Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG14_LEIMA

TriTrypDb:

LmjF.13.1400 , LMJLV39_130018300 , LMJSD75_130018300

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QG14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.524
CLV_C14_Caspase3-7	453	457	PF00656	0.439
CLV_NRD_NRD_1	295	297	PF00675	0.637
CLV_NRD_NRD_1	448	450	PF00675	0.489
CLV_NRD_NRD_1	533	535	PF00675	0.505
CLV_NRD_NRD_1	62	64	PF00675	0.501
CLV_PCSK_KEX2_1	29	31	PF00082	0.567
CLV_PCSK_KEX2_1	295	297	PF00082	0.637
CLV_PCSK_KEX2_1	448	450	PF00082	0.403
CLV_PCSK_KEX2_1	533	535	PF00082	0.505
CLV_PCSK_KEX2_1	62	64	PF00082	0.502
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.567
CLV_PCSK_SKI1_1	363	367	PF00082	0.538
CLV_PCSK_SKI1_1	388	392	PF00082	0.620
CLV_PCSK_SKI1_1	449	453	PF00082	0.346
CLV_PCSK_SKI1_1	533	537	PF00082	0.525
CLV_PCSK_SKI1_1	62	66	PF00082	0.562
CLV_Separin_Metazoa	627	631	PF03568	0.622
DEG_APCC_DBOX_1	414	422	PF00400	0.499
DEG_APCC_DBOX_1	53	61	PF00400	0.656
DEG_SCF_FBW7_1	537	542	PF00400	0.579
DOC_ANK_TNKS_1	46	53	PF00023	0.614
DOC_CKS1_1	431	436	PF01111	0.476
DOC_CKS1_1	500	505	PF01111	0.555
DOC_CYCLIN_yCln2_LP_2	3	6	PF00134	0.561
DOC_MAPK_DCC_7	395	405	PF00069	0.465
DOC_MAPK_gen_1	67	76	PF00069	0.632
DOC_MAPK_MEF2A_6	411	418	PF00069	0.558
DOC_PP2B_LxvP_1	3	6	PF13499	0.527
DOC_PP2B_LxvP_1	414	417	PF13499	0.479
DOC_USP7_MATH_1	111	115	PF00917	0.495
DOC_USP7_MATH_1	129	133	PF00917	0.719
DOC_USP7_MATH_1	305	309	PF00917	0.650
DOC_USP7_MATH_1	383	387	PF00917	0.623
DOC_USP7_MATH_1	539	543	PF00917	0.572
DOC_USP7_MATH_1	87	91	PF00917	0.528
DOC_USP7_UBL2_3	653	657	PF12436	0.504
DOC_WW_Pin1_4	127	132	PF00397	0.566
DOC_WW_Pin1_4	139	144	PF00397	0.476
DOC_WW_Pin1_4	200	205	PF00397	0.506
DOC_WW_Pin1_4	258	263	PF00397	0.625
DOC_WW_Pin1_4	430	435	PF00397	0.473
DOC_WW_Pin1_4	499	504	PF00397	0.451
DOC_WW_Pin1_4	535	540	PF00397	0.535
LIG_14-3-3_CanoR_1	184	189	PF00244	0.492
LIG_14-3-3_CanoR_1	346	354	PF00244	0.585
LIG_14-3-3_CanoR_1	388	393	PF00244	0.595
LIG_14-3-3_CanoR_1	395	403	PF00244	0.500
LIG_14-3-3_CanoR_1	415	425	PF00244	0.205
LIG_14-3-3_CanoR_1	449	459	PF00244	0.480
LIG_14-3-3_CanoR_1	533	538	PF00244	0.484
LIG_14-3-3_CanoR_1	641	647	PF00244	0.618
LIG_FHA_1	197	203	PF00498	0.565
LIG_FHA_1	375	381	PF00498	0.599
LIG_FHA_1	395	401	PF00498	0.519
LIG_FHA_1	500	506	PF00498	0.509
LIG_FHA_1	615	621	PF00498	0.490
LIG_FHA_1	637	643	PF00498	0.508
LIG_FHA_2	165	171	PF00498	0.344
LIG_FHA_2	18	24	PF00498	0.582
LIG_FHA_2	389	395	PF00498	0.522
LIG_FHA_2	484	490	PF00498	0.632
LIG_FHA_2	73	79	PF00498	0.559
LIG_LIR_Gen_1	556	564	PF02991	0.488
LIG_LIR_Gen_1	648	656	PF02991	0.655
LIG_LIR_Nem_3	518	522	PF02991	0.382
LIG_LIR_Nem_3	648	654	PF02991	0.620
LIG_LIR_Nem_3	98	103	PF02991	0.516
LIG_MYND_1	2	6	PF01753	0.623
LIG_Pex14_2	602	606	PF04695	0.415
LIG_SH2_CRK	651	655	PF00017	0.630
LIG_SH2_NCK_1	522	526	PF00017	0.460
LIG_SH2_SRC	511	514	PF00017	0.465
LIG_SH2_SRC	522	525	PF00017	0.362
LIG_SH2_STAP1	290	294	PF00017	0.548
LIG_SH2_STAT3	186	189	PF00017	0.493
LIG_SH2_STAT3	478	481	PF00017	0.536
LIG_SH2_STAT5	164	167	PF00017	0.357
LIG_SH2_STAT5	186	189	PF00017	0.408
LIG_SH2_STAT5	247	250	PF00017	0.472
LIG_SH2_STAT5	478	481	PF00017	0.426
LIG_SH2_STAT5	632	635	PF00017	0.536
LIG_SH3_3	201	207	PF00018	0.618
LIG_SH3_3	421	427	PF00018	0.398
LIG_SH3_3	637	643	PF00018	0.572
LIG_SUMO_SIM_anti_2	71	78	PF11976	0.602
LIG_SUMO_SIM_par_1	71	78	PF11976	0.617
LIG_TRAF2_1	136	139	PF00917	0.714
LIG_TRAF2_1	486	489	PF00917	0.646
LIG_TRAF2_1	69	72	PF00917	0.704
LIG_TRFH_1	535	539	PF08558	0.560
LIG_WW_3	627	631	PF00397	0.622
MOD_CDK_SPxK_1	127	133	PF00069	0.583
MOD_CDK_SPxxK_3	203	210	PF00069	0.646
MOD_CK1_1	125	131	PF00069	0.610
MOD_CK1_1	203	209	PF00069	0.610
MOD_CK1_1	309	315	PF00069	0.598
MOD_CK1_1	86	92	PF00069	0.440
MOD_CK2_1	17	23	PF00069	0.635
MOD_CK2_1	483	489	PF00069	0.632
MOD_CK2_1	616	622	PF00069	0.551
MOD_CK2_1	642	648	PF00069	0.614
MOD_Cter_Amidation	60	63	PF01082	0.574
MOD_GlcNHglycan	113	116	PF01048	0.551
MOD_GlcNHglycan	123	127	PF01048	0.479
MOD_GlcNHglycan	194	197	PF01048	0.495
MOD_GlcNHglycan	262	265	PF01048	0.612
MOD_GlcNHglycan	308	311	PF01048	0.541
MOD_GlcNHglycan	349	352	PF01048	0.638
MOD_GlcNHglycan	385	388	PF01048	0.664
MOD_GlcNHglycan	577	582	PF01048	0.768
MOD_GlcNHglycan	85	88	PF01048	0.439
MOD_GlcNHglycan	89	92	PF01048	0.526
MOD_GSK3_1	125	132	PF00069	0.527
MOD_GSK3_1	192	199	PF00069	0.567
MOD_GSK3_1	305	312	PF00069	0.610
MOD_GSK3_1	331	338	PF00069	0.520
MOD_GSK3_1	374	381	PF00069	0.614
MOD_GSK3_1	535	542	PF00069	0.486
MOD_GSK3_1	573	580	PF00069	0.753
MOD_GSK3_1	610	617	PF00069	0.503
MOD_GSK3_1	79	86	PF00069	0.497
MOD_GSK3_1	87	94	PF00069	0.509
MOD_LATS_1	361	367	PF00433	0.459
MOD_N-GLC_1	196	201	PF02516	0.604
MOD_NEK2_1	192	197	PF00069	0.449
MOD_NEK2_1	396	401	PF00069	0.452
MOD_NEK2_1	450	455	PF00069	0.529
MOD_NEK2_1	83	88	PF00069	0.458
MOD_NEK2_2	290	295	PF00069	0.507
MOD_NEK2_2	460	465	PF00069	0.438
MOD_NEK2_2	636	641	PF00069	0.506
MOD_PKA_1	29	35	PF00069	0.567
MOD_PKA_1	295	301	PF00069	0.443
MOD_PKA_1	533	539	PF00069	0.474
MOD_PKA_2	116	122	PF00069	0.461
MOD_PKA_2	29	35	PF00069	0.567
MOD_PKA_2	295	301	PF00069	0.443
MOD_PKA_2	318	324	PF00069	0.526
MOD_PKA_2	394	400	PF00069	0.475
MOD_PKA_2	533	539	PF00069	0.488
MOD_Plk_1	17	23	PF00069	0.632
MOD_Plk_1	290	296	PF00069	0.620
MOD_Plk_1	91	97	PF00069	0.562
MOD_Plk_2-3	72	78	PF00069	0.585
MOD_Plk_4	331	337	PF00069	0.477
MOD_Plk_4	396	402	PF00069	0.425
MOD_Plk_4	474	480	PF00069	0.567
MOD_Plk_4	610	616	PF00069	0.605
MOD_Plk_4	72	78	PF00069	0.581
MOD_Plk_4	79	85	PF00069	0.491
MOD_Plk_4	95	101	PF00069	0.317
MOD_ProDKin_1	127	133	PF00069	0.580
MOD_ProDKin_1	139	145	PF00069	0.470
MOD_ProDKin_1	200	206	PF00069	0.510
MOD_ProDKin_1	258	264	PF00069	0.614
MOD_ProDKin_1	430	436	PF00069	0.481
MOD_ProDKin_1	499	505	PF00069	0.443
MOD_ProDKin_1	535	541	PF00069	0.544
TRG_DiLeu_BaEn_1	524	529	PF01217	0.470
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.565
TRG_ENDOCYTIC_2	599	602	PF00928	0.503
TRG_ENDOCYTIC_2	651	654	PF00928	0.597
TRG_ER_diArg_1	294	296	PF00400	0.392
TRG_ER_diArg_1	448	450	PF00400	0.488
TRG_ER_diArg_1	533	535	PF00400	0.505
TRG_ER_diArg_1	62	64	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM77	Leptomonas seymouri	57%	80%
A0A1X0NK49	Trypanosomatidae	34%	93%
A0A3Q8II43	Leishmania donovani	94%	100%
A4H7C2	Leishmania braziliensis	81%	84%
A4HVR8	Leishmania infantum	94%	100%
D0A6H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
E9APG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5BHJ9	Trypanosoma cruzi	36%	98%