Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG12_LEIMA

TriTrypDb:

LmjF.13.1420 , LMJLV39_130018500 , LMJSD75_130018600

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.400
CLV_NRD_NRD_1	54	56	PF00675	0.501
CLV_PCSK_KEX2_1	112	114	PF00082	0.400
CLV_PCSK_KEX2_1	231	233	PF00082	0.572
CLV_PCSK_KEX2_1	54	56	PF00082	0.501
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.628
CLV_PCSK_SKI1_1	196	200	PF00082	0.345
CLV_PCSK_SKI1_1	2	6	PF00082	0.432
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SPOP_SBC_1	74	78	PF00917	0.560
DOC_CKS1_1	44	49	PF01111	0.471
DOC_MAPK_gen_1	190	199	PF00069	0.438
DOC_MAPK_RevD_3	98	113	PF00069	0.380
DOC_USP7_MATH_1	30	34	PF00917	0.664
DOC_USP7_MATH_1	84	88	PF00917	0.432
DOC_WW_Pin1_4	135	140	PF00397	0.551
DOC_WW_Pin1_4	150	155	PF00397	0.611
DOC_WW_Pin1_4	26	31	PF00397	0.621
DOC_WW_Pin1_4	43	48	PF00397	0.486
LIG_14-3-3_CanoR_1	137	143	PF00244	0.531
LIG_14-3-3_CanoR_1	147	156	PF00244	0.600
LIG_14-3-3_CanoR_1	175	182	PF00244	0.479
LIG_14-3-3_CanoR_1	232	239	PF00244	0.530
LIG_14-3-3_CanoR_1	54	58	PF00244	0.551
LIG_Actin_WH2_2	6	24	PF00022	0.408
LIG_FHA_1	120	126	PF00498	0.452
LIG_FHA_1	151	157	PF00498	0.524
LIG_FHA_1	5	11	PF00498	0.413
LIG_FHA_1	69	75	PF00498	0.719
LIG_FHA_2	125	131	PF00498	0.438
LIG_FHA_2	44	50	PF00498	0.487
LIG_LIR_Gen_1	111	118	PF02991	0.408
LIG_LIR_Gen_1	48	57	PF02991	0.465
LIG_LIR_Nem_3	111	117	PF02991	0.369
LIG_LIR_Nem_3	48	53	PF02991	0.455
LIG_MYND_1	154	158	PF01753	0.471
LIG_SH2_STAP1	114	118	PF00017	0.440
LIG_SH2_STAT5	92	95	PF00017	0.455
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.457
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.480
LIG_SUMO_SIM_par_1	124	130	PF11976	0.391
LIG_SUMO_SIM_par_1	196	202	PF11976	0.407
LIG_TRAF2_1	161	164	PF00917	0.564
LIG_UBA3_1	5	12	PF00899	0.442
MOD_CK1_1	150	156	PF00069	0.598
MOD_CK1_1	43	49	PF00069	0.467
MOD_CK2_1	124	130	PF00069	0.449
MOD_CK2_1	174	180	PF00069	0.333
MOD_CK2_1	5	11	PF00069	0.389
MOD_CK2_1	53	59	PF00069	0.456
MOD_GlcNHglycan	2	5	PF01048	0.489
MOD_GlcNHglycan	33	36	PF01048	0.723
MOD_GlcNHglycan	48	53	PF01048	0.603
MOD_GlcNHglycan	77	80	PF01048	0.622
MOD_GSK3_1	126	133	PF00069	0.396
MOD_GSK3_1	26	33	PF00069	0.627
MOD_GSK3_1	73	80	PF00069	0.654
MOD_NEK2_1	5	10	PF00069	0.408
MOD_PKA_2	174	180	PF00069	0.378
MOD_PKA_2	53	59	PF00069	0.544
MOD_Plk_1	48	54	PF00069	0.474
MOD_Plk_1	59	65	PF00069	0.546
MOD_Plk_2-3	124	130	PF00069	0.461
MOD_Plk_4	40	46	PF00069	0.543
MOD_Plk_4	5	11	PF00069	0.434
MOD_ProDKin_1	135	141	PF00069	0.556
MOD_ProDKin_1	150	156	PF00069	0.608
MOD_ProDKin_1	26	32	PF00069	0.625
MOD_ProDKin_1	43	49	PF00069	0.478
MOD_SUMO_for_1	216	219	PF00179	0.475
MOD_SUMO_rev_2	186	191	PF00179	0.443
MOD_SUMO_rev_2	219	224	PF00179	0.513
TRG_DiLeu_BaEn_1	130	135	PF01217	0.509
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.460
TRG_ENDOCYTIC_2	114	117	PF00928	0.443
TRG_ENDOCYTIC_2	92	95	PF00928	0.438
TRG_ER_diArg_1	112	114	PF00400	0.408
TRG_ER_diArg_1	17	20	PF00400	0.466
TRG_ER_diArg_1	53	55	PF00400	0.494
TRG_NLS_MonoCore_2	230	235	PF00514	0.643
TRG_NLS_MonoExtC_3	230	236	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Q3	Leptomonas seymouri	49%	100%
A0A3S7WSS0	Leishmania donovani	88%	97%
A0A422P490	Trypanosoma rangeli	34%	100%
A4H7C4	Leishmania braziliensis	75%	97%
A4HVS9	Leishmania infantum	88%	97%
E9APG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%