Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QG15_LEIMA

TriTrypDb:

LmjF.13.1390 , LMJLV39_130018200 , LMJSD75_130018200

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.517
CLV_NRD_NRD_1	142	144	PF00675	0.382
CLV_NRD_NRD_1	376	378	PF00675	0.578
CLV_PCSK_KEX2_1	142	144	PF00082	0.475
CLV_PCSK_KEX2_1	15	17	PF00082	0.580
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.632
CLV_PCSK_SKI1_1	292	296	PF00082	0.378
CLV_PCSK_SKI1_1	31	35	PF00082	0.560
CLV_PCSK_SKI1_1	378	382	PF00082	0.576
DOC_AGCK_PIF_3	398	401	PF00069	0.424
DOC_MAPK_FxFP_2	11	14	PF00069	0.716
DOC_PP1_RVXF_1	101	107	PF00149	0.433
DOC_PP4_FxxP_1	11	14	PF00568	0.716
DOC_PP4_FxxP_1	137	140	PF00568	0.378
DOC_PP4_FxxP_1	186	189	PF00568	0.378
DOC_SPAK_OSR1_1	389	393	PF12202	0.469
DOC_USP7_MATH_1	138	142	PF00917	0.415
DOC_USP7_MATH_1	18	22	PF00917	0.640
DOC_USP7_MATH_1	202	206	PF00917	0.475
DOC_USP7_MATH_1	303	307	PF00917	0.378
DOC_USP7_MATH_1	90	94	PF00917	0.652
DOC_USP7_UBL2_3	171	175	PF12436	0.475
DOC_WW_Pin1_4	130	135	PF00397	0.341
DOC_WW_Pin1_4	222	227	PF00397	0.347
DOC_WW_Pin1_4	324	329	PF00397	0.378
LIG_14-3-3_CanoR_1	377	381	PF00244	0.528
LIG_14-3-3_CanoR_1	89	93	PF00244	0.599
LIG_APCC_ABBA_1	343	348	PF00400	0.378
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_4	69	73	PF00653	0.457
LIG_BRCT_BRCA1_1	140	144	PF00533	0.475
LIG_CtBP_PxDLS_1	315	319	PF00389	0.378
LIG_deltaCOP1_diTrp_1	240	250	PF00928	0.378
LIG_FHA_1	359	365	PF00498	0.435
LIG_FHA_2	205	211	PF00498	0.378
LIG_FHA_2	377	383	PF00498	0.526
LIG_LIR_Apic_2	10	14	PF02991	0.573
LIG_LIR_Apic_2	136	140	PF02991	0.378
LIG_LIR_Apic_2	183	189	PF02991	0.378
LIG_LIR_Apic_2	198	202	PF02991	0.475
LIG_LIR_Gen_1	307	318	PF02991	0.378
LIG_LIR_Gen_1	387	398	PF02991	0.430
LIG_LIR_Nem_3	269	273	PF02991	0.640
LIG_LIR_Nem_3	286	290	PF02991	0.456
LIG_LIR_Nem_3	30	36	PF02991	0.502
LIG_LIR_Nem_3	307	313	PF02991	0.321
LIG_LIR_Nem_3	387	393	PF02991	0.379
LIG_LIR_Nem_3	69	74	PF02991	0.507
LIG_PDZ_Class_2	396	401	PF00595	0.425
LIG_Pex14_2	124	128	PF04695	0.378
LIG_Pex14_2	195	199	PF04695	0.475
LIG_Pex14_2	71	75	PF04695	0.445
LIG_Rb_pABgroove_1	118	126	PF01858	0.378
LIG_SH2_STAT5	293	296	PF00017	0.378
LIG_SH3_3	58	64	PF00018	0.602
LIG_SUMO_SIM_par_1	157	162	PF11976	0.378
LIG_UBA3_1	392	397	PF00899	0.510
LIG_WRC_WIRS_1	267	272	PF05994	0.472
MOD_CDK_SPK_2	324	329	PF00069	0.378
MOD_CK1_1	133	139	PF00069	0.338
MOD_CK1_1	205	211	PF00069	0.377
MOD_CK1_1	21	27	PF00069	0.654
MOD_CK1_1	4	10	PF00069	0.608
MOD_CK1_1	40	46	PF00069	0.341
MOD_CK2_1	257	263	PF00069	0.718
MOD_CK2_1	268	274	PF00069	0.471
MOD_CK2_1	381	387	PF00069	0.575
MOD_CK2_1	90	96	PF00069	0.642
MOD_CMANNOS	243	246	PF00535	0.378
MOD_GlcNHglycan	233	236	PF01048	0.475
MOD_GlcNHglycan	270	273	PF01048	0.687
MOD_GlcNHglycan	42	45	PF01048	0.661
MOD_GSK3_1	126	133	PF00069	0.378
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	114	119	PF00069	0.416
MOD_NEK2_1	376	381	PF00069	0.521
MOD_NEK2_1	54	59	PF00069	0.441
MOD_NEK2_1	81	86	PF00069	0.512
MOD_PIKK_1	108	114	PF00454	0.391
MOD_PIKK_1	126	132	PF00454	0.378
MOD_PK_1	381	387	PF00069	0.575
MOD_PKA_2	376	382	PF00069	0.524
MOD_PKA_2	88	94	PF00069	0.482
MOD_Plk_1	381	387	PF00069	0.494
MOD_Plk_4	18	24	PF00069	0.582
MOD_Plk_4	263	269	PF00069	0.665
MOD_Plk_4	305	311	PF00069	0.378
MOD_ProDKin_1	130	136	PF00069	0.341
MOD_ProDKin_1	222	228	PF00069	0.347
MOD_ProDKin_1	324	330	PF00069	0.378
MOD_SUMO_rev_2	210	220	PF00179	0.475
MOD_SUMO_rev_2	24	33	PF00179	0.577
TRG_DiLeu_BaEn_1	263	268	PF01217	0.660
TRG_ENDOCYTIC_2	166	169	PF00928	0.466
TRG_ENDOCYTIC_2	310	313	PF00928	0.319
TRG_ENDOCYTIC_2	68	71	PF00928	0.450
TRG_ER_diArg_1	142	144	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW4	Leptomonas seymouri	63%	99%
A0A0S4IRF8	Bodo saltans	32%	87%
A0A179HLJ8	Purpureocillium lilacinum	31%	100%
A0A3S5H6P9	Leishmania donovani	94%	99%
A4HVR7	Leishmania infantum	94%	99%
E9APG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P64760	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	36%	100%
P9WKP2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	100%
P9WKP3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	100%
Q02883	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	86%
Q58CN9	Bos taurus	39%	100%
Q5RCU3	Pongo abelii	38%	100%
Q6IQ20	Homo sapiens	39%	100%
Q769K2	Rattus norvegicus	39%	100%
Q8BH82	Mus musculus	38%	100%
Q965X7	Caenorhabditis elegans	32%	100%
Q965X9	Caenorhabditis elegans	33%	100%