_ENDOCYTIC_2	183	186	PF00928	0.516
TRG_ENDOCYTIC_2	332	335	PF00928	0.529
TRG_ER_diArg_1	361	363	PF00400	0.487
TRG_ER_diArg_1	412	415	PF00400	0.640
TRG_NLS_MonoCore_2	410	415	PF00514	0.654
TRG_NLS_MonoExtC_3	410	415	PF00514	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I976	Leptomonas seymouri	42%	96%
A0A3Q8ICY4	Leishmania donovani	91%	100%
A4H7B6	Leishmania braziliensis	68%	100%
A4HVR1	Leishmania infantum	89%	100%
E9APF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%