Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein, putative

Species:

Leishmania major

UniProt:

Q4QG16_LEIMA

TriTrypDb:

LmjF.13.1380 , LMJLV39_130018100 , LMJSD75_130018100

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QG16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG16

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0072657	protein localization to membrane	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	417	419	PF00675	0.231
CLV_NRD_NRD_1	422	424	PF00675	0.227
CLV_NRD_NRD_1	439	441	PF00675	0.356
CLV_NRD_NRD_1	98	100	PF00675	0.500
CLV_PCSK_KEX2_1	417	419	PF00082	0.230
CLV_PCSK_KEX2_1	421	423	PF00082	0.228
CLV_PCSK_KEX2_1	98	100	PF00082	0.460
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.460
CLV_PCSK_PC7_1	413	419	PF00082	0.243
CLV_PCSK_PC7_1	94	100	PF00082	0.399
CLV_PCSK_SKI1_1	413	417	PF00082	0.239
CLV_PCSK_SKI1_1	440	444	PF00082	0.319
DEG_APCC_DBOX_1	207	215	PF00400	0.300
DOC_MAPK_gen_1	349	358	PF00069	0.438
DOC_PP2B_LxvP_1	342	345	PF13499	0.496
DOC_PP2B_LxvP_1	442	445	PF13499	0.503
DOC_PP2B_PxIxI_1	361	367	PF00149	0.257
DOC_PP2B_PxIxI_1	455	461	PF00149	0.398
DOC_PP4_FxxP_1	270	273	PF00568	0.521
DOC_PP4_FxxP_1	341	344	PF00568	0.562
DOC_PP4_FxxP_1	359	362	PF00568	0.178
DOC_USP7_MATH_1	21	25	PF00917	0.499
DOC_USP7_MATH_1	322	326	PF00917	0.199
DOC_USP7_MATH_1	345	349	PF00917	0.478
DOC_USP7_MATH_1	495	499	PF00917	0.396
DOC_USP7_MATH_1	74	78	PF00917	0.253
DOC_WW_Pin1_4	164	169	PF00397	0.333
LIG_14-3-3_CanoR_1	19	28	PF00244	0.565
LIG_14-3-3_CanoR_1	195	200	PF00244	0.329
LIG_14-3-3_CanoR_1	210	215	PF00244	0.269
LIG_14-3-3_CanoR_1	234	243	PF00244	0.459
LIG_14-3-3_CanoR_1	306	316	PF00244	0.289
LIG_14-3-3_CanoR_1	417	425	PF00244	0.500
LIG_APCC_ABBA_1	458	463	PF00400	0.398
LIG_BRCT_BRCA1_1	181	185	PF00533	0.229
LIG_BRCT_BRCA1_1	196	200	PF00533	0.229
LIG_BRCT_BRCA1_1	51	55	PF00533	0.178
LIG_BRCT_BRCA1_1	516	520	PF00533	0.310
LIG_BRCT_BRCA1_1	91	95	PF00533	0.178
LIG_FHA_1	146	152	PF00498	0.326
LIG_FHA_1	200	206	PF00498	0.363
LIG_FHA_1	285	291	PF00498	0.413
LIG_FHA_1	313	319	PF00498	0.343
LIG_FHA_1	322	328	PF00498	0.245
LIG_FHA_1	355	361	PF00498	0.281
LIG_FHA_1	370	376	PF00498	0.250
LIG_FHA_1	492	498	PF00498	0.271
LIG_FHA_1	500	506	PF00498	0.271
LIG_FHA_2	120	126	PF00498	0.305
LIG_FHA_2	196	202	PF00498	0.301
LIG_FHA_2	66	72	PF00498	0.329
LIG_GBD_Chelix_1	211	219	PF00786	0.310
LIG_GBD_Chelix_1	228	236	PF00786	0.195
LIG_HCF-1_HBM_1	114	117	PF13415	0.178
LIG_LIR_Apic_2	268	273	PF02991	0.501
LIG_LIR_Apic_2	357	362	PF02991	0.221
LIG_LIR_Gen_1	276	283	PF02991	0.481
LIG_LIR_Gen_1	293	302	PF02991	0.431
LIG_LIR_Gen_1	315	322	PF02991	0.455
LIG_LIR_Gen_1	332	342	PF02991	0.247
LIG_LIR_Gen_1	372	379	PF02991	0.404
LIG_LIR_Gen_1	463	471	PF02991	0.389
LIG_LIR_Gen_1	50	61	PF02991	0.245
LIG_LIR_Gen_1	502	509	PF02991	0.282
LIG_LIR_Gen_1	528	538	PF02991	0.276
LIG_LIR_Nem_3	148	153	PF02991	0.313
LIG_LIR_Nem_3	259	265	PF02991	0.436
LIG_LIR_Nem_3	276	282	PF02991	0.426
LIG_LIR_Nem_3	293	298	PF02991	0.323
LIG_LIR_Nem_3	315	319	PF02991	0.335
LIG_LIR_Nem_3	357	361	PF02991	0.316
LIG_LIR_Nem_3	381	387	PF02991	0.295
LIG_LIR_Nem_3	463	467	PF02991	0.386
LIG_LIR_Nem_3	486	492	PF02991	0.314
LIG_LIR_Nem_3	50	56	PF02991	0.240
LIG_LIR_Nem_3	502	506	PF02991	0.296
LIG_LIR_Nem_3	528	534	PF02991	0.264
LIG_MYND_1	432	436	PF01753	0.414
LIG_NRBOX	2	8	PF00104	0.485
LIG_NRBOX	218	224	PF00104	0.385
LIG_NRBOX	68	74	PF00104	0.308
LIG_Pex14_1	262	266	PF04695	0.443
LIG_Pex14_1	350	354	PF04695	0.533
LIG_Pex14_2	196	200	PF04695	0.224
LIG_Pex14_2	354	358	PF04695	0.415
LIG_Pex14_2	369	373	PF04695	0.415
LIG_Pex14_2	395	399	PF04695	0.238
LIG_Pex14_2	457	461	PF04695	0.374
LIG_Pex14_2	464	468	PF04695	0.340
LIG_Pex14_2	534	538	PF04695	0.367
LIG_SH2_CRK	181	185	PF00017	0.286
LIG_SH2_CRK	480	484	PF00017	0.243
LIG_SH2_CRK	53	57	PF00017	0.240
LIG_SH2_CRK	554	558	PF00017	0.369
LIG_SH2_GRB2like	192	195	PF00017	0.321
LIG_SH2_NCK_1	181	185	PF00017	0.286
LIG_SH2_NCK_1	266	270	PF00017	0.521
LIG_SH2_PTP2	150	153	PF00017	0.308
LIG_SH2_PTP2	490	493	PF00017	0.347
LIG_SH2_SRC	266	269	PF00017	0.459
LIG_SH2_STAP1	104	108	PF00017	0.261
LIG_SH2_STAP1	119	123	PF00017	0.235
LIG_SH2_STAP1	177	181	PF00017	0.237
LIG_SH2_STAP1	192	196	PF00017	0.207
LIG_SH2_STAP1	266	270	PF00017	0.500
LIG_SH2_STAP1	51	55	PF00017	0.284
LIG_SH2_STAP1	531	535	PF00017	0.282
LIG_SH2_STAP1	552	556	PF00017	0.250
LIG_SH2_STAT5	150	153	PF00017	0.244
LIG_SH2_STAT5	204	207	PF00017	0.317
LIG_SH2_STAT5	28	31	PF00017	0.330
LIG_SH2_STAT5	330	333	PF00017	0.372
LIG_SH2_STAT5	365	368	PF00017	0.429
LIG_SH2_STAT5	386	389	PF00017	0.294
LIG_SH2_STAT5	414	417	PF00017	0.468
LIG_SH2_STAT5	447	450	PF00017	0.390
LIG_SH2_STAT5	490	493	PF00017	0.341
LIG_SH2_STAT5	527	530	PF00017	0.262
LIG_SH2_STAT5	536	539	PF00017	0.300
LIG_SH2_STAT5	554	557	PF00017	0.358
LIG_SH2_STAT5	571	574	PF00017	0.269
LIG_SH2_STAT5	576	579	PF00017	0.512
LIG_SH3_1	433	439	PF00018	0.429
LIG_SH3_2	436	441	PF14604	0.486
LIG_SH3_3	181	187	PF00018	0.240
LIG_SH3_3	433	439	PF00018	0.430
LIG_SH3_3	54	60	PF00018	0.169
LIG_SUMO_SIM_anti_2	218	224	PF11976	0.394
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.410
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.391
LIG_SUMO_SIM_par_1	220	226	PF11976	0.321
LIG_SUMO_SIM_par_1	287	293	PF11976	0.372
LIG_SUMO_SIM_par_1	447	452	PF11976	0.351
LIG_TRAF2_1	60	63	PF00917	0.261
LIG_TRFH_1	358	362	PF08558	0.374
LIG_TYR_ITIM	488	493	PF00017	0.345
LIG_TYR_ITSM	146	153	PF00017	0.308
LIG_WRC_WIRS_1	313	318	PF05994	0.430
LIG_WRC_WIRS_1	500	505	PF05994	0.374
LIG_WW_3	437	441	PF00397	0.521
MOD_CDC14_SPxK_1	167	170	PF00782	0.321
MOD_CDK_SPxK_1	164	170	PF00069	0.321
MOD_CK1_1	24	30	PF00069	0.338
MOD_CK1_1	300	306	PF00069	0.321
MOD_CK1_1	470	476	PF00069	0.347
MOD_CK1_1	5	11	PF00069	0.554
MOD_CK1_1	77	83	PF00069	0.320
MOD_CK2_1	119	125	PF00069	0.284
MOD_CK2_1	185	191	PF00069	0.352
MOD_CK2_1	195	201	PF00069	0.305
MOD_CK2_1	65	71	PF00069	0.328
MOD_GlcNHglycan	21	24	PF01048	0.538
MOD_GlcNHglycan	258	262	PF01048	0.286
MOD_GlcNHglycan	324	327	PF01048	0.355
MOD_GlcNHglycan	331	334	PF01048	0.334
MOD_GlcNHglycan	451	454	PF01048	0.398
MOD_GSK3_1	1	8	PF00069	0.579
MOD_GSK3_1	159	166	PF00069	0.369
MOD_GSK3_1	195	202	PF00069	0.232
MOD_GSK3_1	206	213	PF00069	0.184
MOD_GSK3_1	466	473	PF00069	0.417
MOD_GSK3_1	491	498	PF00069	0.288
MOD_N-GLC_1	159	164	PF02516	0.444
MOD_N-GLC_1	215	220	PF02516	0.345
MOD_N-GLC_1	89	94	PF02516	0.483
MOD_NEK2_1	1	6	PF00069	0.578
MOD_NEK2_1	145	150	PF00069	0.290
MOD_NEK2_1	163	168	PF00069	0.321
MOD_NEK2_1	179	184	PF00069	0.159
MOD_NEK2_1	223	228	PF00069	0.323
MOD_NEK2_1	230	235	PF00069	0.315
MOD_NEK2_1	290	295	PF00069	0.334
MOD_NEK2_1	354	359	PF00069	0.294
MOD_NEK2_1	449	454	PF00069	0.317
MOD_NEK2_1	466	471	PF00069	0.253
MOD_NEK2_1	483	488	PF00069	0.312
MOD_NEK2_1	520	525	PF00069	0.271
MOD_NEK2_1	537	542	PF00069	0.253
MOD_NEK2_1	572	577	PF00069	0.421
MOD_NEK2_2	74	79	PF00069	0.178
MOD_PIKK_1	284	290	PF00454	0.391
MOD_PK_1	514	520	PF00069	0.508
MOD_PKA_2	194	200	PF00069	0.333
MOD_PKA_2	273	279	PF00069	0.515
MOD_PKA_2	305	311	PF00069	0.288
MOD_PKA_2	416	422	PF00069	0.500
MOD_PKB_1	208	216	PF00069	0.286
MOD_Plk_1	119	125	PF00069	0.261
MOD_Plk_1	159	165	PF00069	0.208
MOD_Plk_1	215	221	PF00069	0.345
MOD_Plk_1	62	68	PF00069	0.263
MOD_Plk_2-3	186	192	PF00069	0.303
MOD_Plk_4	139	145	PF00069	0.255
MOD_Plk_4	179	185	PF00069	0.260
MOD_Plk_4	195	201	PF00069	0.295
MOD_Plk_4	2	8	PF00069	0.551
MOD_Plk_4	210	216	PF00069	0.240
MOD_Plk_4	223	229	PF00069	0.282
MOD_Plk_4	24	30	PF00069	0.453
MOD_Plk_4	290	296	PF00069	0.450
MOD_Plk_4	297	303	PF00069	0.373
MOD_Plk_4	354	360	PF00069	0.380
MOD_Plk_4	369	375	PF00069	0.349
MOD_Plk_4	467	473	PF00069	0.322
MOD_Plk_4	495	501	PF00069	0.298
MOD_Plk_4	567	573	PF00069	0.269
MOD_Plk_4	74	80	PF00069	0.178
MOD_ProDKin_1	164	170	PF00069	0.333
MOD_SUMO_for_1	169	172	PF00179	0.303
MOD_SUMO_for_1	241	244	PF00179	0.503
MOD_SUMO_rev_2	32	37	PF00179	0.256
TRG_DiLeu_BaEn_2	32	38	PF01217	0.275
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.436
TRG_ENDOCYTIC_2	150	153	PF00928	0.308
TRG_ENDOCYTIC_2	181	184	PF00928	0.286
TRG_ENDOCYTIC_2	266	269	PF00928	0.437
TRG_ENDOCYTIC_2	334	337	PF00928	0.474
TRG_ENDOCYTIC_2	447	450	PF00928	0.417
TRG_ENDOCYTIC_2	480	483	PF00928	0.237
TRG_ENDOCYTIC_2	490	493	PF00928	0.271
TRG_ENDOCYTIC_2	53	56	PF00928	0.247
TRG_ENDOCYTIC_2	531	534	PF00928	0.310
TRG_ENDOCYTIC_2	554	557	PF00928	0.342
TRG_ER_diArg_1	208	211	PF00400	0.263
TRG_ER_diArg_1	416	418	PF00400	0.430
TRG_ER_diArg_1	421	423	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.228

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	26%	88%
A0A0N1I2B1	Leptomonas seymouri	24%	93%
A0A0N1I6Y7	Leptomonas seymouri	25%	95%
A0A0N1IME8	Leptomonas seymouri	60%	100%
A0A0S4IV41	Bodo saltans	29%	92%
A0A0S4J9X2	Bodo saltans	22%	91%
A0A0S4JBB1	Bodo saltans	26%	92%
A0A0S4JCH7	Bodo saltans	24%	86%
A0A0S4JEU5	Bodo saltans	26%	92%
A0A0S4JIF4	Bodo saltans	24%	92%
A0A0S4JWZ9	Bodo saltans	25%	96%
A0A0S4JZ31	Bodo saltans	30%	100%
A0A1X0NJN3	Trypanosomatidae	36%	99%
A0A1X0NK64	Trypanosomatidae	24%	93%
A0A1X0NLM6	Trypanosomatidae	28%	100%
A0A1X0NZX5	Trypanosomatidae	23%	91%
A0A1X0P2G3	Trypanosomatidae	22%	93%
A0A1X0P6M4	Trypanosomatidae	21%	77%
A0A1X0PA12	Trypanosomatidae	25%	93%
A0A3Q8IBT4	Leishmania donovani	86%	100%
A0A3Q8IFM1	Leishmania donovani	23%	92%
A0A3Q8IHT3	Leishmania donovani	22%	92%
A0A3R7MBZ3	Trypanosoma rangeli	25%	93%
A0A3S7X2L7	Leishmania donovani	21%	86%
A0A422NED2	Trypanosoma rangeli	22%	91%
A0A422NMS9	Trypanosoma rangeli	23%	90%
A0A422P482	Trypanosoma rangeli	36%	98%
A4H7C1	Leishmania braziliensis	70%	100%
A4HB85	Leishmania braziliensis	22%	94%
A4HHH4	Leishmania braziliensis	22%	87%
A4HHY3	Leishmania braziliensis	23%	92%
A4HVR6	Leishmania infantum	86%	100%
A4I4M3	Leishmania infantum	21%	86%
A4I563	Leishmania infantum	23%	92%
A4IAD3	Leishmania infantum	22%	92%
A4IFE9	Bos taurus	28%	97%
A5D7E2	Bos taurus	26%	92%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	93%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	94%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AE21	Leishmania major	21%	86%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	86%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	89%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	92%
F4HW17	Arabidopsis thaliana	28%	100%
F4JRE0	Arabidopsis thaliana	25%	90%
F4KIB2	Arabidopsis thaliana	27%	91%
O15321	Homo sapiens	28%	97%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	88%
P58021	Mus musculus	26%	89%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	88%
Q4KLL4	Rattus norvegicus	29%	91%
Q4Q2H8	Leishmania major	22%	92%
Q4Q7S3	Leishmania major	25%	100%
Q54ZW0	Dictyostelium discoideum	27%	100%
Q55FP0	Dictyostelium discoideum	25%	92%
Q5R8F1	Pongo abelii	28%	97%
Q5R8Y6	Pongo abelii	25%	89%
Q5RDY2	Pongo abelii	26%	92%
Q66HF2	Rattus norvegicus	27%	100%
Q66HG5	Rattus norvegicus	25%	89%
Q7YTA6	Dictyostelium discoideum	24%	90%
Q8BH24	Mus musculus	29%	91%
Q8RWW1	Arabidopsis thaliana	24%	92%
Q92544	Homo sapiens	26%	92%
Q940G0	Arabidopsis thaliana	31%	100%
Q940S0	Arabidopsis thaliana	29%	99%
Q99805	Homo sapiens	25%	89%
Q9C5N2	Arabidopsis thaliana	26%	91%
Q9C720	Arabidopsis thaliana	28%	92%
Q9DBU0	Mus musculus	28%	97%
Q9ET30	Mus musculus	32%	100%
Q9FHT4	Arabidopsis thaliana	27%	99%
Q9FYQ8	Arabidopsis thaliana	30%	89%
Q9HD45	Homo sapiens	32%	100%
Q9LIC2	Arabidopsis thaliana	29%	92%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
Q9ZPS7	Arabidopsis thaliana	29%	99%
V5BCD5	Trypanosoma cruzi	24%	93%
V5BHS7	Trypanosoma cruzi	25%	100%
V5D9U0	Trypanosoma cruzi	26%	91%
V5DII3	Trypanosoma cruzi	34%	98%